LOCUS       NM_014665               5337 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens leucine rich repeat containing 14 (LRRC14), transcript
            variant 2, mRNA.
ACCESSION   NM_014665
VERSION     NM_014665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5337)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5337)
  AUTHORS   Wu,C., Yang,Y., Ou,J., Zhu,L., Zhao,W. and Cui,J.
  TITLE     LRRC14 attenuates Toll-like receptor-mediated NF-kappaB signaling
            through disruption of IKK complex
  JOURNAL   Exp Cell Res 347 (1), 65-73 (2016)
   PUBMED   27426725
  REMARK    GeneRIF: TLR signaling led to lower expression of LRRC14.
REFERENCE   3  (bases 1 to 5337)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   4  (bases 1 to 5337)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084125.9, D25216.1 and BU634522.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014665.3.
            
            Summary: This gene encodes a leucine-rich repeat-containing
            protein. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.170789.1, D25216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292524.6/ ENSP00000292524.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC084125.9         110745-110759       c
            16-233              D25216.1           1-218
            234-234             AC084125.9         108953-108953       c
            235-2265            D25216.1           220-2250
            2266-5287           AC084125.9         103629-106650       c
            5288-5337           BU634522.1         20-69               c
FEATURES             Location/Qualifiers
     source          1..5337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..5337
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
                     /note="leucine rich repeat containing 14"
                     /db_xref="GeneID:9684"
                     /db_xref="HGNC:HGNC:20419"
                     /db_xref="MIM:619368"
     exon            1..50
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
                     /inference="alignment:Splign:2.1.0"
     exon            51..490
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1643
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 14"
                     /protein_id="NP_055480.1"
                     /db_xref="CCDS:CCDS6432.1"
                     /db_xref="GeneID:9684"
                     /db_xref="HGNC:HGNC:20419"
                     /db_xref="MIM:619368"
                     /translation="MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKT
                     VVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTSEPG
                     ASTQPLCRKHALRVLDMTGLLDDGVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGP
                     APIPVEVRVDLRVNRASYAFLREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLD
                     AGCLRRVDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYF
                     LAQMGRFTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPH
                     AAHLKKLDLSGNDLSGSQLAPFQGLLQASAATLLHLELTECQLADTQLLATLPILTQC
                     ASLRYLGLYGNPLSMAGLKELLRDSVAQAELRTVVHPFPVDCYEGLPWPPPASVLLEA
                     SINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL"
     exon            491..1075
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..5337
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5289..5294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
