LOCUS       NM_201550               2344 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat containing 10 (LRRC10), mRNA.
ACCESSION   NM_201550
VERSION     NM_201550.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Siri-Angkul,N. and Kamp,T.J.
  TITLE     Cardiac L-type calcium channel regulation by Leucine-Rich
            Repeat-Containing Protein 10
  JOURNAL   Channels (Austin) 18 (1), 2355121 (2024)
   PUBMED   38762910
  REMARK    GeneRIF: Cardiac L-type calcium channel regulation by Leucine-Rich
            Repeat-Containing Protein 10.
            Review article
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   Woon,M.T., Long,P.A., Reilly,L., Evans,J.M., Keefe,A.M., Lea,M.R.,
            Beglinger,C.J., Balijepalli,R.C., Lee,Y., Olson,T.M. and Kamp,T.J.
  TITLE     Pediatric Dilated Cardiomyopathy-Associated LRRC10 (Leucine-Rich
            Repeat-Containing 10) Variant Reveals LRRC10 as an Auxiliary
            Subunit of Cardiac L-Type Ca2+ Channels
  JOURNAL   J Am Heart Assoc 7 (3), e006428 (2018)
   PUBMED   29431102
  REMARK    GeneRIF: Examination of a patient with dilated cardiomyopathy
            revealed homozygosity for a previously unreported LRRC10 variant:
            I195T. Wild-type and I195T LRRC10 function as cardiac-specific
            subunits of L-type Ca(2+) channels and exert dramatically different
            effects on channel gating, providing a potential link to DCM.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Huang,L., Tang,S., Chen,Y., Zhang,L., Yin,K., Wu,Y., Zheng,J.,
            Wu,Q., Makielski,J.C. and Cheng,J.
  TITLE     Molecular pathological study on LRRC10 in sudden unexplained
            nocturnal death syndrome in the Chinese Han population
  JOURNAL   Int J Legal Med 131 (3), 621-628 (2017)
   PUBMED   28032242
  REMARK    GeneRIF: LRRC10 may be a new susceptible gene for Sudden
            unexplained nocturnal death syndrome, and LRRC10 variant was
            initially and genetically linked to Brugada syndrome associated
            arrhythmia.
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Brody,M.J., Feng,L., Grimes,A.C., Hacker,T.A., Olson,T.M.,
            Kamp,T.J., Balijepalli,R.C. and Lee,Y.
  TITLE     LRRC10 is required to maintain cardiac function in response to
            pressure overload
  JOURNAL   Am J Physiol Heart Circ Physiol 310 (2), H269-H278 (2016)
   PUBMED   26608339
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   Qu,X.K., Yuan,F., Li,R.G., Xu,L., Jing,W.F., Liu,H., Xu,Y.J.,
            Zhang,M., Liu,X., Fang,W.Y., Yang,Y.Q. and Qiu,X.B.
  TITLE     Prevalence and spectrum of LRRC10 mutations associated with
            idiopathic dilated cardiomyopathy
  JOURNAL   Mol Med Rep 12 (3), 3718-3724 (2015)
   PUBMED   26017719
  REMARK    GeneRIF: This study firstly reports the association of LRRC10
            mutations with enhanced susceptibility to dilated cardiomyopathy in
            humans.
REFERENCE   6  (bases 1 to 2344)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   7  (bases 1 to 2344)
  AUTHORS   Nakane,T., Satoh,T., Inada,Y., Nakayama,J., Itoh,F. and Chiba,S.
  TITLE     Molecular cloning and expression of HRLRRP, a novel
            heart-restricted leucine-rich repeat protein
  JOURNAL   Biochem Biophys Res Commun 314 (4), 1086-1092 (2004)
   PUBMED   14751244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090881.1 and AC018921.22.
