LOCUS       NM_002337              10446 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LDL receptor related protein associated protein 1
            (LRPAP1), transcript variant 1, mRNA.
ACCESSION   NM_002337
VERSION     NM_002337.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10446)
  AUTHORS   Reid,K.M. and Brown,G.C.
  TITLE     LRPAP1 is released from activated microglia and inhibits microglial
            phagocytosis and amyloid beta aggregation
  JOURNAL   Front Immunol 14, 1286474 (2023)
   PUBMED   38035103
  REMARK    GeneRIF: LRPAP1 is released from activated microglia and inhibits
            microglial phagocytosis and amyloid beta aggregation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10446)
  AUTHORS   Wagner,M.C., Sandoval,R.M., Yadav,S.P.S., Campos,S.B., Rhodes,G.J.,
            Phillips,C.L. and Molitoris,B.A.
  TITLE     Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and
            Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside
            Nephrotoxicity
  JOURNAL   Kidney360 4 (5), 591-605 (2023)
   PUBMED   36848531
  REMARK    GeneRIF: Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated
            and Clathrin Independent Endocytosis, Ameliorating Renal
            Aminoglycoside Nephrotoxicity.
REFERENCE   3  (bases 1 to 10446)
  AUTHORS   Podgorska,D., Ciesla,M., Majdan,M., Podgorski,R. and Kolarz,B.
  TITLE     The relationship of ADAMTSL2 and LRPAP1 gene methylation level with
            rheumatoid arthritis activity
  JOURNAL   Clin Exp Rheumatol 40 (11), 2052-2059 (2022)
   PUBMED   34936547
  REMARK    GeneRIF: The relationship of ADAMTSL2 and LRPAP1 gene methylation
            level with rheumatoid arthritis activity.
REFERENCE   4  (bases 1 to 10446)
  AUTHORS   Grosskopf,H., Vogel,S., Muller,C.D., Kohling,S., Durig,J.N.,
            Moller,S., Schnabelrauch,M., Rademann,J., Hempel,U., von Bergen,M.
            and Schubert,K.
  TITLE     Identification of intracellular glycosaminoglycan-interacting
            proteins by affinity purification mass spectrometry
  JOURNAL   Biol Chem 402 (11), 1427-1440 (2021)
   PUBMED   34472763
  REMARK    GeneRIF: Identification of intracellular
            glycosaminoglycan-interacting proteins by affinity purification
            mass spectrometry.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10446)
  AUTHORS   Van Leuven,F., Hilliker,C., Serneels,L., Umans,L., Overbergh,L., De
            Strooper,B., Fryns,J.P. and Van den Berghe,H.
  TITLE     Cloning, characterization, and chromosomal localization to 4p16 of
            the human gene (LRPAP1) coding for the alpha 2-macroglobulin
            receptor-associated protein and structural comparison with the
            murine gene coding for the 44-kDa heparin-binding protein
  JOURNAL   Genomics 25 (2), 492-500 (1995)
   PUBMED   7789983
REFERENCE   6  (bases 1 to 10446)
  AUTHORS   Kounnas,M.Z., Argraves,W.S. and Strickland,D.K.
  TITLE     The 39-kDa receptor-associated protein interacts with two members
            of the low density lipoprotein receptor family, alpha
            2-macroglobulin receptor and glycoprotein 330
  JOURNAL   J Biol Chem 267 (29), 21162-21166 (1992)
   PUBMED   1400426
REFERENCE   7  (bases 1 to 10446)
  AUTHORS   Williams,S.E., Ashcom,J.D., Argraves,W.S. and Strickland,D.K.
  TITLE     A novel mechanism for controlling the activity of alpha
            2-macroglobulin receptor/low density lipoprotein receptor-related
            protein. Multiple regulatory sites for 39-kDa receptor-associated
            protein
  JOURNAL   J Biol Chem 267 (13), 9035-9040 (1992)
   PUBMED   1374383
REFERENCE   8  (bases 1 to 10446)
  AUTHORS   Herz,J., Goldstein,J.L., Strickland,D.K., Ho,Y.K. and Brown,M.S.
