LOCUS       NM_001414250            5003 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 6 (LRP6), transcript
            variant 8, mRNA.
ACCESSION   NM_001414250
VERSION     NM_001414250.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5003)
  AUTHORS   Zhong,S., Guo,Q., Chen,X., Luo,X., Long,Y., Chong,T., Ye,M., He,H.,
            Lu,A., Ao,K., Yin,M., Xu,A., Li,X., Hao,Y. and Guo,X.
  TITLE     The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism
            and suppresses lymph node metastasis in cervical cancer
  JOURNAL   Int J Biol Sci 20 (3), 916-936 (2024)
   PUBMED   38250152
  REMARK    GeneRIF: The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid
            metabolism and suppresses lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5003)
  AUTHORS   Li,J., Liu,Z., Ren,Y., Shao,H. and Li,S.
  TITLE     LRP5-/6 gene polymorphisms and its association with risk of
            abnormal bone mass in postmenopausal women
  JOURNAL   J Orthop Surg Res 18 (1), 369 (2023)
   PUBMED   37202775
  REMARK    GeneRIF: LRP5-/6 gene polymorphisms and its association with risk
            of abnormal bone mass in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5003)
  AUTHORS   Hao,H., Liu,Q., Chen,J. and Zhou,H.
  TITLE     Overexpression of circRNAs LRP6 in gestational diabetes mellitus
            predicts foetal malformation and intrauterine death
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 70 (2), 124-129 (2023)
   PUBMED   36925229
  REMARK    GeneRIF: Overexpression of circRNAs LRP6 in gestational diabetes
            mellitus predicts foetal malformation and intrauterine death.
REFERENCE   4  (bases 1 to 5003)
  AUTHORS   Wang,J., Yang,H., Ma,X., Liu,J., Li,L., Chen,L. and Wei,F.
  TITLE     LRP6/filamentous-actin signaling facilitates osteogenic commitment
            in mechanically induced periodontal ligament stem cells
  JOURNAL   Cell Mol Biol Lett 28 (1), 7 (2023)
   PUBMED   36694134
  REMARK    GeneRIF: LRP6/filamentous-actin signaling facilitates osteogenic
            commitment in mechanically induced periodontal ligament stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5003)
  AUTHORS   Jones,M.E., Buchler,J., Dufor,T., Palomer,E., Teo,S.,
            Martin-Flores,N., Boroviak,K., Metzakopian,E., Gibb,A. and
            Salinas,P.C.
  TITLE     A genetic variant of the Wnt receptor LRP6 accelerates synapse
            degeneration during aging and in Alzheimer's disease
  JOURNAL   Sci Adv 9 (2), eabo7421 (2023)
   PUBMED   36638182
  REMARK    GeneRIF: A genetic variant of the Wnt receptor LRP6 accelerates
            synapse degeneration during aging and in Alzheimer's disease.
REFERENCE   6  (bases 1 to 5003)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   7  (bases 1 to 5003)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   8  (bases 1 to 5003)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   9  (bases 1 to 5003)
  AUTHORS   Baens,M., Wlodarska,I., Corveleyn,A., Hoornaert,I., Hagemeijer,A.
            and Marynen,P.
  TITLE     A physical, transcript, and deletion map of chromosome region
            12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6
            CpG island in two leukemia patients with hemizygous del(12p)
  JOURNAL   Genomics 56 (1), 40-50 (1999)
   PUBMED   10036184
REFERENCE   10 (bases 1 to 5003)
  AUTHORS   Brown,S.D., Twells,R.C., Hey,P.J., Cox,R.D., Levy,E.R.,
            Soderman,A.R., Metzker,M.L., Caskey,C.T., Todd,J.A. and Hess,J.F.
  TITLE     Isolation and characterization of LRP6, a novel member of the low
            density lipoprotein receptor gene family
  JOURNAL   Biochem Biophys Res Commun 248 (3), 879-888 (1998)
   PUBMED   9704021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007621.34, AC007537.3 and
            KF455603.1.
