LOCUS       NM_018214               3159 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 1 (LRRC1), mRNA.
ACCESSION   NM_018214 XM_001134252 XM_001134288
VERSION     NM_018214.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3159)
  AUTHORS   Wang,Y., Li,X., Guan,X., Song,Z., Liu,H., Guan,Z., Wang,J., Zhu,L.,
            Zhang,D., Zhao,L., Xie,P., Wei,X., Shang,N., Liu,Y., Jin,Z., Ji,Z.
            and Dai,G.
  TITLE     The Upregulation of Leucine-Rich Repeat Containing 1 Expression
            Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by
            Stabilizing Phosphorylated Smad2/3
  JOURNAL   Int J Mol Sci 25 (5), 2735 (2024)
   PUBMED   38473980
  REMARK    GeneRIF: The Upregulation of Leucine-Rich Repeat Containing 1
            Expression Activates Hepatic Stellate Cells and Promotes Liver
            Fibrosis by Stabilizing Phosphorylated Smad2/3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3159)
  AUTHORS   Wang,Y., Tong,H., Wang,J., Hu,L. and Huang,Z.
  TITLE     LRRC1 knockdown downregulates MACF1 to inhibit the malignant
            progression of acute myeloid leukemia by inactivating
            beta-catenin/c-Myc signaling
  JOURNAL   J Mol Histol 55 (1), 37-50 (2024)
   PUBMED   38165568
  REMARK    GeneRIF: LRRC1 knockdown downregulates MACF1 to inhibit the
            malignant progression of acute myeloid leukemia by inactivating
            beta-catenin/c-Myc signaling.
REFERENCE   3  (bases 1 to 3159)
  AUTHORS   Wang,X., Liu,J., Wang,T., Ma,B., Wu,P., Xu,X. and Xiong,J.
  TITLE     The downstream PPARgamma target LRRC1 participates in early stage
            adipocytic differentiation
  JOURNAL   Mol Cell Biochem 478 (7), 1465-1473 (2023)
   PUBMED   36370237
  REMARK    GeneRIF: The downstream PPARgamma target LRRC1 participates in
            early stage adipocytic differentiation.
REFERENCE   4  (bases 1 to 3159)
  AUTHORS   Wu,H., Mu,X., Liu,L., Wu,H., Hu,X., Chen,L., Liu,J., Mu,Y.,
            Yuan,F., Liu,W. and Zhao,Y.
  TITLE     Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a
            reduces cisplatin resistance of non-small cell lung cancer cells
            via targeting LRRC1
  JOURNAL   Cell Death Dis 11 (9), 801 (2020)
   PUBMED   32978367
  REMARK    GeneRIF: Bone marrow mesenchymal stem cells-derived exosomal
            microRNA-193a reduces cisplatin resistance of non-small cell lung
            cancer cells via targeting LRRC1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3159)
  AUTHORS   Daulat,A.M., Wagner,M.S., Walton,A., Baudelet,E., Audebert,S.,
            Camoin,L. and Borg,J.P.
  TITLE     The Tumor Suppressor SCRIB is a Negative Modulator of the
            Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Proteomics 19 (21-22), e1800487 (2019)
   PUBMED   31513346
  REMARK    GeneRIF: Common and specific sets of proteins associated to SCRIB
            and LANO by MS are identified and an extensive landscape of their
            associated networks and the first comparative analysis of their
            respective interactomes are provided
REFERENCE   6  (bases 1 to 3159)
  AUTHORS   Lopez Almeida,L., Sebbagh,M., Bertucci,F., Finetti,P., Wicinski,J.,
            Marchetto,S., Castellano,R., Josselin,E., Charafe-Jauffret,E.,
            Ginestier,C., Borg,J.P. and Santoni,M.J.
  TITLE     The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate
            through WNT/beta-Catenin Signaling
  JOURNAL   Stem Cell Reports 11 (5), 1040-1050 (2018)
   PUBMED   30344009
  REMARK    GeneRIF: Lano/LRRC1-depleted cells secrete increased levels of WNT
            ligands.
REFERENCE   7  (bases 1 to 3159)
  AUTHORS   Li,Y., Zhou,B., Dai,J., Liu,R. and Han,Z.G.
  TITLE     Aberrant upregulation of LRRC1 contributes to human hepatocellular
            carcinoma
  JOURNAL   Mol Biol Rep 40 (7), 4543-4551 (2013)
   PUBMED   23645086
  REMARK    GeneRIF: LRRC1 contributes to HCC development, and may be a
            potential target for therapeutic intervention in this disease.