  TITLE     39-kDa protein modulates binding of ligands to low density
            lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
  JOURNAL   J Biol Chem 266 (31), 21232-21238 (1991)
   PUBMED   1718973
REFERENCE   9  (bases 1 to 10446)
  AUTHORS   Strickland,D.K., Ashcom,J.D., Williams,S., Battey,F., Behre,E.,
            McTigue,K., Battey,J.F. and Argraves,W.S.
  TITLE     Primary structure of alpha 2-macroglobulin receptor-associated
            protein. Human homologue of a Heymann nephritis antigen
  JOURNAL   J Biol Chem 266 (20), 13364-13369 (1991)
   PUBMED   1712782
REFERENCE   10 (bases 1 to 10446)
  AUTHORS   Furukawa,T., Ozawa,M., Huang,R.P. and Muramatsu,T.
  TITLE     A heparin binding protein whose expression increases during
            differentiation of embryonal carcinoma cells to parietal endoderm
            cells: cDNA cloning and sequence analysis
  JOURNAL   J Biochem 108 (2), 297-302 (1990)
   PUBMED   2229028
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB035408.1, BC112067.1,
            BX647984.1, AK222504.1 and AL590235.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 23, 2018 this sequence version replaced NM_002337.3.
            
            Summary: This gene encodes a protein that interacts with the low
            density lipoprotein (LDL) receptor-related protein and facilitates
            its proper folding and localization by preventing the binding of
            ligands. Mutations in this gene have been identified in individuals
            with myopia 23. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.257620.1,
                                           SRR1803613.284814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650182.1/ ENSP00000497444.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               DB035408.1         138-557
            421-1245            BC112067.1         471-1295
            1246-1489           BX647984.1         1246-1489
            1490-1495           AK222504.1         1490-1495
            1496-10446          AL590235.23        59457-68407
FEATURES             Location/Qualifiers
     source          1..10446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..10446
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /note="LDL receptor related protein associated protein 1"
                     /db_xref="GeneID:4043"
                     /db_xref="HGNC:HGNC:6701"
                     /db_xref="MIM:104225"
     exon            1..214
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1084
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /note="low density lipoprotein-related protein-associated
                     protein 1 (alpha-2-macroglobulin receptor-associated
                     protein 1); low density lipoprotein receptor-related
                     protein associated protein 1; 39 kDa receptor-associated
                     protein"
                     /codon_start=1
                     /product="alpha-2-macroglobulin receptor-associated