            
            Summary: This gene encodes a member of the low density lipoprotein
            (LDL) receptor gene family. LDL receptors are transmembrane cell
            surface proteins involved in receptor-mediated endocytosis of
            lipoprotein and protein ligands. The protein encoded by this gene
            functions as a receptor or, with Frizzled, a co-receptor for Wnt
            and thereby transmits the canonical Wnt/beta-catenin signaling
            cascade. Through its interaction with the Wnt/beta-catenin
            signaling cascade this gene plays a role in the regulation of cell
            differentiation, proliferation, and migration and the development
            of many cancer types. This protein undergoes gamma-secretase
            dependent RIP- (regulated intramembrane proteolysis) processing but
            the precise locations of the cleavage sites have not been
            determined.[provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1349859.1,
                                           SRR14038193.1589278.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC007621.34        47033-47396         c
            365-758             AC007621.34        24614-25007         c
            759-956             AC007537.3         172409-172606       c
            957-1153            AC007537.3         156129-156325       c
            1154-1285           AC007537.3         153186-153317       c
            1286-1682           AC007537.3         150249-150645       c
            1683-1854           AC007537.3         149016-149187       c
            1855-2071           AC007537.3         134285-134501       c
            2072-2361           AC007537.3         133479-133768       c
            2362-2588           AC007537.3         131399-131625       c
            2589-2773           AC007537.3         128986-129170       c
            2774-3100           AC007537.3         128035-128361       c
            3101-3242           AC007537.3         120103-120244       c
            3243-3303           KF455603.1         330-390             c
            3304-3515           AC007537.3         118148-118359       c
            3516-3706           AC007537.3         116572-116762       c
            3707-3916           AC007537.3         107531-107740       c
            3917-4042           AC007537.3         104381-104506       c
            4043-4279           AC007537.3         101027-101263       c
            4280-4390           AC007537.3         99989-100099        c
            4391-4621           AC007537.3         95897-96127         c
            4622-4758           AC007537.3         94502-94638         c
            4759-4856           AC007537.3         93771-93868         c
            4857-5003           AC007537.3         92388-92534         c
FEATURES             Location/Qualifiers
     source          1..5003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..5003
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
     exon            1..364
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..4869
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="isoform g precursor is encoded by transcript
                     variant 8; low-density lipoprotein receptor-related
                     protein 6; LRP-6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform g precursor"
                     /protein_id="NP_001401179.1"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
                     /translation="MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENAT
                     IVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLAC
                     DWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEV
                     PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQA
                     VVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQ
                     QRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLA
                     RRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS
                     GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
                     IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGD
                     AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAERE
                     VIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDM
                     KTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDIS
                     LKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ
                     VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTI
                     DYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIE
                     RANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVC
                     GCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDY
                     DPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYW
                     TCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAAL
                     DGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQ
                     PVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQ
                     HPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID
                     CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
                     NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVI
                     GVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSL
                     PGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATE
                     RSHYTMEFGYSSNSPSTHRSYSFFF"
     exon            365..758
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            759..956
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1153
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1285
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1682
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1854
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2071
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2361
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2588
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2773
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..3100
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3303
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3515
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3706
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3916
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4042
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4279
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4280..4390
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4621
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4758
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4856
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..5003
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4981..4986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="hexamer: AATAAA"
     polyA_site      5003
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctgc gccgctgcgc gaggcagagg ctgaatgagg agctgcgcgg gggaagcggg
       61 gcgccggggg aggaggcggc gggatggaag cagacgctgg cgtcgcgcga gcccggggcc
      121 gagcggcgcg gtagagaggg cggcggcggc gcgcgcggaa ccttgacgtg cccctttctt
      181 tcttctctcg ctgggaagct gggaagtatg agcgtgcagc cctgccgctg cggcggccgc
      241 cccggctcct cgcctccccc acttctggcc acccctcgcc ggtgagagaa gagaacgcga
      301 gaagggaaga tgggggccgt cctgaggagc ctcctggcct gcagcttctg tgtgctcctg
      361 agagcggccc ctttgttgct ttatgcaaac agacgggact tgcgattggt tgatgctaca
      421 aatggcaaag agaatgctac gattgtagtt ggaggcttgg aggatgcagc tgcggtggac
      481 tttgtgttta gtcatggctt gatatactgg agtgatgtca gcgaagaagc cattaaacga
      541 acagaattta acaaaactga gagtgtgcag aatgttgttg tttctggatt attgtccccc
      601 gatgggctgg catgtgattg gcttggagaa aaattgtact ggacagattc tgaaactaat
      661 cggattgaag tttctaattt agatggatct ttacgaaaag ttttattttg gcaagagttg
      721 gatcaaccca gagctattgc cttagatcct tcaagtgggt tcatgtactg gacagactgg
      781 ggagaagtgc caaagataga acgtgctgga atggatggtt caagtcgctt cattataata
      841 aacagtgaaa tttactggcc aaatggactg actttggatt atgaagaaca aaagctttat
      901 tgggcagatg caaaacttaa tttcatccac aaatcaaatc tggatggaac aaatcggcag
      961 gcagtggtta aaggttccct tccacatcct tttgccttga cgttatttga ggacatattg
     1021 tactggactg actggagcac acactccatt ttggcttgca acaagtatac tggtgagggt
     1081 ctgcgtgaaa tccattctga catcttctct cccatggata tacatgcctt cagccaacag
     1141 aggcagccaa atgccacaaa tccatgtgga attgacaatg ggggttgttc ccatttgtgt
     1201 ttgatgtctc cagtcaagcc tttttatcag tgtgcttgcc ccactggggt caaactcctg
     1261 gagaatggaa aaacctgcaa agatggtgcc acagaattat tgcttttagc tcgaaggaca
     1321 gacttgagac gcatttcttt ggatacacca gattttacag acattgttct gcagttagaa
     1381 gacatccgtc atgccattgc catagattac gatcctgtgg aaggctacat ctactggact
     1441 gatgatgaag tgagggccat acgccgttca tttatagatg gatctggcag tcagtttgtg
