LOCUS       NM_152329               1502 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens leucine rich repeat protein 1 (LRR1), transcript
            variant 1, mRNA.
ACCESSION   NM_152329
VERSION     NM_152329.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Fan,Y., Koberlin,M.S., Ratnayeke,N., Liu,C., Deshpande,M.,
            Gerhardt,J. and Meyer,T.
  TITLE     LRR1-mediated replisome disassembly promotes DNA replication by
            recycling replisome components
  JOURNAL   J Cell Biol 220 (8) (2021)
   PUBMED   34037657
  REMARK    GeneRIF: LRR1-mediated replisome disassembly promotes DNA
            replication by recycling replisome components.
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Starostina,N.G., Simpliciano,J.M., McGuirk,M.A. and Kipreos,E.T.
  TITLE     CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C.
            elegans and actin-based motility regulation in human cells
  JOURNAL   Dev Cell 19 (5), 753-764 (2010)
   PUBMED   21074724
  REMARK    GeneRIF: Results identify the CRL2(LRR-1) ubiquitin ligase as a
            conserved regulator of Cip/Kip CKIs that promotes the degradation
            of C. elegans CKI-1 and human p21.
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Jang,L.K., Lee,Z.H., Kim,H.H., Hill,J.M., Kim,J.D. and Kwon,B.S.
  TITLE     A novel leucine-rich repeat protein (LRR-1): potential involvement
            in 4-1BB-mediated signal transduction
  JOURNAL   Mol Cells 12 (3), 304-312 (2001)
   PUBMED   11804328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI825814.1, BX248298.1 and
            BX648029.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152329.3.
            
            Summary: The protein encoded by this gene contains a leucine-rich
            repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a
            member of the tumor necrosis factor receptor (TNFR) superfamily.
            Overexpression of this gene suppresses the activation of NF-kappa B
            induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2),
            which suggests that this protein is a negative regulator of
            TNFRSF9-mediated signaling cascades. Alternative splicing results
            in multiple transcript variants.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Isoform 1 has also been named LRR-1a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.284120.1,
                                           SRR1163655.313515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298288.11/ ENSP00000298288.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               BI825814.1         171-533
            364-1451            BX248298.1         350-1437
            1452-1502           BX648029.1         1838-1888
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..1502
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /note="leucine rich repeat protein 1"
                     /db_xref="GeneID:122769"
                     /db_xref="HGNC:HGNC:19742"
                     /db_xref="MIM:609193"
     exon            1..264
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1326
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclophilin-like 5; 4-1BB-mediated signaling molecule;
                     LRR-repeat protein 1; peptidylprolyl isomerase-like 5;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="leucine-rich repeat protein 1 isoform 1"
                     /protein_id="NP_689542.2"
                     /db_xref="CCDS:CCDS9686.1"
                     /db_xref="GeneID:122769"
                     /db_xref="HGNC:HGNC:19742"
                     /db_xref="MIM:609193"
                     /translation="MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVR
                     AFLLISTLKDKRGTRYELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKG
                     FLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQ
                     TSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVA
                     LCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRF
                     LSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHN
                     RIPYGSHIIPFHLCQDLDTAKICVCGRFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGT
                     EAPIISYFCSLGCYVNSSDMLK"
     exon            265..363
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /inference="alignment:Splign:2.1.0"
     exon            364..1085
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1502
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /note="hexamer: ATTAAA"
     polyA_site      1502
                     /gene="LRR1"
                     /gene_synonym="4-1BBLRR; LRR-1; PPIL5"
                     /note="major polyA site"
ORIGIN      
        1 gaggaccccg atggcggcgc cgggtggcgg gaaggaggaa gtttcaaagc cagcttgacg
       61 tggttgtggc cgttgggcga gatgaagcta cactgtgagg tggaggtgat cagccggcac
      121 ttgcccgcct tggggcttag gaaccggggc aagggcgtcc gagccgtgtt gagcctctgt
      181 cagcagactt ccaggagtca gccgccggtc cgagccttcc tgctcatctc caccctgaag
      241 gacaagcgcg ggacccgcta tgagctaagg gagaacattg agcaattctt caccaaattt
      301 gtagatgagg ggaaagccac tgttcggtta aaggagcctc ctgtggatat ctgtctaagt
      361 aaggccattt ccagcagttt aaaaggtttc ctttcagcta tgagactggc tcatagaggc
      421 tgtaatgttg atacaccagt ttcaacgctc acaccagtga agacttcaga atttgaaaac
      481 tttaaaacta aaatggttat cacatccaaa aaagactatc ctctaagtaa gaattttcca
      541 tattccttgg aacatcttca gacttcttac tgtgggcttg tccgagttga tatgcgtatg
      601 ctttgcttaa aaagccttag gaaattagac ttgagtcaca accatataaa aaagcttcca
      661 gctacaattg gagacctcat acaccttcaa gaacttaacc tgaatgacaa tcacttggag
      721 tcatttagtg tagccttgtg tcattctaca ctccagaagt cacttcggag tttggacctc
      781 agcaagaaca aaatcaaggc actccctgtg cagttttgcc agctccagga acttaagaat
      841 ttaaaacttg acgataatga attgattcaa tttccttgca agataggaca actaataaac
      901 cttcgctttt tgtcagcagc tcgaaataag cttccatttt tgcctagtga atttagaaat
      961 ttatcccttg aatacttgga tctttttgga aatacttttg aacaaccaaa agtccttcca
     1021 gtaataaagc tgcaagcacc attaacttta ttggaatctt ctgcacgaac catattacat
     1081 aataggattc catatggctc tcatatcatt ccattccatc tctgccaaga tttggatacc
     1141 gcaaaaattt gtgtttgtgg aagattctgt ctgaactctt tcattcaagg aactactacc
     1201 atgaatctgc attctgttgc ccacactgtg gtcttagtag ataatttggg tggtactgaa
     1261 gcacctatta tctcttattt ctgttctcta ggctgttatg ttaattcctc tgatatgtta
     1321 aagtaatggg tgagaccaga aaaagaaatt tcaataacag atcagtttgg ggtgcatgta
     1381 tgattttgca gcgtcaaatt ggagtaaggg aagatttctg tatacttgct ggagaggagg
     1441 aatgtgtata gttactcatt tagatgactc caaaactttt attaaaacca attttagttt
     1501 ta
//
