LOCUS       NM_022901               3588 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens leucine rich repeat containing 19 (LRRC19), mRNA.
ACCESSION   NM_022901
VERSION     NM_022901.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Xie,R., Gu,Y., Li,M., Li,L., Yang,Y., Sun,Y., Zhou,B., Liu,T.,
            Wang,S., Liu,W., Yang,R., Su,X., Zhong,W., Wang,B. and Cao,H.
  TITLE     Desulfovibrio vulgaris interacts with novel gut epithelial immune
            receptor LRRC19 and exacerbates colitis
  JOURNAL   Microbiome 12 (1), 4 (2024)
   PUBMED   38172943
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Zhang,Y., Wang,J. and Liu,X.
  TITLE     LRRC19-A Bridge between Selenium Adjuvant Therapy and Renal Clear
            Cell Carcinoma: A Study Based on Datamining
  JOURNAL   Genes (Basel) 11 (4), 440 (2020)
   PUBMED   32316597
  REMARK    GeneRIF: LRRC19-A Bridge between Selenium Adjuvant Therapy and
            Renal Clear Cell Carcinoma: A Study Based on Datamining.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Chai,L., Dai,L., Che,Y., Xu,J., Liu,G., Zhang,Z. and Yang,R.
  TITLE     LRRC19, a novel member of the leucine-rich repeat protein family,
            activates NF-kappaB and induces expression of proinflammatory
            cytokines
  JOURNAL   Biochem Biophys Res Commun 388 (3), 543-548 (2009)
   PUBMED   19679103
  REMARK    GeneRIF: LRRC19 may play an important role in inducing innate
            immune responses in certain tissues such as the kidney.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK024955.1, BC126156.1, AL355432.7, AK025070.1 and BF431646.1.
            
            On May 17, 2019 this sequence version replaced NM_022901.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024955.1, BC136298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380055.6/ ENSP00000369395.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1735              AK024955.1         1-1735
            1736-1752           BC126156.1         1716-1732
            1753-1923           AK024955.1         1754-1924
            1924-1924           AL355432.7         142650-142650
            1925-2500           AK024955.1         1926-2501
            2501-3130           AK025070.1         1403-2032
            3131-3516           BF431646.1         2-387               c
            3517-3588           AK025070.1         2419-2490
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2"
     gene            1..3588
                     /gene="LRRC19"
                     /note="leucine rich repeat containing 19"
                     /db_xref="GeneID:64922"
                     /db_xref="HGNC:HGNC:23379"
                     /db_xref="MIM:619068"
     exon            1..81
                     /gene="LRRC19"
                     /inference="alignment:Splign:2.1.0"
     exon            82..171
                     /gene="LRRC19"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1203
                     /gene="LRRC19"
                     /note="leucine-rich repeat-containing protein 19"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 19
                     precursor"
                     /protein_id="NP_075052.1"
                     /db_xref="CCDS:CCDS6518.1"
                     /db_xref="GeneID:64922"
                     /db_xref="HGNC:HGNC:23379"
                     /db_xref="MIM:619068"
                     /translation="MKVTGITILFWPLSMILLSDKIQSSKREVQCNFTEKNYTLIPAD
                     IKKDVTILDLSYNQITLNGTDTRVLQTYFLLTELYLIENKVTILHNNGFGNLSSLEIL
                     NICRNSIYVIQQGAFLGLNKLKQLYLCQNKIEQLNADVFVPLRSLKLLNLQGNLISYL
                     DVPPLFHLELITLYGNLWNCSCSLFNLQNWLNTSNVTLENENITMCSYPNSLQSYNIK
                     TVPHKAECHSKFPSSVTEDLYIHFQPISNSIFNSSSNNLTRNSEHEPLGKSWAFLVGV
                     VVTVLTTSLLIFIAIKCPIWYNILLSYNHHRLEEHEAETYEDGFTGNPSSLSQIPETN
                     SEETTVIFEQLHSFVVDDDGFIEDKYIDIHELCEEN"
     exon            172..685
                     /gene="LRRC19"
                     /inference="alignment:Splign:2.1.0"
     exon            686..874
                     /gene="LRRC19"
                     /inference="alignment:Splign:2.1.0"
     exon            875..3588
                     /gene="LRRC19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3058..3063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC19"
                     /note="hexamer: AATAAA"
     polyA_site      3079
                     /gene="LRRC19"
                     /note="major polyA site"
ORIGIN      
