LOCUS       NM_001414247            5301 bp    mRNA    linear   PRI 09-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 6 (LRP6), transcript
            variant 5, mRNA.
ACCESSION   NM_001414247
VERSION     NM_001414247.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5301)
  AUTHORS   Zhong,S., Guo,Q., Chen,X., Luo,X., Long,Y., Chong,T., Ye,M., He,H.,
            Lu,A., Ao,K., Yin,M., Xu,A., Li,X., Hao,Y. and Guo,X.
  TITLE     The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolism
            and suppresses lymph node metastasis in cervical cancer
  JOURNAL   Int J Biol Sci 20 (3), 916-936 (2024)
   PUBMED   38250152
  REMARK    GeneRIF: The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid
            metabolism and suppresses lymph node metastasis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5301)
  AUTHORS   Li,J., Liu,Z., Ren,Y., Shao,H. and Li,S.
  TITLE     LRP5-/6 gene polymorphisms and its association with risk of
            abnormal bone mass in postmenopausal women
  JOURNAL   J Orthop Surg Res 18 (1), 369 (2023)
   PUBMED   37202775
  REMARK    GeneRIF: LRP5-/6 gene polymorphisms and its association with risk
            of abnormal bone mass in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5301)
  AUTHORS   Hao,H., Liu,Q., Chen,J. and Zhou,H.
  TITLE     Overexpression of circRNAs LRP6 in gestational diabetes mellitus
            predicts foetal malformation and intrauterine death
  JOURNAL   Endocrinol Diabetes Nutr (Engl Ed) 70 (2), 124-129 (2023)
   PUBMED   36925229
  REMARK    GeneRIF: Overexpression of circRNAs LRP6 in gestational diabetes
            mellitus predicts foetal malformation and intrauterine death.
REFERENCE   4  (bases 1 to 5301)
  AUTHORS   Wang,J., Yang,H., Ma,X., Liu,J., Li,L., Chen,L. and Wei,F.
  TITLE     LRP6/filamentous-actin signaling facilitates osteogenic commitment
            in mechanically induced periodontal ligament stem cells
  JOURNAL   Cell Mol Biol Lett 28 (1), 7 (2023)
   PUBMED   36694134
  REMARK    GeneRIF: LRP6/filamentous-actin signaling facilitates osteogenic
            commitment in mechanically induced periodontal ligament stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5301)
  AUTHORS   Jones,M.E., Buchler,J., Dufor,T., Palomer,E., Teo,S.,
            Martin-Flores,N., Boroviak,K., Metzakopian,E., Gibb,A. and
            Salinas,P.C.
  TITLE     A genetic variant of the Wnt receptor LRP6 accelerates synapse
            degeneration during aging and in Alzheimer's disease
  JOURNAL   Sci Adv 9 (2), eabo7421 (2023)
   PUBMED   36638182
  REMARK    GeneRIF: A genetic variant of the Wnt receptor LRP6 accelerates
            synapse degeneration during aging and in Alzheimer's disease.
REFERENCE   6  (bases 1 to 5301)
  AUTHORS   Bafico,A., Liu,G., Yaniv,A., Gazit,A. and Aaronson,S.A.
  TITLE     Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1
            interaction with LRP6/Arrow
  JOURNAL   Nat Cell Biol 3 (7), 683-686 (2001)
   PUBMED   11433302
REFERENCE   7  (bases 1 to 5301)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   8  (bases 1 to 5301)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   9  (bases 1 to 5301)
  AUTHORS   Baens,M., Wlodarska,I., Corveleyn,A., Hoornaert,I., Hagemeijer,A.
            and Marynen,P.
  TITLE     A physical, transcript, and deletion map of chromosome region
            12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6
            CpG island in two leukemia patients with hemizygous del(12p)
  JOURNAL   Genomics 56 (1), 40-50 (1999)
   PUBMED   10036184
REFERENCE   10 (bases 1 to 5301)
  AUTHORS   Brown,S.D., Twells,R.C., Hey,P.J., Cox,R.D., Levy,E.R.,
            Soderman,A.R., Metzker,M.L., Caskey,C.T., Todd,J.A. and Hess,J.F.
  TITLE     Isolation and characterization of LRP6, a novel member of the low
            density lipoprotein receptor gene family
  JOURNAL   Biochem Biophys Res Commun 248 (3), 879-888 (1998)
   PUBMED   9704021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007621.34, AC007537.3 and
            KF455603.1.
