LOCUS       XM_011545030            5549 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens LDL receptor related protein 5 (LRP5),
            transcript variant X3, mRNA.
ACCESSION   XM_011545030
VERSION     XM_011545030.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000011.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011545030.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..5549
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /note="LDL receptor related protein 5; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 52 ESTs, 248 long SRA reads, 12 Proteins, and
                     99% coverage of the annotated genomic feature by RNAseq
                     alignments, including 8 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4041"
                     /db_xref="HGNC:HGNC:6697"
                     /db_xref="MIM:603506"
     CDS             470..5344
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     5 isoform X3"
                     /protein_id="XP_011543332.1"
                     /db_xref="GeneID:4041"
                     /db_xref="HGNC:HGNC:6697"
                     /db_xref="MIM:603506"
                     /translation="MSTLGTHWDGAVSCRKGGVRAGQCLSSRNGKEEAAQYFPASPLL
                     LFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLN
                     QTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLD
                     QPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKL
                     YWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRT
                     GGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPT
                     GVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPL
                     EGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIE
                     VTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVN
                     ASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDF
                     IYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHL
                     CFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTG
                     VKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKN
                     LYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRA
                     FMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPH
                     PFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLND
                     CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDD
                     QHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQN
                     PDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG
                     YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIE
                     SCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRV
                     AHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTC
                     GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCV
                     DLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELM
                     CEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYV
                     SGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSS
                     SSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPC
                     STDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYF
                     HLFPPPPSPCTDSS"
ORIGIN      
        1 ccatgggatt gtttgagaat taccaacatg tagggaaaac ctgcgatcct ggcctgcaga
