LOCUS       NM_130830               5881 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens leucine rich repeat containing 15 (LRRC15), transcript
            variant 2, mRNA.
ACCESSION   NM_130830
VERSION     NM_130830.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5881)
  AUTHORS   Gong,S., Xiang,K., Chen,L., Zhuang,H., Song,Y. and Chen,J.
  TITLE     Integrated bioinformatics analysis identified leucine rich repeat
            containing 15 and secreted phosphoprotein 1 as hub genes for
            calcific aortic valve disease and osteoarthritis
  JOURNAL   IET Syst Biol 18 (3), 77-91 (2024)
   PUBMED   38566328
  REMARK    GeneRIF: Integrated bioinformatics analysis identified leucine rich
            repeat containing 15 and secreted phosphoprotein 1 as hub genes for
            calcific aortic valve disease and osteoarthritis.
REFERENCE   2  (bases 1 to 5881)
  AUTHORS   Wang,Q.W., Jia,Y.L., Li,P. and Yu,G.Y.
  TITLE     Effect of LRRC15 on autophagy in A549 cells
  JOURNAL   Yi Chuan 46 (5), 398-407 (2024)
   PUBMED   38763774
  REMARK    GeneRIF: Effect of LRRC15 on autophagy in A549 cells.
REFERENCE   3  (bases 1 to 5881)
  AUTHORS   Kim,H.J., Kim,D.J., Kim,S.M. and Jang,Y.J.
  TITLE     Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is
            Essential for Integrin Signaling in TGF-beta1-Induced PDL
            Fibroblastic Differentiation
  JOURNAL   Stem Cells 42 (3), 251-265 (2024)
   PUBMED   38051601
  REMARK    GeneRIF: Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion
            Is Essential for Integrin Signaling in TGF-beta1-Induced PDL
            Fibroblastic Differentiation.
REFERENCE   4  (bases 1 to 5881)
  AUTHORS   Loo,L., Waller,M.A., Moreno,C.L., Cole,A.J., Stella,A.O., Pop,O.T.,
            Jochum,A.K., Ali,O.H., Denes,C.E., Hamoudi,Z., Chung,F.,
            Aggarwal,A., Low,J.K.K., Patel,K., Siddiquee,R., Kang,T.,
            Mathivanan,S., Mackay,J.P., Jochum,W., Flatz,L., Hesselson,D.,
            Turville,S. and Neely,G.G.
  TITLE     Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and
            controls antiviral and antifibrotic transcriptional programs
  JOURNAL   PLoS Biol 21 (2), e3001967 (2023)
   PUBMED   36757924
  REMARK    GeneRIF: Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2
            spike and controls antiviral and antifibrotic transcriptional
            programs.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5881)
  AUTHORS   Shilts,J., Crozier,T.W.M., Teixeira-Silva,A., Gabaev,I.,
            Gerber,P.P., Greenwood,E.J.D., Watson,S.J., Ortmann,B.M.,
            Gawden-Bone,C.M., Pauzaite,T., Hoffmann,M., Nathan,J.A.,
            Pohlmann,S., Matheson,N.J., Lehner,P.J. and Wright,G.J.
  TITLE     LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike
            protein
  JOURNAL   PLoS Biol 21 (2), e3001959 (2023)
   PUBMED   36735681
  REMARK    GeneRIF: LRRC15 mediates an accessory interaction with the
            SARS-CoV-2 spike protein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5881)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 5881)
  AUTHORS   O'Prey,J., Wilkinson,S. and Ryan,K.M.
  TITLE     Tumor antigen LRRC15 impedes adenoviral infection: implications for
            virus-based cancer therapy
  JOURNAL   J Virol 82 (12), 5933-5939 (2008)
   PUBMED   18385238
  REMARK    GeneRIF: Tumor antigen LRRC15 impedes adenoviral infection:
            implications for virus-based cancer therapy are presented.
REFERENCE   8  (bases 1 to 5881)
  AUTHORS   Satoh,K., Hata,M., Shimizu,T., Yokota,H., Akatsu,H., Yamamoto,T.,
            Kosaka,K. and Yamada,T.
  TITLE     Lib, transcriptionally induced in senile plaque-associated
            astrocytes, promotes glial migration through extracellular matrix
  JOURNAL   Biochem Biophys Res Commun 335 (2), 631-636 (2005)
   PUBMED   16098915
  REMARK    GeneRIF: Lib may contribute to regulation of cell-matrix adhesion
            interactions with respect to astrocyte recruitment around senile
            plaques in Alzheimer's disease brain
REFERENCE   9  (bases 1 to 5881)
  AUTHORS   Reynolds,P.A., Smolen,G.A., Palmer,R.E., Sgroi,D., Yajnik,V.,
            Gerald,W.L. and Haber,D.A.
