LOCUS       NM_001135217            1698 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens leucine rich repeat containing 23 (LRRC23), transcript
            variant 3, mRNA.
ACCESSION   NM_001135217
VERSION     NM_001135217.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Tang,S.X., Liu,S.Y., Xiao,H., Zhang,X., Xiao,Z., Zhou,S.,
            Ding,Y.L., Yang,P., Chen,Q., Huang,H.L., Chen,X., Lin,X., Zhou,H.L.
            and Liu,M.X.
  TITLE     Novel mutations in LRRC23 cause asthenozoospermia in a
            nonconsanguineous family
  JOURNAL   Asian J Androl 26 (5), 484-489 (2024)
   PUBMED   39054792
  REMARK    GeneRIF: Novel mutations in LRRC23 cause asthenozoospermia in a
            nonconsanguineous family.
REFERENCE   2  (bases 1 to 1698)
  AUTHORS   Hwang,J.Y., Chai,P., Nawaz,S., Choi,J., Lopez-Giraldez,F.,
            Hussain,S., Bilguvar,K., Mane,S., Lifton,R.P., Ahmad,W., Zhang,K.
            and Chung,J.J.
  TITLE     LRRC23 truncation impairs radial spoke 3 head assembly and sperm
            motility underlying male infertility
  JOURNAL   Elife 12, 90095 (2023)
   PUBMED   38091523
  REMARK    GeneRIF: LRRC23 truncation impairs radial spoke 3 head assembly and
            sperm motility underlying male infertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1698)
  AUTHORS   Li,Y., Zhang,Q., Tan,Q., Sha,X., Gao,Y., Hua,R., Zhou,P., Wei,Z.,
            He,X., Cao,Y., Li,T. and Wu,H.
  TITLE     LRRC23 deficiency causes male infertility with idiopathic
            asthenozoospermia by disrupting the assembly of radial spokes
  JOURNAL   Clin Genet 104 (6), 694-699 (2023)
   PUBMED   37804054
  REMARK    GeneRIF: LRRC23 deficiency causes male infertility with idiopathic
            asthenozoospermia by disrupting the assembly of radial spokes.
REFERENCE   4  (bases 1 to 1698)
  AUTHORS   Zhang,X., Sun,J., Lu,Y., Zhang,J., Shimada,K., Noda,T., Zhao,S.,
            Koyano,T., Matsuyama,M., Zhou,S., Wu,J., Ikawa,M. and Liu,M.
  TITLE     LRRC23 is a conserved component of the radial spoke that is
            necessary for sperm motility and male fertility in mice
  JOURNAL   J Cell Sci 134 (20) (2021)
   PUBMED   34585727
REFERENCE   5  (bases 1 to 1698)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1698)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 1698)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1698)
  AUTHORS   Tasheva,E.S., An,K., Boyle,D.L. and Conrad,G.W.
  TITLE     Expression and localization of leucine-rich B7 protein in human
            ocular tissues
  JOURNAL   Mol Vis 11, 452-460 (2005)
   PUBMED   16030496
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1698)
  AUTHORS   Ansari-Lari,M.A., Shen,Y., Muzny,D.M., Lee,W. and Gibbs,R.A.
  TITLE     Large-scale sequencing in human chromosome 12p13: experimental and
            computational gene structure determination
  JOURNAL   Genome Res 7 (3), 268-280 (1997)
   PUBMED   9074930
REFERENCE   10 (bases 1 to 1698)
  AUTHORS   Ansari-Lari,M.A., Muzny,D.M., Lu,J., Lu,F., Lilley,C.E., Spanos,S.,
            Malley,T. and Gibbs,R.A.
