LOCUS       NM_002335               5177 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens LDL receptor related protein 5 (LRP5), transcript
            variant 1, mRNA.
ACCESSION   NM_002335
VERSION     NM_002335.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5177)
  AUTHORS   Chang,H.H., Wang,A.G., Niu,D.M., Chen,Y.R. and Weng,C.C.
  TITLE     Unveiling novel LRP5 pathogenic variant in familial exudative
            vitreoretinopathy: Diverse phenotypic expressions in a
            mother-daughter duo
  JOURNAL   Eur J Ophthalmol 34 (5), NP8-NP12 (2024)
   PUBMED   38720524
  REMARK    GeneRIF: Unveiling novel LRP5 pathogenic variant in familial
            exudative vitreoretinopathy: Diverse phenotypic expressions in a
            mother-daughter duo.
REFERENCE   2  (bases 1 to 5177)
  AUTHORS   Ren,N., Lv,S., Li,X., Shao,C., Wang,Z., Mei,Y., Yang,W., Fu,W.,
            Hu,Y., Sha,L., Hu,W., Zhang,Z. and Wang,C.
  TITLE     Clinical features, treatment, and follow-up of OPPG and
            high-bone-mass disorders: LRP5 is a key regulator of bone mass
  JOURNAL   Osteoporos Int 35 (8), 1395-1406 (2024)
   PUBMED   38625381
  REMARK    GeneRIF: Clinical features, treatment, and follow-up of OPPG and
            high-bone-mass disorders: LRP5 is a key regulator of bone mass.
REFERENCE   3  (bases 1 to 5177)
  AUTHORS   Roca-Ayats,N., Maceda,I., Bruque,C.D., Martinez-Gil,N.,
            Garcia-Giralt,N., Cozar,M., Mellibovsky,L., Van Hul,W., Lao,O.,
            Grinberg,D. and Balcells,S.
  TITLE     Evolutionary and functional analyses of LRP5 in archaic and extant
            modern humans
  JOURNAL   Hum Genomics 18 (1), 53 (2024)
   PUBMED   38802968
  REMARK    GeneRIF: Evolutionary and functional analyses of LRP5 in archaic
            and extant modern humans.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5177)
  AUTHORS   Li,J., Li,Y., Li,S., Lu,Y. and Rai,P.
  TITLE     Relationship between polymorphisms and mutations at rs7125942 and
            rs3736228 of LRP5 gene and bone metabolism in postmenopausal women
  JOURNAL   J Orthop Surg Res 19 (1), 104 (2024)
   PUBMED   38302983
  REMARK    GeneRIF: Relationship between polymorphisms and mutations at
            rs7125942 and rs3736228 of LRP5 gene and bone metabolism in
            postmenopausal women.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5177)
  AUTHORS   Li,J., Wang,C., Zhang,S., Cai,B., Pan,B., Sun,C., Qi,X., Ma,C.,
            Fang,W., Jin,K., Bi,X., Jin,Z. and Zhuang,W.
  TITLE     Genetic detection of two novel LRP5 pathogenic variants in patients
            with familial exudative vitreoretinopathy
  JOURNAL   BMC Ophthalmol 23 (1), 489 (2023)
   PUBMED   38030997
  REMARK    GeneRIF: Genetic detection of two novel LRP5 pathogenic variants in
            patients with familial exudative vitreoretinopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5177)
  AUTHORS   Hey,P.J., Twells,R.C., Phillips,M.S., Yusuke,Nakagawa., Brown,S.D.,
            Kawaguchi,Y., Cox,R., Guochun,Xie., Dugan,V., Hammond,H.,
            Metzker,M.L., Todd,J.A. and Hess,J.F.
  TITLE     Cloning of a novel member of the low-density lipoprotein receptor
            family
  JOURNAL   Gene 216 (1), 103-111 (1998)
   PUBMED   9714764
REFERENCE   7  (bases 1 to 5177)
  AUTHORS   Johnson,M.L., Gong,G., Kimberling,W., Recker,S.M., Kimmel,D.B. and
            Recker,R.B.
  TITLE     Linkage of a gene causing high bone mass to human chromosome 11
            (11q12-13)
  JOURNAL   Am J Hum Genet 60 (6), 1326-1332 (1997)
   PUBMED   9199553
REFERENCE   8  (bases 1 to 5177)
  AUTHORS   Gong,Y., Vikkula,M., Boon,L., Liu,J., Beighton,P., Ramesar,R.,
            Peltonen,L., Somer,H., Hirose,T., Dallapiccola,B., De Paepe,A.,
            Swoboda,W., Zabel,B., Superti-Furga,A., Steinmann,B., Brunner,H.G.,
            Jans,A., Boles,R.G., Adkins,W., van den Boogaard,M.J., Olsen,B.R.
            and Warman,M.L.