                     protein precursor"
                     /protein_id="NP_002328.1"
                     /db_xref="CCDS:CCDS3371.1"
                     /db_xref="GeneID:4043"
                     /db_xref="HGNC:HGNC:6701"
                     /db_xref="MIM:104225"
                     /translation="MAPRRVRSFLRGLPALLLLLLFLGPWPAASHGGKYSREKNQPKP
                     SPKRESGEEFRMEKLNQLWEKAQRLHLPPVRLAELHADLKIQERDELAWKKLKLDGLD
                     EDGEKEARLIRNLNVILAKYGLDGKKDARQVTSNSLSGTQEDGLDDPRLEKLWHKAKT
                     SGKFSGEELDKLWREFLHHKEKVHEYNVLLETLSRTEEIHENVISPSDLSDIKGSVLH
                     SRHTELKEKLRSINQGLDRLRRVSHQGYSTEAEFEEPRVIDLWDLAQSANLTDKELEA
                     FREELKHFEAKIEKHNHYQKQLEIAHEKLRHAESVGDGERVSRSREKHALLEGRTKEL
                     GYTVKKHLQDLSGRISRARHNEL"
     exon            215..359
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            360..481
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            482..602
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            603..761
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            762..844
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1021
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..10446
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1469..1474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /note="hexamer: AATAGA"
     polyA_site      1491
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /note="major polyA site"
     regulatory      4904..4909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
                     /note="hexamer: AATGAA"
     polyA_site      4924
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
     polyA_site      10446
                     /gene="LRPAP1"
                     /gene_synonym="A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP;
                     MYP23; RAP"
ORIGIN      
        1 gcagaggaag atggcgccgc ggagggtcag gtcgtttctg cgcgggctcc cggcgctgct
       61 actgctgctg ctcttcctcg ggccctggcc cgctgcgagc cacggcggca agtactcgcg
      121 ggagaagaac cagcccaagc cgtccccgaa acgcgagtcc ggagaggagt tccgcatgga
      181 gaagttgaac cagctgtggg agaaggccca gcgactgcat cttcctcccg tgaggctggc
      241 cgagctccac gctgatctga agatacagga gagggacgaa ctcgcctgga agaaactaaa
      301 gcttgacggc ttggacgaag atggggagaa ggaagcgaga ctcatacgca acctcaatgt
      361 catcttggcc aagtatggtc tggacggaaa gaaggacgct cggcaggtga ccagcaactc
      421 cctcagtggc acccaggaag acgggctgga tgaccccagg ctggaaaagc tgtggcacaa
      481 ggcgaagacc tctgggaaat tctccggcga agaactggac aagctctggc gggagttcct
      541 gcatcacaaa gagaaagttc acgagtacaa cgtcctgctg gagaccctga gcaggaccga
      601 agaaatccac gagaacgtca ttagcccctc ggacctgagc gacatcaagg gcagcgtcct
      661 gcacagcagg cacacggagc tgaaggagaa gctgcgcagc atcaaccagg gcctggaccg
      721 cctgcgcagg gtcagccacc agggctacag cactgaggct gagttcgagg agcccagggt
      781 gattgacctg tgggacctgg cgcagtccgc caacctcacg gacaaggagc tggaggcgtt
      841 ccgggaggag ctcaagcact tcgaagccaa aatcgagaag cacaaccact accagaagca