        1 atacgatgta ctttttttaa tgccgttgaa acagagttaa tttcctttag cacacaagtc
       61 ttagagacaa aagaaaaaaa ggtctgcaac atgaaagtca caggcatcac aatcctcttt
      121 tggcccctct ccatgatatt attatcagac aaaatccagt cttctaaaag agaagtccaa
      181 tgtaatttta ctgaaaaaaa ttataccttg attccagcag atatcaagaa agatgttact
      241 atacttgatc tcagttataa ccaaattact cttaatggta cagacacaag agttctacag
      301 acatactttt tactcacaga gctctatttg attgagaaca aggttactat cttacataat
      361 aacggttttg gtaacctctc cagtctagaa attttaaata tctgtagaaa ctccatctat
      421 gtaattcaac agggtgcatt tttaggctta aataaactaa aacagttata tctctgccaa
      481 aacaaaatag aacaactgaa tgctgatgta tttgtgcctc taagaagcct aaaacttctg
      541 aatctgcaag gcaatttgat tagctatttg gatgtaccac cactatttca tctggaatta
      601 ataactttat atggaaacct atggaactgc tcttgcagtc tatttaattt gcagaactgg
      661 ttgaacacat caaatgtgac attagaaaat gagaacatca ccatgtgtag ctaccccaac
      721 agcctgcaga gctacaatat caaaacagta cctcataagg ctgaatgcca ctcaaaattt
      781 ccttcatcag taactgaaga tctttatatt cattttcagc ccatcagcaa ttcaatattt
      841 aatagctctt cgaacaactt aacaagaaat tcagaacatg aacctcttgg aaaaagttgg
      901 gcttttcttg ttggtgttgt tgtcactgta ctgacgactt cacttctcat ttttattgct
      961 atcaaatgcc caatatggta caatattctg cttagttata atcatcatcg cctggaagag
     1021 catgaagcag aaacctatga agatggtttt actggaaatc caagctctct ttcacagata
     1081 ccagaaacaa actctgaaga aactacagta atatttgaac aattacattc atttgtggta
     1141 gatgatgatg gatttattga agacaaatat atagatatcc atgaattatg tgaagaaaat
     1201 taatttcttt caaagtttgc tttttaaagc aaagttatca gctcactcag tttagatatg
     1261 gagattttgc tatgtgacat aacaaaatac agctggcagg cattcatatt aatgacaaca
     1321 tacatgaata tcataaaatt atgttctttg cattatattg agcaagcagg ttcaaataca
     1381 gtaactgaca ctcctcggta gttgacagtt acatagtcta caatactagc actactattc
     1441 ttagcagtgc ttgggtgacc atacgaacta gtaaaaaggt ctaaattatt catgaattaa
     1501 aatgaatgga ttctcatatt aacacaggta tttgacataa tatgtattaa gttatactaa
     1561 tgtttcaatc agtaaagaaa taaaagttta ggatttatta atatatggaa gtcaaagtga
     1621 ggaacagaga tagcttaaat aatacactaa gattgatttt atgctcccag aataaaatca
     1681 tagagttgga aaatattttt ttgaaatgct tcctgaaata gcacaataaa tttccttaaa
     1741 atttcatagc aatttaaagc acaagcacaa tgttcaggca taatccctaa taagtcacta
     1801 ttgattctgg ttataaagaa aggctgtcac cataatgcag gatcactaca gtttaatgtc
     1861 atactggctt ccaaagtggg catcacaatt atctataaat cttgttttaa aaatacatat
     1921 ttccacctct ctctgggaga tttttattca aattggtctg tgctgacact aaggaatctt
     1981 catgtggtcc atggacagct atttctatct attcagtaga tagagcaatg tttcccaaat
     2041 tgtttttcta gaatactaat ttccagagag acattcacaa gtatttacag aagaagaagg
     2101 aggtacatgg tcaaattact acaggaaaaa ctagtagttt aaacaaggtg aaacaagatt
     2161 ctttttcttt tttttttttt tttttttgag acaaagtctc gcactgtctc ccaggctgga
     2221 ctgcagcagc gcagtctcag atcactgcaa cctccgcctc ctgggttcaa gcaattcttc
     2281 tgactcagcc tcccgagtag ctgggagtac aggtgcacac caccatgcct ggctaatttc
     2341 tgtattttta gtagagacag ggtttcacca tgttggccag gctggtctcg aacgcctgac
     2401 ctcatgatct acccgcctcg gcctcccaaa gtgctgggat tacaggcatg gagcaccgtg
     2461 cctggccaag attctttaca ataggattta tgtaaaactt tactaagcta aactgctctc
     2521 tgattattca agagcaaagt attaaaaatt tctcaaactt acttgacaac aaaacccatt
     2581 ctttcagtta catctactaa gagctcgtag ttcaataaca ttccaaagaa cgtagtttgg
     2641 aaaacactgg cctatcggct gtaataggaa gggtctaaag aaaattattt gctgagtcct
     2701 cataatcaat tggctataat cacaatttaa taatttatca atgcaaacag tacattaaaa
     2761 actgtagcac aatctataat ttttaccttc atatgcagag aaattaagaa tttacatctt
     2821 ttacaaatat gtatatctct gaaataatga aatatattga tgggtgaaat aatatttctg
     2881 gtattttctt cattataaca cgtggaatgg aacagtggct agaggtatgg atggagcaag
     2941 gtcaaatatg agctgatgga gctgggagct aaataagggt ataatatgct acttctgtgt
     3001 atgttgtgta tggtatagta tgctatttct gtgtatgttc aaattgttta tgtatataat
     3061 aaagttttaa aaatttgtat gtacttgaca attccttaga aaaaagaggc taaaataaaa
     3121 tagatctatg tcataatcta tagaatagtc attttaaaag ttacataatt agtaaattca
     3181 atacaaatgt ctactgagag aaaataaaaa ctaggatgat atacctgtaa aatagaagaa
     3241 cttactaatt tataatacat atttgcttgt gtttacagac acatgttttc aacaaaggat
     3301 ataagtatat tatggctaat gtttctttat atatcaatta tactttgttt taaaccttaa
     3361 ttataagaat gagatgatta taggaacata aaatatcttt ttctaaacaa tgtatcattc
     3421 tgctaaatta tttcctaatt ataagatgca aatattaata tttgagaaat gtagcaaaat
     3481 gaaatataat tgcaaatgag caaagactac acttaagctt ttatattcaa gggcctctgt
     3541 tgaatatggg gtattcaata aatatctgac tacacaaaga aaaataaa
//