            
            On May 17, 2019 this sequence version replaced NM_201550.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC090881.1, AK123908.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361484.5/ ENSP00000355166.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1248              BC090881.1         256-1503
            1249-1249           AC018921.22        34221-34221
            1250-2344           BC090881.1         1505-2599
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..2344
                     /gene="LRRC10"
                     /gene_synonym="HRLRRP; LRRC10A"
                     /note="leucine rich repeat containing 10"
                     /db_xref="GeneID:376132"
                     /db_xref="HGNC:HGNC:20264"
                     /db_xref="MIM:610846"
     exon            1..2344
                     /gene="LRRC10"
                     /gene_synonym="HRLRRP; LRRC10A"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..903
                     /gene="LRRC10"
                     /gene_synonym="HRLRRP; LRRC10A"
                     /note="heart-restricted leucine-rich repeat protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 10"
                     /protein_id="NP_963844.2"
                     /db_xref="CCDS:CCDS31856.1"
                     /db_xref="GeneID:376132"
                     /db_xref="HGNC:HGNC:20264"
                     /db_xref="MIM:610846"
                     /translation="MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRF
                     PLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCI
                     LYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLP
                     GQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVI
                     YDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALVREESQELQAPVPLLPPTN
                     S"
ORIGIN      
        1 agcagtcagc tgagccagcc ccgctcagtg agtctgtcct ctggggctcg ccatgccccc
       61 agcctccgca tggggaacac catcagggcc ctcgtggcct tcatccctgc tgaccgttgc
      121 cagaactatg tggtcaggga cctccgtgag atgccgctgg acaagatggt ggatctgagt
      181 gggagccagt tacgccgctt ccccctgcac gtgtgctcct tcagggagct ggtcaagctc
      241 tacctgagcg acaaccacct caatagcctg cctccggagc tggggcagct acagaacctg
      301 cagattctgg ccttggattt caacaacttc aaggctctgc cccaggtggt gtgcaccttg
      361 aaacagctct gcatcctcta cctgggcaac aacaaactct gcgacctccc cagtgagctg
      421 agcctgctcc agaacctcag gaccctgtgg atcgaggcca actgcctcac ccagctgccg
      481 gatgtggtct gtgagctgag tctccttaag actctgcatg ccggctccaa cgccctgcgt
      541 ttgctgccag gccagctccg gcgcctccag gagctgagga ccatctggct ctcgggcaac
      601 cggctaactg actttcccac tgtgctgctt cacatgccct tcctggaggt gattgatgtg
      661 gactggaaca gcatccgtta cttccccagc ctggcgcacc tgtcaagtct gaagctggtc
      721 atctatgacc acaatccttg caggaacgca cccaaggtgg ccaaaggtgt gcgccgtgtg
      781 gggagatggg cagaggagac gccagagccc gaccctagaa aagccaggcg ctatgcgttg
      841 gtcagagagg aaagccagga gctacaggca ccagtccctc tacttcctcc taccaactcc
      901 tgaggagctt cagttgcaag tcaatgccaa ggacccaact gcagcatgtt ctggaagcct
      961 ctccattgga gtggaaagga tggctctggg tcatttggga gtggctctgc tagtagagac
     1021 tgatggagag agccaggtgg aatgccataa atcacactga gaaaatattt ctggcaaaca
     1081 gctcctcttc cagaggggag ttgtgtgcca atgatggcat gacaatccag agatcataac
     1141 ttctttgcaa gaaaacagct tctccacaca tgtattttga aacactgaag agcaaaaggg
     1201 gctgggacac tctgaactcc tgcactctcc agaagtgact ggtcatgaag ctcatgagct
     1261 cctcaaataa ggtatttgcc atagaactaa atattctggt ggtctgtctc tttgcaggac
     1321 atattttctt tactgtaaat gaccataaac agtatcaatg tatcactgag gccaccgaaa
     1381 aggacatttc tacctaggca atcagtcaga ttcacagaaa aaagttgttt gttgttgtaa
     1441 aggctcaaga tgaaactctt tccccagcag tttagtgcct gctgaaaaga tccctgatgg
     1501 acaatacttc ttggtggact ccagctgccc cttttattat tattagagac aaggtctcac
     1561 tctgttgcta ggctggagtg cagtggcaca atcatggctc actgcagccc cgaactactg
     1621 ggctcaagcc ttcctcccgc ctcagcctgc ccagtaactg gtactacaga tgtgcacacc
     1681 tggctaagtc tttaattttt tcgtagagat gaggtcttgc tatgttgccc aagctagttt
     1741 caaactcctg ggctcaagcg atgctcctgc ttcagcctcc caaagtgctg gggttacagg
     1801 catgagccac cacacccagc cttcagctgt caccttaaac ttgacagtgg ctcatgctga
     1861 tttagttcat tttccctaaa aggtttgtcc caagatctgc tcccaacagt tgactgtcac
     1921 tgacaatgtt ggaagtcatc tggaaaagag aacctctgtg gtaatgtggt ctcattaaag
     1981 tcaagccttg ttgtgattcc tgtctacctc cctgaagcaa agcccttctg tttattcaca
     2041 ctaatgagcc agagctgagc taaattgaat ccctgtcctt ggaggaaaac cacatttcca
     2101 gaagcatgtt agtttaaagg tagtaggtga gaaatgtgtt ctcttgaaac aagcactttg
     2161 aaatttgaat aggaagttgt agtgtatata ggaagtctct gcctctttcg cctagtatct
     2221 ctgcctttgt ttcaatttgt tttgattttt acagactgtt ttgacaatgt ataaaccaag
     2281 gtattttgtt ttttggaagt atgtaaattg tgaccttccc acaaatatat aaactttaaa
     2341 gaaa
//
