LOCUS       NP_570843                581 aa            linear   PRI 04-AUG-2024
DEFINITION  leucine-rich repeat-containing protein 15 isoform b precursor [Homo
            sapiens].
ACCESSION   NP_570843
VERSION     NP_570843.2
DBSOURCE    REFSEQ: accession NM_130830.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 581)
  AUTHORS   Gong,S., Xiang,K., Chen,L., Zhuang,H., Song,Y. and Chen,J.
  TITLE     Integrated bioinformatics analysis identified leucine rich repeat
            containing 15 and secreted phosphoprotein 1 as hub genes for
            calcific aortic valve disease and osteoarthritis
  JOURNAL   IET Syst Biol 18 (3), 77-91 (2024)
   PUBMED   38566328
  REMARK    GeneRIF: Integrated bioinformatics analysis identified leucine rich
            repeat containing 15 and secreted phosphoprotein 1 as hub genes for
            calcific aortic valve disease and osteoarthritis.
REFERENCE   2  (residues 1 to 581)
  AUTHORS   Wang,Q.W., Jia,Y.L., Li,P. and Yu,G.Y.
  TITLE     Effect of LRRC15 on autophagy in A549 cells
  JOURNAL   Yi Chuan 46 (5), 398-407 (2024)
   PUBMED   38763774
  REMARK    GeneRIF: Effect of LRRC15 on autophagy in A549 cells.
REFERENCE   3  (residues 1 to 581)
  AUTHORS   Kim,H.J., Kim,D.J., Kim,S.M. and Jang,Y.J.
  TITLE     Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is
            Essential for Integrin Signaling in TGF-beta1-Induced PDL
            Fibroblastic Differentiation
  JOURNAL   Stem Cells 42 (3), 251-265 (2024)
   PUBMED   38051601
  REMARK    GeneRIF: Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion
            Is Essential for Integrin Signaling in TGF-beta1-Induced PDL
            Fibroblastic Differentiation.
REFERENCE   4  (residues 1 to 581)
  AUTHORS   Loo,L., Waller,M.A., Moreno,C.L., Cole,A.J., Stella,A.O., Pop,O.T.,
            Jochum,A.K., Ali,O.H., Denes,C.E., Hamoudi,Z., Chung,F.,
            Aggarwal,A., Low,J.K.K., Patel,K., Siddiquee,R., Kang,T.,
            Mathivanan,S., Mackay,J.P., Jochum,W., Flatz,L., Hesselson,D.,
            Turville,S. and Neely,G.G.
  TITLE     Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and
            controls antiviral and antifibrotic transcriptional programs
  JOURNAL   PLoS Biol 21 (2), e3001967 (2023)
   PUBMED   36757924
  REMARK    GeneRIF: Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2
            spike and controls antiviral and antifibrotic transcriptional
            programs.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 581)
  AUTHORS   Shilts,J., Crozier,T.W.M., Teixeira-Silva,A., Gabaev,I.,
            Gerber,P.P., Greenwood,E.J.D., Watson,S.J., Ortmann,B.M.,
            Gawden-Bone,C.M., Pauzaite,T., Hoffmann,M., Nathan,J.A.,
            Pohlmann,S., Matheson,N.J., Lehner,P.J. and Wright,G.J.
  TITLE     LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike
            protein
  JOURNAL   PLoS Biol 21 (2), e3001959 (2023)
   PUBMED   36735681
  REMARK    GeneRIF: LRRC15 mediates an accessory interaction with the
            SARS-CoV-2 spike protein.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 581)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 581)
  AUTHORS   O'Prey,J., Wilkinson,S. and Ryan,K.M.
  TITLE     Tumor antigen LRRC15 impedes adenoviral infection: implications for
            virus-based cancer therapy
  JOURNAL   J Virol 82 (12), 5933-5939 (2008)
   PUBMED   18385238
  REMARK    GeneRIF: Tumor antigen LRRC15 impedes adenoviral infection:
            implications for virus-based cancer therapy are presented.
REFERENCE   8  (residues 1 to 581)
  AUTHORS   Satoh,K., Hata,M., Shimizu,T., Yokota,H., Akatsu,H., Yamamoto,T.,
            Kosaka,K. and Yamada,T.