  TITLE     Identification of a DNA-binding site and transcriptional target for
            the EWS-WT1(+KTS) oncoprotein
  JOURNAL   Genes Dev 17 (17), 2094-2107 (2003)
   PUBMED   12923058
  REMARK    GeneRIF: LRRC15 is induced by EWS-WT1(+KTS) in the tumor DSRCT and
            may play a role in cellular invasion.
REFERENCE   10 (bases 1 to 5881)
  AUTHORS   Satoh,K., Hata,M. and Yokota,H.
  TITLE     A novel member of the leucine-rich repeat superfamily induced in
            rat astrocytes by beta-amyloid
  JOURNAL   Biochem Biophys Res Commun 290 (2), 756-762 (2002)
   PUBMED   11785964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK125112.1 and AC174158.3.
            
            On Jun 2, 2019 this sequence version replaced NM_130830.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks a portion of the 5' coding region, compared to variant 1. The
            resulting isoform (b) is shorter at the N-terminus, compared to
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125112.1, BC101065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347624.4/ ENSP00000306276.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1500              AK125112.1         1-1500
            1501-5881           AC174158.3         6172-10552
FEATURES             Location/Qualifiers
     source          1..5881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..5881
                     /gene="LRRC15"
                     /gene_synonym="LIB"
                     /note="leucine rich repeat containing 15"
                     /db_xref="GeneID:131578"
                     /db_xref="HGNC:HGNC:20818"
                     /db_xref="MIM:619327"
     exon            1..83
                     /gene="LRRC15"
                     /gene_synonym="LIB"
                     /inference="alignment:Splign:2.1.0"
     exon            84..5881
                     /gene="LRRC15"
                     /gene_synonym="LIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1832
                     /gene="LRRC15"
                     /gene_synonym="LIB"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; leucine-rich repeat protein induced by beta
                     amyloid; leucine-rich repeat-containing protein 15; hLib;
                     leucine-rich repeat protein induced by beta-amyloid
                     homolog"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 15
                     isoform b precursor"
                     /protein_id="NP_570843.2"
                     /db_xref="CCDS:CCDS3306.1"
                     /db_xref="GeneID:131578"
                     /db_xref="HGNC:HGNC:20818"
                     /db_xref="MIM:619327"
                     /translation="MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARI
                     VAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGS
                     LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNH
                     LEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFD
                     GLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTL
                     FGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISP
                     GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLM
                     AIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTV
                     PVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTEL
                     TSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALACSLAACVGCCCCKK
                     RSQAVLMQMKAPNEC"
     regulatory      5863..5868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC15"
                     /gene_synonym="LIB"
                     /note="hexamer: AATAAA"
     polyA_site      5881
                     /gene="LRRC15"
