LOCUS       NM_001278212            3074 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 20 (LRRC20), transcript
            variant 5, mRNA.
ACCESSION   NM_001278212
VERSION     NM_001278212.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Jahanshad,N., Rajagopalan,P., Hua,X., Hibar,D.P., Nir,T.M.,
            Toga,A.W., Jack,C.R. Jr., Saykin,A.J., Green,R.C., Weiner,M.W.,
            Medland,S.E., Montgomery,G.W., Hansell,N.K., McMahon,K.L., de
            Zubicaray,G.I., Martin,N.G., Wright,M.J. and Thompson,P.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide scan of healthy human connectome discovers SPON1 gene
            variant influencing dementia severity
  JOURNAL   Proc Natl Acad Sci U S A 110 (12), 4768-4773 (2013)
   PUBMED   23471985
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Kariuki,S.N., Franek,B.S., Kumar,A.A., Arrington,J.,
            Mikolaitis,R.A., Utset,T.O., Jolly,M., Crow,M.K., Skol,A.D. and
            Niewold,T.B.
  TITLE     Trait-stratified genome-wide association study identifies novel and
            diverse genetic associations with serologic and cytokine phenotypes
            in systemic lupus erythematosus
  JOURNAL   Arthritis Res Ther 12 (4), R151 (2010)
   PUBMED   20659327
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 3074)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 3074)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022532.13 and AL355138.19.
            
            On Nov 22, 2018 this sequence version replaced NM_001278212.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 4, and 5 all encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.672759.1,
                                           SRR1163657.225191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03568911 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446961.4/ ENSP00000413745.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC022532.13        146770-146846
            78-222              AC022532.13        152799-152943
            223-372             AC022532.13        188693-188842
            373-540             AC022532.13        205365-205532
            541-3074            AL355138.19        56640-59173         c
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..3074
                     /gene="LRRC20"
                     /note="leucine rich repeat containing 20"
                     /db_xref="GeneID:55222"
                     /db_xref="HGNC:HGNC:23421"
     exon            1..77
                     /gene="LRRC20"
                     /inference="alignment:Splign:2.1.0"
     exon            78..222
                     /gene="LRRC20"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..695
                     /gene="LRRC20"
                     /note="isoform 1 is encoded by transcript variant 5;
                     leucine-rich repeat-containing protein 20"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 20
                     isoform 1"
                     /protein_id="NP_001265141.1"
                     /db_xref="CCDS:CCDS7302.1"
                     /db_xref="GeneID:55222"
                     /db_xref="HGNC:HGNC:23421"
                     /translation="MLKKMGEAVARVARKVNETVESGSDTLDLAECKLVSFPIGIYKV
                     LRNVSGQIHLITLANNELKSLTSKFMTTFSQLRELHLEGNFLHRLPSEVSALQHLKAI
                     DLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV
                     RVIAPPLIKFDMLMSPEGARAPLP"
     exon            223..372
                     /gene="LRRC20"
                     /inference="alignment:Splign:2.1.0"
     exon            373..540
                     /gene="LRRC20"
                     /inference="alignment:Splign:2.1.0"
     exon            541..3074
                     /gene="LRRC20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3053..3058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC20"
                     /note="hexamer: AATAAA"
     polyA_site      3074
