LOCUS       NM_001414254            5495 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 6 (LRP6), transcript
            variant 12, mRNA.
ACCESSION   NM_001414254
VERSION     NM_001414254.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5495)
  AUTHORS   Zhong,S., Guo,Q., Chen,X., Luo,X., Long,Y., Chong,T., Ye,M., He,H.,
            Lu,A., Ao,K., Yin,M., Xu,A., Li,X., Hao,Y. and Guo,X.
  TITLE     The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism
            and suppresses lymph node metastasis in cervical cancer
  JOURNAL   Int J Biol Sci 20 (3), 916-936 (2024)
   PUBMED   38250152
  REMARK    GeneRIF: The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid
            metabolism and suppresses lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5495)
  AUTHORS   Li,J., Liu,Z., Ren,Y., Shao,H. and Li,S.
  TITLE     LRP5-/6 gene polymorphisms and its association with risk of
            abnormal bone mass in postmenopausal women
  JOURNAL   J Orthop Surg Res 18 (1), 369 (2023)
   PUBMED   37202775
  REMARK    GeneRIF: LRP5-/6 gene polymorphisms and its association with risk
            of abnormal bone mass in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5495)
  AUTHORS   Hao,H., Liu,Q., Chen,J. and Zhou,H.
  TITLE     Overexpression of circRNAs LRP6 in gestational diabetes mellitus
            predicts foetal malformation and intrauterine death
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 70 (2), 124-129 (2023)
   PUBMED   36925229
  REMARK    GeneRIF: Overexpression of circRNAs LRP6 in gestational diabetes
            mellitus predicts foetal malformation and intrauterine death.
REFERENCE   4  (bases 1 to 5495)
  AUTHORS   Wang,J., Yang,H., Ma,X., Liu,J., Li,L., Chen,L. and Wei,F.
  TITLE     LRP6/filamentous-actin signaling facilitates osteogenic commitment
            in mechanically induced periodontal ligament stem cells
  JOURNAL   Cell Mol Biol Lett 28 (1), 7 (2023)
   PUBMED   36694134
  REMARK    GeneRIF: LRP6/filamentous-actin signaling facilitates osteogenic
            commitment in mechanically induced periodontal ligament stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5495)
  AUTHORS   Jones,M.E., Buchler,J., Dufor,T., Palomer,E., Teo,S.,
            Martin-Flores,N., Boroviak,K., Metzakopian,E., Gibb,A. and
            Salinas,P.C.
  TITLE     A genetic variant of the Wnt receptor LRP6 accelerates synapse
            degeneration during aging and in Alzheimer's disease
  JOURNAL   Sci Adv 9 (2), eabo7421 (2023)
   PUBMED   36638182
  REMARK    GeneRIF: A genetic variant of the Wnt receptor LRP6 accelerates
            synapse degeneration during aging and in Alzheimer's disease.
REFERENCE   6  (bases 1 to 5495)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   7  (bases 1 to 5495)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   8  (bases 1 to 5495)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   9  (bases 1 to 5495)
  AUTHORS   Baens,M., Wlodarska,I., Corveleyn,A., Hoornaert,I., Hagemeijer,A.
            and Marynen,P.
  TITLE     A physical, transcript, and deletion map of chromosome region
            12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6
            CpG island in two leukemia patients with hemizygous del(12p)
  JOURNAL   Genomics 56 (1), 40-50 (1999)
   PUBMED   10036184
REFERENCE   10 (bases 1 to 5495)
  AUTHORS   Brown,S.D., Twells,R.C., Hey,P.J., Cox,R.D., Levy,E.R.,
            Soderman,A.R., Metzker,M.L., Caskey,C.T., Todd,J.A. and Hess,J.F.
  TITLE     Isolation and characterization of LRP6, a novel member of the low
            density lipoprotein receptor gene family
  JOURNAL   Biochem Biophys Res Commun 248 (3), 879-888 (1998)
   PUBMED   9704021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007621.34, AC007537.3 and
            KF455603.1.
