LOCUS       NM_002336              10252 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 6 (LRP6), transcript
            variant 1, mRNA.
ACCESSION   NM_002336
VERSION     NM_002336.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10252)
  AUTHORS   Zhong,S., Guo,Q., Chen,X., Luo,X., Long,Y., Chong,T., Ye,M., He,H.,
            Lu,A., Ao,K., Yin,M., Xu,A., Li,X., Hao,Y. and Guo,X.
  TITLE     The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism
            and suppresses lymph node metastasis in cervical cancer
  JOURNAL   Int J Biol Sci 20 (3), 916-936 (2024)
   PUBMED   38250152
  REMARK    GeneRIF: The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid
            metabolism and suppresses lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10252)
  AUTHORS   Li,J., Liu,Z., Ren,Y., Shao,H. and Li,S.
  TITLE     LRP5-/6 gene polymorphisms and its association with risk of
            abnormal bone mass in postmenopausal women
  JOURNAL   J Orthop Surg Res 18 (1), 369 (2023)
   PUBMED   37202775
  REMARK    GeneRIF: LRP5-/6 gene polymorphisms and its association with risk
            of abnormal bone mass in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10252)
  AUTHORS   Hao,H., Liu,Q., Chen,J. and Zhou,H.
  TITLE     Overexpression of circRNAs LRP6 in gestational diabetes mellitus
            predicts foetal malformation and intrauterine death
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 70 (2), 124-129 (2023)
   PUBMED   36925229
  REMARK    GeneRIF: Overexpression of circRNAs LRP6 in gestational diabetes
            mellitus predicts foetal malformation and intrauterine death.
REFERENCE   4  (bases 1 to 10252)
  AUTHORS   Wang,J., Yang,H., Ma,X., Liu,J., Li,L., Chen,L. and Wei,F.
  TITLE     LRP6/filamentous-actin signaling facilitates osteogenic commitment
            in mechanically induced periodontal ligament stem cells
  JOURNAL   Cell Mol Biol Lett 28 (1), 7 (2023)
   PUBMED   36694134
  REMARK    GeneRIF: LRP6/filamentous-actin signaling facilitates osteogenic
            commitment in mechanically induced periodontal ligament stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10252)
  AUTHORS   Jones,M.E., Buchler,J., Dufor,T., Palomer,E., Teo,S.,
            Martin-Flores,N., Boroviak,K., Metzakopian,E., Gibb,A. and
            Salinas,P.C.
  TITLE     A genetic variant of the Wnt receptor LRP6 accelerates synapse
            degeneration during aging and in Alzheimer's disease
  JOURNAL   Sci Adv 9 (2), eabo7421 (2023)
   PUBMED   36638182
  REMARK    GeneRIF: A genetic variant of the Wnt receptor LRP6 accelerates
            synapse degeneration during aging and in Alzheimer's disease.
REFERENCE   6  (bases 1 to 10252)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   7  (bases 1 to 10252)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   8  (bases 1 to 10252)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   9  (bases 1 to 10252)
  AUTHORS   Baens,M., Wlodarska,I., Corveleyn,A., Hoornaert,I., Hagemeijer,A.
            and Marynen,P.
  TITLE     A physical, transcript, and deletion map of chromosome region
            12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6
            CpG island in two leukemia patients with hemizygous del(12p)
  JOURNAL   Genomics 56 (1), 40-50 (1999)
   PUBMED   10036184
REFERENCE   10 (bases 1 to 10252)
  AUTHORS   Brown,S.D., Twells,R.C., Hey,P.J., Cox,R.D., Levy,E.R.,
            Soderman,A.R., Metzker,M.L., Caskey,C.T., Todd,J.A. and Hess,J.F.
  TITLE     Isolation and characterization of LRP6, a novel member of the low
            density lipoprotein receptor gene family
  JOURNAL   Biochem Biophys Res Commun 248 (3), 879-888 (1998)
   PUBMED   9704021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007621.34, BP229563.1,
            AF074264.1, BC126405.1, AC007537.3 and AA126261.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002336.2.
