LOCUS       NM_024512               4890 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 2 (LRRC2), mRNA.
ACCESSION   NM_024512
VERSION     NM_024512.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4890)
  AUTHORS   Ng,A. and Xavier,R.J.
  TITLE     Leucine-rich repeat (LRR) proteins: integrators of pattern
            recognition and signaling in immunity
  JOURNAL   Autophagy 7 (9), 1082-1084 (2011)
   PUBMED   21606681
REFERENCE   2  (bases 1 to 4890)
  AUTHORS   Ng,A.C., Eisenberg,J.M., Heath,R.J., Huett,A., Robinson,C.M.,
            Nau,G.J. and Xavier,R.J.
  TITLE     Human leucine-rich repeat proteins: a genome-wide bioinformatic
            categorization and functional analysis in innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 108 Suppl 1 (Suppl 1), 4631-4638 (2011)
   PUBMED   20616063
REFERENCE   3  (bases 1 to 4890)
  AUTHORS   Liu,H., Brannon,A.R., Reddy,A.R., Alexe,G., Seiler,M.W.,
            Arreola,A., Oza,J.H., Yao,M., Juan,D., Liou,L.S., Ganesan,S.,
            Levine,A.J., Rathmell,W.K. and Bhanot,G.V.
  TITLE     Identifying mRNA targets of microRNA dysregulated in cancer: with
            application to clear cell Renal Cell Carcinoma
  JOURNAL   BMC Syst Biol 4, 51 (2010)
   PUBMED   20420713
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4890)
  AUTHORS   Kholodnyuk,I.D., Kozireva,S., Kost-Alimova,M., Kashuba,V., Klein,G.
            and Imreh,S.
  TITLE     Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of
            human chromosome 3-mouse fibrosarcoma hybrids in severe combined
            immunodeficiency mice
  JOURNAL   Int J Cancer 119 (1), 99-107 (2006)
   PUBMED   16432833
REFERENCE   5  (bases 1 to 4890)
  AUTHORS   Kiss,H., Darai,E., Kiss,C., Kost-Alimova,M., Klein,G.,
            Dumanski,J.P. and Imreh,S.
  TITLE     Comparative human/murine sequence analysis of the common eliminated
            region 1 from human 3p21.3
  JOURNAL   Mamm Genome 13 (11), 646-655 (2002)
   PUBMED   12461651
REFERENCE   6  (bases 1 to 4890)
  AUTHORS   Kiss,H., Yang,Y., Kiss,C., Andersson,K., Klein,G., Imreh,S. and
            Dumanski,J.P.
  TITLE     The transcriptional map of the common eliminated region 1 (C3CER1)
            in 3p21.3
  JOURNAL   Eur J Hum Genet 10 (1), 52-61 (2002)
   PUBMED   11896456
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057808.1, AJ308569.2,
            AC098613.2 and BP420656.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024512.4.
            
            Summary: This gene encodes a member of the leucine-rich
            repeat-containing family of proteins, which function in diverse
            biological pathways. This family member may possibly be a nuclear
            protein. Similarity to the RAS suppressor protein, as well as
            expression down-regulation observed in tumor cells, suggests that
            it may function as a tumor suppressor. The gene is located in the
            chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region
            that is commonly deleted in diverse tumors. A related pseudogene
            has been identified on chromosome 2. [provided by RefSeq, Sep
            2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ308569.2, SRR1803613.20479.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395905.8/ ENSP00000379241.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AK057808.1         91-323
            234-578             AJ308569.2         256-600
            579-1566            AK057808.1         669-1656
            1567-4488           AC098613.2         172315-175236       c
            4489-4889           BP420656.1         1-401
            4890-4890           AC098613.2         171913-171913       c
FEATURES             Location/Qualifiers
     source          1..4890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4890
                     /gene="LRRC2"
                     /note="leucine rich repeat containing 2"
                     /db_xref="GeneID:79442"
                     /db_xref="HGNC:HGNC:14676"
