LOCUS       NM_001414252            5105 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 6 (LRP6), transcript
            variant 10, mRNA.
ACCESSION   NM_001414252 XM_011520671
VERSION     NM_001414252.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5105)
  AUTHORS   Zhong,S., Guo,Q., Chen,X., Luo,X., Long,Y., Chong,T., Ye,M., He,H.,
            Lu,A., Ao,K., Yin,M., Xu,A., Li,X., Hao,Y. and Guo,X.
  TITLE     The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism
            and suppresses lymph node metastasis in cervical cancer
  JOURNAL   Int J Biol Sci 20 (3), 916-936 (2024)
   PUBMED   38250152
  REMARK    GeneRIF: The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid
            metabolism and suppresses lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5105)
  AUTHORS   Li,J., Liu,Z., Ren,Y., Shao,H. and Li,S.
  TITLE     LRP5-/6 gene polymorphisms and its association with risk of
            abnormal bone mass in postmenopausal women
  JOURNAL   J Orthop Surg Res 18 (1), 369 (2023)
   PUBMED   37202775
  REMARK    GeneRIF: LRP5-/6 gene polymorphisms and its association with risk
            of abnormal bone mass in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5105)
  AUTHORS   Hao,H., Liu,Q., Chen,J. and Zhou,H.
  TITLE     Overexpression of circRNAs LRP6 in gestational diabetes mellitus
            predicts foetal malformation and intrauterine death
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 70 (2), 124-129 (2023)
   PUBMED   36925229
  REMARK    GeneRIF: Overexpression of circRNAs LRP6 in gestational diabetes
            mellitus predicts foetal malformation and intrauterine death.
REFERENCE   4  (bases 1 to 5105)
  AUTHORS   Wang,J., Yang,H., Ma,X., Liu,J., Li,L., Chen,L. and Wei,F.
  TITLE     LRP6/filamentous-actin signaling facilitates osteogenic commitment
            in mechanically induced periodontal ligament stem cells
  JOURNAL   Cell Mol Biol Lett 28 (1), 7 (2023)
   PUBMED   36694134
  REMARK    GeneRIF: LRP6/filamentous-actin signaling facilitates osteogenic
            commitment in mechanically induced periodontal ligament stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5105)
  AUTHORS   Jones,M.E., Buchler,J., Dufor,T., Palomer,E., Teo,S.,
            Martin-Flores,N., Boroviak,K., Metzakopian,E., Gibb,A. and
            Salinas,P.C.
  TITLE     A genetic variant of the Wnt receptor LRP6 accelerates synapse
            degeneration during aging and in Alzheimer's disease
  JOURNAL   Sci Adv 9 (2), eabo7421 (2023)
   PUBMED   36638182
  REMARK    GeneRIF: A genetic variant of the Wnt receptor LRP6 accelerates
            synapse degeneration during aging and in Alzheimer's disease.
REFERENCE   6  (bases 1 to 5105)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   7  (bases 1 to 5105)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   8  (bases 1 to 5105)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   9  (bases 1 to 5105)
  AUTHORS   Baens,M., Wlodarska,I., Corveleyn,A., Hoornaert,I., Hagemeijer,A.
            and Marynen,P.
  TITLE     A physical, transcript, and deletion map of chromosome region
            12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6
            CpG island in two leukemia patients with hemizygous del(12p)
  JOURNAL   Genomics 56 (1), 40-50 (1999)
   PUBMED   10036184
REFERENCE   10 (bases 1 to 5105)
  AUTHORS   Brown,S.D., Twells,R.C., Hey,P.J., Cox,R.D., Levy,E.R.,
            Soderman,A.R., Metzker,M.L., Caskey,C.T., Todd,J.A. and Hess,J.F.
  TITLE     Isolation and characterization of LRP6, a novel member of the low
            density lipoprotein receptor gene family
  JOURNAL   Biochem Biophys Res Commun 248 (3), 879-888 (1998)
   PUBMED   9704021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007621.34, AC007537.3 and
            KF455603.1.
            
            On Nov 16, 2022 this sequence version replaced XM_011520671.4.
