LOCUS       NM_001378102            1814 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 18 (LRRC18), transcript
            variant 2, mRNA.
ACCESSION   NM_001378102 XM_006717867
VERSION     NM_001378102.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Yang,Y. and Xu,X.
  TITLE     Identification of key genes in coronary artery disease: an
            integrative approach based on weighted gene co-expression network
            analysis and their correlation with immune infiltration
  JOURNAL   Aging (Albany NY) 13 (6), 8306-8319 (2021)
   PUBMED   33686958
  REMARK    GeneRIF: Identification of key genes in coronary artery disease: an
            integrative approach based on weighted gene co-expression network
            analysis and their correlation with immune infiltration.
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Han,J.W., Zheng,H.F., Cui,Y., Sun,L.D., Ye,D.Q., Hu,Z., Xu,J.H.,
            Cai,Z.M., Huang,W., Zhao,G.P., Xie,H.F., Fang,H., Lu,Q.J., Xu,J.H.,
            Li,X.P., Pan,Y.F., Deng,D.Q., Zeng,F.Q., Ye,Z.Z., Zhang,X.Y.,
            Wang,Q.W., Hao,F., Ma,L., Zuo,X.B., Zhou,F.S., Du,W.H., Cheng,Y.L.,
            Yang,J.Q., Shen,S.K., Li,J., Sheng,Y.J., Zuo,X.X., Zhu,W.F.,
            Gao,F., Zhang,P.L., Guo,Q., Li,B., Gao,M., Xiao,F.L., Quan,C.,
            Zhang,C., Zhang,Z., Zhu,K.J., Li,Y., Hu,D.Y., Lu,W.S., Huang,J.L.,
            Liu,S.X., Li,H., Ren,Y.Q., Wang,Z.X., Yang,C.J., Wang,P.G.,
            Zhou,W.M., Lv,Y.M., Zhang,A.P., Zhang,S.Q., Lin,D., Li,Y.,
            Low,H.Q., Shen,M., Zhai,Z.F., Wang,Y., Zhang,F.Y., Yang,S.,
            Liu,J.J. and Zhang,X.J.
  TITLE     Genome-wide association study in a Chinese Han population
            identifies nine new susceptibility loci for systemic lupus
            erythematosus
  JOURNAL   Nat Genet 41 (11), 1234-1237 (2009)
   PUBMED   19838193
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   O'Donnell,C.J., Cupples,L.A., D'Agostino,R.B., Fox,C.S.,
            Hoffmann,U., Hwang,S.J., Ingellson,E., Liu,C., Murabito,J.M.,
            Polak,J.F., Wolf,P.A. and Demissie,S.
  TITLE     Genome-wide association study for subclinical atherosclerosis in
            major arterial territories in the NHLBI's Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S4 (2007)
   PUBMED   17903303
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Nie,D.S., Xiang,Y., Wang,J., Deng,Y., Tan,X.J., Liang,Y.H. and
            Lu,G.X.
  TITLE     Identification of a novel testis-specific gene mtLR1, which is
            expressed at specific stages of mouse spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 328 (4), 1010-1018 (2005)
   PUBMED   15707978
REFERENCE   6  (bases 1 to 1814)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC060234.11.