      901 gctggagatt gcgcacgaga agctgaggca cgcagagagc gtgggcgacg gcgagcgtgt
      961 gagccgcagc cgcgagaagc acgccctgct ggaggggcgg accaaggagc tgggctacac
     1021 ggtgaagaag catctgcagg acctgtccgg caggatctcc agagctcggc acaacgaact
     1081 ctgaaggcat tggggagccc agcccggcag ggaagaggcc agcgtgaagg acctgggctc
     1141 ttggccgtgg catttccgtg gacagcccgc cgtcagggtg gctggggctg gcacgggtgt
     1201 cgaggcagga aggattgttt ctggtgactg cagccgctgc cgtcgcgaca cagggcttgg
     1261 tggtggtagc atttgggtct gagatcggcc cagctctgac tgaaggggct tggcttccac
     1321 tcagcatcag cgtggcagtc accaccccag tgaggacctc gatgtccagc tgctgtcagg
     1381 tctgatagtc ctctgctaaa acaacacgat ttacataaaa aatcttacac atctgccacc
     1441 ggaaatacca tgcacagagt ccttaaaaaa tagagtgcag tatttaaacc acccgcttgt
     1501 tggctggtca ctaagtgtcc tggtggctgg ggccggagcc agtgctcttg aagggatcgc
     1561 gtcatagcca gcttcccctc tgggccctgt gggtctttgc agccaacctc cttttcccgt
     1621 gagacggccc ggcctgattt aaagccaaga gcgcttgagt tgagtttgag gggaagatgt
     1681 ggagcgtgtg gttctgtgga cagtcagaga ctgtggcctg ggggcagcgt ctttcaactc
     1741 tcacctctgc agctcaggga cctcgggaga cctcaccaaa cctgcagggc ctccgtgtcc
     1801 ctaagtgtgc tgtgtaaatg ccccatctca tgggggagag acagccacgg aggccttcct
     1861 ctgaccatag ctgatggact ggcggttgct caggtccggc tccgagaatg ttcctgtgtc
     1921 tgagcctgga agaggctcgg gtctggctcc aggcgtggtt cccttcccgt gtctgagcct
     1981 ggaagaggct cgggtccggc tccgagcgtg gttcccttcc cgtgtctgag cctggaagag
     2041 gctcgggtcc ggctccgagc gtggttccct tcccgtgtct gagcctggaa gaggctcggg
     2101 tccggctccg agcgtggttc ccttcccgtg tctgagcctg gaagaggctc gggtccggct
     2161 ccgagcgtgg ttcccttccc gtgtctgagc ctggaagagg ctcgggtccg gctctgggcg
     2221 tggttccctt cccgtgtctg agcctggaag aggctcgggt ccggctctgg gcgtggttcc
     2281 cgtgtctgag cctggaagag gctcgggtcc gggtccagct ccgagcgtgg ttcccgtgtt
     2341 tgaacctgga agaggctcca ccaggcgtat tgtgttttga ctgcagctgg atcttggctt
     2401 gactgttgag atctgccaaa catccgctaa gctatcattt ctgagaaagg tcaaggctag
     2461 aggcagcatg tcgggagttg gcgcatcagg gttggaaggg ccccagggta cagcatgtgg
     2521 gtgcctgttc ctttgtggac ttgtgtgtgt gtggctggtg gggcgggggg tggattctgg
     2581 ttcttttttt tcccattatc ctgagagcct taaggtactc agtgtgttgg tgagactcag
     2641 ccctgtcatc tagcagaagt gtgttccttt tcattgctgt atagtattcc attgcatgac
     2701 tgtcctgtgc tctgatttta atgcacttta ttgtgggtgg atatttgagt tgcttccttt
     2761 ctggggtaat aacactcact tggaaatagc tgtggtgaac actcgtgtgg gggtgggggt
     2821 gggggccaac tctaggagca cctaatggat cttacgaagc gtgttgtcca agtatagaga
     2881 tgattccaaa gtggttggac tgtgtttctt tctcccagct gggtggaagg agaacactag
     2941 tggattgctg agacttggtg ctcggtattt ttaattatgg acagcctggc tggcgttttg
     3001 tggtgtctaa ttgcggagta gcgtgtctta ctgtataatg gcctcttttg tatgtgggag
     3061 accatggtgt tgaggggagg cagttacaca aaaaacccag ataccgagtg ttagttccat
     3121 gggtgtggct ggtcatggtg cgcactcacg aaggatgtag gtgatgccct ccactccgca
     3181 gagccagtcc cacaggggta cccattctga ctcctaccac cgcagctccc tacctcccgc
     3241 ctgccatggg ttccacgtgc atggctctgg gcagtctgtg tctttgcgtg cgtctgtgta