            
            Summary: This gene encodes a member of the low density lipoprotein
            (LDL) receptor gene family. LDL receptors are transmembrane cell
            surface proteins involved in receptor-mediated endocytosis of
            lipoprotein and protein ligands. The protein encoded by this gene
            functions as a receptor or, with Frizzled, a co-receptor for Wnt
            and thereby transmits the canonical Wnt/beta-catenin signaling
            cascade. Through its interaction with the Wnt/beta-catenin
            signaling cascade this gene plays a role in the regulation of cell
            differentiation, proliferation, and migration and the development
            of many cancer types. This protein undergoes gamma-secretase
            dependent RIP- (regulated intramembrane proteolysis) processing but
            the precise locations of the cleavage sites have not been
            determined.[provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.6566.1,
                                           SRR11853563.6833.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC007621.34        47033-47396         c
            365-562             AC007537.3         172409-172606       c
            563-759             AC007537.3         156129-156325       c
            760-891             AC007537.3         153186-153317       c
            892-1288            AC007537.3         150249-150645       c
            1289-1460           AC007537.3         149016-149187       c
            1461-1677           AC007537.3         134285-134501       c
            1678-1967           AC007537.3         133479-133768       c
            1968-2194           AC007537.3         131399-131625       c
            2195-2379           AC007537.3         128986-129170       c
            2380-2706           AC007537.3         128035-128361       c
            2707-2848           AC007537.3         120103-120244       c
            2849-2909           KF455603.1         330-390             c
            2910-3121           AC007537.3         118148-118359       c
            3122-3312           AC007537.3         116572-116762       c
            3313-3522           AC007537.3         107531-107740       c
            3523-3648           AC007537.3         104381-104506       c
            3649-3885           AC007537.3         101027-101263       c
            3886-3996           AC007537.3         99989-100099        c
            3997-4227           AC007537.3         95897-96127         c
            4228-4364           AC007537.3         94502-94638         c
            4365-4462           AC007537.3         93771-93868         c
            4463-5105           AC007537.3         89984-90626         c
FEATURES             Location/Qualifiers
     source          1..5105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..5105
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
     exon            1..364
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            365..562
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..4757
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="isoform i is encoded by transcript variant 10;
                     low-density lipoprotein receptor-related protein 6; LRP-6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform i"
                     /protein_id="NP_001401181.1"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
                     /translation="MYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQK
                     LYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKY
                     TGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACP
                     TGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDP
                     VEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRI
                     EVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLV
                     NTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGD
                     YVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSH
                     LCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLT
                     GVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGK
                     NLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDR
                     AAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLP
                     HPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWN
                     ECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI
                     DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSV
                     PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVN
                     PEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDL
                     RRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKV
                     QARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQD
                     ELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCAS
                     GQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKS
                     DELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDY
                     VVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSS
                     SSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPT
                     TPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESC
                     PPSPYTERSYSHHLYPPPPSPCTDSS"
     exon            563..759
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            760..891
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1288
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1460
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1677
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1967
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2194
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2379
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2706
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2909
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3121
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3312
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3522
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3648
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3885
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..3996
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4227
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4364
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4462
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..5105
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5082..5087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="hexamer: AATAAA"
     polyA_site      5105
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctgc gccgctgcgc gaggcagagg ctgaatgagg agctgcgcgg gggaagcggg
       61 gcgccggggg aggaggcggc gggatggaag cagacgctgg cgtcgcgcga gcccggggcc
      121 gagcggcgcg gtagagaggg cggcggcggc gcgcgcggaa ccttgacgtg cccctttctt
      181 tcttctctcg ctgggaagct gggaagtatg agcgtgcagc cctgccgctg cggcggccgc
      241 cccggctcct cgcctccccc acttctggcc acccctcgcc ggtgagagaa gagaacgcga
      301 gaagggaaga tgggggccgt cctgaggagc ctcctggcct gcagcttctg tgtgctcctg
      361 agaggttcat gtactggaca gactggggag aagtgccaaa gatagaacgt gctggaatgg
      421 atggttcaag tcgcttcatt ataataaaca gtgaaattta ctggccaaat ggactgactt
      481 tggattatga agaacaaaag ctttattggg cagatgcaaa acttaatttc atccacaaat
      541 caaatctgga tggaacaaat cggcaggcag tggttaaagg ttcccttcca catccttttg
      601 ccttgacgtt atttgaggac atattgtact ggactgactg gagcacacac tccattttgg
      661 cttgcaacaa gtatactggt gagggtctgc gtgaaatcca ttctgacatc ttctctccca
      721 tggatataca tgccttcagc caacagaggc agccaaatgc cacaaatcca tgtggaattg
      781 acaatggggg ttgttcccat ttgtgtttga tgtctccagt caagcctttt tatcagtgtg
      841 cttgccccac tggggtcaaa ctcctggaga atggaaaaac ctgcaaagat ggtgccacag
      901 aattattgct tttagctcga aggacagact tgagacgcat ttctttggat acaccagatt
      961 ttacagacat tgttctgcag ttagaagaca tccgtcatgc cattgccata gattacgatc
     1021 ctgtggaagg ctacatctac tggactgatg atgaagtgag ggccatacgc cgttcattta
     1081 tagatggatc tggcagtcag tttgtggtca ctgctcaaat tgcccatcct gatggtattg
     1141 ctgtggactg ggttgcacga aatctttatt ggacagacac tggcactgat cgaatagaag
     1201 tgacaaggct caatgggacc atgaggaaga tcttgatttc agaggactta gaggaacccc
     1261 gggctattgt gttagatccc atggttgggt acatgtattg gactgactgg ggagaaattc
     1321 cgaaaattga gcgagcagct ctggatggtt ctgaccgtgt agtattggtt aacacttctc
     1381 ttggttggcc aaatggttta gccttggatt atgatgaagg caaaatatac tggggagatg
     1441 ccaaaacaga caagattgag gttatgaata ctgatggcac tgggagacga gtactagtgg
     1501 aagacaaaat tcctcacata tttggattta ctttgttggg tgactatgtt tactggactg
     1561 actggcagag gcgtagcatt gaaagagttc ataaacgaag tgcagagagg gaagtgatca