                     /gene_synonym="LIB"
                     /note="major polyA site"
ORIGIN      
        1 acactcatgc tgcagccttg agccgtccct cgtcctcctc tcaggctccc tcttgtccac
       61 ggcgggcggg cgccgagctg ctggctatgc cactgaagca ttatctcctt ttgctggtgg
      121 gctgccaagc ctggggtgca gggttggcct accatggctg ccctagcgag tgtacctgct
      181 ccagggcctc ccaggtggag tgcaccgggg cacgcattgt ggcagtgccc acccctctgc
      241 cctggaacgc catgagcctg cagatcctca acacgcacat cactgaactc aatgagtccc
      301 cgttcctcaa tatctcagcc ctcatcgccc tgaggattga gaagaatgag ctgtcgcgca
      361 tcacgcctgg ggccttccga aacctgggct cgctgcgcta tctcagcctc gccaacaaca
      421 agctgcaggt tctgcccatc ggcctcttcc agggcctgga cagcctcgag tctctccttc
      481 tgtccagtaa ccagctgttg cagatccagc cggcccactt ctcccagtgc agcaacctca
      541 aggagctgca gttgcacggc aaccacctgg aatacatccc tgacggagcc ttcgaccacc
      601 tggtaggact cacgaagctc aatctgggca agaatagcct cacccacatc tcacccaggg
      661 tcttccagca cctgggcaac ctccaggtcc tccggctgta tgagaacagg ctcacggata
      721 tccccatggg cacttttgat gggcttgtta acctgcagga actggctctg cagcagaacc
      781 agattggact gctctcccct ggtctcttcc acaacaacca caacctccag agactctacc
      841 tgtccaacaa ccacatctcc cagctgccac ccagcgtctt catgcagctg ccccagctca
      901 accgtcttac tctctttggg aattccctga aggagctctc tccggggatc ttcgggccca
      961 tgcccaacct gcgggagctt tggctctatg acaaccacat ctcttctcta cccgacaatg
     1021 tcttcagcaa cctccgccag ttgcaggtcc tgattcttag ccgcaatcag atcagcttca
     1081 tctccccggg tgccttcaac gggctaacgg agcttcggga gctgtccctc cacaccaacg
     1141 cactgcagga cctggacggg aacgtcttcc gcatgttggc caacctgcag aacatctccc
     1201 tgcagaacaa ccgcctcaga cagctcccag ggaatatctt cgccaacgtc aatggcctca
     1261 tggccatcca gctgcagaac aaccagctgg agaacttgcc cctcggcatc ttcgatcacc
     1321 tggggaaact gtgtgagctg cggctgtatg acaatccctg gaggtgtgac tcagacatcc
     1381 ttccgctccg caactggctc ctgctcaacc agcctaggtt agggacggac actgtacctg
     1441 tgtgtttcag cccagccaat gtccgaggcc agtccctcat tatcatcaat gtcaacgttg
     1501 ctgttccaag cgtccatgtc cccgaggtgc ctagttaccc agaaacacca tggtacccag
     1561 acacacccag ttaccctgac accacatccg tctcttctac cactgagcta accagccctg
     1621 tggaagacta cactgatctg actaccattc aggtcactga tgaccgcagc gtttggggca
     1681 tgacccaggc ccagagcggg ctggccattg ccgccattgt aattggcatt gtcgccctgg
     1741 cctgctccct ggctgcctgc gtcggctgtt gctgctgcaa gaagaggagc caagctgtcc
     1801 tgatgcagat gaaggcaccc aatgagtgtt aaagaggcag gctggagcag ggctggggaa
     1861 tgatgggact ggaggacctg ggaatttcat ctttctgcct ccacccctgg gtccatggag
     1921 ctttcccgtg attgctcttt ctggccccag agaaaggtga gcctacctct tcctgacttg
     1981 cctgattctc ccgtagagaa gcaggtcgtg ccggaccttc ctacaatcag gaagatagat
     2041 ccaactggcc atggcaaaag ccctggggat ttccgattca tacccctggg cttccttcga
     2101 gagggctctt cctccaaatc ctccccacct gtcctccaag aacagccttc cctgcgccca
     2161 ggccccctcc gggcctctgt agactcagtt agtccacagc ctgctcactt cgtgggaata
     2221 gttctccgct gagatagccc ctctcgccta agtattatgt aagttgattt cccttctttt
     2281 gtttctcttg tttgtgctac ggcttgaccc agcatgtccc ctcaaatgaa agttctcccc
     2341 ttgattttct gctcctgaag gcagggtgag ttctctcctc aaagaagact tcaaaccatt
     2401 taactggttt cttaagagcc gtcaatcagc ctggttttgg ggatgctatg aaagagagaa
     2461 ggaaaatcat gccgctcagt tcctggagac agaagagccg tcatcagtgt ctcacttgtg
     2521 atttttatct ggaaaaggaa gaaacacccc agcacagcaa gctcagcctt ttagagaagg
     2581 atatttccaa actgcaaact ttgctttgaa aagtttagcc ctttaaggaa tgaaatcatg
     2641 tagaattttg gacttctaaa aacattaaaa tcagcttatt aatacgggat agagaaagaa
     2701 atctggtgcc tgggggtccc tgtgttcacc cctagagttt gttttaaaat ttttaattga
     2761 agcatgtgaa gtgtacgtgc agaaaagtgg gaacatgata gtgtatggct tggtggattt
     2821 tcacaaactg aacatacctg tgtaatcagc atctagaccc agacccagag catcacaaat