     3301 tgtctgcgtg tatctgctta cattcgctca gcatctgaga ttcacccagg cttttgcgtg
     3361 gatcagcggc agactcctga ttgccgcgtg gcggcctgtt gtgtgggtgt gtgccgcgtg
     3421 tgtatccagt ccctactcag gagtgtacgt ttccagtgtg ggttgcagtc aggatccatt
     3481 tctcccttaa ctttcagatt atttgctgca taggcttttt tctcctaatt tggcgccttt
     3541 gtcagaaatc aactgaccta cctgtgtggg tctgtttctg tttgtcctta cgctcttgcc
     3601 attgccacac tttagacaag gtcttgctct gtccctcagg ctggagtgca gtagcgtgat
     3661 ctcagctcac tgcacccttg acctcccata ctccagcaat cccctcgcct cagtctcctg
     3721 agtagtagct gcgaccacag gcgtgtgtca ccacacccgg ctgattttat tttttttatt
     3781 tttatttttt ttgtagagac ggggttttac tatgttgccc aggcaggtct tgatctgggc
     3841 tcaagtgatg ctcctgtctc agcctcccaa actactggga ttacaggttg taggtgtgag
     3901 ccatggtgcc cggccgccac actgtcttgg ctacagttgg gtttataata aaccctgaat
     3961 cgaggtgatg tgcattttcc aactcttctt tttaaagatt cttgtggctg tttatgtcct
     4021 tggtgtttcc atatatgttt tacaatcagt gtctcaattt ctaccaaaaa aacatgcctt
     4081 ctggaatttc aatagcaatt cccttgaacg catttttgaa taccttttct gaatgtcttg
     4141 aatacatgtt gggaagaatc ggtgtcttaa cagtctccag tgtccacgcg ttgactgccg
     4201 tgtgtgactc cagtcggcgt ctcaacagtc tccagtgtcc acgcgttgac tgccgtgtgt
     4261 gactccagtc ggcgtctcag cagtctccag tgtccacgcg ttgactgccg tgtgtgactc
     4321 cagtcggcgt ctcagcagtc tccagtgtcc acgcgttgac tgccgtgtgt gactccagtc
     4381 ggcgtctcag cagtctccgg tgtccacgcg ttgactgccg tgtgtgactc cagtcggcgt
     4441 ctcaacagtc tccggtgtcc acgcgttgac tgccgtgtgt gactccagtc ggcgtctcaa
     4501 cagtctccgg tgtccacgcg ttgactgccg tgtgtgactc cagtcggcgt ctcaacagtc
     4561 tccggtgtcc acgcgttgac tgccgtgtgt gactccagtc ggcgtctcaa cagtctccgg
     4621 tgtccacgcg ttgactgccg tgtgtgactc cagtcggcgt ctcaacagtc tccggtgtcc
     4681 acgcgttgac tgccgtgtgt gactccagtc ggcgtctcaa cagtctccgg tgtccacgcg
     4741 ttgactgccg tgtgtgactc cagtcggcgt ctcaacagtc tccggtgtcc acgcgttgac
     4801 tgccgtgtgt gactccagtc ggcgtctcaa cagtctccgg tgtccatgcg ttgactgcca
     4861 tgtatgactc caggtattga gttcatcttc aacttctccc aacaatgaac tggagttttc
     4921 tgtgcatgtg tctggcatgt tttcctttag atctagtcct aggtgttcga tatgctattg
     4981 aggactgtgt atttttattt catttgtcac ctgtgcgtgg tgctttaatc ctgtgcccta
     5041 aactcccgcc ttggccatgg cggtgtttct gtggactcgt ggggtttccg tgtgcacacg
     5101 cgtgtcctct gtctgacagt ggctttgctt ccccttgtca gtctgtgcct cggcttctca
     5161 ctgcactggt gaggtgagcc ggcgctcgct aatcttattc ccagtctcgg tgaacatggg
     5221 ctcagtctct cccggctcag tgttgggttt gcactggtgc acttacaggc agaagagctt
     5281 cctcatttgc tgagggcttt tcctgaatcc gtgttgaatg tggtcagctg cctttcctgc
     5341 acctagtgag atgctcatga ggtcacttcc ttaccgcatt actgtagtga attacgctga
     5401 ctttcatatg ccaagatgac ctggcatttc caggtaagtc cctgtggcca tggtgcattg
     5461 gccttttctc tgcatggcca gatgagattt gctcataccg ggctaaggac ctcctgtgta
     5521 ggaatgctct tgagggacac tgggcttgga tgttcattgt cttgtcatgt gatgtgtctg
     5581 tcatggtttg atattgcatt aagtgggcct cctgaaacaa gttctgccat agtttgtata
     5641 ggattggcat tatttgtttc atagagatgt gatgggtgag gccatctatg cctgccattt