       61 gggaggggag gacccctttt gccaggctcc cccaaacatt gagctctcag cttcaccagc
      121 tgcaccccat ggggtcttct ttgccagctt tggcgagggt ctgttcctca ctgcgccaat
      181 gccccggcat gtgatctttg ggctcagtgc caggcccagc tatcctgctg gcacagtagg
      241 aagccagaaa agcccctacc cactcctgct agagcctagg ggctgctgtt ccctctagga
      301 ctccaccagg gagcaggagg ggccttcacg gggctggtgc agacctaaga cctcccacgc
      361 ttgccctcag ccagagccct gagacccaca ccctcctctg ccacctccag aaaaagcctc
      421 cggtcctggg cacctttgat gacttccttt cccatccgtg ctgctggaga tgtctacact
      481 aggaactcac tgggatggag ctgtgtcctg caggaagggc ggggtgagag ccggccagtg
      541 tctgagctcc aggaatggca aagaggaagc tgcacaatat ttcccagcct cgccgctcct
      601 gctatttgcc aaccgccggg acgtacggct ggtggacgcc ggcggagtca agctggagtc
      661 caccatcgtg gtcagcggcc tggaggatgc ggccgcagtg gacttccagt tttccaaggg
      721 agccgtgtac tggacagacg tgagcgagga ggccatcaag cagacctacc tgaaccagac
      781 gggggccgcc gtgcagaacg tggtcatctc cggcctggtc tctcccgacg gcctcgcctg
      841 cgactgggtg ggcaagaagc tgtactggac ggactcagag accaaccgca tcgaggtggc
      901 caacctcaat ggcacatccc ggaaggtgct cttctggcag gaccttgacc agccgagggc
      961 catcgccttg gaccccgctc acgggtacat gtactggaca gactggggtg agacgccccg
     1021 gattgagcgg gcagggatgg atggcagcac ccggaagatc attgtggact cggacattta
     1081 ctggcccaat ggactgacca tcgacctgga ggagcagaag ctctactggg ctgacgccaa
     1141 gctcagcttc atccaccgtg ccaacctgga cggctcgttc cggcagaagg tggtggaggg
     1201 cagcctgacg caccccttcg ccctgacgct ctccggggac actctgtact ggacagactg
     1261 gcagacccgc tccatccatg cctgcaacaa gcgcactggg gggaagagga aggagatcct
     1321 gagtgccctc tactcaccca tggacatcca ggtgctgagc caggagcggc agcctttctt
     1381 ccacactcgc tgtgaggagg acaatggcgg ctgctcccac ctgtgcctgc tgtccccaag
     1441 cgagcctttc tacacatgcg cctgccccac gggtgtgcag ctgcaggaca acggcaggac
     1501 gtgtaaggca ggagccgagg aggtgctgct gctggcccgg cggacggacc tacggaggat
     1561 ctcgctggac acgccggact tcaccgacat cgtgctgcag gtggacgaca tccggcacgc
     1621 cattgccatc gactacgacc cgctagaggg ctatgtctac tggacagatg acgaggtgcg
     1681 ggccatccgc agggcgtacc tggacgggtc tggggcgcag acgctggtca acaccgagat
     1741 caacgacccc gatggcatcg cggtcgactg ggtggcccga aacctctact ggaccgacac
     1801 gggcacggac cgcatcgagg tgacgcgcct caacggcacc tcccgcaaga tcctggtgtc
     1861 ggaggacctg gacgagcccc gagccatcgc actgcacccc gtgatgggcc tcatgtactg
     1921 gacagactgg ggagagaacc ctaaaatcga gtgtgccaac ttggatgggc aggagcggcg
     1981 tgtgctggtc aatgcctccc tcgggtggcc caacggcctg gccctggacc tgcaggaggg
     2041 gaagctctac tggggagacg ccaagacaga caagatcgag gtgatcaatg ttgatgggac
     2101 gaagaggcgg accctcctgg aggacaagct cccgcacatt tttgggttca cgctgctggg
     2161 ggacttcatc tactggactg actggcagcg ccgcagcatc gagcgggtgc acaaggtcaa
     2221 ggccagccgg gacgtcatca ttgaccagct gcccgacctg atggggctca aagctgtgaa
     2281 tgtggccaag gtcgtcggaa ccaacccgtg tgcggacagg aacggggggt gcagccacct
     2341 gtgcttcttc acaccccacg caacccggtg tggctgcccc atcggcctgg agctgctgag
     2401 tgacatgaag acctgcatcg tgcctgaggc cttcttggtc ttcaccagca gagccgccat
     2461 ccacaggatc tccctcgaga ccaataacaa cgacgtggcc atcccgctca cgggcgtcaa
     2521 ggaggcctca gccctggact ttgatgtgtc caacaaccac atctactgga cagacgtcag
     2581 cctgaagacc atcagccgcg ccttcatgaa cgggagctcg gtggagcacg tggtggagtt
     2641 tggccttgac taccccgagg gcatggccgt tgactggatg ggcaagaacc tctactgggc
     2701 cgacactggg accaacagaa tcgaagtggc gcggctggac gggcagttcc ggcaagtcct
     2761 cgtgtggagg gacttggaca acccgaggtc gctggccctg gatcccacca agggctacat