                     /note="hexamer: TATAAA"
     polyA_site      5311
                     /gene="LRRC14"
                     /gene_synonym="LRRC14A"
ORIGIN      
        1 ggcggacggt ctaggcgggg ctggaggcgg tggctgcggt tgcgggaccg gcactatgct
       61 gggccttcct accacttgtg tgtggcttgg tagtggccta gggtctctcc tccctgctga
      121 agtccctctc ctgcaggtgg ccgtctgccc ggcccagcac catgcacacg cttgtgttct
      181 tgagcacacg gcaggtgctg cagtgccagc cagctgcctg ccaggccctg cccttgctgc
      241 cacgcgaact cttccccctg ctgttcaagg tggccttcat ggacaagaag acagtggtac
      301 tgcgcgagtt ggtacacacg tggcccttcc cgctgctcag tttccagcag ctgctacagg
      361 agtgtgccca ctgcagccgt gccctcctgc aggagcggcc tagcactgag agcatgcagg
      421 ctgttatcct ggggctgact gcccggctcc acacctcaga gcctggggcc agcacacagc
      481 ccctctgcag gaagcatgcg ctgcgggtgc tggacatgac gggcctcttg gatgatggtg
      541 tggaacagga tcctggcacc atgagcatgt gggactgtac tgctgccgta gctcgcacat
      601 gcattgccca gcagcagggt ggggccgcag agcctgggcc agcccccatc cccgtggagg
      661 tgcgcgtgga cctgcgggtg aaccgggcct cctatgcgtt cctgcgggag gcactccgaa
      721 gcagcgtggg cagcccgctg cggctctgct gccgggacct gcgagctgag gacctgccca
      781 tgcgcaacac tgtggccctg ctgcagcttc tggatgcagg ctgcctgcgc cgcgtggacc
      841 tgcgcttcaa caatctgggc ctgcgcggcc tgtctgtgat catcccacac gtggcccgct
      901 tccagcacct ggccagcctg cggctccact atgtgcatgg ggattcaagg cagccctccg
      961 tggatggcga ggacaacttc cgctacttcc ttgcccagat gggccgcttc acctgtctgc
     1021 gtgagctcag catgggctcc tctctccttt cagggaggct ggaccagctg ctcagcaccc
     1081 tgcagagccc cctggagagc ctggagttgg ccttctgtgc tctgctgcct gaggacctac
     1141 gcttcctggc acggagccca catgctgccc acctcaagaa gttggacctg agtggtaacg
     1201 acctgtctgg cagccagctg gcacccttcc agggtctgtt gcaggcatca gcagccacac
     1261 tgttgcatct ggagctgact gagtgtcagc tcgcagacac ccagctgttg gccacactac
     1321 ccatcctgac tcagtgcgcc agtctccggt accttggcct ctatggcaac ccactgtcca
     1381 tggcgggcct caaggagctg ctgcgggact cagtggcaca ggctgagctg cgtactgtgg
     1441 tgcacccctt ccctgtggac tgctatgagg gcttgccctg gccgccgcct gcctctgtcc
     1501 tgctggaggc ctccatcaat gaggagaagt ttgcccgcgt agaagctgag ttgcaccagc
     1561 tgcttctagc ctcaggccgt gcccatgtgc tctggaccac ggacatctac gggcgactgg
     1621 ctgcggacta cttcagccta tgatgaagta gctctgggtg agacacaggc cgccctgcag
     1681 tctctttagg taggcagggc ctttgctggg acccctggtg gaggccttca caaaagcact
     1741 ggttactggt ttcctgctgg gtctaccttg cttctgggca cacctcaagc ctcccctgct
     1801 ttctgcagtg ccccacgcgg ttttccctgc acttgctcca taattggctg atcatctgtg
     1861 ggccccgggg ctggatgtca ggcctccatt gccctgctca gtttggctgc atttggctgc
     1921 cgtctggggt cctggtcctt tgtgcaaatg ctttgggatt ccagttgtga gctgagagag
     1981 atgatggcct ctctgggcct ttcctctccc tttactgaga gctcagtgct tctggggttg
     2041 aagttggaca gaggcctgct tcagggaagc tgggagtccc caggcactca cgcctcttac
     2101 gtgttcccta ccctgccacc cagccacccc actgggctgg gctcgggctg gagggggtca
     2161 tcaaggtaca catgtgcctg gaagttgaat ttgtggctgt ttttttttct gtccacgttg
     2221 gtcaccctta tccttatctc tgctgtcacc cccaacatgg ccacccggca acaactgcca
     2281 tccagcctgt cgccccgccc ttcgcggggc agccccgtcg gcactgccgg ccagtccttg
     2341 ctcttcccac ctttcggagg cccaagatcc tactgtggcc ggccagggcc agcgagggac
     2401 cccccccatg cagagctgga ggttggggtg atgtcttttc ggaagagctt caagggaggt
     2461 gttggggcct ccccggccac cttccattgc taccccagga ttcccgagtg caacgttccc
     2521 ggctcgcgcc ccacacacgg ctcagcgcac actgcgcggc ttccaccttt actgacggag