  TITLE     Lib, transcriptionally induced in senile plaque-associated
            astrocytes, promotes glial migration through extracellular matrix
  JOURNAL   Biochem Biophys Res Commun 335 (2), 631-636 (2005)
   PUBMED   16098915
  REMARK    GeneRIF: Lib may contribute to regulation of cell-matrix adhesion
            interactions with respect to astrocyte recruitment around senile
            plaques in Alzheimer's disease brain
REFERENCE   9  (residues 1 to 581)
  AUTHORS   Reynolds,P.A., Smolen,G.A., Palmer,R.E., Sgroi,D., Yajnik,V.,
            Gerald,W.L. and Haber,D.A.
  TITLE     Identification of a DNA-binding site and transcriptional target for
            the EWS-WT1(+KTS) oncoprotein
  JOURNAL   Genes Dev 17 (17), 2094-2107 (2003)
   PUBMED   12923058
  REMARK    GeneRIF: LRRC15 is induced by EWS-WT1(+KTS) in the tumor DSRCT and
            may play a role in cellular invasion.
REFERENCE   10 (residues 1 to 581)
  AUTHORS   Satoh,K., Hata,M. and Yokota,H.
  TITLE     A novel member of the leucine-rich repeat superfamily induced in
            rat astrocytes by beta-amyloid
  JOURNAL   Biochem Biophys Res Commun 290 (2), 756-762 (2002)
   PUBMED   11785964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK125112.1 and AC174158.3.
            
            On Feb 5, 2010 this sequence version replaced NP_570843.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks a portion of the 5' coding region, compared to variant 1. The
            resulting isoform (b) is shorter at the N-terminus, compared to
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125112.1, BC101065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347624.4/ ENSP00000306276.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     Protein         1..581
                     /product="leucine-rich repeat-containing protein 15
                     isoform b precursor"
                     /note="leucine-rich repeat protein induced by beta
                     amyloid; leucine-rich repeat-containing protein 15; hLib;
                     leucine-rich repeat protein induced by beta-amyloid
                     homolog"
                     /calculated_mol_wt=62130
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2255
     mat_peptide     22..581
                     /product="Leucine-rich repeat-containing protein 15.
                     /id=PRO_0000021605"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
                     /calculated_mol_wt=62130
     Region          44..443
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          54..75
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Site            75
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          78..99
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          82..102
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..123
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          103..150
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..147
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          150..171
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          151..174
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..195
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          175..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          198..219
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          199..222
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          222..243
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          223..246
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          246..267
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          247..270
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          270..291
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          271..294
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          294..315
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          295..318
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          318..339
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          319..342
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          342..363
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          343..364
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..387
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          367..387
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            369
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          390..411
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Region          391..412
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          489..509
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     Site            539..559
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TF66.2)"
     CDS             1..581
                     /gene="LRRC15"
                     /gene_synonym="LIB"
                     /coded_by="NM_130830.5:87..1832"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS3306.1"
                     /db_xref="GeneID:131578"
                     /db_xref="HGNC:HGNC:20818"
                     /db_xref="MIM:619327"
ORIGIN      
        1 mplkhyllll vgcqawgagl ayhgcpsect csrasqvect garivavptp lpwnamslqi
       61 lnthitelne spflnisali alrieknels ritpgafrnl gslrylslan nklqvlpigl
      121 fqgldslesl llssnqllqi qpahfsqcsn lkelqlhgnh leyipdgafd hlvgltklnl
      181 gknslthisp rvfqhlgnlq vlrlyenrlt dipmgtfdgl vnlqelalqq nqigllspgl
      241 fhnnhnlqrl ylsnnhisql ppsvfmqlpq lnrltlfgns lkelspgifg pmpnlrelwl
      301 ydnhisslpd nvfsnlrqlq vlilsrnqis fispgafngl telrelslht nalqdldgnv
      361 frmlanlqni slqnnrlrql pgnifanvng lmaiqlqnnq lenlplgifd hlgklcelrl
      421 ydnpwrcdsd ilplrnwlll nqprlgtdtv pvcfspanvr gqsliiinvn vavpsvhvpe
      481 vpsypetpwy pdtpsypdtt svssttelts pvedytdltt iqvtddrsvw gmtqaqsgla
      541 iaaivigiva lacslaacvg cccckkrsqa vlmqmkapne c
//