     5701 tctttttgct taggtttttc attaagaact tgatttttaa aaatagacat gaggcctggc
     5761 atggtggctc acgcttgtaa tcccagcact ttgggaggcc aacgtggatg gatcacctga
     5821 ggtcaggagt ttgagaccaa cctagtcaac atggtgaaac cccgtctcca ttaaaaatat
     5881 aaaaattagc agggtgtggt ggtgcatgcc tgtaatccca gctactctgg aggctgaggc
     5941 aggagaatca cttgaactca ggaggtggag gttgcagtga gctgagatca caccactgca
     6001 ctccagcctg ggcaacagag cgaggctctg tctcaaaaaa aaagacatga ggcttttgga
     6061 ttttctgttt cttcctttgt cattttttta aagataggtt tgtcgcagaa tttcatctaa
     6121 gttatcaaaa caatttacat aaatcattca cagtatcctc tgtgcagtga tgtccattct
     6181 cattcctgct ctgggccatt tgtgttttct tttccccctg atcagactag ctaagagttt
     6241 atcattttta cagatatttt ccccaaagaa acctactttt gggtccattg attttttttt
     6301 tctattgttt tctttttcat tgacttttgc tcttttctta tgaatttcct ttcttctacc
     6361 tattttgtgt tcaatttgct gtccttgttt taggttcttt tgatagaggc ttagatcatt
     6421 gatgaagaat atgaaagaat gggataatac agttaaaaac ttggtctact tatgcccatt
     6481 agagaaaaca ttcttaagca cgcatggaat cttttaaaaa tggacgaggt actaggaccc
     6541 aaagcaaatg tcagtaattc gcagatgata atgtataaat atatgatatg taggtaaata
     6601 atacaaatca cattctttgg ccagagtgca attgaggagg aaatcagtaa caaaaagaca
     6661 attaaatcca tttgattctt ttgttttcgt tttgtagtaa cttgcacttc cctggtgcca
     6721 gaggcatgac acctttttgt ctgctcttgg ccatttgggt ggcgtctttg ggaagggcct
     6781 acttaattct tttgcctatt taaaaaactg ggtcttggaa atcttgtctt tttttttgag
     6841 tcaggatctt tctcgcacag gcttggagtg cagtggtgcg atcatagctc actgcaacct
     6901 caaactcctg ggctcaagcg agcctcccac ctcggtcttc tgagtagctg ggactacagg
     6961 catgcatcac tatgctctgc taatttaaag aaaaggtttt ttttatagag actgggtctc
     7021 gctgtgttgc ccaggctggt ctcggagtcc tggtctcaag tgattcacct gcctccacct
     7081 cgcggagtgc caggattaca ggtggcggga gccgccacac ccagcctggt cttagcgtta
     7141 ttcccaggtc taggtgtgag tccttcctca gatatgtgtt gtgaataatt tccgatcctc
     7201 tggcttgcta ttttactttc ttaatggtta tcttttggaa agcaaaggtt tccagtttga
     7261 tgaaatctaa tttttatttt ttatttttcc gttctagtgg tctttctatt ttctcatcaa
     7321 attgagactt tggggaaact acacagcagc aaaccaggat atatcctctt aaaaacagct
     7381 cgagccggcc gggtgcggtg gctcatgcct ggaatcccag cactttggga ggtggaggtg
     7441 ggcggatcac gtgaggtcag gagtttgaga ccagcctggc caacatggtg aaaccccatc
     7501 tctactaaaa ataaaaaatt agccaggcat ggtggcaggc acctgtaatc ccagctactt
     7561 gggaggctga ggcaggagaa tggcttgaac ctgggaggca gaggttgcag tgagccgaga
     7621 tcgcgccatt gcactccggc ctggggacaa gagcaagact tcgcctcaaa aaaaaaaaaa
     7681 aacccagctt gagccaagtg tgggtggctc ccgcctggaa tcccagcact ttgggaggct
     7741 gaggcgggca gatcacttga ggccaggagt ttgagaccag cctggccaac atcacaaaat
     7801 cccatctcta ctaaaaatac aaaaattaac caggagtggt ggcagcatct gcctataatc
     7861 ccagctactc gggagcctaa ggcacgagaa tcacttgaag ctgggagaca gagtttgcag
     7921 tgagccaaaa tcgtgccatt gctctccagc atggataaca gagcaagact ctgtctcaaa
     7981 aaaaaaaagc ttgaaaattt aaaaatatct caataattat gagatgcagt gatttttttt