REFERENCE   8  (bases 1 to 3159)
  AUTHORS   Suzuki,T., Morita,R., Sugimoto,Y., Sugawara,T., Bai,D.S.,
            Alonso,M.E., Medina,M.T., Bailey,J.N., Rasmussen,A., Ramos-Peek,J.,
            Cordova,S., Rubio-Donnadieu,F., Ochoa,A., Jara-Prado,A.,
            Inazawa,J., Delgado-Escueta,A.V. and Yamakawa,K.
  TITLE     Identification and mutational analysis of candidate genes for
            juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and
            CLIC5
  JOURNAL   Epilepsy Res 50 (3), 265-275 (2002)
   PUBMED   12200217
REFERENCE   9  (bases 1 to 3159)
  AUTHORS   Saito,H., Santoni,M.J., Arsanto,J.P., Jaulin-Bastard,F., Le
            Bivic,A., Marchetto,S., Audebert,S., Isnardon,D., Adelaide,J.,
            Birnbaum,D. and Borg,J.P.
  TITLE     Lano, a novel LAP protein directly connected to MAGUK proteins in
            epithelial cells
  JOURNAL   J Biol Chem 276 (34), 32051-32055 (2001)
   PUBMED   11440998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC003193.1 and AL033384.2.
            
            On Nov 22, 2018 this sequence version replaced NM_018214.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.85050.1,
                                           SRR1660803.37683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370888.6/ ENSP00000359925.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2081              BC003193.1         26-2106
            2082-3155           AL033384.2         15886-16959
            3156-3159           AL033384.2         16960-16963
FEATURES             Location/Qualifiers
     source          1..3159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..3159
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /note="leucine rich repeat containing 1"
                     /db_xref="GeneID:55227"
                     /db_xref="HGNC:HGNC:14307"
                     /db_xref="MIM:608195"
     exon            1..411
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1827
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /note="LAP (leucine-rich repeats and PDZ) and no PDZ
                     protein; LANO adapter protein; LAP and no PDZ protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 1"
                     /protein_id="NP_060684.4"
                     /db_xref="CCDS:CCDS4953.2"
                     /db_xref="GeneID:55227"
                     /db_xref="HGNC:HGNC:14307"
                     /db_xref="MIM:608195"
                     /translation="MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLD
                     ANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS
                     FCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRE
                     NLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGN
                     LKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN
                     RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGC
                     CSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQS
                     QPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDEAWNER
                     AVNRVSAIRFVEDEKDEEDNETRTLLRRATPHPGELKHMKKTVENLRNDMNAAKGLDS
                     NKNEVNHAIDRVTTSV"
     exon            412..529
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            530..608
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            609..698
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            699..755
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            756..819
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            820..894
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1039
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1158
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1242
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1358
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1531
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1668
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..3159
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /note="hexamer: AATACA"
     polyA_site      2088
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /note="major polyA site"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /note="hexamer: AATAAA"
     polyA_site      2896