            
            Summary: This gene encodes a member of the low density lipoprotein
            (LDL) receptor gene family. LDL receptors are transmembrane cell
            surface proteins involved in receptor-mediated endocytosis of
            lipoprotein and protein ligands. The protein encoded by this gene
            functions as a receptor or, with Frizzled, a co-receptor for Wnt
            and thereby transmits the canonical Wnt/beta-catenin signaling
            cascade. Through its interaction with the Wnt/beta-catenin
            signaling cascade this gene plays a role in the regulation of cell
            differentiation, proliferation, and migration and the development
            of many cancer types. This protein undergoes gamma-secretase
            dependent RIP- (regulated intramembrane proteolysis) processing but
            the precise locations of the cleavage sites have not been
            determined.[provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1514145.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC007621.34        47033-47396         c
            365-754             AC007621.34        24618-25007         c
            755-952             AC007537.3         172409-172606       c
            953-1149            AC007537.3         156129-156325       c
            1150-1281           AC007537.3         153186-153317       c
            1282-1678           AC007537.3         150249-150645       c
            1679-1850           AC007537.3         149016-149187       c
            1851-2067           AC007537.3         134285-134501       c
            2068-2357           AC007537.3         133479-133768       c
            2358-2584           AC007537.3         131399-131625       c
            2585-2769           AC007537.3         128986-129170       c
            2770-3096           AC007537.3         128035-128361       c
            3097-3238           AC007537.3         120103-120244       c
            3239-3299           KF455603.1         330-390             c
            3300-3511           AC007537.3         118148-118359       c
            3512-3702           AC007537.3         116572-116762       c
            3703-3912           AC007537.3         107531-107740       c
            3913-4038           AC007537.3         104381-104506       c
            4039-4275           AC007537.3         101027-101263       c
            4276-4386           AC007537.3         99989-100099        c
            4387-4617           AC007537.3         95897-96127         c
            4618-4754           AC007537.3         94502-94638         c
            4755-4852           AC007537.3         93771-93868         c
            4853-5495           AC007537.3         89984-90626         c
FEATURES             Location/Qualifiers
     source          1..5495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..5495
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
     exon            1..364
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            365..754
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            755..952
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             759..5147
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="isoform i is encoded by transcript variant 12;
                     low-density lipoprotein receptor-related protein 6; LRP-6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform i"
                     /protein_id="NP_001401183.1"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
                     /translation="MYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQK
                     LYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY
                     TGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACP
                     TGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDP
                     VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRI
                     EVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLV
                     NTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGD
                     YVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSH
                     LCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLT
                     GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGK
                     NLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDR
                     AAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLP
                     HPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWN
                     ECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI
                     DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSV
                     PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVN
                     PEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDL
                     RRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKV
                     QARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQD
                     ELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCAS
                     GQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKS
                     DELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDY
                     VVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSS
                     SSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPT
                     TPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESC
                     PPSPYTERSYSHHLYPPPPSPCTDSS"
     exon            953..1149
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1281
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1678
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1850
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2067
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2357
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2584
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2769
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..3096
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3299
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3511
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3702
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3912
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4038
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4039..4275
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4386
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4387..4617
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4754
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4755..4852
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4853..5495
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5472..5477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="hexamer: AATAAA"
     polyA_site      5495
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctgc gccgctgcgc gaggcagagg ctgaatgagg agctgcgcgg gggaagcggg
       61 gcgccggggg aggaggcggc gggatggaag cagacgctgg cgtcgcgcga gcccggggcc
      121 gagcggcgcg gtagagaggg cggcggcggc gcgcgcggaa ccttgacgtg cccctttctt
      181 tcttctctcg ctgggaagct gggaagtatg agcgtgcagc cctgccgctg cggcggccgc
      241 cccggctcct cgcctccccc acttctggcc acccctcgcc ggtgagagaa gagaacgcga
      301 gaagggaaga tgggggccgt cctgaggagc ctcctggcct gcagcttctg tgtgctcctg
      361 agagcggccc ctttgttgct ttatgcaaac agacgggact tgcgattggt tgatgctaca
      421 aatggcaaag agaatgctac gattgtagtt ggaggcttgg aggatgcagc tgcggtggac
      481 tttgtgttta gtcatggctt gatatactgg agtgatgtca gcgaagaagc cattaaacga
      541 acagaattta acaaaactga gagtgtgcag aatgttgttg tttctggatt attgtccccc
      601 gatgggctgg catgtgattg gcttggagaa aaattgtact ggacagattc tgaaactaat
      661 cggattgaag tttctaattt agatggatct ttacgaaaag ttttattttg gcaagagttg
      721 gatcaaccca gagctattgc cttagatcct tcaagttcat gtactggaca gactggggag
      781 aagtgccaaa gatagaacgt gctggaatgg atggttcaag tcgcttcatt ataataaaca
      841 gtgaaattta ctggccaaat ggactgactt tggattatga agaacaaaag ctttattggg
      901 cagatgcaaa acttaatttc atccacaaat caaatctgga tggaacaaat cggcaggcag
      961 tggttaaagg ttcccttcca catccttttg ccttgacgtt atttgaggac atattgtact
     1021 ggactgactg gagcacacac tccattttgg cttgcaacaa gtatactggt gagggtctgc
     1081 gtgaaatcca ttctgacatc ttctctccca tggatataca tgccttcagc caacagaggc
     1141 agccaaatgc cacaaatcca tgtggaattg acaatggggg ttgttcccat ttgtgtttga
     1201 tgtctccagt caagcctttt tatcagtgtg cttgccccac tggggtcaaa ctcctggaga
     1261 atggaaaaac ctgcaaagat ggtgccacag aattattgct tttagctcga aggacagact
     1321 tgagacgcat ttctttggat acaccagatt ttacagacat tgttctgcag ttagaagaca
     1381 tccgtcatgc cattgccata gattacgatc ctgtggaagg ctacatctac tggactgatg
     1441 atgaagtgag ggccatacgc cgttcattta tagatggatc tggcagtcag tttgtggtca
     1501 ctgctcaaat tgcccatcct gatggtattg ctgtggactg ggttgcacga aatctttatt
     1561 ggacagacac tggcactgat cgaatagaag tgacaaggct caatgggacc atgaggaaga
     1621 tcttgatttc agaggactta gaggaacccc gggctattgt gttagatccc atggttgggt
     1681 acatgtattg gactgactgg ggagaaattc cgaaaattga gcgagcagct ctggatggtt
     1741 ctgaccgtgt agtattggtt aacacttctc ttggttggcc aaatggttta gccttggatt
     1801 atgatgaagg caaaatatac tggggagatg ccaaaacaga caagattgag gttatgaata