            
            Summary: This gene encodes a member of the low density lipoprotein
            (LDL) receptor gene family. LDL receptors are transmembrane cell
            surface proteins involved in receptor-mediated endocytosis of
            lipoprotein and protein ligands. The protein encoded by this gene
            functions as a receptor or, with Frizzled, a co-receptor for Wnt
            and thereby transmits the canonical Wnt/beta-catenin signaling
            cascade. Through its interaction with the Wnt/beta-catenin
            signaling cascade this gene plays a role in the regulation of cell
            differentiation, proliferation, and migration and the development
            of many cancer types. This protein undergoes gamma-secretase
            dependent RIP- (regulated intramembrane proteolysis) processing but
            the precise locations of the cleavage sites have not been
            determined.[provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2563509.1, AF074264.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261349.9/ ENSP00000261349.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC007621.34        47230-47396         c
            168-232             BP229563.1         1-65
            233-3303            AF074264.1         1-3071
            3304-5184           BC126405.1         3029-4909
            5185-10078          AC007537.3         85405-90298         c
            10079-10252         AA126261.1         4-177               c
FEATURES             Location/Qualifiers
     source          1..10252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..10252
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
     exon            1..364
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..5151
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="isoform b precursor is encoded by transcript
                     variant 1; low-density lipoprotein receptor-related
                     protein 6; LRP-6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform b precursor"
                     /protein_id="NP_002327.2"
                     /db_xref="CCDS:CCDS8647.1"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
                     /translation="MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENAT
                     IVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLAC
                     DWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEV
                     PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQA
                     VVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQ
                     QRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLA
                     RRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS
                     GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
                     IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD
                     AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAERE
                     VIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDM
                     KTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDIS
                     LKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ
                     VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTI
                     DYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIE
                     RANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVC
                     GCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDY
                     DPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYW
                     TCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAAL
                     DGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQ
                     PVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQ
                     HPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID
                     CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
                     NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVI
                     GVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSL
                     PGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATE
                     RSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVAT
                     AKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCT
                     DSS"
     exon            365..758
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            759..956
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1153
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1285
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1682
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1854
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2071
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2361
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2588
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2773
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..3100
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3303
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3515
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3706
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3916
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4042
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4279
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4390
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4621
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4758
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4856
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..10252
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10230..10235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="hexamer: AATAAA"
     polyA_site      10252
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctgc gccgctgcgc gaggcagagg ctgaatgagg agctgcgcgg gggaagcggg
       61 gcgccggggg aggaggcggc gggatggaag cagacgctgg cgtcgcgcga gcccggggcc
      121 gagcggcgcg gtagagaggg cggcggcggc gcgcgcggaa ccttgacgtg cccctttctt
      181 tcttctctcg ctgggaagct gggaagtatg agcgtgcagc cctgccgctg cggcggccgc
      241 cccggctcct cgcctccccc acttctggcc acccctcgcc ggtgagagaa gagaacgcga
      301 gaagggaaga tgggggccgt cctgaggagc ctcctggcct gcagcttctg tgtgctcctg
      361 agagcggccc ctttgttgct ttatgcaaac agacgggact tgcgattggt tgatgctaca
      421 aatggcaaag agaatgctac gattgtagtt ggaggcttgg aggatgcagc tgcggtggac
      481 tttgtgttta gtcatggctt gatatactgg agtgatgtca gcgaagaagc cattaaacga
      541 acagaattta acaaaactga gagtgtgcag aatgttgttg tttctggatt attgtccccc
      601 gatgggctgg catgtgattg gcttggagaa aaattgtact ggacagattc tgaaactaat
      661 cggattgaag tttctaattt agatggatct ttacgaaaag ttttattttg gcaagagttg
      721 gatcaaccca gagctattgc cttagatcct tcaagtgggt tcatgtactg gacagactgg
      781 ggagaagtgc caaagataga acgtgctgga atggatggtt caagtcgctt cattataata
      841 aacagtgaaa tttactggcc aaatggactg actttggatt atgaagaaca aaagctttat
      901 tgggcagatg caaaacttaa tttcatccac aaatcaaatc tggatggaac aaatcggcag
      961 gcagtggtta aaggttccct tccacatcct tttgccttga cgttatttga ggacatattg
     1021 tactggactg actggagcac acactccatt ttggcttgca acaagtatac tggtgagggt
     1081 ctgcgtgaaa tccattctga catcttctct cccatggata tacatgcctt cagccaacag
     1141 aggcagccaa atgccacaaa tccatgtgga attgacaatg ggggttgttc ccatttgtgt
     1201 ttgatgtctc cagtcaagcc tttttatcag tgtgcttgcc ccactggggt caaactcctg
     1261 gagaatggaa aaacctgcaa agatggtgcc acagaattat tgcttttagc tcgaaggaca
