LOCUS       NM_001024678            1762 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens leucine rich repeat containing 24 (LRRC24), mRNA.
ACCESSION   NM_001024678 XM_496997
VERSION     NM_001024678.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084125.9 and BC111067.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001024678.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111067.1, BX419109.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568, SAMEA2154125
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000529415.7/ ENSP00000434849.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC084125.9         101718-101726
            10-1613             BC111067.1         1-1604
            1614-1614           AC084125.9         106215-106215
            1615-1762           BC111067.1         1606-1753
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1762
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /note="leucine rich repeat containing 24"
                     /db_xref="GeneID:441381"
                     /db_xref="HGNC:HGNC:28947"
                     /db_xref="MIM:620672"
     exon            1..74
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /inference="alignment:Splign:2.1.0"
     exon            75..292
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1675
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /note="leucine-rich repeat-containing protein 24"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 24
                     precursor"
                     /protein_id="NP_001019849.2"
                     /db_xref="CCDS:CCDS34969.1"
                     /db_xref="GeneID:441381"
                     /db_xref="HGNC:HGNC:28947"
                     /db_xref="MIM:620672"
                     /translation="MALRAPALLPLLLLLLPLRAAGCPAACRCYSATVECGALRLRVV
                     PLGIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLE
                     LALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIEL
                     LEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAW
                     IKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLGED
                     LRVACQASGYPQPLVTWRKVPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSN
                     ITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPEAG
                     SMAFRALGVATQTAIAAAIALLALTALLLVAMICRRRRRRKKARGPPGEGALFVNDYL
                     DGPCTFAQLEELRDERGHEMFVINRSKPLFAEGPAEAPADCGPEQGAGPGLRVPPPVA
                     YEIHC"
     exon            293..571
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /inference="alignment:Splign:2.1.0"
     exon            572..740
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1762
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1742..1747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /note="hexamer: AGTAAA"
     polyA_site      1762
                     /gene="LRRC24"
                     /gene_synonym="LRRC14OS"
                     /note="major polyA site"
ORIGIN      
        1 ctcccagccc ggcgactgct cgggcccggc cgccacctgc acggcggggg agccgctcgc
       61 cgcgggagcg tcaggagggc acgcgtctgc ggctgaaccg cggaagggcc ggtgaggaac
      121 cgggcctcgg gagatggccc tgagggcccc cgcactgctg ccgctgctgc tgctactact
      181 gccgctccgc gccgccggct gcccagcagc ctgccgctgc tacagcgcca cggtggagtg
      241 tggcgccctg cggttgcgcg tcgtcccgct gggaatcccg ccagggacgc agacactgtt
      301 cctgcaggac aacaacatcg cccgcctaga gccgggagcc ctggcgccac tcgccgctct
      361 gcgccggctc tacctgcaca acaacagcct gcgcgccctg gaggccggcg ccttccgcgc
      421 gcagccgcgc ctgctggagc tggcgctcac tagcaaccgg ctgcgcggct tgcgcagcgg
      481 cgccttcgta ggcctggccc agctgcgcgt gctctacctg gcgggcaacc agctggcgcg
      541 gctgctggat ttcaccttct tgcacctgcc gcgactgcag gagcttcacc tgcaagaaaa
      601 cagcattgag ctgctggagg accaggctct agcggggctg tcctccctag cactgctgga
      661 cctcagcagg aaccagctgg gcaccatcag ccgagaggcc ctgcagcccc tggccagtct
      721 gcaagtcctg cgcctcacag agaacccatg gcgctgtgac tgcgccctgc actggctggg
      781 tgcctggatc aaggagggcg gccagcggct gctcacctcc agggacagga agatcatgtg
      841 tgcagagccc ccgcgcctgg cgctccagag tctcctggac gtatcccaca gcagcctcat
      901 ctgcattccg ccctctgtcc acgtgcagcc gctggagctc acagccaacc tgggtgagga
      961 cctgcgggtt gcctgccaag cctccggcta cccgcagcca ttggtgacct ggagaaaggt
     1021 gccccagcct cgcgagggcc ggccgcgagc ccaggcccag ctagaaggcg ggttgctggg
     1081 cctgggcgga cactcggcat ccgacacggg cagcggcatg ctcttcctca gcaacatcac
     1141 gctggcgcac gccggtaagt acgagtgcga ggcctccaac gccggcggcg ctgcccgcgt
     1201 gcccttccgg ctcctggtca acgcgtcccg gcagcagccg cagcagcccg cgcaaccgcc
     1261 gcctccggcc gcccgccccg ccggcagcga gccccggccc gaggcgggca gcatggcctt
     1321 ccgcgccctg ggcgtggcca cacagacggc cattgcggcg gccatcgcgc tgctggcgct
     1381 cacggcgctg ctcctggtcg ccatgatctg tcgccggcgc cgcaggcgaa aaaaggcgcg
     1441 ggggcctccg ggggagggag cgctgttcgt caacgactac ttggacggcc cctgtacgtt
     1501 cgcacagcta gaggagctcc gcgacgagcg cggccacgag atgttcgtca tcaaccgctc
     1561 caagccgctc ttcgccgagg gtccggcgga ggcgcccgct gactgcggcc cggaacaggg
     1621 ggcggggccg ggactccgcg tgcccccgcc ggtcgcctac gagatccact gctagggccg
     1681 cgggcgcgcg gatgacgtgg gcgccggaga ttggccggtg cggcctcgcg catgctccgt
     1741 cagtaaaggt ggaagccgcg ca
//