     1861 ctgatggcac tgggagacga gtactagtgg aagacaaaat tcctcacata tttggattta
     1921 ctttgttggg tgactatgtt tactggactg actggcagag gcgtagcatt gaaagagttc
     1981 ataaacgaag tgcagagagg gaagtgatca tagatcagct gcctgacctc atgggcctaa
     2041 aggctacaaa tgttcatcga gtgattggtt ccaacccctg tgctgaggaa aacgggggat
     2101 gtagccatct ctgcctctat agacctcagg gccttcgctg tgcttgccct attggctttg
     2161 aactcatcag tgacatgaag acctgcattg tcccagaggc tttccttttg ttttcacgga
     2221 gagcagatat cagacgaatt tctctggaaa caaacaataa taatgtggct attccactca
     2281 ctggtgtcaa agaagcttct gctttggatt ttgatgtgac agacaaccga atttattgga
     2341 ctgatatatc actcaagacc atcagcagag cctttatgaa tggcagtgca ctggaacatg
     2401 tggtagaatt cggcttagat tatccagaag gcatggcagt agactggctt gggaagaact
     2461 tgtactgggc agacacagga acgaatcgaa ttgaggtgtc aaagttggat gggcagcacc
     2521 gacaagtttt ggtgtggaaa gacctagata gtcccagagc tctcgcgttg gaccctgccg
     2581 aaggatttat gtattggact gaatggggtg gaaaacctaa gatagacaga gctgcaatgg
     2641 atggaagtga acgtactacc ttagttccaa atgtggggcg ggcaaacggc ctaactattg
     2701 attatgctaa aaggaggctt tattggacag acctggacac caacttaata gaatcttcaa
     2761 atatgcttgg gctcaaccgt gaagttatag cagatgactt gcctcatcct tttggcttaa
     2821 ctcagtacca agattatatc tactggacgg actggagccg acgcagcatt gagcgtgcca
     2881 acaaaaccag tggccaaaac cgcaccatca ttcagggcca tttggattat gtgatggaca
     2941 tcctcgtctt tcactcatct cgacagtcag ggtggaatga atgtgcttcc agcaatgggc
     3001 actgctccca cctctgcttg gctgtgccag ttgggggttt tgtttgtgga tgccctgccc
     3061 actactctct taatgctgac aacaggactt gtagtgctcc tacgactttc ctgctcttca
     3121 gtcaaaagag tgccatcaac cgcatggtga ttgatgaaca acagagcccc gacatcatcc
     3181 ttcccatcca cagccttcgg aatgtccggg ccattgacta tgacccactg gacaagcaac
     3241 tctattggat tgactcacga caaaacatga tccgaaaggc acaagaagat ggcagccagg
     3301 gctttactgt ggttgtgagc tcagttccga gtcagaacct ggaaatacaa ccctatgacc
     3361 tcagcattga tatttacagc cgctacatct actggacttg tgaggctacc aatgtcatta
     3421 atgtgacaag attagatggg agatcagttg gagtggtgct gaaaggcgag caggacagac
     3481 ctcgagccgt tgtggtaaac ccagagaaag ggtatatgta ttttaccaat cttcaggaaa
     3541 ggtctcctaa aattgaacgg gctgctttgg atgggacaga acgggaggtc ctctttttca
     3601 gtggcttaag taaaccaatt gctttagccc ttgatagcag gctgggcaag ctcttttggg
     3661 ctgattcaga tctccggcga attgaaagca gtgatctctc aggtgctaac cggatagtat
     3721 tagaagactc caatatcttg cagcctgtgg gacttactgt gtttgaaaac tggctctatt
     3781 ggattgataa acagcagcaa atgattgaaa aaattgacat gacaggtcga gagggtagaa
     3841 ccaaagtcca agctcgaatt gcccagctta gtgacattca tgcagtaaag gagctgaacc
     3901 ttcaagaata cagacagcac ccttgtgctc aggataatgg tggctgttca catatttgtc
     3961 ttgtaaaggg ggatggtact acaaggtgtt cttgccccat gcacctggtt ctacttcaag
     4021 atgagctatc atgtggagaa cctccaacat gttctcctca gcagtttact tgtttcacgg
     4081 gggaaattga ctgtatccct gtggcttggc ggtgcgatgg gtttactgaa tgtgaagacc
     4141 acagtgatga actcaattgt cctgtatgct cagagtccca gttccagtgt gccagtgggc
     4201 agtgtattga tggtgccctc cgatgcaatg gagatgcaaa ctgccaggac aaatcagatg
     4261 agaagaactg tgaagtgctt tgtttaattg atcagttccg ctgtgccaat ggtcagtgca
     4321 ttggaaagca caagaagtgt gatcataatg tggattgcag tgacaagtca gatgaactgg
     4381 attgttatcc gactgaagaa ccagcaccac aggccaccaa tacagttggt tctgttattg
     4441 gcgtaattgt caccattttt gtgtctggaa ctgtatactt tatctgccag aggatgttgt
     4501 gtccacgtat gaagggagat ggggaaacta tgactaatga ctatgtagtt catggaccag
     4561 cttctgtgcc tcttggttat gtgccacacc caagttcttt gtcaggatct cttccaggaa
     4621 tgtctcgagg taaatcaatg atcagctccc tcagtatcat ggggggaagc agtggacccc
     4681 cctatgaccg agcccatgtt acaggagcat catcaagtag ttcttcaagc accaaaggca
     4741 cttacttccc tgcaattttg aaccctccac catccccagc cacagagcga tcacattaca
     4801 ctatggaatt tggatattct tcaaacagtc cttccactca taggtcatac agctacaggc
     4861 catatagcta ccggcacttt gcacccccca ccacaccctg cagcacagat gtttgtgaca
     4921 gtgactatgc tcctagtcgg agaatgacct cagtggcaac agccaagggc tataccagtg
     4981 acttgaacta tgattcagaa cctgtgcccc cacctcccac accccgaagc caatacttgt
     5041 cagcagagga gaactatgaa agctgcccac cttctccata cacagagagg agctattctc
     5101 atcacctcta cccaccgcca ccctctccct gtacagactc ctcctgagga ggggccctcc
     5161 tcctctgact gcctccaacg taaaaatgta aatataaatt tggttgagat ctggaggggg
     5221 ggagggagct attagagaag gatgaggcag accatgtaca gttaaaatta taaaatgggg
     5281 tagggaatac tggagatatt tgtacagaag aaaaggatat ttatatattt tcttaaaaca
     5341 gcagatttgc tgcttgtgcc ataaaagttt gtataaaaaa aatttgtact aaaagtttta
     5401 tttttgcaaa ctaaatacac aaagcatgcc ttaaacccag tgaagcaact gagtacaaag
     5461 gaaacaggaa taataaaggc atcactgacc aggaa
//