     1321 gacttgagac gcatttcttt ggatacacca gattttacag acattgttct gcagttagaa
     1381 gacatccgtc atgccattgc catagattac gatcctgtgg aaggctacat ctactggact
     1441 gatgatgaag tgagggccat acgccgttca tttatagatg gatctggcag tcagtttgtg
     1501 gtcactgctc aaattgccca tcctgatggt attgctgtgg actgggttgc acgaaatctt
     1561 tattggacag acactggcac tgatcgaata gaagtgacaa ggctcaatgg gaccatgagg
     1621 aagatcttga tttcagagga cttagaggaa ccccgggcta ttgtgttaga tcccatggtt
     1681 gggtacatgt attggactga ctggggagaa attccgaaaa ttgagcgagc agctctggat
     1741 ggttctgacc gtgtagtatt ggttaacact tctcttggtt ggccaaatgg tttagccttg
     1801 gattatgatg aaggcaaaat atactgggga gatgccaaaa cagacaagat tgaggttatg
     1861 aatactgatg gcactgggag acgagtacta gtggaagaca aaattcctca catatttgga
     1921 tttactttgt tgggtgacta tgtttactgg actgactggc agaggcgtag cattgaaaga
     1981 gttcataaac gaagtgcaga gagggaagtg atcatagatc agctgcctga cctcatgggc
     2041 ctaaaggcta caaatgttca tcgagtgatt ggttccaacc cctgtgctga ggaaaacggg
     2101 ggatgtagcc atctctgcct ctatagacct cagggccttc gctgtgcttg ccctattggc
     2161 tttgaactca tcagtgacat gaagacctgc attgtcccag aggctttcct tttgttttca
     2221 cggagagcag atatcagacg aatttctctg gaaacaaaca ataataatgt ggctattcca
     2281 ctcactggtg tcaaagaagc ttctgctttg gattttgatg tgacagacaa ccgaatttat
     2341 tggactgata tatcactcaa gaccatcagc agagccttta tgaatggcag tgcactggaa
     2401 catgtggtag aattcggctt agattatcca gaaggcatgg cagtagactg gcttgggaag
     2461 aacttgtact gggcagacac aggaacgaat cgaattgagg tgtcaaagtt ggatgggcag
     2521 caccgacaag ttttggtgtg gaaagaccta gatagtccca gagctctcgc gttggaccct
     2581 gccgaaggat ttatgtattg gactgaatgg ggtggaaaac ctaagataga cagagctgca
     2641 atggatggaa gtgaacgtac taccttagtt ccaaatgtgg ggcgggcaaa cggcctaact
     2701 attgattatg ctaaaaggag gctttattgg acagacctgg acaccaactt aatagaatct
     2761 tcaaatatgc ttgggctcaa ccgtgaagtt atagcagatg acttgcctca tccttttggc
     2821 ttaactcagt accaagatta tatctactgg acggactgga gccgacgcag cattgagcgt
     2881 gccaacaaaa ccagtggcca aaaccgcacc atcattcagg gccatttgga ttatgtgatg
     2941 gacatcctcg tctttcactc atctcgacag tcagggtgga atgaatgtgc ttccagcaat
     3001 gggcactgct cccacctctg cttggctgtg ccagttgggg gttttgtttg tggatgccct
     3061 gcccactact ctcttaatgc tgacaacagg acttgtagtg ctcctacgac tttcctgctc
     3121 ttcagtcaaa agagtgccat caaccgcatg gtgattgatg aacaacagag ccccgacatc
     3181 atccttccca tccacagcct tcggaatgtc cgggccattg actatgaccc actggacaag
     3241 caactctatt ggattgactc acgacaaaac atgatccgaa aggcacaaga agatggcagc
     3301 cagggcttta ctgtggttgt gagctcagtt ccgagtcaga acctggaaat acaaccctat
     3361 gacctcagca ttgatattta cagccgctac atctactgga cttgtgaggc taccaatgtc
     3421 attaatgtga caagattaga tgggagatca gttggagtgg tgctgaaagg cgagcaggac
     3481 agacctcgag ccgttgtggt aaacccagag aaagggtata tgtattttac caatcttcag
     3541 gaaaggtctc ctaaaattga acgggctgct ttggatggga cagaacggga ggtcctcttt
     3601 ttcagtggct taagtaaacc aattgcttta gcccttgata gcaggctggg caagctcttt
     3661 tgggctgatt cagatctccg gcgaattgaa agcagtgatc tctcaggtgc taaccggata
     3721 gtattagaag actccaatat cttgcagcct gtgggactta ctgtgtttga aaactggctc
     3781 tattggattg ataaacagca gcaaatgatt gaaaaaattg acatgacagg tcgagagggt
     3841 agaaccaaag tccaagctcg aattgcccag cttagtgaca ttcatgcagt aaaggagctg
     3901 aaccttcaag aatacagaca gcacccttgt gctcaggata atggtggctg ttcacatatt
     3961 tgtcttgtaa agggggatgg tactacaagg tgttcttgcc ccatgcacct ggttctactt
     4021 caagatgagc tatcatgtgg agaacctcca acatgttctc ctcagcagtt tacttgtttc
     4081 acgggggaaa ttgactgtat ccctgtggct tggcggtgcg atgggtttac tgaatgtgaa
     4141 gaccacagtg atgaactcaa ttgtcctgta tgctcagagt cccagttcca gtgtgccagt
     4201 gggcagtgta ttgatggtgc cctccgatgc aatggagatg caaactgcca ggacaaatca