                     /gene="LRRC20"
                     /note="major polyA site"
ORIGIN      
        1 cggaactcgc ctggggcgcc gccggcggcg gagggagcgt gactgcgctg cgcagggcgc
       61 taggaggcat tgtcgccgct caggcccttt tgtgagaagc agaccagcct gggggctggc
      121 ggcaggacac ctgtgtctgc atgctgaaga agatgggtga ggccgtggcc agagtagcaa
      181 ggaaggtcaa cgagacggtg gagagcggct ctgacactct ggacctggcc gagtgcaagc
      241 tggtctcctt tcccattggc atctacaagg tcctgcggaa tgtctctggc cagatccacc
      301 tcatcaccct ggctaacaac gagcttaagt ccctcaccag caagttcatg accacattca
      361 gtcagctccg agagctccac ctggagggga acttcctaca ccgcctcccc agcgaggtca
      421 gtgccctgca gcacctcaag gccattgacc tgtcccggaa ccagttccag gacttccctg
      481 agcagcttac cgccctgccg gcgctggaga ccatcaacct ggaggagaac gagatcgtag
      541 atgtgcccgt ggagaagctg gccgccatgc cagccttgcg cagcatcaac ctccgcttca
      601 acccactcaa cgccgaggtg cgcgtgatcg ccccgccgct catcaagttt gacatgctca
      661 tgtctccgga aggcgcaaga gcccccctac cttaggccac cctcctcatg cccacccagc
      721 aaggggcaga ggccacaggc ctggaaccct ggaagggagg gaggcccatg ggaggccaag
      781 cctgggggct gggggcgggt gggccgagca gcacgtggtg ggtggggtgc agctggtctg
      841 gatagatagc ttacagcagt agtgggctct ggaatgccca agggaagagg caaggtgggg
      901 cctgcagcct ggactcggca ctcacagctg ctgtgcaaac tcaggcagat ctcctgccct
      961 ctctgagcct tgtcacttga aaaaaacagg accctttccc tcctttgggc tccctggagg
     1021 tttttaagca gtacgtgcct ccaagttacc tccagatcag caggcacagg tgggcattgc
     1081 caggtatttt ctgagcccct gcgggtttga ggccttgttt ttagtgctga gagccagttg
     1141 ctgccctgag aagagaagac aacctccatc tatttattgc ttcctgagaa ctgacctgga
     1201 tgcggccctc tgcagggccc agtcttcagt cctgtggtcc ctggactggt gggaacctga
     1261 actaggagtc ctgggagagc tgtggtggga atatgggctg gcactgctgc agggcaagaa
     1321 cattcatgta ggagcccgag gaccagcagg ctgggaatgg ggagcaagtc acgtcagctc
     1381 tgtcattccc cacagttaac aaattggcgg ggtgggaagt cctgagtgct ccgtccctct
     1441 agcatcactc ctgagctgcg ggagaggtgg cccagagaac agcagagtca gttacacctg
     1501 cagctcttgt ctaaagtgat tagatggcca ccctcaccac tgtccagtcc agcagcagcc
     1561 tggctgcctt gtcatggcct cctgggggca gaaggcgatg tggaccacgg gatttgtagc
     1621 cagccagctc ccaggccaac gcccaaagcc ctgatgacct ggttcttctg aggccctcaa
     1681 cctggcatct tagggtatgg tcaggcaaca gggtgaccag ctgtcctggt ttcccaggac
     1741 atggaacttt caatgctaaa actgggacag tacccagcaa gtggggatgg ttggtcccct
     1801 accaggagag ggcctggggc tcttgcttcc cgagaacgcc tgtggcttga agaaccttga
     1861 ctgcttggtc ctcaggtatc tacctcccac cttctcctca tctgtggagc aagccaactc
     1921 agtgccccag accccacctg atctgcatct ttgtttgcat ctccagagac acctgaggcc
     1981 ccagagcttg aggcaaagcc aggccgtcca aatcctgtgt gccgtggacg agtggccact
     2041 ttactactcc taaggctaag atgttgagag ctcagaccac tgctcagagc agtaatccct
     2101 gctcagaatg ctcccagttc cctcgtccct gcccaggtct cttgtctctt gggaaggaac
     2161 tgataggtcg ggccattgtt gggccatcac tgagcgctca gtatctcaag agactctgtt
     2221 cattctgctc gtatcccaag gcctggttgg tcaaactctg ggcaaagggt tttcaggatg
     2281 aggaggtcaa gacaggatct ccagagctac cgagttcatc tgtgggtgtt gggggcaagt
     2341 gggggctgaa gtcctgtgca ggctgcgctg gccccacctg ccttgtgccc tggagtgggg
     2401 tttctccttg ttgaagaaga ggcatccttc tctgatgtgc acaaacacaa tgtatgacca
     2461 gagccttgca actcaaagtg tggtctgtgg accagcagcg gcagtgacac ctgggagctt
     2521 gttaggaatg cagagtctag gcctcaccct atacctcccg actcagaccc tgcattttag
     2581 caagaccccc agctgattcc tataagcact ttagagtttg agaagcaagg acctaggctg
     2641 gggatgtcct ccgagcagag ggtgaagttt ctctcagttc tctccctgcc acttccaggg
     2701 atctgagcct gtgctcagcc tcctccctaa cccaccctgg gagacacttg gcctgttaga
     2761 ttgttccaga gtctgcatgg cactcctgaa gaagggagtg tgacctgcag tcaccaggag
     2821 atgagggtta ggtgtgccca gccctccaga cccggccttt ctggttaacc cctgcatgcc
     2881 aagctgcctg ctgccccagg tcctcacctc aggcctttga aggggcagct tctggaagtt
     2941 gttttctcct ctgcttggag agtttgccct tgtctgtctt ggaaagtgtg ggcagccaca
     3001 gatgccccca aatcagagct cacagtgagt gagcccctaa gcttcagtct gcaataaaga
     3061 atgcattggt ttca
//