                     /db_xref="MIM:607180"
     exon            1..126
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            127..270
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1261
                     /gene="LRRC2"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 2"
                     /protein_id="NP_078788.2"
                     /db_xref="CCDS:CCDS2741.1"
                     /db_xref="GeneID:79442"
                     /db_xref="HGNC:HGNC:14676"
                     /db_xref="MIM:607180"
                     /translation="MGHKVVVFDISVIRALWETRVKKHKAWQKKEVERLEKSALEKIK
                     EEWNFVAECRRKGIPQAVYCKNGFIDTSVRLLDKIERNTLTRQSSLPKDRGKRSSAFV
                     FELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLP
                     AEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTF
                     VDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLP
                     YSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPIDNAQCEDGNEIMESE
                     RDRQHFDKEVMKAYIEDLKERESVPSYTTKVSFSLQL"
     exon            271..478
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..635
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..772
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..918
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1074
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1211
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..4890
                     /gene="LRRC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4561..4566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC2"
                     /note="hexamer: AATAAA"
     polyA_site      4586
                     /gene="LRRC2"
     regulatory      4867..4872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC2"
                     /note="hexamer: AATAAA"
     polyA_site      4890
                     /gene="LRRC2"
                     /note="major polyA site"
ORIGIN      
        1 aggcttcttc cggctcggcc gtgctgctca gcgggtgtaa acagcctctg cggtgtaaac
       61 agcctctgcg gtgtaaacag ccgcggcggg caggccagga ctgtcagtgc ccgcccctcg
      121 gggcaggtaa tttcatgctc ccaaaatggg acataaagtg gttgtcttcg acatttctgt
      181 catcagagcc ttgtgggaaa ctcgtgtcaa gaagcacaaa gcttggcaga agaaggaggt
      241 ggaaaggctt gagaagagcg ccttggagaa gataaaggag gagtggaact ttgtggccga
      301 atgcaggagg aagggcatcc cccaggctgt atactgcaag aatggcttca tagacaccag
      361 cgtgcggctt ctggacaaga ttgaaaggaa cactctcaca aggcagagtt cacttcccaa
      421 ggacagaggc aaacggagca gtgcgtttgt gtttgaactt tctggggagc actggacgga
      481 gctcccagat tcattgaagg agcagacaca cctgagagaa tggtacataa gcaatacctt
      541 gattcaaatc attcctacat atattcagtt atttcaagcg atgagaattc tggatctgcc
      601 aaaaaaccaa atctcacatc ttccagcaga aatcggttgt ttgaagaacc tgaaagaact
      661 caatgtgggt ttcaactatc tgaagagcat tcctccagaa ttgggagatt gtgaaaatct
      721 agagagactg gattgttctg gaaatctaga attaatggag ctgccctttg aattaagtaa
      781 tttgaagcaa gttacatttg tagatatctc agcaaacaag ttttccagtg tcccaatctg
      841 tgtcctgcgg atgtcgaatt tgcagtggtt ggatatcagc agcaataacc tgaccgacct
      901 gccgcaagat atagacaggc tagaggagct gcagagcttt ctcttgtata aaaacaagtt
      961 gacctacctt ccctattcca tgctgaacct gaagaagctc actctgttag tcgtcagtgg
     1021 ggaccatttg gtggagctcc caactgccct ttgtgactca tccacacctt taaaatttgt
     1081 aagccttatg gacaatccta ttgataatgc ccaatgtgaa gatggcaatg aaataatgga
     1141 aagtgaacgg gatcgccaac attttgataa agaagttatg aaagcctata ttgaagacct
     1201 taaagaaaga gaatctgttc ccagctatac caccaaagtg tcttttagcc ttcaactttg
     1261 atatccatca gaagactgca aatctcacta ttctctggag ctatatataa atctttgtta
     1321 tgatcatgtc atataggaag aatggcttgt gcttaaggac aaagtctaga aaccactatc
     1381 atagttgcta aaaaaaatgg ttttcaaatg tcaaatacat gagtatctcc ctccatggac
     1441 tggagaattg aaaaattggt ttgtatattg atatttccag gttcatttgc atatactttt
     1501 ttccaaataa tgcacattta atatgtttta aaatgtctta tttttaagaa ttataactaa
     1561 aagaccaaat actgaagtta agtgcattgt tttcaggaat caaaagataa aggggccggg
     1621 tgtggtggct cacacctgta atcccagcac tttgggaggc cgaagtgggt ggatcacctg