     4261 gatgagaaga actgtgaagt gctttgttta attgatcagt tccgctgtgc caatggtcag
     4321 tgcattggaa agcacaagaa gtgtgatcat aatgtggatt gcagtgacaa gtcagatgaa
     4381 ctggattgtt atccgactga agaaccagca ccacaggcca ccaatacagt tggttctgtt
     4441 attggcgtaa ttgtcaccat ttttgtgtct ggaactgtat actttatctg ccagaggatg
     4501 ttgtgtccac gtatgaaggg agatggggaa actatgacta atgactatgt agttcatgga
     4561 ccagcttctg tgcctcttgg ttatgtgcca cacccaagtt ctttgtcagg atctcttcca
     4621 ggaatgtctc gaggtaaatc aatgatcagc tccctcagta tcatgggggg aagcagtgga
     4681 cccccctatg accgagccca tgttacagga gcatcatcaa gtagttcttc aagcaccaaa
     4741 ggcacttact tccctgcaat tttgaaccct ccaccatccc cagccacaga gcgatcacat
     4801 tacactatgg aatttggata ttcttcaaac agtccttcca ctcataggtc atacagctac
     4861 aggccatata gctaccggca ctttgcaccc cccaccacac cctgcagcac agatgtttgt
     4921 gacagtgact atgctcctag tcggagaatg acctcagtgg caacagccaa gggctatacc
     4981 agtgacttga actatgattc agaacctgtg cccccacctc ccacaccccg aagccaatac
     5041 ttgtcagcag aggagaacta tgaaagctgc ccaccttctc catacacaga gaggagctat
     5101 tctcatcacc tctacccacc gccaccctct ccctgtacag actcctcctg aggaggggcc
     5161 ctcctcctct gactgcctcc aacgtaaaaa tgtaaatata aatttggttg agatctggag
     5221 ggggggaggg agctattaga gaaggatgag gcagaccatg tacagttaaa attataaaat
     5281 ggggtaggga atactggaga tatttgtaca gaagaaaagg atatttatat attttcttaa
     5341 aacagcagat ttgctgcttg tgccataaaa gtttgtataa aaaaaatttg tactaaaagt
     5401 tttatttttg caaactaaat acacaaagca tgccttaaac ccagtgaagc aactgagtac
     5461 aaaggaaaca ggaataataa aggcatcact gaccaggaat atctgggctt tattgatacc
     5521 aaaaataaaa aagaggaaga agaaaaatta agtccatctc agagcagcaa accatagata
     5581 catggatgta gccagatagc cttcagttaa ctaacatttg agggccaaca agtaagaaat
     5641 gatgaaagga aaaaaatgca attaatacta accttggacg aagggctttg ttttctctag
     5701 gaatccaaca gtgctagtga ggaaagtaga tatttctaaa aacccattct gggtgttgct
     5761 gttgtaggag agatcagccc tctggtaaga tgccatgaag ctgtgtgtgt gtgcaagtct
     5821 ctgtccctac ctttagaatc catacctctg tcaaaatgaa tttttttctc taggtatgtt
     5881 taccttgctg cctcctccag caacttggta agtcattttg ctaagatacc atgatttttt
     5941 taagctgaag cattgactaa atggaatttt ctaaattaaa cttgatttta atatttcttc
     6001 tagctccatt ccccagtagg cttagctctt caatttgact gctgtttttg cataatgatc
     6061 aaaagttaga catattattt ctcttcttcc aagattgttt taatgctcat taaaatgtct
     6121 ttttacaaca catatagaca atgtttaaga attaaaaatt taaccattat gtttttgttg
     6181 taaatctcat atccttgcac tactttcagc atatatcaca gtacgaaatc atttatatat
     6241 atatatatat atatatatat atatatatat atatatatat atatattttg tttgtttgtt
     6301 tgttttctga gtaaaacatt taaatatgtt ctggttagag acaatctatt taaaaagatt
     6361 tttttcttat taggattttc cctatattaa cagtttgtga tgttttcatg ttctttagac
     6421 cggtttttct cagaataatg tctacataca tacctcttct aatgtgtgac atgaatttaa
     6481 tatctttctg ttacccactg tgaatgttag gctgttttca aattatccac aaattattct
     6541 tgtaatcacc caatattttt atgtgggtcc tctcttaccc attatggatt aagatagttt
     6601 aacaaattta acaatgagga ttaaatgaga aggcaaactg ttaacttctc agctgtcaga
     6661 atttgggtgg aagggaataa tggaagcctc ttttgtgatc tgcctgacct gctgtcatgt
     6721 atggtactgg ggctgctaca tcttgagcta tcagggctga cctgtggaat gattctagca
     6781 cttgctctgc caccttgcca gaagttcgtt tcctgctttt tacacatgtg tagcacttct
     6841 ctgctaaaat tgaatggttt taaactaatg tatttttagc ttaagaggtg ttggtcagtt
     6901 aattattgaa tttttttttt ttctttttta attctgtctt gccaaggcct ctctgggttt
     6961 cagggcccaa gagaaaacag tggaagaaag gattcagaat ttgggcaagg gtgaagtaac
     7021 tgttcatgca agttaaaaat acctaagtaa agtttttgaa gataaaattg tggtttcaga
     7081 ataatgctga ttgttggaga ctgtaagaat caggtgcact tgattttgca tataagcaaa
     7141 tggtaaatct atcagaatcc taaaacagac aagcatgaac tcttcccatt gctggaacta
     7201 agtgcccaca gtgtcagaca aaatggacat tgaacttgga ttctgtgata cacagggcac
