LOCUS       NM_001414255            4992 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 6 (LRP6), transcript
            variant 13, mRNA.
ACCESSION   NM_001414255
VERSION     NM_001414255.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4992)
  AUTHORS   Zhong,S., Guo,Q., Chen,X., Luo,X., Long,Y., Chong,T., Ye,M., He,H.,
            Lu,A., Ao,K., Yin,M., Xu,A., Li,X., Hao,Y. and Guo,X.
  TITLE     The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism
            and suppresses lymph node metastasis in cervical cancer
  JOURNAL   Int J Biol Sci 20 (3), 916-936 (2024)
   PUBMED   38250152
  REMARK    GeneRIF: The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid
            metabolism and suppresses lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4992)
  AUTHORS   Li,J., Liu,Z., Ren,Y., Shao,H. and Li,S.
  TITLE     LRP5-/6 gene polymorphisms and its association with risk of
            abnormal bone mass in postmenopausal women
  JOURNAL   J Orthop Surg Res 18 (1), 369 (2023)
   PUBMED   37202775
  REMARK    GeneRIF: LRP5-/6 gene polymorphisms and its association with risk
            of abnormal bone mass in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4992)
  AUTHORS   Hao,H., Liu,Q., Chen,J. and Zhou,H.
  TITLE     Overexpression of circRNAs LRP6 in gestational diabetes mellitus
            predicts foetal malformation and intrauterine death
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 70 (2), 124-129 (2023)
   PUBMED   36925229
  REMARK    GeneRIF: Overexpression of circRNAs LRP6 in gestational diabetes
            mellitus predicts foetal malformation and intrauterine death.
REFERENCE   4  (bases 1 to 4992)
  AUTHORS   Wang,J., Yang,H., Ma,X., Liu,J., Li,L., Chen,L. and Wei,F.
  TITLE     LRP6/filamentous-actin signaling facilitates osteogenic commitment
            in mechanically induced periodontal ligament stem cells
  JOURNAL   Cell Mol Biol Lett 28 (1), 7 (2023)
   PUBMED   36694134
  REMARK    GeneRIF: LRP6/filamentous-actin signaling facilitates osteogenic
            commitment in mechanically induced periodontal ligament stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4992)
  AUTHORS   Jones,M.E., Buchler,J., Dufor,T., Palomer,E., Teo,S.,
            Martin-Flores,N., Boroviak,K., Metzakopian,E., Gibb,A. and
            Salinas,P.C.
  TITLE     A genetic variant of the Wnt receptor LRP6 accelerates synapse
            degeneration during aging and in Alzheimer's disease
  JOURNAL   Sci Adv 9 (2), eabo7421 (2023)
   PUBMED   36638182
  REMARK    GeneRIF: A genetic variant of the Wnt receptor LRP6 accelerates
            synapse degeneration during aging and in Alzheimer's disease.
REFERENCE   6  (bases 1 to 4992)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   7  (bases 1 to 4992)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   8  (bases 1 to 4992)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   9  (bases 1 to 4992)
  AUTHORS   Baens,M., Wlodarska,I., Corveleyn,A., Hoornaert,I., Hagemeijer,A.
            and Marynen,P.
  TITLE     A physical, transcript, and deletion map of chromosome region
            12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6
            CpG island in two leukemia patients with hemizygous del(12p)
  JOURNAL   Genomics 56 (1), 40-50 (1999)
   PUBMED   10036184
REFERENCE   10 (bases 1 to 4992)
  AUTHORS   Brown,S.D., Twells,R.C., Hey,P.J., Cox,R.D., Levy,E.R.,
            Soderman,A.R., Metzker,M.L., Caskey,C.T., Todd,J.A. and Hess,J.F.
  TITLE     Isolation and characterization of LRP6, a novel member of the low
            density lipoprotein receptor gene family
  JOURNAL   Biochem Biophys Res Commun 248 (3), 879-888 (1998)
   PUBMED   9704021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007621.34, AC007537.3 and
            KF455603.1.