     8041 ttacttccct aagctgggtt tccaggtatc tctaggttca gctcctccgg ggctggaagt
     8101 acatgaaggg cagcattgcc caccttgacc agagcaggct cggagcaggg cagtggaaga
     8161 gctggtccca gctcagccca gcctgctggg tcagcatcca tctgaaaggt catctctacc
     8221 caggaacttg atggcttcca gctccaccct aacagaaacc tccccagcat cttgccgagt
     8281 tgtaatccag ggtggtggta tagacggtct tggggtagct ggtatagacg gtcttggcgt
     8341 agctggtata gacggtcttg gggtagctgg tatagacggt cttggggtag ctggtataga
     8401 cggtcttggg gtagctggta tagacgggct tggggtagct ggtagtggtg ctcaggaggc
     8461 gtgtgggctg ctggtgcagc tggaagcgca cctcagccat ggtgttgtgc caggtgtggt
     8521 tggggatgca ggggacgttc cggccgcagg aggcccctgc caggcacagg cagctgcgcg
     8581 gtgtggaaga agtgccgctc ggagtcatgc ttgacaagga agtacacctt actcctctca
     8641 gtggtgaggg gtcaaaccac tccttcccag cgatggggcc agcagcctgg cgagggctag
     8701 gcaccgggga gggatgctgg atttggagct ggggggaagg ggtcaccctg cattgggctc
     8761 cagtgctccg ggtgccatgc ctgctccccc accactgcca ccgcagccgc tgcgggacac
     8821 caggggctgg ggctgaagag cagcctcgag ctgggctgtc caggacacgg tcgcccttct
     8881 tcctcgtgtc cgtgagctca ggcacaacct gcagcttagc cagcccacta tggctgcgtg
     8941 cgtggcagga cccgggccac catggctgcg tgcatggtag ggcacatgat tattttagcc
     9001 tctggtatca ctaaccatcc ctaaagtctc caatggtctg ttcctgtctt tccctctggt
     9061 tcacttgtgg ggtcatgttg tcttctgttc tttgttattt atttttttct tgagacggag
     9121 tcttgctctg tcgcccaggc tggagtgcgt tggtgcgatc tcggctcact gcaacctctg
     9181 cctcccaggt tcatgcgatt cccctgcctc agcctcccaa gtagctggga ttatgggcac
     9241 ctgccaccat acccagctaa tttttctgtg tgtgtgtgtg ttttgttttt tggttttttt
     9301 tttttttttt ttgagatgga atctcaattg ctcaggctgc agtgcaatgg cgcaatcttg
     9361 gctcactgca acctccacct cctgggttca agaaattctc ctgcctcagc ctcgcaagta
     9421 gctgggatta caggccccta ccaccacagt gggctaatgt ttgtattttt agtagagaca
     9481 gggtttcacc atgttggcca ggctggtctc gaactcctga cctcaggcaa tccgcccacc
     9541 tcggcctccc aaagtgctgg gattgtaggc atgagccacc atgcctggcc taatttttct
     9601 gtttttagta gagacaggac ttcaccatgt tggccaggct ggtctcaaat tcctgacctc
     9661 aagtgatgtg cccacctcgg ctgcccaaag tgctgggatt acaggcatga gcttctgtgc
     9721 ccggcctgaa ctgttaagtg tttgtgaaga attatttggg ggcctatttg agagctgtta
     9781 tatggatcat cctcctggag agggttctta agcctctgag accgggtttg gggctgaggc
     9841 tttctgaccc acacaagtca tgctgacccc tgaagggccg caggccagat cttgccaggt
     9901 gagcactttc cccgctcaca ttcaggatag ggcgaggggg ttggtaccga ttcaccctca
     9961 gggcctagat ttgggggctt cagcttgctg cagataggtg ctcccttcac tctcacctga
    10021 ggctgggctg gagcctggtg tctgccccac cctgctggtc agccccctag gacctgagcc
    10081 ccgtaagcct ggactggcca cgccctgggg cagcagcact gggtgcttgg cgctcacgac
    10141 cttcctgggc ccctgggtcc ctcacttctc ccttgtttct accttcctgg cttgtcagat
    10201 tcccacagct cttaaggaga aattcagtat ttactgcagc atgtgttttc agtgtgatgg
    10261 ttcatctagg taccctagcc tgtcattgct ggagttggaa atctctgttg tctgctgttg
    10321 ttttgtgaaa caagcgcgtg aggttataag tttccctcaa cgtaccacac taaccacatt
    10381 tccctaagtt ttgatgtgta gtgttttcac tgccattcag ttcaaaatat tttctcattt
    10441 caagta
//