     7261 ttgatgctta aatgaagatg gaaaggttag caatacctgg gtgtcagtta gaatttgaga
     7321 attctatatg tttacatatt taaatgtgca tcttgatctg gtgggcttcc catgtggaga
     7381 cttgcactct aattaactaa gaagaatatt gccttgttgg atctcagtcc acgtgcttgc
     7441 actgcgatgg caatggcctc ttcttcaaaa tactaatttg tgtgccaatt tgtttaaaat
     7501 tatttgaagg cagttcagcc taatctcagt gttctctttc tggggtagat gagatggatt
     7561 cttaatattt ctgggagtac tttttaatga gagaattgtc aaatttggaa agatttattg
     7621 agccttaggt tacatggaca gttaagctta agtaaactgt atattgatta tcaaacacaa
     7681 gctgtaattg gaaaagttga gaggaaaagc atgagatcac aaattagggg gaaaaaagaa
     7741 aagggatttt taaatttggt gtattaaatt cattgtccaa gggggaaaat gaataatgtt
     7801 tcattagatt ccttatatgc aaaagtattt attttgaaca tgtgtcctaa aatatatgca
     7861 ctaactgatg tgattaaaat tgtccaagaa ataaacttga gcataacata ctttgtgtgc
     7921 accacagtaa gctattctgc attgaagtgg tcttttataa ctaaggcctg gactttgctc
     7981 caacagagtc gtggtcttct gaatagtgac ttaaggagtt ttgtttgctt aagtcagata
     8041 atagcacatt cacagggaaa caaagagagt tggtggatag aattttctga ctattaattt
     8101 ttcttccatg aaattttatt atgcctttgg cactttctgc cactcttaca gcatatcaca
     8161 agatatctgt ttagcagaag attatgtagt tactttaatt ttaatataaa agtagcttgt
     8221 gatacattac caagagatct ctgattcttt agtaagtttg agaacaccta ttctacagag
     8281 atgataggta cttagaaatg aagactttaa agtacatttt aatctaatat aggccagtaa
     8341 ttgggggaag gggctttgag cagtacaatt ttaagatgat tttgagggtt gtatttcttt
     8401 atcatttaaa aatatcctaa agtcagtaat ttatatgaag gaaactcatt cattattgaa
     8461 ggtattaaaa atagccatca tctgtattag gtagcagttt tggaggatca tctttttctt
     8521 ttgctataaa gccctattaa tgaagaatac ttccagtaga gttaatagct gtagcttacc
     8581 tagtgtgtta atgaagtgtg tttatttatg tgacttgata ccagtagtca taatagagac
     8641 tgaagaggta tgcgttaagc acgcctactt ctatgcagta aacaggctgc agctgcctag
     8701 attagattct tagaaatgtc atattttgaa ttgttttatt tcttgtaggg gaagctttgt
     8761 cccacttcat tcatttgcat gccataggaa ttacatattg gttatcatta cgtatctaac
     8821 aagattcaga aacaaaaatc ttggactttt cacatccgaa atatgtcagc tcttaataaa
     8881 tgtgtggtgc ttaagtctac atatggcatc catagttgat ttagagtatg gatatgagtg
     8941 tgttgaccag ttatcagtag gtggacaaat atttgggcat ctacagatga gactatgcac
     9001 taagtgtgga ctgagtccta aagaagctta tagtcaggtg ttgtttaaaa cattatcaga
     9061 attcttaaac ccaaggaatt taattttatt tggtatttct taagcctaaa atgaaccaag
     9121 agaaagatga ttttagaaag tacttgtagt gaaagatgat tttagaaagt acttgtagtg
     9181 catgtgtggc ttctgacttt tgggatggca ccattttata atagtttcaa aatttagctt
     9241 ttgaaattct caacatttta tggtagaaga ctttggacct caagtataaa attatacgtt
     9301 tataattttt ttaaaattta aattataagt attgtgaatt cacactctca ggctattgtc
     9361 tgacttgatc tacgtctcat aaagcctgta cctgagtgga gtggaaggtg gagtcttagg
     9421 ttaatcagtt actgactcta ccctcaccct ctttcaattg aggtaaactt tgctgttttt
     9481 ctttttcata aagcattctc aaattgttga gtttattgct gaaaaaaatc tccatgactt
     9541 tacagataga attacaaact aaatgatgtc ttgtatttag aagcagagta cagacctaac
     9601 gaactgttag attctccacc atcacttagg gtttgcccag aagcaacacc agagaattac
     9661 agacaacgcg cttttgctga actgtccatt ttggtggttg tgtttttcag tcaaatataa
     9721 gcaggatggg cgatagagat atatttatat atagatacat attctatata tctaatgcct
     9781 aaatatgggt attaaaggga aaatttttaa agtctgatta aatccaatat gacatgaaat
     9841 taaatatatg gattagtaag gaaaaatgtt aaaaagtaga gaggatacca agaagattaa
     9901 actggactag ccttatttgc aagtgaagga tctggtgctg ctttcagatg tttatctttt
     9961 atttttttcc cttaagcttt aatcttcgtc attgtcttaa agtcaactgg tgtttcttgt
    10021 tcattgactt tggtacgatg gtgctttgca aggatgtatt tatgttataa tggccaacat
    10081 ttggtcagcc cttgtccact tattcacttc cctccttttg taaaataagt gctttaatta
    10141 taaactgtat aaaaatacct tgtataaacc ccttttttga ttattacaat aaataagctg
    10201 aattgtaaca aatgaaattt gatttttgta ataaaacagt ggaaaagtaa aa
//