     2821 ctactggacc gagtggggcg gcaagccgag gatcgtgcgg gccttcatgg acgggaccaa
     2881 ctgcatgacg ctggtggaca aggtgggccg ggccaacgac ctcaccattg actacgctga
     2941 ccagcgcctc tactggaccg acctggacac caacatgatc gagtcgtcca acatgctggg
     3001 tcaggagcgg gtcgtgattg ccgacgatct cccgcacccg ttcggtctga cgcagtacag
     3061 cgattatatc tactggacag actggaatct gcacagcatt gagcgggccg acaagactag
     3121 cggccggaac cgcaccctca tccagggcca cctggacttc gtgatggaca tcctggtgtt
     3181 ccactcctcc cgccaggatg gcctcaatga ctgtatgcac aacaacgggc agtgtgggca
     3241 gctgtgcctt gccatccccg gcggccaccg ctgcggctgc gcctcacact acaccctgga
     3301 ccccagcagc cgcaactgca gcccgcccac caccttcttg ctgttcagcc agaaatctgc
     3361 catcagtcgg atgatcccgg acgaccagca cagcccggat ctcatcctgc ccctgcatgg
     3421 actgaggaac gtcaaagcca tcgactatga cccactggac aagttcatct actgggtgga
     3481 tgggcgccag aacatcaagc gagccaagga cgacgggacc cagccctttg ttttgacctc
     3541 tctgagccaa ggccaaaacc cagacaggca gccccacgac ctcagcatcg acatctacag
     3601 ccggacactg ttctggacgt gcgaggccac caataccatc aacgtccaca ggctgagcgg
     3661 ggaagccatg ggggtggtgc tgcgtgggga ccgcgacaag cccagggcca tcgtcgtcaa
     3721 cgcggagcga gggtacctgt acttcaccaa catgcaggac cgggcagcca agatcgaacg
     3781 cgcagccctg gacggcaccg agcgcgaggt cctcttcacc accggcctca tccgccctgt
     3841 ggccctggtg gtggacaaca cactgggcaa gctgttctgg gtggacgcgg acctgaagcg
     3901 cattgagagc tgtgacctgt caggggccaa ccgcctgacc ctggaggacg ccaacatcgt
     3961 gcagcctctg ggcctgacca tccttggcaa gcatctctac tggatcgacc gccagcagca
     4021 gatgatcgag cgtgtggaga agaccaccgg ggacaagcgg actcgcatcc agggccgtgt
     4081 cgcccacctc actggcatcc atgcagtgga ggaagtcagc ctggaggagt tctcagccca
     4141 cccatgtgcc cgtgacaatg gtggctgctc ccacatctgt attgccaagg gtgatgggac
     4201 accacggtgc tcatgcccag tccacctcgt gctcctgcag aacctgctga cctgtggaga
     4261 gccgcccacc tgctccccgg accagtttgc atgtgccaca ggggagatcg actgtatccc
     4321 cggggcctgg cgctgtgacg gctttcccga gtgcgatgac cagagcgacg aggagggctg
     4381 ccccgtgtgc tccgccgccc agttcccctg cgcgcggggt cagtgtgtgg acctgcgcct
     4441 gcgctgcgac ggcgaggcag actgtcagga ccgctcagac gaggcggact gtgacgccat
     4501 ctgcctgccc aaccagttcc ggtgtgcgag cggccagtgt gtcctcatca aacagcagtg
     4561 cgactccttc cccgactgta tcgacggctc cgacgagctc atgtgtgaaa tcaccaagcc
     4621 gccctcagac gacagcccgg cccacagcag tgccatcggg cccgtcattg gcatcatcct
     4681 ctctctcttc gtcatgggtg gtgtctattt tgtgtgccag cgcgtggtgt gccagcgcta
     4741 tgcgggggcc aacgggccct tcccgcacga gtatgtcagc gggaccccgc acgtgcccct
     4801 caatttcata gccccgggcg gttcccagca tggccccttc acaggcatcg catgcggaaa
     4861 gtccatgatg agctccgtga gcctgatggg gggccggggc ggggtgcccc tctacgaccg
     4921 gaaccacgtc acaggggcct cgtccagcag ctcgtccagc acgaaggcca cgctgtaccc
     4981 gccgatcctg aacccgccgc cctccccggc cacggacccc tccctgtaca acatggacat
     5041 gttctactct tcaaacattc cggccactgc gagaccgtac aggccctaca tcattcgagg
     5101 aatggcgccc ccgacgacgc cctgcagcac cgacgtgtgt gacagcgact acagcgccag
     5161 ccgctggaag gccagcaagt actacctgga tttgaactcg gactcagacc cctatccacc
     5221 cccacccacg ccccacagcc agtacctgtc ggcggaggac agctgcccgc cctcgcccgc
     5281 caccgagagg agctacttcc atctcttccc gccccctccg tccccctgca cggactcatc
     5341 ctgacctcgg ccgggccact ctggcttctc tgtgcccctg taaatagttt taaatatgaa
     5401 caaagaaaaa aatatatttt atgatttaaa aaataaatat aattgggatt ttaaaaacat
     5461 gagaaatgtg aactgtgatg gggtgggcag ggctgggaga actttgtaca gtggagaaat
     5521 atttataaac ttaattttgt aaaacagaa
//