            
            Summary: This gene encodes a member of the low density lipoprotein
            (LDL) receptor gene family. LDL receptors are transmembrane cell
            surface proteins involved in receptor-mediated endocytosis of
            lipoprotein and protein ligands. The protein encoded by this gene
            functions as a receptor or, with Frizzled, a co-receptor for Wnt
            and thereby transmits the canonical Wnt/beta-catenin signaling
            cascade. Through its interaction with the Wnt/beta-catenin
            signaling cascade this gene plays a role in the regulation of cell
            differentiation, proliferation, and migration and the development
            of many cancer types. This protein undergoes gamma-secretase
            dependent RIP- (regulated intramembrane proteolysis) processing but
            the precise locations of the cleavage sites have not been
            determined.[provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.6834.1,
                                           SRR18074969.1721158.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               AC007621.34        47033-47396         c
            365-758             AC007621.34        24614-25007         c
            759-955             AC007537.3         156129-156325       c
            956-1087            AC007537.3         153186-153317       c
            1088-1484           AC007537.3         150249-150645       c
            1485-1656           AC007537.3         149016-149187       c
            1657-1873           AC007537.3         134285-134501       c
            1874-2163           AC007537.3         133479-133768       c
            2164-2390           AC007537.3         131399-131625       c
            2391-2575           AC007537.3         128986-129170       c
            2576-2902           AC007537.3         128035-128361       c
            2903-3044           AC007537.3         120103-120244       c
            3045-3105           KF455603.1         330-390             c
            3106-3317           AC007537.3         118148-118359       c
            3318-3508           AC007537.3         116572-116762       c
            3509-3718           AC007537.3         107531-107740       c
            3719-3844           AC007537.3         104381-104506       c
            3845-4081           AC007537.3         101027-101263       c
            4082-4192           AC007537.3         99989-100099        c
            4193-4423           AC007537.3         95897-96127         c
            4424-4560           AC007537.3         94502-94638         c
            4561-4658           AC007537.3         93771-93868         c
            4659-5301           AC007537.3         89984-90626         c
FEATURES             Location/Qualifiers
     source          1..5301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..5301
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="LDL receptor related protein 6"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
     exon            1..364
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..4953
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="isoform d is encoded by transcript variant 5;
                     low-density lipoprotein receptor-related protein 6; LRP-6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 isoform d"
                     /protein_id="NP_001401176.1"
                     /db_xref="GeneID:4040"
                     /db_xref="HGNC:HGNC:6698"
                     /db_xref="MIM:603507"
                     /translation="MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENAT
                     IVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLAC
                     DWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGQAVVKGSLPH
                     PFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATN
                     PCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRI
                     SLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTA
                     QIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVG
                     YMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEV
                     MNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPD
                     LMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEA
                     FLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAF
                     MNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLD
                     SPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLY
                     WTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQ
                     NRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSL
                     NADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLY
                     WIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVI
                     NVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVL
                     FFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFE
                     NWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNG
                     GCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRC
                     DGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLI
                     DQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFV
                     SGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKS
                     MISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEF
                     GYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDL
                     NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS"
     exon            365..758
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            759..955
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1087
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1484
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1656
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1873
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2163
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2390
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2575
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2902
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3105
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3317
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3508
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3718
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3719..3844
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4081
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4192
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4193..4423
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4424..4560
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4658
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     exon            4659..5301
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5278..5283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="hexamer: AATAAA"
     polyA_site      5301
                     /gene="LRP6"
                     /gene_synonym="ADCAD2; STHAG7"
                     /note="major polyA site"
ORIGIN      
        1 gtatccctgc gccgctgcgc gaggcagagg ctgaatgagg agctgcgcgg gggaagcggg
       61 gcgccggggg aggaggcggc gggatggaag cagacgctgg cgtcgcgcga gcccggggcc
      121 gagcggcgcg gtagagaggg cggcggcggc gcgcgcggaa ccttgacgtg cccctttctt
      181 tcttctctcg ctgggaagct gggaagtatg agcgtgcagc cctgccgctg cggcggccgc
      241 cccggctcct cgcctccccc acttctggcc acccctcgcc ggtgagagaa gagaacgcga
      301 gaagggaaga tgggggccgt cctgaggagc ctcctggcct gcagcttctg tgtgctcctg
      361 agagcggccc ctttgttgct ttatgcaaac agacgggact tgcgattggt tgatgctaca
      421 aatggcaaag agaatgctac gattgtagtt ggaggcttgg aggatgcagc tgcggtggac
      481 tttgtgttta gtcatggctt gatatactgg agtgatgtca gcgaagaagc cattaaacga
      541 acagaattta acaaaactga gagtgtgcag aatgttgttg tttctggatt attgtccccc
      601 gatgggctgg catgtgattg gcttggagaa aaattgtact ggacagattc tgaaactaat
      661 cggattgaag tttctaattt agatggatct ttacgaaaag ttttattttg gcaagagttg
      721 gatcaaccca gagctattgc cttagatcct tcaagtgggc aggcagtggt taaaggttcc
      781 cttccacatc cttttgcctt gacgttattt gaggacatat tgtactggac tgactggagc
      841 acacactcca ttttggcttg caacaagtat actggtgagg gtctgcgtga aatccattct
      901 gacatcttct ctcccatgga tatacatgcc ttcagccaac agaggcagcc aaatgccaca
      961 aatccatgtg gaattgacaa tgggggttgt tcccatttgt gtttgatgtc tccagtcaag
     1021 cctttttatc agtgtgcttg ccccactggg gtcaaactcc tggagaatgg aaaaacctgc
     1081 aaagatggtg ccacagaatt attgctttta gctcgaagga cagacttgag acgcatttct
     1141 ttggatacac cagattttac agacattgtt ctgcagttag aagacatccg tcatgccatt
     1201 gccatagatt acgatcctgt ggaaggctac atctactgga ctgatgatga agtgagggcc
     1261 atacgccgtt catttataga tggatctggc agtcagtttg tggtcactgc tcaaattgcc
     1321 catcctgatg gtattgctgt ggactgggtt gcacgaaatc tttattggac agacactggc
     1381 actgatcgaa tagaagtgac aaggctcaat gggaccatga ggaagatctt gatttcagag
     1441 gacttagagg aaccccgggc tattgtgtta gatcccatgg ttgggtacat gtattggact
     1501 gactggggag aaattccgaa aattgagcga gcagctctgg atggttctga ccgtgtagta
     1561 ttggttaaca cttctcttgg ttggccaaat ggtttagcct tggattatga tgaaggcaaa