     2881 atcccccatc ctgggctttt cccagaggag atgggggctt ctgaagatgg acttacctgg
     2941 gacctgcccc ccatgagcca ggacggtccc cccacagtca gcctgtgcaa aggccccgtg
     3001 gccaggggtg gaggagaata tgtgggtgtg gacaggatgg gagactgtgg cctgaacagg
     3061 agattttatt atatctggag accctgagag accctgagac ctggggcacc atggctggcc
     3121 aggtcagaag catcctgact gcagaggtcc gtgcagccac accctcttcc ctgccagcaa
     3181 gctgtctgcg gctcatcgga ggcccctccg cctggagcct tctatggacg tgatatgcct
     3241 gtatctgttt ttaattttca ttcttcactt aggggaagtg aaatcgctca gagatgagat
     3301 cctttaattg aaaacgaagt gtaacggaat ctagtgtctt tctaatgtgg taaaattctc
     3361 catcaacatc acagtcagct ggcagctgaa cttcagaatc tcacttacag caggcgacac
     3421 gggggtacac cgatgggtca cactgggtct gggggctccc tggagctcct cctgcgtgtg
     3481 gtctggttag gagttgagtt gtttgctcca gggttattct cctcctcgag tcacagtcac
     3541 acgaatacct gccttctctg gctttcctgc tatacacata ttcacatggc gctcaagaag
     3601 ttaggctcat ggcaacgtgt gtctttctct ggacaactgg cccagtttac agtgaaatgg
     3661 agaatttcag gtctccacgt ctgcccagga aagaacttca gctgactcca cggggatctg
     3721 gaaatccacg accaatcccg atcggctctt attagctccc cgctccacaa gacacctgtg
     3781 ctttggaaat ccaccaccaa tcccgatcgg ctcttattag ctccccgctc cacaagacac
     3841 ctgtgatctg gaaatctacc accaatcccg atcggctctt attagctccc cgctccacaa
     3901 gacacctgtg acatcctcca gggccacagg agcacgtgct gaccagtttt cccttccagt
     3961 tcctgcacaa aaagtgtcca gagggctgtt tgcaaacact agtgcacttt gtagcttttc
     4021 accctctgtc ccagggaatc taggagagat gaggcccgtc agagtcaaga gatgtcatcc
     4081 ccccagggtc tccaaggcat ttccacacta ttggtggcac ctggaggaca tgcaccaagg
     4141 cttgccagag ccaacaggaa gtgagcccag agcatggcac atgagcatca cccgctgatg
     4201 gtggcctgct gtgcctggtg ccaacagggg catcccggcc cgtacccctc cagacaggaa
     4261 gcatgggttt gcccacagac ctgtcgggtg ctcctgtgag tggcctccag atgtctttgt
     4321 gcataggcac aagtgggcca gggctggagg gaggtgggaa acctcatcat ccggtgggcc
     4381 ctgccaatct taacccagaa cccttaggta ttcctggcag tagccatgac attggagcac
     4441 cttcctctcc agccagaggc tgacctgagg gccactgtcc tcagatgaca ccacccagga
     4501 gcaccctagg tgaggggtga gggccccctt atgtgaacct cttgcctctt cctttctccc
     4561 atcagagtgg ttggatggag ccattggcct ccttttcttc agcgggccct tcaacctctc
     4621 tgcaccatgt tgtctggctg aggagctact agaaaagctg agtggagtct cctttccaac
     4681 aggatgatgc atttgctcaa ttctcagggc tggaatgagc cggctggtcc cccagaaagc
     4741 tggagtgggg tacagagttc agttttcctc tctgtttaca gctccttgac agtcccacgc
     4801 ccatctggag tgggagctgg gagtcagtgt tggagaagaa acaacaaaag ccaattagaa
     4861 ccactatttt taaaaagtgc ttactgtgca cagatactct tcaagcactg gacgtggatt
     4921 ctctctctag ccctcagcac ccctgcggta ggagtgccgc ctctacccac ttgtgatggg
     4981 gtacagaggc acttgctctt ctgcatggtg ttcaataggc tgggagtttt atttatctct
     5041 tcaaactttg tacaagagct catggcttgt cttgggcttt cgtcattaaa ccaaaggaaa
     5101 tggaagccat tcccctgttg ctctccttag tcttggtcat cagaacctca cttggtacca
     5161 tatagatcaa aagctttgta accacaggaa aaaataaact cttccatccc ttaaagaata
     5221 gaatagtttg tccctctcat gggaattggg ctgtatgtat attgttcttc ctccttagaa
     5281 tttagagata caagagttct acttagaact tttcatggac acaatttcca caacctttca
     5341 gatgctgatg tagagctatt gggaaagaac ttccaaactc aggaagtttg cagagagcag
     5401 acagctagag ataactcggg acccagagtt ggtcgacaga tgttagatgt atcctagctt
     5461 ttagctataa accactcaaa gattcagccc ccagatccca cagtcagaac tgaatctgcg
     5521 ttgttgggaa gccagcagtg gccttgggaa ggaagccatg gctgtggttc agagagggtg
     5581 ggctggcaag ccacttccgg ggaaaactcc ttccgcccca ggtttcttct tctcttaagg
     5641 agagattgtt ctcaccaacc cgctgccttc atgctgcctt caaagctaga tcatgtttgc
     5701 cttgcttaga gaattactgc aaatcagccc cagtgcttgg cgatgcattt acagatttct
     5761 aggccctcag ggttttgtag agtgtgagcc ctggtgggca gggttggggg gtctgtcttc
     5821 tgctggatgc tgcttgtaat ccatttggtg tacagaatca acaataaata atatacatgt
     5881 a
//