     1621 tagatcagct gcctgacctc atgggcctaa aggctacaaa tgttcatcga gtgattggtt
     1681 ccaacccctg tgctgaggaa aacgggggat gtagccatct ctgcctctat agacctcagg
     1741 gccttcgctg tgcttgccct attggctttg aactcatcag tgacatgaag acctgcattg
     1801 tcccagaggc tttccttttg ttttcacgga gagcagatat cagacgaatt tctctggaaa
     1861 caaacaataa taatgtggct attccactca ctggtgtcaa agaagcttct gctttggatt
     1921 ttgatgtgac agacaaccga atttattgga ctgatatatc actcaagacc atcagcagag
     1981 cctttatgaa tggcagtgca ctggaacatg tggtagaatt cggcttagat tatccagaag
     2041 gcatggcagt agactggctt gggaagaact tgtactgggc agacacagga acgaatcgaa
     2101 ttgaggtgtc aaagttggat gggcagcacc gacaagtttt ggtgtggaaa gacctagata
     2161 gtcccagagc tctcgcgttg gaccctgccg aaggatttat gtattggact gaatggggtg
     2221 gaaaacctaa gatagacaga gctgcaatgg atggaagtga acgtactacc ttagttccaa
     2281 atgtggggcg ggcaaacggc ctaactattg attatgctaa aaggaggctt tattggacag
     2341 acctggacac caacttaata gaatcttcaa atatgcttgg gctcaaccgt gaagttatag
     2401 cagatgactt gcctcatcct tttggcttaa ctcagtacca agattatatc tactggacgg
     2461 actggagccg acgcagcatt gagcgtgcca acaaaaccag tggccaaaac cgcaccatca
     2521 ttcagggcca tttggattat gtgatggaca tcctcgtctt tcactcatct cgacagtcag
     2581 ggtggaatga atgtgcttcc agcaatgggc actgctccca cctctgcttg gctgtgccag
     2641 ttgggggttt tgtttgtgga tgccctgccc actactctct taatgctgac aacaggactt
     2701 gtagtgctcc tacgactttc ctgctcttca gtcaaaagag tgccatcaac cgcatggtga
     2761 ttgatgaaca acagagcccc gacatcatcc ttcccatcca cagccttcgg aatgtccggg
     2821 ccattgacta tgacccactg gacaagcaac tctattggat tgactcacga caaaacatga
     2881 tccgaaaggc acaagaagat ggcagccagg gctttactgt ggttgtgagc tcagttccga
     2941 gtcagaacct ggaaatacaa ccctatgacc tcagcattga tatttacagc cgctacatct
     3001 actggacttg tgaggctacc aatgtcatta atgtgacaag attagatggg agatcagttg
     3061 gagtggtgct gaaaggcgag caggacagac ctcgagccgt tgtggtaaac ccagagaaag
     3121 ggtatatgta ttttaccaat cttcaggaaa ggtctcctaa aattgaacgg gctgctttgg
     3181 atgggacaga acgggaggtc ctctttttca gtggcttaag taaaccaatt gctttagccc
     3241 ttgatagcag gctgggcaag ctcttttggg ctgattcaga tctccggcga attgaaagca
     3301 gtgatctctc aggtgctaac cggatagtat tagaagactc caatatcttg cagcctgtgg
     3361 gacttactgt gtttgaaaac tggctctatt ggattgataa acagcagcaa atgattgaaa
     3421 aaattgacat gacaggtcga gagggtagaa ccaaagtcca agctcgaatt gcccagctta
     3481 gtgacattca tgcagtaaag gagctgaacc ttcaagaata cagacagcac ccttgtgctc
     3541 aggataatgg tggctgttca catatttgtc ttgtaaaggg ggatggtact acaaggtgtt
     3601 cttgccccat gcacctggtt ctacttcaag atgagctatc atgtggagaa cctccaacat
     3661 gttctcctca gcagtttact tgtttcacgg gggaaattga ctgtatccct gtggcttggc
     3721 ggtgcgatgg gtttactgaa tgtgaagacc acagtgatga actcaattgt cctgtatgct
     3781 cagagtccca gttccagtgt gccagtgggc agtgtattga tggtgccctc cgatgcaatg
     3841 gagatgcaaa ctgccaggac aaatcagatg agaagaactg tgaagtgctt tgtttaattg
     3901 atcagttccg ctgtgccaat ggtcagtgca ttggaaagca caagaagtgt gatcataatg
     3961 tggattgcag tgacaagtca gatgaactgg attgttatcc gactgaagaa ccagcaccac
     4021 aggccaccaa tacagttggt tctgttattg gcgtaattgt caccattttt gtgtctggaa
     4081 ctgtatactt tatctgccag aggatgttgt gtccacgtat gaagggagat ggggaaacta
     4141 tgactaatga ctatgtagtt catggaccag cttctgtgcc tcttggttat gtgccacacc
     4201 caagttcttt gtcaggatct cttccaggaa tgtctcgagg taaatcaatg atcagctccc
     4261 tcagtatcat ggggggaagc agtggacccc cctatgaccg agcccatgtt acaggagcat
     4321 catcaagtag ttcttcaagc accaaaggca cttacttccc tgcaattttg aaccctccac
     4381 catccccagc cacagagcga tcacattaca ctatggaatt tggatattct tcaaacagtc
     4441 cttccactca taggtcatac agctacaggc catatagcta ccggcacttt gcacccccca
     4501 ccacaccctg cagcacagat gtttgtgaca gtgactatgc tcctagtcgg agaatgacct
     4561 cagtggcaac agccaagggc tataccagtg acttgaacta tgattcagaa cctgtgcccc
     4621 cacctcccac accccgaagc caatacttgt cagcagagga gaactatgaa agctgcccac
     4681 cttctccata cacagagagg agctattctc atcacctcta cccaccgcca ccctctccct
     4741 gtacagactc ctcctgagga ggggccctcc tcctctgact gcctccaacg taaaaatgta
     4801 aatataaatt tggttgagat ctggaggggg ggagggagct attagagaag gatgaggcag
     4861 accatgtaca gttaaaatta taaaatgggg tagggaatac tggagatatt tgtacagaag
     4921 aaaaggatat ttatatattt tcttaaaaca gcagatttgc tgcttgtgcc ataaaagttt
     4981 gtataaaaaa aatttgtact aaaagtttta tttttgcaaa ctaaatacac aaagcatgcc
     5041 ttaaacccag tgaagcaact gagtacaaag gaaacaggaa taataaaggc atcactgacc
     5101 aggaa
//