     1681 aggtccggag ttcgaggctg gtttggccag catggcgaaa ccccatctct actaaaaata
     1741 caaaaaatta gctgggcatg gtggcagttg cctgtaatcc tagctactca ggaggctgag
     1801 gcaggagaat cgcttgaacc tgggaggtgg agttgcagtg agccgagatc atgcgactgc
     1861 actccagcct gggtgacaga gccagactct gtctcaaaaa aaaaaaaaaa gaaaagaaaa
     1921 agataaaggg attgtgaaaa gagcatttat attggactaa tcagatgaga gtgttttgtt
     1981 attttgaaag agtttctttt actgagaata atcttccttg agtttatata aactgctatt
     2041 tccatatgtt ttaagttata ttttggcaag tgtagactcc caggagagac ttgtaggtac
     2101 aatctaggcc ttgaagaaac aaaggctgga atatctgccc atgctttggg catgagatgc
     2161 tcagatggtg cgtgggtaga tctagttgag gaagtgtggg cctggctgtt catgggaagt
     2221 cttcagtggc cttcatggat ggccatccag tcctgagtgg tcaccctggg ggtcctggga
     2281 cacacctcag taaagagcaa aggcaacgcc ctcagggtcc cttcctccaa gatggccatg
     2341 tagggtaatg gagatgacca gtccacactg ataaggagtt cctagcaagg cttccttgtg
     2401 ggtaccacag gacaactctg cccatagcaa agatgcttca gtccagaggg agcccatggg
     2461 ctgtttgaat ttgggagagg tgggattcat tacaagactt tgggctctta tgtcacatca
     2521 catgatttgg agaaattaga cacaatctct tatttttata ccactgtctt gggctaaaat
     2581 aaacaggttg tggctgatgg tgttgaagat aaataagctt aaacaaataa ctttggccgg
     2641 gcacggtggc tcacacctat aatcccagca ctatgggagg ctgaggcaag caggttgttt
     2701 gagcccagga atttgagaac aggattttga gaacagcttg gacatcatga cgaaacccca
     2761 tctccacaaa aaaattcaaa aaattagcca ggtgtggtgg catgtgcctg tggtcccagc
     2821 tactcaggag gctgaggtgg gaaaatcact tgagcccagg aggtcgaggc tgcagtgtgc
     2881 tgtgattgtg acactgccct ccagcctggg tgacagagtg agaccctgtc tcaaaagcaa
     2941 aacaaacagc aataacaata ttattattgt tataactaaa aaaaaaaaaa caaaaacaag
     3001 cagcttttgt gactaagaag gaaaatatgc atatagtggc atatttttat atgaatcatc
     3061 tcctctgtgg tcttgcccag taccatccag tggagctttc tgcagtgacg gaaatgttct
     3121 gtatttgcgt tgtccaacgt ggtaaaccag acacatgtga ttcttgagca cttgaacaat
     3181 gactgatgtg attgaagaac ccatctttca attcaattaa atttaaatag ccacatttaa
     3241 ctccagcctt gggtttgacc tgatggaaaa ttcccatgag agagtgctcc aaaccgttcc
     3301 aaggtggggc cagttgcgat tctaaaggaa gaagcactaa atggcagggt gatcagtcca
     3361 aagcatttat gaggggagct tacatacagc atgggctgca gcgtccttgt gatgggcagt
     3421 gagacaaggg atgttctacc tgggcatgtc cccagcgagg gggttggggg atggagttca
     3481 catgaagatg taaggaattt gggtgggggc tgggctggct tctacatgtt tagcaacacg
     3541 gctgatcttt cagtgtttcc agcaacaacc taagcaccgt tatcagtgcc taggaatgtt
     3601 caaggcccag gctggggttc agacctgcag aggaaaacat cagctggctg ggtcaaggca
     3661 ccatgtgtta cttggtcagg acagagacaa aaatgaggaa aactagggga ccccacacac
     3721 atgtggctac catactcctg aacaggtcta gctagttatt tgtttttttg gaagttaatc
     3781 tggggtagaa atgtatggtg atttttattt tctctgtctg aagaaccagc catttttaaa
     3841 aaggttatta ttgacatccc aatattttgt cttggtgggc ttactcataa gtccaaacat
     3901 tttattctca acaggtgtaa aacaggcaga gcattctaaa accacatggt agtgctttgg
     3961 tggaggactg cttccactta gaaacaaact ctgagaagta ggctaagaga agacaagagg
     4021 gccgggcgcg gtgactcacg cctataatcc cagcactttg ggaggccgag atgggtgaat
     4081 catgaggtca ggagttcgag accagcctaa acaacatagt gaaaccctgt ctctattaaa
     4141 aatgcaaaaa attagccggg cgtggtgggc acccgtaatc ccagctactc aggaggctga
     4201 ggcaggagaa ttgcttgaac ccaggaagca gaggttgcag taagctgaga tcccaccatt
     4261 gcactccagc ctgggcaaca gagtgagact ccatctcaaa aaaaaaaaaa aaaaaaaaaa
     4321 aagagagaga gatgaaaaga gtaggaaaat gagaaatcac cttcgttgaa tcttaaatag
     4381 ttacattttt ttctttttaa cactaaaaat acaattcaaa tttattagct ctactacttg
     4441 aatgattttg gaattttatg tcatgctaag gtatgtgtta catatggcca agtggaaaat
     4501 atatctgaag aggggctttc atacaaatag actgttcata atttatgtaa attttatttt
     4561 aataaaatca gttttttgtt taaaaacctt gtttcactgt cacatatgaa aaaaatactg
     4621 cattgatata taattatttc atgttacata ataacccaaa acaaataatt acttgaatat
     4681 gtttgtagag atactattta atttattcat ataaatgtgc agaaagattc caaaggagaa
     4741 tatatatctt gtgaaaatat ggagatttga aaatttgaca tgatgcaaat agactgatac
     4801 ataatttgga aaggttattt acatggcaga atacatgtat gaatattaaa gtaatatgaa
     4861 tgaaagaata aaatattctt agaagaaaaa
//