            
            Summary: This gene encodes a member of the low density lipoprotein
            (LDL) receptor gene family. LDL receptors are transmembrane cell
            surface proteins involved in receptor-mediated endocytosis of
            lipoprotein and protein ligands. The protein encoded by this gene
            functions as a receptor or, with Frizzled, a co-receptor for Wnt
            and thereby transmits the canonical Wnt/beta-catenin signaling
            cascade. Through its interaction with the Wnt/beta-catenin
            signaling cascade this gene plays a role in the regulation of cell
            differentiation, proliferation, and migration and the development
            of many cancer types. This protein undergoes gamma-secretase
            dependent RIP- (regulated intramembrane proteolysis) processing but
            the precise locations of the cleavage sites have not been
            determined.[provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1279281.1,
                                           SRR14038194.2022782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC007621.34        47033-47396         c
            365-758             AC007621.34        24614-25007         c
            759-956             AC007537.3         172409-172606       c
            957-1153            AC007537.3         156129-156325       c
            1154-1285           AC007537.3         153186-153317       c
            1286-1682           AC007537.3         150249-150645       c
            1683-1854           AC007537.3         149016-149187       c
            1855-2081           AC007537.3         131399-131625       c
            2082-2266           AC007537.3         128986-129170       c
            2267-2593           AC007537.3         128035-128361       c
            2594-2735           AC007537.3         120103-120244       c
            2736-2796           KF455603.1         330-390             c
            2797-3008           AC007537.3         118148-118359       c
            3009-3199           AC007537.3         116572-116762       c
            3200-3409           AC007537.3         107531-107740       c
            3410-3535           AC007537.3         104381-104506       c
            3536-3772           AC007537.3         101027-101263       c
            3773-3883           AC007537.3         99989-100099        c
            3884-4114           AC007537.3         95897-96127         c
            4115-4251           AC007537.3         94502-94638         c
            4252-4349           AC007537.3         93771-93868         c
            4350-4992           AC007537.3         89984-90626         c
FEATURES             Location/Qualifiers
     source          1..4992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..4992
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
     exon            1..364
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..4644
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="isoform j is encoded by transcript variant 13;
                     low-density lipoprotein receptor-related protein 6; LRP-6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform j"
                     /protein_id="NP_001401184.1"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
                     /translation="MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENAT
                     IVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLAC
                     DWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEV
                     PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQA
                     VVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQ
                     QRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLA
                     RRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS
                     GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
                     IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD
                     AKTDKIETISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLD
                     GQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRA
                     NGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWS
                     RRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPV
                     GGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV
                     RAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYS
                     RYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKI
                     ERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLED
                     SNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNL
                     QEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCF
                     TGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQD
                     KSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNT
                     VGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSS
                     LSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPP
                     SPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRM
                     TSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPP
                     PSPCTDSS"
     exon            365..758
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            759..956
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1153
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1285
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1682
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1854
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2081
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2266
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2593
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2796
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..3008
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3199
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3409
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3535
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3772
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3883
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..4114
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4115..4251
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4349
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4350..4992
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4969..4974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="hexamer: AATAAA"
     polyA_site      4992
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctgc gccgctgcgc gaggcagagg ctgaatgagg agctgcgcgg gggaagcggg
       61 gcgccggggg aggaggcggc gggatggaag cagacgctgg cgtcgcgcga gcccggggcc
      121 gagcggcgcg gtagagaggg cggcggcggc gcgcgcggaa ccttgacgtg cccctttctt
      181 tcttctctcg ctgggaagct gggaagtatg agcgtgcagc cctgccgctg cggcggccgc
      241 cccggctcct cgcctccccc acttctggcc acccctcgcc ggtgagagaa gagaacgcga
      301 gaagggaaga tgggggccgt cctgaggagc ctcctggcct gcagcttctg tgtgctcctg
      361 agagcggccc ctttgttgct ttatgcaaac agacgggact tgcgattggt tgatgctaca
      421 aatggcaaag agaatgctac gattgtagtt ggaggcttgg aggatgcagc tgcggtggac
      481 tttgtgttta gtcatggctt gatatactgg agtgatgtca gcgaagaagc cattaaacga
      541 acagaattta acaaaactga gagtgtgcag aatgttgttg tttctggatt attgtccccc
      601 gatgggctgg catgtgattg gcttggagaa aaattgtact ggacagattc tgaaactaat
      661 cggattgaag tttctaattt agatggatct ttacgaaaag ttttattttg gcaagagttg
      721 gatcaaccca gagctattgc cttagatcct tcaagtgggt tcatgtactg gacagactgg
      781 ggagaagtgc caaagataga acgtgctgga atggatggtt caagtcgctt cattataata
      841 aacagtgaaa tttactggcc aaatggactg actttggatt atgaagaaca aaagctttat
      901 tgggcagatg caaaacttaa tttcatccac aaatcaaatc tggatggaac aaatcggcag
      961 gcagtggtta aaggttccct tccacatcct tttgccttga cgttatttga ggacatattg
     1021 tactggactg actggagcac acactccatt ttggcttgca acaagtatac tggtgagggt
     1081 ctgcgtgaaa tccattctga catcttctct cccatggata tacatgcctt cagccaacag
     1141 aggcagccaa atgccacaaa tccatgtgga attgacaatg ggggttgttc ccatttgtgt
     1201 ttgatgtctc cagtcaagcc tttttatcag tgtgcttgcc ccactggggt caaactcctg
     1261 gagaatggaa aaacctgcaa agatggtgcc acagaattat tgcttttagc tcgaaggaca
     1321 gacttgagac gcatttcttt ggatacacca gattttacag acattgttct gcagttagaa
     1381 gacatccgtc atgccattgc catagattac gatcctgtgg aaggctacat ctactggact
     1441 gatgatgaag tgagggccat acgccgttca tttatagatg gatctggcag tcagtttgtg
     1501 gtcactgctc aaattgccca tcctgatggt attgctgtgg actgggttgc acgaaatctt
