LOCUS       NM_001031692            2116 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 17 (LRRC17), transcript
            variant 1, mRNA.
ACCESSION   NM_001031692
VERSION     NM_001031692.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   Liu,F., Yuan,Y., Bai,L., Yuan,L., Li,L., Liu,J., Chen,Y., Lu,Y.,
            Cheng,J. and Zhang,J.
  TITLE     LRRc17 controls BMSC senescence via mitophagy and inhibits the
            therapeutic effect of BMSCs on ovariectomy-induced bone loss
  JOURNAL   Redox Biol 43, 101963 (2021)
   PUBMED   33865167
  REMARK    GeneRIF: LRRc17 controls BMSC senescence via mitophagy and inhibits
            the therapeutic effect of BMSCs on ovariectomy-induced bone loss.
REFERENCE   2  (bases 1 to 2116)
  AUTHORS   Oh,C.K., Park,J.J., Ha,M., Heo,H.J., Kang,J., Kwon,E.J., Kang,J.W.,
            Kim,Y., Kang,J.M., Yoon,S.Z., Ko,Y., Ko,D.S. and Kim,Y.H.
  TITLE     LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a
            p53-dependent Anti-apoptotic Function
  JOURNAL   Anticancer Res 40 (10), 5601-5609 (2020)
   PUBMED   32988884
  REMARK    GeneRIF: LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a
            p53-dependent Anti-apoptotic Function.
REFERENCE   3  (bases 1 to 2116)
  AUTHORS   Hong,N., Kim,B.J., Kim,C.H., Baek,K.H., Min,Y.K., Kim,D.Y.,
            Lee,S.H., Koh,J.M., Kang,M.I. and Rhee,Y.
  TITLE     Low Plasma Level of Leucine-Rich Repeat-Containing 17 (LRRc17) Is
            an Independent and Additive Risk Factor for Osteoporotic Fractures
            in Postmenopausal Women
  JOURNAL   J Bone Miner Res 31 (12), 2106-2114 (2016)
   PUBMED   27355564
  REMARK    GeneRIF: low circulating plasma level of LRRc17 might serve as an
            independent and additive risk factor for osteoporotic fractures.
REFERENCE   4  (bases 1 to 2116)
  AUTHORS   Hsia,L.T., Ashley,N., Ouaret,D., Wang,L.M., Wilding,J. and
            Bodmer,W.F.
  TITLE     Myofibroblasts are distinguished from activated skin fibroblasts by
            the expression of AOC3 and other associated markers
  JOURNAL   Proc Natl Acad Sci U S A 113 (15), E2162-E2171 (2016)
   PUBMED   27036009
  REMARK    GeneRIF: Whole-genome microarray mRNA-expression profiles of
            myofibroblasts and skin fibroblasts revealed four additional genes
            that are significantly differentially expressed in these two cell
            types: NKX2-3 and LRRC17 in myofibroblasts and SHOX2 and TBX5 in
            skin fibroblasts
REFERENCE   5  (bases 1 to 2116)
  AUTHORS   Kim,T., Kim,K., Lee,S.H., So,H.S., Lee,J., Kim,N. and Choi,Y.
  TITLE     Identification of LRRc17 as a negative regulator of receptor
            activator of NF-kappaB ligand (RANKL)-induced osteoclast
            differentiation
  JOURNAL   J Biol Chem 284 (22), 15308-15316 (2009)
   PUBMED   19336404
REFERENCE   6  (bases 1 to 2116)
  AUTHORS   Kim,D., LaQuaglia,M.P. and Yang,S.Y.
