LOCUS       NM_001080478            2570 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 14B (LRRC14B), mRNA.
ACCESSION   NM_001080478 XM_371722
VERSION     NM_001080478.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021087.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080478.2.
            
            Summary: The protein encoded by this gene is a leucine-rich repeat
            containing protein that is a member of the PRAME family. [provided
            by RefSeq, Apr 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.126157.1,
                                           SRR1803616.10834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328278.4/ ENSP00000327675.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-943               AC021087.5         47085-48027
            944-2570            AC021087.5         50298-51924
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..2570
                     /gene="LRRC14B"
                     /note="leucine rich repeat containing 14B"
                     /db_xref="GeneID:389257"
                     /db_xref="HGNC:HGNC:37268"
     exon            1..943
                     /gene="LRRC14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1589
                     /gene="LRRC14B"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 14B"
                     /protein_id="NP_001073947.1"
                     /db_xref="CCDS:CCDS47184.1"
                     /db_xref="GeneID:389257"
                     /db_xref="HGNC:HGNC:37268"
                     /translation="MDTMRSLRFISAEALVSHPQVARQSLDSVAHNLYPLLFKASYLL
                     EQAEVTRAVLGRWPLEEFRLGALLGPGADHPQDLRDRTCRACLEALVRGLADHVLQDR
                     SRRRLRVADLTGIRDVQVQRCPCGRALGRWGRTQLLARTCCELQAEPLAAGRPVEVLA
                     DLFVTEGNFEAVVQALRPAGPAPLRVHCPSFRADSLSPSQLLHVLRLAGPGALRKLEV
                     VHNVRLHAGHVQQLLAQVGFPRLASLTLPTKAFDAPPTYASTPDGEDPLLASIARELS
                     KMAQLTELSVAFSTLTGKIPTLLGPLQTPLRVLDLANCALNHTDMAFLADCAHAAHLE
                     VLDLSGHNLVSLYPSTFFRLLSQASRTLRILTLEECGIVDSHVGMLILGLSPCHRLRQ
                     LKFLGNPLSARALRRLFTALCELPELRCIEFPVPKDCYPEGAAYPQDELAMSKFNQQK
                     YDEIAEELRAVLLRADREDIQVSTPLFGSFDPDIQETSNELGAFLLQAFKTALENFSR
                     ALKQIE"
     exon            944..2570
                     /gene="LRRC14B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2548..2553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC14B"
                     /note="hexamer: AATAAA"
     polyA_site      2570
                     /gene="LRRC14B"
                     /note="major polyA site"
ORIGIN      
        1 acacgccttg gggaaagtcg tggggagcgg tcctgtctcg ggccatggac acaatgaggt
       61 cactccgctt catttctgca gaagctctgg tgtcccaccc ccaggtggcc cggcagagcc
      121 tggacagcgt ggcccacaac ctctacccac tcctgttcaa agccagctac ctgctggagc
      181 aggcggaggt gacgcgcgcg gtgctggggc gctggcccct ggaggagttc cggctgggag
      241 cgctgctggg tcctggtgcc gaccaccccc aggacctgcg cgacagaacc tgcagggcct
      301 gcctggaggc gctggtgcgc ggcctcgcgg accacgtgct gcaggaccgg agccgccggc
      361 ggctgcgggt ggctgacctc acgggcatcc gagatgtgca ggtgcagcgg tgcccgtgcg
      421 ggagggcgct gggcaggtgg ggccgcaccc agctgctggc caggacctgc tgtgagctgc
      481 aggcagagcc cctcgcagcc gggcgccccg tcgaggtcct cgccgacctc ttcgtcactg
      541 agggcaactt cgaggcggtg gtgcaggctc tgaggccagc gggcccggcc cctctgcggg
      601 tgcactgccc ctcgttccgg gcggacagcc tgagccccag ccagctcctg cacgtgctgc
      661 gtctggctgg cccgggtgcc ctgcgcaagc tggaggtggt gcacaacgtg cggctgcatg
      721 cgggccacgt gcagcagctt ctggcccagg tgggcttccc ccggctggcc tcgctcaccc
      781 tgcccaccaa ggcctttgat gcacccccca cctacgcctc cactcccgac ggcgaggacc
      841 ccctcctcgc ctccatcgcc cgggagctca gcaagatggc gcagctcact gagctcagtg
      901 tggccttctc cacgctgacc gggaagatcc cgacgctgct tggcccccta cagaccccgc
      961 tgcgagtact ggacctggcc aactgtgccc tgaaccacac ggacatggcc ttcttggcag
     1021 actgtgccca cgctgcccac ctggaggtgc tggacctcag tggacacaac ctggtcagcc
     1081 tgtacccctc gaccttcttc aggctgctca gccaggcttc ccggacgctg aggatcctga
     1141 cactggagga gtgtggcatc gtagacagcc acgttggcat gctgatcctg ggcctgagcc
     1201 cctgccaccg gctgcgccag ctcaagttcc tcgggaaccc gctgtcggcc cgcgccctcc
     1261 ggcgcctctt caccgcactc tgtgagctcc ccgagctgcg ctgcattgag ttcccggtgc
     1321 ccaaggactg ctaccccgag ggtgccgcct acccacagga cgagctggcc atgtccaagt
     1381 tcaaccagca gaaatacgac gagatcgccg aggagctgcg tgccgtgctg ctgcgggctg
     1441 accgagagga catccaagtc tccacacctc tctttggaag ttttgaccca gacattcaag
     1501 aaacaagcaa tgagcttggt gctttcttgc tgcaagcttt caaaactgct ctagaaaact
     1561 tctccagagc actcaaacaa atagagtagt tcctccactc gcaccagtga caggtcttgc
     1621 atttcagcct gcaggtgccc cgggctttag tcctggatct gaggcttggg cccggcattc
     1681 atccccacca ccaccaccac caaaagcagt tcttagtgaa aattgtaggc gagcctgtta
     1741 agcgttgtag aagaggaagc cttccaggag aggtgccatg cggtgccctt tagtggcagc
     1801 acggcaaggt tctggaggcg ggggaagcca ccaagagaca gtgacagggt cagcgggggc
     1861 agacgccaca tggcaaagag cagagaagcc cgggaggtgt gaggagtggc cgacctggcc
     1921 tcagcgcatc tgggcactgg gcgcaagatg aagcttcagg gggcagatgt gactgggctc
     1981 cacagcaggg agggggaggg gaagagagaa cacatcacag aaactgcaca aaataagcag
     2041 cccatgaaaa acaaccgaga aaaagaggcg aaaaatgaac agcaaaccgg accctgcttc
     2101 ctccagcagg aggctcccac ccactgctgg tcacaacccg ctgtctggac ctgccgctta
     2161 cgggatgagg tgggcctgca gggaacgcgg ggcttctggt tgctgttagt ggtggctttt
     2221 cttctcactt tgtgtagccc ccagaaccgt gaggggcatc cgagtgggtg agcacaggcg
     2281 tccgctgaag agccgcctgg accagggcgg tcagcgctgc ggggaggcct ttgcccgacc
     2341 gcgccactgt ttctcaccaa cattcactgt gtcctgcggg gcttgaggct tagactgacg
     2401 ggagctattc cgggtgttta attgaaggtc tagcacttga ccagcccctg gaggagctga
     2461 caaccaccta agacacattt ggacttggtg tccaccaaga gtgactttgt gcaaagaaat
     2521 ggctgagcac tagaataact aaatgcaaat aaaatgcgtc tttcagtgca
//