     1561 tattggacag acactggcac tgatcgaata gaagtgacaa ggctcaatgg gaccatgagg
     1621 aagatcttga tttcagagga cttagaggaa ccccgggcta ttgtgttaga tcccatggtt
     1681 gggtacatgt attggactga ctggggagaa attccgaaaa ttgagcgagc agctctggat
     1741 ggttctgacc gtgtagtatt ggttaacact tctcttggtt ggccaaatgg tttagccttg
     1801 gattatgatg aaggcaaaat atactgggga gatgccaaaa cagacaagat tgagaccatc
     1861 agcagagcct ttatgaatgg cagtgcactg gaacatgtgg tagaattcgg cttagattat
     1921 ccagaaggca tggcagtaga ctggcttggg aagaacttgt actgggcaga cacaggaacg
     1981 aatcgaattg aggtgtcaaa gttggatggg cagcaccgac aagttttggt gtggaaagac
     2041 ctagatagtc ccagagctct cgcgttggac cctgccgaag gatttatgta ttggactgaa
     2101 tggggtggaa aacctaagat agacagagct gcaatggatg gaagtgaacg tactacctta
     2161 gttccaaatg tggggcgggc aaacggccta actattgatt atgctaaaag gaggctttat
     2221 tggacagacc tggacaccaa cttaatagaa tcttcaaata tgcttgggct caaccgtgaa
     2281 gttatagcag atgacttgcc tcatcctttt ggcttaactc agtaccaaga ttatatctac
     2341 tggacggact ggagccgacg cagcattgag cgtgccaaca aaaccagtgg ccaaaaccgc
     2401 accatcattc agggccattt ggattatgtg atggacatcc tcgtctttca ctcatctcga
     2461 cagtcagggt ggaatgaatg tgcttccagc aatgggcact gctcccacct ctgcttggct
     2521 gtgccagttg ggggttttgt ttgtggatgc cctgcccact actctcttaa tgctgacaac
     2581 aggacttgta gtgctcctac gactttcctg ctcttcagtc aaaagagtgc catcaaccgc
     2641 atggtgattg atgaacaaca gagccccgac atcatccttc ccatccacag ccttcggaat
     2701 gtccgggcca ttgactatga cccactggac aagcaactct attggattga ctcacgacaa
     2761 aacatgatcc gaaaggcaca agaagatggc agccagggct ttactgtggt tgtgagctca
     2821 gttccgagtc agaacctgga aatacaaccc tatgacctca gcattgatat ttacagccgc
     2881 tacatctact ggacttgtga ggctaccaat gtcattaatg tgacaagatt agatgggaga
     2941 tcagttggag tggtgctgaa aggcgagcag gacagacctc gagccgttgt ggtaaaccca
     3001 gagaaagggt atatgtattt taccaatctt caggaaaggt ctcctaaaat tgaacgggct
     3061 gctttggatg ggacagaacg ggaggtcctc tttttcagtg gcttaagtaa accaattgct
     3121 ttagcccttg atagcaggct gggcaagctc ttttgggctg attcagatct ccggcgaatt
     3181 gaaagcagtg atctctcagg tgctaaccgg atagtattag aagactccaa tatcttgcag
     3241 cctgtgggac ttactgtgtt tgaaaactgg ctctattgga ttgataaaca gcagcaaatg
     3301 attgaaaaaa ttgacatgac aggtcgagag ggtagaacca aagtccaagc tcgaattgcc
     3361 cagcttagtg acattcatgc agtaaaggag ctgaaccttc aagaatacag acagcaccct
     3421 tgtgctcagg ataatggtgg ctgttcacat atttgtcttg taaaggggga tggtactaca
     3481 aggtgttctt gccccatgca cctggttcta cttcaagatg agctatcatg tggagaacct
     3541 ccaacatgtt ctcctcagca gtttacttgt ttcacggggg aaattgactg tatccctgtg
     3601 gcttggcggt gcgatgggtt tactgaatgt gaagaccaca gtgatgaact caattgtcct
     3661 gtatgctcag agtcccagtt ccagtgtgcc agtgggcagt gtattgatgg tgccctccga
     3721 tgcaatggag atgcaaactg ccaggacaaa tcagatgaga agaactgtga agtgctttgt
     3781 ttaattgatc agttccgctg tgccaatggt cagtgcattg gaaagcacaa gaagtgtgat
     3841 cataatgtgg attgcagtga caagtcagat gaactggatt gttatccgac tgaagaacca
     3901 gcaccacagg ccaccaatac agttggttct gttattggcg taattgtcac catttttgtg
     3961 tctggaactg tatactttat ctgccagagg atgttgtgtc cacgtatgaa gggagatggg
     4021 gaaactatga ctaatgacta tgtagttcat ggaccagctt ctgtgcctct tggttatgtg
     4081 ccacacccaa gttctttgtc aggatctctt ccaggaatgt ctcgaggtaa atcaatgatc
     4141 agctccctca gtatcatggg gggaagcagt ggacccccct atgaccgagc ccatgttaca
     4201 ggagcatcat caagtagttc ttcaagcacc aaaggcactt acttccctgc aattttgaac
     4261 cctccaccat ccccagccac agagcgatca cattacacta tggaatttgg atattcttca
     4321 aacagtcctt ccactcatag gtcatacagc tacaggccat atagctaccg gcactttgca
     4381 ccccccacca caccctgcag cacagatgtt tgtgacagtg actatgctcc tagtcggaga
     4441 atgacctcag tggcaacagc caagggctat accagtgact tgaactatga ttcagaacct
     4501 gtgcccccac ctcccacacc ccgaagccaa tacttgtcag cagaggagaa ctatgaaagc
     4561 tgcccacctt ctccatacac agagaggagc tattctcatc acctctaccc accgccaccc
     4621 tctccctgta cagactcctc ctgaggaggg gccctcctcc tctgactgcc tccaacgtaa
     4681 aaatgtaaat ataaatttgg ttgagatctg gaggggggga gggagctatt agagaaggat
     4741 gaggcagacc atgtacagtt aaaattataa aatggggtag ggaatactgg agatatttgt
     4801 acagaagaaa aggatattta tatattttct taaaacagca gatttgctgc ttgtgccata
     4861 aaagtttgta taaaaaaaat ttgtactaaa agttttattt ttgcaaacta aatacacaaa
     4921 gcatgcctta aacccagtga agcaactgag tacaaaggaa acaggaataa taaaggcatc
     4981 actgaccagg aa
//