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
     regulatory      3132..3137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
                     /note="hexamer: AATAAA"
     polyA_site      3159
                     /gene="LRRC1"
                     /gene_synonym="dJ523E19.1; LANO"
ORIGIN      
        1 ggcgacggcg actggcgggt gggagtggag gcaccggctg gcgggcgggg gtacagggac
       61 ggggcagggg ctcccgctcc aggttccttg aagcacttcc gaccgcgaag cccggcgcga
      121 gaagcgagct aacccaagag ccaacaacga gcgcggagag ggcagcggac tgagcggagc
      181 cgccggccag agcgggctcg gagcccgggt ctccgccgct cgggacccgg ctaggcggcg
      241 gcgggggcgg cgatgttcca ctgcatcccc ctgtggcggt gcaaccgtca tgtggagagc
      301 atcgacaagc gccactgctc gctggtctac gtccccgagg agatctaccg ctatgcccgg
      361 agcctggagg agctgctgct ggacgccaac cagctccgcg agctgcccga gcaatttttc
      421 cagctagtca aattacgaaa gcttggactt agtgataatg aaattcagcg gctccctcca
      481 gaaatagcaa acttcatgca gctggtggaa ctagatgtgt ctcgaaatga gattcctgaa
      541 attccagaaa gcatttcatt ctgtaaagca ctgcaggtag ctgacttcag cggaaaccca
      601 ctgactaggt tgccagaaag ctttcctgaa ttacagaatt taacatgtct ttctgtaaat
      661 gacatctcac tacagtctct acctgaaaat attggcaatc tttataacct ggcttcactg
      721 gaactgagag agaatcttct tacatatctt cctgactctc ttacccagct gcgaagacta
      781 gaagaacttg atttaggaaa caatgaaata tataatttgc cagaatcaat tggagccctc
      841 ttacatctaa aagatctctg gttggatgga aatcaactgt cagaattacc tcaggaaata
      901 ggaaatctga agaacctgct gtgtttagat gtctctgaaa acaggttgga aagacttcct
      961 gaagaaatca gtggcctgac ttcattaacg gatttagtca tttcccagaa cttattagaa
     1021 acgattccgg atggcattgg aaaactaaag aaactgtcaa tcttgaaggt ggatcagaat
     1081 agactcacac agttgcctga agcagttggg gaatgtgaaa gtctcactga gttagttctt
     1141 acagaaaatc agctcctgac cctgcctaaa agcattggaa aactaaagaa gttgagcaac
     1201 ttgaatgcag acagaaataa attagtgtcc ttaccaaaag agatcggcgg gtgctgcagc
     1261 ctcactgtgt tctgtgtacg tgacaacaga ctaactcgga tacctgcaga ggtgtcacag
     1321 gcaacagaac ttcatgtcct ggatgtggca gggaacaggt tgctgcatct acctttatcc
     1381 ctgactgcct tgaagttgaa ggctctgtgg ctatctgaca accagtccca gcccctgctt
     1441 acattccaga cagacacaga ctacaccaca ggagagaaga ttttaacctg tgtcttactt
     1501 cctcagctgc cttctgaacc tacttgtcaa gagaatctgc ctcgctgtgg tgcactggag
     1561 aacttggtaa atgatgtctc tgatgaagcc tggaacgagc gtgctgtcaa cagagtcagt
     1621 gcgatccgat ttgtggagga tgagaaagat gaagaagaca atgagacgag aacacttcta
     1681 aggcgagcca ctccacaccc aggggagtta aagcacatga aaaagacagt ggagaattta
     1741 cggaatgaca tgaatgctgc taaaggactg gactcaaaca aaaacgaggt caatcatgcc
     1801 attgaccgag tgaccacttc tgtgtagagt ttcacctcca agttttacct cctgtgtctt
     1861 cctctgctgt cgagacgttc ctgtctgctt cccgggagcc tcacgtgctc cttgtcctaa
     1921 ccagcccccg cgcgccatct tcccgtggag tgtggggaag ctgctgtctc ccaggaagtg
     1981 ccttactcat cccgcaacca gtcagcgcac cagtggtctc ccggtgtgat tttttttttt
     2041 tttaatttca gttgtttgta ataagtagaa tacactactg taaacatacg acctttgttt
     2101 ttgtcttatg ttggggtaaa ggaaagcagg aaggggaatt tttatcctcc tcccttccgt
     2161 aaagtgctgg gatattttga atcccccaag ttcccttgga cctactgatg agagatagtt
     2221 ttatgtatgg ggaaaaatgg atacttttta aacctttttt ggcagctcag atggtgtaaa
     2281 ttttaaaatt ttgtataggt atttcataac aaaaatatgt atttcttttt tgttatttta
     2341 tcttgaaaac ggtacatatt ttagtatttg tgcagaaaaa caagtcctaa agtatttgtt
     2401 tttatttgta ccatccactt gtgccttact gtatcctgtg tcatgtccaa tcagttgtaa
     2461 acaatggcat ctttgaacag tgtgatgaga ataggaatgt ggtgttttaa agcagtgttg
     2521 cattttaatc agtaatctac ctggtggatt tgtttttaac caaaaagatg aattatcaat
     2581 gatttgtaat tatatcagtt gatttttttt gaaaagatga accaaaggat ttgactgcta
     2641 atattttatt ccttacactt tttttctgaa taagtctctc ataatgagtg cagtgtcaga
     2701 ctgtgcctac tctgatggta tgtgccattt gtaaaataaa atagagcaga aaaacacaaa
     2761 aagagaacac tggttcagac attcagtggg caagtaaatt atggactgca aaataatgat
     2821 ttttattcaa gaaagcttta aaagttttat atccagatat acaaccacaa taaagcaaaa
     2881 taacctacta tcaaaataga aatgttgcta tctttataag tgcaatttaa tttgtaaata
     2941 gagtttgaat caaagtatca caaaatactg cttcaagatt taattttaaa tctgctaatt
     3001 taagggatat tgggaaaagt tttggtgtgt ttctgttgat ttcttttttg tatgctgtga
     3061 taaaagagaa atgaaaagtg ccagtcactg tgtggtgtct aggaaaatca tatatatttt
     3121 tttctccaag aaataaattc atcctggaca ttggccata
//