     2581 catgcgcgag gccgcaccgg ccaatctccg gcgcccacgt catccgcgcg cccgcggccc
     2641 tagcagtgga tctcgtaggc gaccggcggg ggcacgcgga gtcccggccc cgccccctgt
     2701 tccgggccgc agtcagcggg cgcctccgcc ggaccctcgg cgaagagcgg cttggagcgg
     2761 ttgatgacga acatctcgtg gccgcgctcg tcgcggagct cctctagctg tgcgaacgta
     2821 caggggccgt ccaagtagtc gttgacgaac agcgctccct cccccggagg cccccgcgcc
     2881 ttttttcgcc tgcggcgccg gcgacagatc atggcgacca ggagcagcgc cgtgagcgcc
     2941 agcagcgcga tggccgccgc aatggccgtc tgtgtggcca cgcccagggc gcggaaggcc
     3001 atgctgcccg cctcgggccg gggctcgctg ccggcggggc gggcggccgg aggcggcggt
     3061 tgcgcgggct gctgcggctg ctgccgggac gcgttgacca ggagccggaa gggcacgcgg
     3121 gcagcgccgc cggcgttgga ggcctcgcac tcgtacttac cggcgtgcgc cagcgtgatg
     3181 ttgctgagga agagcatgcc gctgcccgtg tcggatgccg agtgtccgcc caggcccagc
     3241 aacccgcctt ctagctgggc ctgggctcgc ggccggccct cgcgaggctg gggcaccttt
     3301 ctccaggtca ccaatggctg cgggtagccg gaggcttggc aggcaacccg caggtcctca
     3361 cccaggttgg ctgtgagctc cagcggctgc acgtggacag agggcggaat gcagatgagg
     3421 ctgctgtggg atacgtccag gagactctgg agcgccaggc gcgggggctc tgcacacatg
     3481 atcttcctgt ccctggaggt gagcagccgc tggccgccct ccttgatcca ggcacccagc
     3541 cagtgcaggg cgcagtcaca gcgccatggg ttctctgtgg gagagcagcg ttaggcaggt
     3601 ggcttgaggg tgctgctaaa acagcctgtg cagttggggt tttgcaggcc aggacagagg
     3661 cctctttccc acctcccaca gcgttttcac acggagtcca aggccctgcc accccttcct
     3721 tgaccccaag ctccttgggg cggcaggccc ttcaccctcg cccccctccc ctttagctct
     3781 gtgatgcctg cctgttacag atcacttctc cgtcggtctc tgagaaagca cctgctcctt
     3841 aagtcttcct gcaacaagtg ccactgtttt taggaacctg ggcgtccaca tagacatctc
     3901 accagcactg aaacctcaca agtcctctca gccttgcctt tggatgccct ctcttgggaa
     3961 tgtccccagt cctggtcagc tgtctctctc ctttgcaatt ttgtctgcct cccctcagcc
     4021 taaaagtgtg cagaaccctc aattctgtta agtcaccctg tggagttcct gtcttctgtt
     4081 ttccccaggc agggtgcctg agctgtattc cccagcacac ccactcccgc agccctccag
     4141 tgtggctgca ggcggtggtg cagccttcca gactgctgcc cagttgcctg atgtcagagc
     4201 ccctccacac atgagcctgc tccctactgc caacaccgtg gcccagacag agacgctttc
     4261 cgaggaagag gtacctgtga ggcgcaggac ttgcagactg gccaggggct gcagggcctc
     4321 tcggctgatg gtgcccagct ggttcctgct gaggtccagc agtgctaggg aggacagccc
     4381 cgctagagcc tggtcctcca gcagctcaat gctgttttct tgcaggtgaa gctcctgcag
     4441 tcgctgaagt aaggacagca gatcgtgagg aaaaagggcg ccgaggttgg gggcatgtct
     4501 ctcttcttac caagctagac tgggttgcct tttctaacta ttccagccct acagggcgag
     4561 gggccataat ggagtatccc gcccctttag accccaggcg ctcaccggca ggtgcaagaa
     4621 ggtgaaatcc agcagccgcg ccagctggtt gcccgccagg tagagcacgc gcagctgggc
     4681 caggcctacg aaggcgccgc tgcgcaagcc gcgcagccgg ttgctagtga gcgccagctc
     4741 cagcaggcgc ggctgcgcgc ggaaggcgcc ggcctccagg gcgcgcaggc tgttgttgtg
     4801 caggtagagc cggcgcagag cggcgagtgg cgccagggct cccggctcta ggcgggcgat
     4861 gttgttgtcc tgcaggaaca gtgtctgcag gccggggaaa gaggaggcgc ttaccccgtt
     4921 gcgggggtct tcctctccct gggggcaccc cgtcctcccg cagctccaca cggtgcccac
     4981 ctgcgtccct ggcgggattc ccagcgggac gacgcgcaac cgcagggcgc cacactccac
     5041 cgtggcgctg tagcagcggc aggctgctgg gcagccggcg gcgcggagcg gcagtagtag
     5101 cagcagcagc ggcagcagtg cgggggccct cagggccatc tcccgaggcc cggttcctca
     5161 ccggcccttc cgcggttcag ccgcagacgc gtgccctcct gaaacacagg ttggcaggcc
     5221 agtctcggca gtcgagagcc agccaataga tggaatggag gcctgcacct gcgtctaact
     5281 tttgacgcta taaataggtt caagaaacta ataaaacgtt ctggttttct cctttga
//