     1621 atatactggg gagatgccaa aacagacaag attgaggtta tgaatactga tggcactggg
     1681 agacgagtac tagtggaaga caaaattcct cacatatttg gatttacttt gttgggtgac
     1741 tatgtttact ggactgactg gcagaggcgt agcattgaaa gagttcataa acgaagtgca
     1801 gagagggaag tgatcataga tcagctgcct gacctcatgg gcctaaaggc tacaaatgtt
     1861 catcgagtga ttggttccaa cccctgtgct gaggaaaacg ggggatgtag ccatctctgc
     1921 ctctatagac ctcagggcct tcgctgtgct tgccctattg gctttgaact catcagtgac
     1981 atgaagacct gcattgtccc agaggctttc cttttgtttt cacggagagc agatatcaga
     2041 cgaatttctc tggaaacaaa caataataat gtggctattc cactcactgg tgtcaaagaa
     2101 gcttctgctt tggattttga tgtgacagac aaccgaattt attggactga tatatcactc
     2161 aagaccatca gcagagcctt tatgaatggc agtgcactgg aacatgtggt agaattcggc
     2221 ttagattatc cagaaggcat ggcagtagac tggcttggga agaacttgta ctgggcagac
     2281 acaggaacga atcgaattga ggtgtcaaag ttggatgggc agcaccgaca agttttggtg
     2341 tggaaagacc tagatagtcc cagagctctc gcgttggacc ctgccgaagg atttatgtat
     2401 tggactgaat ggggtggaaa acctaagata gacagagctg caatggatgg aagtgaacgt
     2461 actaccttag ttccaaatgt ggggcgggca aacggcctaa ctattgatta tgctaaaagg
     2521 aggctttatt ggacagacct ggacaccaac ttaatagaat cttcaaatat gcttgggctc
     2581 aaccgtgaag ttatagcaga tgacttgcct catccttttg gcttaactca gtaccaagat
     2641 tatatctact ggacggactg gagccgacgc agcattgagc gtgccaacaa aaccagtggc
     2701 caaaaccgca ccatcattca gggccatttg gattatgtga tggacatcct cgtctttcac
     2761 tcatctcgac agtcagggtg gaatgaatgt gcttccagca atgggcactg ctcccacctc
     2821 tgcttggctg tgccagttgg gggttttgtt tgtggatgcc ctgcccacta ctctcttaat
     2881 gctgacaaca ggacttgtag tgctcctacg actttcctgc tcttcagtca aaagagtgcc
     2941 atcaaccgca tggtgattga tgaacaacag agccccgaca tcatccttcc catccacagc
     3001 cttcggaatg tccgggccat tgactatgac ccactggaca agcaactcta ttggattgac
     3061 tcacgacaaa acatgatccg aaaggcacaa gaagatggca gccagggctt tactgtggtt
     3121 gtgagctcag ttccgagtca gaacctggaa atacaaccct atgacctcag cattgatatt
     3181 tacagccgct acatctactg gacttgtgag gctaccaatg tcattaatgt gacaagatta
     3241 gatgggagat cagttggagt ggtgctgaaa ggcgagcagg acagacctcg agccgttgtg
     3301 gtaaacccag agaaagggta tatgtatttt accaatcttc aggaaaggtc tcctaaaatt
     3361 gaacgggctg ctttggatgg gacagaacgg gaggtcctct ttttcagtgg cttaagtaaa
     3421 ccaattgctt tagcccttga tagcaggctg ggcaagctct tttgggctga ttcagatctc
     3481 cggcgaattg aaagcagtga tctctcaggt gctaaccgga tagtattaga agactccaat
     3541 atcttgcagc ctgtgggact tactgtgttt gaaaactggc tctattggat tgataaacag
     3601 cagcaaatga ttgaaaaaat tgacatgaca ggtcgagagg gtagaaccaa agtccaagct
     3661 cgaattgccc agcttagtga cattcatgca gtaaaggagc tgaaccttca agaatacaga
     3721 cagcaccctt gtgctcagga taatggtggc tgttcacata tttgtcttgt aaagggggat
     3781 ggtactacaa ggtgttcttg ccccatgcac ctggttctac ttcaagatga gctatcatgt
     3841 ggagaacctc caacatgttc tcctcagcag tttacttgtt tcacggggga aattgactgt
     3901 atccctgtgg cttggcggtg cgatgggttt actgaatgtg aagaccacag tgatgaactc
     3961 aattgtcctg tatgctcaga gtcccagttc cagtgtgcca gtgggcagtg tattgatggt
     4021 gccctccgat gcaatggaga tgcaaactgc caggacaaat cagatgagaa gaactgtgaa
     4081 gtgctttgtt taattgatca gttccgctgt gccaatggtc agtgcattgg aaagcacaag
     4141 aagtgtgatc ataatgtgga ttgcagtgac aagtcagatg aactggattg ttatccgact
     4201 gaagaaccag caccacaggc caccaataca gttggttctg ttattggcgt aattgtcacc
     4261 atttttgtgt ctggaactgt atactttatc tgccagagga tgttgtgtcc acgtatgaag
     4321 ggagatgggg aaactatgac taatgactat gtagttcatg gaccagcttc tgtgcctctt
     4381 ggttatgtgc cacacccaag ttctttgtca ggatctcttc caggaatgtc tcgaggtaaa
     4441 tcaatgatca gctccctcag tatcatgggg ggaagcagtg gaccccccta tgaccgagcc
     4501 catgttacag gagcatcatc aagtagttct tcaagcacca aaggcactta cttccctgca
     4561 attttgaacc ctccaccatc cccagccaca gagcgatcac attacactat ggaatttgga
     4621 tattcttcaa acagtccttc cactcatagg tcatacagct acaggccata tagctaccgg
     4681 cactttgcac cccccaccac accctgcagc acagatgttt gtgacagtga ctatgctcct
     4741 agtcggagaa tgacctcagt ggcaacagcc aagggctata ccagtgactt gaactatgat
     4801 tcagaacctg tgcccccacc tcccacaccc cgaagccaat acttgtcagc agaggagaac
     4861 tatgaaagct gcccaccttc tccatacaca gagaggagct attctcatca cctctaccca
     4921 ccgccaccct ctccctgtac agactcctcc tgaggagggg ccctcctcct ctgactgcct
     4981 ccaacgtaaa aatgtaaata taaatttggt tgagatctgg agggggggag ggagctatta
     5041 gagaaggatg aggcagacca tgtacagtta aaattataaa atggggtagg gaatactgga
     5101 gatatttgta cagaagaaaa ggatatttat atattttctt aaaacagcag atttgctgct
     5161 tgtgccataa aagtttgtat aaaaaaaatt tgtactaaaa gttttatttt tgcaaactaa
     5221 atacacaaag catgccttaa acccagtgaa gcaactgagt acaaaggaaa caggaataat
     5281 aaaggcatca ctgaccagga a
//