            
            On Jan 28, 2020 this sequence version replaced XM_006717867.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: DRR138524.1084613.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000374160.8/ ENSP00000363275.3
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC060234.11        57237-57331         c
            96-194              AC060234.11        52668-52766         c
            195-1035            AC060234.11        30883-31723         c
            1036-1814           AC060234.11        26971-27749         c
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..1814
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /note="leucine rich repeat containing 18"
                     /db_xref="GeneID:474354"
                     /db_xref="HGNC:HGNC:23199"
                     /db_xref="MIM:619002"
     exon            1..95
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /inference="alignment:Splign:2.1.0"
     exon            96..194
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /inference="alignment:Splign:2.1.0"
     exon            195..1035
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1057
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 18"
                     /protein_id="NP_001365031.1"
                     /db_xref="CCDS:CCDS31197.1"
                     /db_xref="GeneID:474354"
                     /db_xref="HGNC:HGNC:23199"
                     /db_xref="MIM:619002"
                     /translation="MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPK
                     CILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLN
                     VSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIP
                     VSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNAR
                     DNLNRIKNMATTTPRKTIFPNLISPNSMAKDSWEDWRIRLTSS"
     exon            1036..1814
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1789..1794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /note="hexamer: AATAAA"
     polyA_site      1814
                     /gene="LRRC18"
                     /gene_synonym="UNQ933; UNQ9338; VKGE9338"
                     /note="major polyA site"
ORIGIN      
        1 atttcattgg ctatcagctt caaggaagtt ccattatttc tggtaccatc agagaaagac
       61 gccattacca gcagttccag gacacctaac caaaggctgg tgtcaagact gtgctaatga
      121 cctccaggtc ctaagtctct tgttgcctgg tgacaaagtt tcacagttga ggaggagaag
      181 ctgggactag caggtttttc atgatttttc ctcacactga tcactatcca atcagaacaa
      241 taaacttcta acactccctt actaaaagaa catggttaag ggtgagaaag gccccaaggg
      301 caagaagatc accctcaagg tggccaggaa ttgcatcaaa atcacttttg atgggaaaaa
      361 gcgccttgac ttgagcaaga tgggaattac caccttcccc aagtgtattc tgcgccttag
      421 tgacatggac gagctggacc ttagccggaa tcttatcagg aagatccctg actccatctc
      481 caagttccag aacctccggt ggctggacct gcacagcaac tacatagaca agctgcctga
      541 gtccattggc cagatgacca gcctgctcta cctcaacgtc agcaacaacc ggctgaccag
      601 caacgggctg cccgtggagc tgaagcaact caagaacatc cgcgctgtga acctaggctt
      661 gaaccacctg gacagcgtgc ccaccacact gggggccctg aaggagctcc acgaggtagg
      721 gctccatgac aacctactga acaacatccc cgtgagcatc tccaagctcc ccaagctgaa
      781 aaagctcaac ataaagcgga acccctttcc aaagccaggt gagtcggaaa tattcataga
      841 ctccatcagg aggctggaga acttgtatgt tgtggaggag aaggatctgt gtgcggcttg
      901 cctgagaaaa tgccaaaacg cccgggacaa cctgaataga atcaagaaca tggccacgac
      961 gacaccgaga aagaccatct ttcccaatct gatctcaccc aattccatgg ccaaggactc
     1021 ctgggaagac tggagaatac gcttgacatc ttcctagagt agctgtggca aaatcttgaa
     1081 gactactcag ctaacagaat aaacgactct gaagaggaga agcccccagt taggagaaga
     1141 cagagtggca agtgagatgt tctggaaacc aggctcgccg gagctggcca agccaccgac
     1201 ttgcttctca aattcacttc acctccctta gctttagccc acctgtgtgt gaaaatgact
     1261 ttgggaaata tttgatgtgg tttttaaaat gtatatagaa aaaaatttaa gaaaattaca
     1321 gattatatat tatagacaac taaatattta agactttaag acttaaaagg cttactgcct
     1381 ctacatttca ctcagactag tacatctcaa tgccagtagt ctgtgataaa tttatgtagg
     1441 tataatgaga tactgatatg gtttgggcat ttgtctcctc caaacctcat gttgagattt
     1501 gatccccagt gttggaggtg gggcctaatg gaaggtcatg ggggtgggtc cctcatgaat
     1561 ggcctggtgc catccttttg gtaatgagtg agttctcact gtattagatc ctgttgaaaa
     1621 ttgattgtta aaaagacctt ggcacctccc tctcctctct ctctcttcct ctcactatgt
     1681 gatgcctgct ccccttcacc ttccaccatg agtggaagca cctatacccc aaagccctca
     1741 ccagaaggag gtgccggcac ctgtacagct tgtaagaacc atgactcaaa taaacttctt
     1801 ttctttataa atta
//
