LOCUS       NM_001013653            1209 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens leucine rich repeat containing 26 (LRRC26), mRNA.
ACCESSION   NM_001013653 XM_372161
VERSION     NM_001013653.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1209)
  AUTHORS   Li,Q., Fan,F., Kwak,H.R. and Yan,J.
  TITLE     Molecular basis for differential modulation of BK channel
            voltage-dependent gating by auxiliary gamma subunits
  JOURNAL   J Gen Physiol 145 (6), 543-554 (2015)
   PUBMED   26009545
  REMARK    GeneRIF: Suggest that BK channel modulation by auxiliary gamma
            subunits depends on intra- and/or juxta-membrane mechanisms.
REFERENCE   2  (bases 1 to 1209)
  AUTHORS   Tian,Y., Ullrich,F., Xu,R., Heinemann,S.H., Hou,S. and Hoshi,T.
  TITLE     Two distinct effects of PIP2 underlie auxiliary subunit-dependent
            modulation of Slo1 BK channels
  JOURNAL   J Gen Physiol 145 (4), 331-343 (2015)
   PUBMED   25825171
REFERENCE   3  (bases 1 to 1209)
  AUTHORS   Gonzalez-Perez,V., Xia,X.M. and Lingle,C.J.
  TITLE     Functional regulation of BK potassium channels by gamma1 auxiliary
            subunits
  JOURNAL   Proc Natl Acad Sci U S A 111 (13), 4868-4873 (2014)
   PUBMED   24639523
  REMARK    GeneRIF: Regulation of the Ca(2+)- and voltage-activated large
            conductance Ca(2+)-activated K(+) (BK) channel by associated
            gamma1-subunits, was investigated.
REFERENCE   4  (bases 1 to 1209)
  AUTHORS   Yan,J. and Aldrich,R.W.
  TITLE     BK potassium channel modulation by leucine-rich repeat-containing
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 109 (20), 7917-7922 (2012)
   PUBMED   22547800
REFERENCE   5  (bases 1 to 1209)
  AUTHORS   Liu,X.F., Xiang,L., Zhang,Y., Becker,K.G., Bera,T.K. and Pastan,I.
  TITLE     CAPC negatively regulates NF-kappaB activation and suppresses tumor
            growth and metastasis
  JOURNAL   Oncogene 31 (13), 1673-1682 (2012)
   PUBMED   21822313
  REMARK    GeneRIF: The role of CAPC in the suppression of tumor growth and
            metastasis may be through its alteration of the tumor
            microenvironment.
REFERENCE   6  (bases 1 to 1209)
  AUTHORS   Yan,J. and Aldrich,R.W.
  TITLE     LRRC26 auxiliary protein allows BK channel activation at resting
            voltage without calcium
  JOURNAL   Nature 466 (7305), 513-516 (2010)
   PUBMED   20613726
  REMARK    GeneRIF: in non-excitable LNCaP prostate cancer cells, BK channels
            can be activated at negative voltages without rises in [Ca(2+)](i)
            through their complex with an auxiliary protein, leucine-rich
            repeat (LRR)-containing protein 26 (LRRC26)
REFERENCE   7  (bases 1 to 1209)
  AUTHORS   Anaganti,S., Hansen,J.K., Ha,D., Hahn,Y., Chertov,O., Pastan,I. and
            Bera,T.K.
  TITLE     Non-AUG translational initiation of a short CAPC transcript
            generating protein isoform
  JOURNAL   Biochem Biophys Res Commun 380 (3), 508-513 (2009)
   PUBMED   19250639
  REMARK    GeneRIF: CAPC transcripts have differential expression in cancer
            cell lines, and that S-CAPC is translated into a 7.5 kDa protein
            using a non-AUG start codon.
REFERENCE   8  (bases 1 to 1209)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   9  (bases 1 to 1209)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 1209)
  AUTHORS   Egland,K.A., Liu,X.F., Squires,S., Nagata,S., Man,Y.G., Bera,T.K.,
            Onda,M., Vincent,J.J., Strausberg,R.L., Lee,B. and Pastan,I.
  TITLE     High expression of a cytokeratin-associated protein in many cancers
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5929-5934 (2006)
   PUBMED   16585525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929554.20.