     1501 gtcactgctc aaattgccca tcctgatggt attgctgtgg actgggttgc acgaaatctt
     1561 tattggacag acactggcac tgatcgaata gaagtgacaa ggctcaatgg gaccatgagg
     1621 aagatcttga tttcagagga cttagaggaa ccccgggcta ttgtgttaga tcccatggtt
     1681 gggtacatgt attggactga ctggggagaa attccgaaaa ttgagcgagc agctctggat
     1741 ggttctgacc gtgtagtatt ggttaacact tctcttggtt ggccaaatgg tttagccttg
     1801 gattatgatg aaggcaaaat atactgggga gatgccaaaa cagacaagat tgaggttatg
     1861 aatactgatg gcactgggag acgagtacta gtggaagaca aaattcctca catatttgga
     1921 tttactttgt tgggtgacta tgtttactgg actgactggc agaggcgtag cattgaaaga
     1981 gttcataaac gaagtgcaga gagggaagtg atcatagatc agctgcctga cctcatgggc
     2041 ctaaaggcta caaatgttca tcgagtgatt ggttccaacc cctgtgctga ggaaaacggg
     2101 ggatgtagcc atctctgcct ctatagacct cagggccttc gctgtgcttg ccctattggc
     2161 tttgaactca tcagtgacat gaagacctgc attgtcccag aggctttcct tttgttttca
     2221 cggagagcag atatcagacg aatttctctg gaaacaaaca ataataatgt ggctattcca
     2281 ctcactggtg tcaaagaagc ttctgctttg gattttgatg tgacagacaa ccgaatttat
     2341 tggactgata tatcactcaa gaccatcagc agagccttta tgaatggcag tgcactggaa
     2401 catgtggtag aattcggctt agattatcca gaaggcatgg cagtagactg gcttgggaag
     2461 aacttgtact gggcagacac aggaacgaat cgaattgagg tgtcaaagtt ggatgggcag
     2521 caccgacaag ttttggtgtg gaaagaccta gatagtccca gagctctcgc gttggaccct
     2581 gccgaaggat ttatgtattg gactgaatgg ggtggaaaac ctaagataga cagagctgca
     2641 atggatggaa gtgaacgtac taccttagtt ccaaatgtgg ggcgggcaaa cggcctaact
     2701 attgattatg ctaaaaggag gctttattgg acagacctgg acaccaactt aatagaatct
     2761 tcaaatatgc ttgggctcaa ccgtgaagtt atagcagatg acttgcctca tccttttggc
     2821 ttaactcagt accaagatta tatctactgg acggactgga gccgacgcag cattgagcgt
     2881 gccaacaaaa ccagtggcca aaaccgcacc atcattcagg gccatttgga ttatgtgatg
     2941 gacatcctcg tctttcactc atctcgacag tcagggtgga atgaatgtgc ttccagcaat
     3001 gggcactgct cccacctctg cttggctgtg ccagttgggg gttttgtttg tggatgccct
     3061 gcccactact ctcttaatgc tgacaacagg acttgtagtg ctcctacgac tttcctgctc
     3121 ttcagtcaaa agagtgccat caaccgcatg gtgattgatg aacaacagag ccccgacatc
     3181 atccttccca tccacagcct tcggaatgtc cgggccattg actatgaccc actggacaag
     3241 caactctatt ggattgactc acgacaaaac atgatccgaa aggcacaaga agatggcagc
     3301 cagggcttta ctgtggttgt gagctcagtt ccgagtcaga acctggaaat acaaccctat
     3361 gacctcagca ttgatattta cagccgctac atctactgga cttgtgaggc taccaatgtc
     3421 attaatgtga caagattaga tgggagatca gttggagtgg tgctgaaagg cgagcaggac
     3481 agacctcgag ccgttgtggt aaacccagag aaagggtata tgtattttac caatcttcag
     3541 gaaaggtctc ctaaaattga acgggctgct ttggatggga cagaacggga ggtcctcttt
     3601 ttcagtggct taagtaaacc aattgcttta gcccttgata gcaggctggg caagctcttt
     3661 tgggctgatt cagatctccg gcgaattgaa agcagtgatc tctcaggtgc taaccggata
     3721 gtattagaag actccaatat cttgcagcct gtgggactta ctgtgtttga aaactggctc
     3781 tattggattg ataaacagca gcaaatgatt gaaaaaattg acatgacagg tcgagagggt
     3841 agaaccaaag tccaagctcg aattgcccag cttagtgaca ttcatgcagt aaaggagctg
     3901 aaccttcaag aatacagaca gcacccttgt gctcaggata atggtggctg ttcacatatt
     3961 tgtcttgtaa agggggatgg tactacaagg tgttcttgcc ccatgcacct ggttctactt
     4021 caagatgagc tatcatgtgg agaacctcca acatgttctc ctcagcagtt tacttgtttc
     4081 acgggggaaa ttgactgtat ccctgtggct tggcggtgcg atgggtttac tgaatgtgaa
     4141 gaccacagtg atgaactcaa ttgtcctgta tgctcagagt cccagttcca gtgtgccagt
     4201 gggcagtgta ttgatggtgc cctccgatgc aatggagatg caaactgcca ggacaaatca
     4261 gatgagaaga actgtgaagt gctttgttta attgatcagt tccgctgtgc caatggtcag
     4321 tgcattggaa agcacaagaa gtgtgatcat aatgtggatt gcagtgacaa gtcagatgaa
     4381 ctggattgtt atccgactga agaaccagca ccacaggcca ccaatacagt tggttctgtt
     4441 attggcgtaa ttgtcaccat ttttgtgtct ggaactgtat actttatctg ccagaggatg
     4501 ttgtgtccac gtatgaaggg agatggggaa actatgacta atgactatgt agttcatgga
     4561 ccagcttctg tgcctcttgg ttatgtgcca cacccaagtt ctttgtcagg atctcttcca
     4621 ggaatgtctc gaggtaaatc aatgatcagc tccctcagta tcatgggggg aagcagtgga
     4681 cccccctatg accgagccca tgttacagga gcatcatcaa gtagttcttc aagcaccaaa
     4741 ggcacttact tccctgcaat tttgaaccct ccaccatccc cagccacaga gcgatcacat
     4801 tacactatgg aatttggata ttcttcaaac agtccttcca ctcataggtc atacagtttc
     4861 ttcttctagg aagccaaaac agaaaaagca gaagcctgaa aattgagaaa ggagaaagat
     4921 acaaaatttt attttttaaa agtaatgtcc ttaattcaaa ttgactaagg cactcatcag
     4981 aataaacacg attgcataaa aaa
//