  TITLE     A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR)
            protein, p37NB, isolated from S-type neuroblastoma cell has a
            differential tissue distribution
  JOURNAL   Biochim Biophys Acta 1309 (3), 183-188 (1996)
   PUBMED   8982252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA749917.1, BC027903.1, AC073127.11 and AI961444.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001031692.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225701.1, SRR1660803.207957.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339431.9/ ENSP00000344242.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DA749917.1         104-162
            60-1948             BC027903.1         41-1929
            1949-2108           AC073127.11        20944-21103
            2109-2116           AI961444.1         32-39               c
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2116
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /note="leucine rich repeat containing 17"
                     /db_xref="GeneID:10234"
                     /db_xref="HGNC:HGNC:16895"
                     /db_xref="MIM:618749"
     exon            1..146
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /inference="alignment:Splign:2.1.0"
     exon            147..1058
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1612
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 37 kDa leucine-rich repeat (LRR) protein;
                     leucine-rich repeat-containing protein 17"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 17
                     isoform 1 precursor"
                     /protein_id="NP_001026862.1"
                     /db_xref="CCDS:CCDS34721.1"
                     /db_xref="GeneID:10234"
                     /db_xref="HGNC:HGNC:16895"
                     /db_xref="MIM:618749"
                     /translation="MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNP
                     VKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFS
                     KFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRL
                     YDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKE
                     QLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLS
                     YNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYG
                     VLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVHFNGLECKTPEEYKGWSVGKY
                     IRSYYEECPKDKLPAYPESFDQDTEDDEWEKKHRDHTAKKQSVIITIVG"
     exon            1059..1214
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..2116
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1929..1934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /note="hexamer: AAGAAA"
     polyA_site      1954
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
     regulatory      2023..2028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /note="hexamer: AATAAA"
     polyA_site      2049
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /note="major polyA site"
     regulatory      2080..2085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /note="hexamer: AATAAA"
     polyA_site      2116
                     /gene="LRRC17"
                     /gene_synonym="P37NB"
                     /note="major polyA site"
ORIGIN      
        1 attagtataa cgtgagggct gaatgcagcc cattctctgg agaacttcct cacacaccgc
       61 agcaaagaga agactgaaag acaaacctgg gtgcagccag agaggtccag atagatgagc
      121 ttgtggcatc cattccccaa gttcagccta gggactccac gtaccccagc tgggtctcat
      181 tgttccagaa ctgcattagt taagattacc cagacttgga tttcaaagga atactttcat
      241 tgttccgtct gtaacacgaa gtaattgggg ccagctggat gtcaggatgc gtgtggttac
      301 cattgtaatc ttgctctgct tttgcaaagc ggctgagctg cgcaaagcaa gcccaggcag
      361 tgtgagaagc cgagtgaatc atggccgggc gggtggaggc cggagaggct ccaacccggt
      421 caaacgctac gcaccaggcc tcccgtgtga cgtgtacaca tatctccatg agaaatactt
      481 agattgtcaa gaaagaaaat tagtttatgt gctgcctggt tggcctcagg atttgctgca
      541 catgctgcta gcaagaaaca agatccgcac attgaagaac aacatgtttt ccaagtttaa
      601 aaagctgaaa agcctggatc tgcagcagaa tgagatctct aaaattgaga gtgaggcgtt
      661 ctttggttta aacaaactca ccaccctctt actgcagcac aaccagatca aagtcttgac
      721 ggaggaagtg ttcatttaca cacctctctt gagctacctg cgtctttatg acaacccctg
      781 gcactgtact tgtgagatag aaacgcttat ttcaatgttg cagattccca ggaaccggaa
      841 tttggggaac tacgccaagt gtgaaagtcc acaagaacaa aaaaataaaa aactgcggca
      901 gataaaatct gaacagttgt gtaatgaaga agaaaaggaa caattggacc cgaaacccca
      961 agtgtcaggg agacccccag tcatcaagcc tgaggtggac tcaacttttt gccacaatta
     1021 tgtgtttccc atacaaacac tggactgcaa aaggaaagag ttgaaaaaag tgccaaacaa
     1081 catccctcca gatattgtta aacttgactt gtcatacaat aaaatcaacc aacttcgacc
     1141 caaggaattt gaagatgttc atgagctgaa gaaattaaac ctcagcagca atggcattga
     1201 attcatcgat cctgccgctt ttttagggct cacacattta gaagaattag atttatcaaa
     1261 caacagtctg caaaactttg actatggcgt attagaagac ttgtattttt tgaaactctt
     1321 gtggctcaga gataaccctt ggagatgtga ctacaacatt cactacctct actactggtt
     1381 aaagcaccac tacaatgtcc attttaatgg cctggaatgc aaaacgcctg aagaatacaa
     1441 aggatggtct gtgggaaaat atattagaag ttactatgaa gaatgcccca aagacaagtt
     1501 accagcatat cctgagtcat ttgaccaaga cacagaagat gatgaatggg aaaaaaaaca
     1561 tagagatcac accgcaaaga agcaaagcgt aataattact atagtaggat aaggtagaaa
     1621 ttgttctgat tgtaattagt tttgtatttt ctatactggt gttagaaaac atatgtttac
     1681 atttgattaa ctgtgttgcc tatttatgca gggtaatcca gctaaaggaa gctttcttta
     1741 attataagta ttattgtgac tattatagta atcaagagaa tgctatcatc ctgcttgcct
     1801 gtccatttgt ggaacagcat ctggtgatat gcaattccac actggtaacc tgcagcagtt
     1861 gggtcctaat gatggcatta gactttcata atgtcctgta taaatgtttt tactgctttt
     1921 agaaaataaa gaaaaaaaac ttggttcatg tttacatgcc tttcgatagc tgtttgtgca
     1981 tacttaaaga tgatcaaaat gattttatac aaatgctgtt ataataaaat gtcattccct
     2041 acccctctac tttttttcag taagtcatct tatacattaa ataaatttcc atttctgatt
     2101 tctgtgcatt ccaaaa
//