            
            On Jun 8, 2020 this sequence version replaced NM_001013653.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140911.1, SRR18074968.1226872.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2150585
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371542.3/ ENSP00000360597.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-781               AL929554.20        82534-83314         c
            782-1209            AL929554.20        82021-82448         c
FEATURES             Location/Qualifiers
     source          1..1209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1209
                     /gene="LRRC26"
                     /gene_synonym="bA350O14.10; CAPC"
                     /note="leucine rich repeat containing 26"
                     /db_xref="GeneID:389816"
                     /db_xref="HGNC:HGNC:31409"
                     /db_xref="MIM:613505"
     exon            1..781
                     /gene="LRRC26"
                     /gene_synonym="bA350O14.10; CAPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1113
                     /gene="LRRC26"
                     /gene_synonym="bA350O14.10; CAPC"
                     /note="cytokeratin associated protein; leucine-rich
                     repeat-containing protein 26; cytokeratin-associated
                     protein in cancer; BK channel auxilliary gamma subunit
                     LRRC26; BK channel auxiliary gamma subunit LRRC26"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 26
                     precursor"
                     /protein_id="NP_001013675.1"
                     /db_xref="CCDS:CCDS35184.1"
                     /db_xref="GeneID:389816"
                     /db_xref="HGNC:HGNC:31409"
                     /db_xref="MIM:613505"
                     /translation="MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCP
                     EVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDL
                     RENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEP
                     AALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR
                     HPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVS
                     LASCLALGSGLTACRARRRRLRTAALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA
                     "
     exon            782..1209
                     /gene="LRRC26"
                     /gene_synonym="bA350O14.10; CAPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1188..1193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC26"
                     /gene_synonym="bA350O14.10; CAPC"
                     /note="hexamer: AACAAG"
     polyA_site      1209
                     /gene="LRRC26"
                     /gene_synonym="bA350O14.10; CAPC"
                     /note="major polyA site"
ORIGIN      
        1 aatatttgtg caggcgccgc aggaacgggc tccgcggacg acgggctcca gggacgcaca
       61 ggcagcgggc ctcccaccgc gggtgccggg ggcggggggg ctgcccccat gcggggccct
      121 tcctggtcgc ggcctcggcc gctgctgctg ctgttgctgc tgctgtcgcc ttggcctgtc
      181 tgggcccagg tgtcggccac ggcctcgccc tcggggtccc tgggcgcccc ggactgcccc
      241 gaggtgtgca cgtgcgtgcc gggaggcctg gccagctgct cggcactctc gctgcccgcc
      301 gtgcccccgg gcctgagcct gcgcctgcgc gcgctgctgc tggaccacaa ccgcgtccgt
      361 gcgctgccgc caggtgcctt cgcgggagcg ggcgcgctac agcgcctgga cctgcgcgag
      421 aacgggctgc actcggtgca tgtgcgagcc ttctggggcc tgggcgcgct gcagctgctg
      481 gacctgagcg ccaaccagct ggaagcactg gcaccaggga ctttcgcgcc gctgcgcgcg
      541 ctgcgcaacc tctcattggc cggcaaccgg ctggcgcgcc tggagcccgc ggcgctaggc
      601 gcgctcccgc tgctgcgctc actcagcctg caggacaacg agctggcggc actcgcgccg
      661 gggctgctgg gccgcctgcc cgctctagac gcgctgcacc tgcgcggcaa cccttggggc
      721 tgcgggtgcg cgctgcgccc gctctgcgcc tggctgcgcc ggcacccgct gcccgcgtca
      781 gaggccgaga cggtgctctg cgtgtggccg ggacgcctga cgctcagccc cctgactgcc
      841 ttttccgacg ccgcctttag ccattgcgcg cagccgctcg ccctgcggga cctggccgtg
      901 gtttacacgc tcgggccggc ctccttcctc gtcagcctgg cttcctgcct ggcgctgggc
      961 tctgggctca ccgcctgccg tgcgcgccgc cgccgcctcc gcaccgccgc cctccgcccg
     1021 ccgagaccgc cagacccgaa ccccgatccc gacccccacg gctgtgcctc gcccgcggac
     1081 ccggggagcc ccgccgctgc cgcccaagcc tgagcggccg cggccgcctg gagcgctcga
     1141 agcttccccc atgcctttgc cctcccttta cactgtctgc cggcgtcaac aagcgacaca
     1201 gaccgaaaa
//