  TITLE     A gene-rich cluster between the CD4 and triosephosphate isomerase
            genes at human chromosome 12p13
  JOURNAL   Genome Res 6 (4), 314-326 (1996)
   PUBMED   8723724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292367.1, DB027456.1, AK292291.1 and AI524335.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001135217.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 3 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292291.1, AK223535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443597.7/ ENSP00000390932.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AK292367.1         90-130
            42-148              DB027456.1         1-107
            149-1697            AK292291.1         1-1549
            1698-1698           AI524335.1         36-36               c
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1698
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /note="leucine rich repeat containing 23"
                     /db_xref="GeneID:10233"
                     /db_xref="HGNC:HGNC:19138"
                     /db_xref="MIM:620708"
     exon            1..254
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     exon            255..429
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1335
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /note="isoform a is encoded by transcript variant 3;
                     leucine-rich repeat-containing protein 23; leucine-rich
                     protein B7"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 23
                     isoform a"
                     /protein_id="NP_001128689.1"
                     /db_xref="CCDS:CCDS8569.1"
                     /db_xref="GeneID:10233"
                     /db_xref="HGNC:HGNC:19138"
                     /db_xref="MIM:620708"
                     /translation="MSDEDDLEDSEPDQDDSEKEEDEKETEEGEDYRKEGEEFPEEWL
                     PTPLTEDMMKEGLSLLCKTGNGLAHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENH
                     LTDLSPLNYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETL
                     NLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGINLPKLKNLYLAQNMLKKVEGL
                     EDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALV
                     LLDNPCTDETSYRQEALVQMPYLERLDKEFYEEEERAEADVIRQRLKEEKEQEPEPQR
                     DLEPEQSLI"
     exon            430..539
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     exon            540..793
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     exon            794..924
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1061
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1359
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1698
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1679..1684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /note="hexamer: AATAAA"
     polyA_site      1698
                     /gene="LRRC23"
                     /gene_synonym="LRPB7; SPGF92"
                     /note="major polyA site"
ORIGIN      
        1 atccgggttc ccgggacggg aaagtggcgt ggtaaccagg caactactga tcaatcccct
       61 ccccggctga tttgcgcatc aggtagtcgc cgctctactc tcaacggtgg cgagctgcag
      121 ttgccaagtg ccccgtcccc gttgccataa cagcagtaca caacccctcc ttcccctcgc
      181 ccgcttgcta aacagtcctt ccctctcggg accaagggcc tctccagaac tgcttctgat
      241 tgagcagaaa cagggaggag gactgagctt atctgactcc agagctttca ggagggaaga
      301 aagatgtcag atgaagatga tctagaagac tctgagccag accaggatga ttctgagaaa
      361 gaagaggacg agaaggagac agaggagggg gaggactaca gaaaagaggg ggaagagttc
      421 cctgaggaat ggctgcccac ccccctcacg gaggacatga tgaaggaagg gctttctctg
      481 ctctgtaaga caggcaatgg gctggctcat gcttatgtca agctggaggt taaagagagg
      541 gacctgacag acatctactt gctgcgctcc tacatccatc tgcgctatgt ggatatttct
      601 gagaaccacc tgacagacct gtctccactc aactacctca cccacctgct ctggctcaag
      661 gctgatggca atcggctgcg aagtgcccag atgaatgaac tgccctacct gcagattgct
      721 agttttgctt ataaccagat tactgacact gaaggcatct ctcatcctcg tcttgaaacc
      781 ctgaatctca aagggaacag catccacatg gtgacaggtc tggaccccga gaagttgatc
      841 agcctgcaca cagtggagct tcgggggaac cagctggaaa gcaccctggg aatcaatctt
      901 cctaagctga agaacctcta cctggcccaa aacatgctga agaaggtgga aggcttggag
      961 gatctgagca atctcaccac cttgcatctt cgagacaacc agattgacac cctgagtggc
     1021 ttctccagag aaatgaaatc attgcagtac ctcaacctga ggggcaacat ggtggccaac
     1081 ctgggggagc tggccaagct tcgagacctg cccaagctgc gagcgttggt gctgcttgat
     1141 aacccatgca cggacgaaac cagctaccgc caggaggccc tggtgcagat gccatacctt
     1201 gaacgcctgg acaaggaatt ctatgaggag gaggaacggg ctgaggctga tgtgattcga
     1261 cagaggctga aggaagaaaa ggagcaggag cctgagcccc agcgtgacct ggaacccgaa
     1321 cagtcattga tctagcagca gttctagcct ctaaagatag agatcaaaga cgctggcctt
     1381 cagacctgat cagactccca ggggcagcca ccacatgtat gacagagaac agaggatgcc
     1441 tgtttttgcc ccaaagctgg aaattcatca caacctgagg cccaggatct gctctgtgcc
     1501 ggtcctctgg gcagtgtggg gtgcagaatg gggtgcctag gcctgagcgt tgcctggagc
     1561 ctaggccggg ggccgccctc gggcaggcgt gggtgagagc caagaccgcg tgggccgcgg
     1621 ggtgctggta ggagtggttg gagagacttg cgaaggcggc tggggtgttc ggatttccaa
     1681 taaagaaaca gagtgatg
//