  TITLE     Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal
            strength and vision, is assigned to chromosome region 11q12-13
  JOURNAL   Am J Hum Genet 59 (1), 146-151 (1996)
   PUBMED   8659519
REFERENCE   9  (bases 1 to 5177)
  AUTHORS   Godyna,S., Liau,G., Popa,I., Stefansson,S. and Argraves,W.S.
  TITLE     Identification of the low density lipoprotein receptor-related
            protein (LRP) as an endocytic receptor for thrombospondin-1
  JOURNAL   J Cell Biol 129 (5), 1403-1410 (1995)
   PUBMED   7775583
REFERENCE   10 (bases 1 to 5177)
  AUTHORS   Toomes,C. and Downey,L.
  TITLE     Familial Exudative Vitreoretinopathy, Autosomal Dominant - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301326
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002813.4, DN999254.1,
            BC150595.1, AP000807.4, AB017498.1 and AI583742.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002335.3.
            
            Summary: This gene encodes a transmembrane low-density lipoprotein
            receptor that binds and internalizes ligands in the process of
            receptor-mediated endocytosis. This protein also acts as a
            co-receptor with Frizzled protein family members for transducing
            signals by Wnt proteins and was originally cloned on the basis of
            its association with type 1 diabetes mellitus in humans. This
            protein plays a key role in skeletal homeostasis and many bone
            density related diseases are caused by mutations in this gene.
            Mutations in this gene also cause familial exudative
            vitreoretinopathy. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF077820.1, AF064548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294304.12/ ENSP00000294304.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AP002813.4         178577-178594
            19-76               DN999254.1         8-65
            77-1770             BC150595.1         1-1694
            1771-1771           AP000807.4         82021-82021
            1772-3480           BC150595.1         1696-3404
            3481-3481           AB017498.1         3460-3460
            3482-5115           BC150595.1         3406-5039
            5116-5177           AI583742.1         10-71               c
FEATURES             Location/Qualifiers
     source          1..5177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..5177
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /note="LDL receptor related protein 5"
                     /db_xref="GeneID:4041"
                     /db_xref="HGNC:HGNC:6697"
                     /db_xref="MIM:603506"
     exon            1..215
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..4972
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; low density lipoprotein receptor-related
                     protein 7; low density lipoprotein receptor-related
                     protein 5"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     5 isoform 1 precursor"
                     /protein_id="NP_002326.2"
                     /db_xref="CCDS:CCDS8181.1"
                     /db_xref="GeneID:4041"
                     /db_xref="HGNC:HGNC:6697"
                     /db_xref="MIM:603506"
                     /translation="MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVR
                     LVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNV
                     VISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDP
                     AHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF
                     IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILS
                     ALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGR
                     TCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDD
                     EVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
                     KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGL
                     ALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRR
                     SIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATR
                     CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDF
                     DVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTN
                     RIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMT
                     LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD
                     YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCG
                     QLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILP
                     LHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS
                     IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQD
                     RAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR
                     LTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAV
                     EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPD
                     QFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE
                     ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSD
                     DSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLN
                     FIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLY
                     PPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDY
                     SASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSP
                     CTDSS"
     exon            216..612
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..810
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1007
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1139
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1536
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1708
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1925
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2215
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2442
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2627
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2951
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3151
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3360
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3551
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3761
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3887
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4124
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4235
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4472
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4473..4612
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4613..4710
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..5177
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5064..5069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /note="hexamer: AATATA"
     polyA_site      5090
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
     regulatory      5152..5157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /note="hexamer: TATAAA"
     polyA_site      5177
                     /gene="LRP5"
                     /gene_synonym="BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7;
                     LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtcctgg tccgcggcgc ccgagggggg aggcggaggc gccgggagcc gcgcgaggag
       61 ccgccgccgc cgcgccatgg agcccgagtg agcgcggcgc gggcccgtcc ggccgccgga
      121 caacatggag gcagcgccgc ccgggccgcc gtggccgctg ctgctgctgc tgctgctgct
      181 gctggcgctg tgcggctgcc cggcccccgc cgcggcctcg ccgctcctgc tatttgccaa
      241 ccgccgggac gtacggctgg tggacgccgg cggagtcaag ctggagtcca ccatcgtggt
      301 cagcggcctg gaggatgcgg ccgcagtgga cttccagttt tccaagggag ccgtgtactg
      361 gacagacgtg agcgaggagg ccatcaagca gacctacctg aaccagacgg gggccgccgt
      421 gcagaacgtg gtcatctccg gcctggtctc tcccgacggc ctcgcctgcg actgggtggg
      481 caagaagctg tactggacgg actcagagac caaccgcatc gaggtggcca acctcaatgg
      541 cacatcccgg aaggtgctct tctggcagga ccttgaccag ccgagggcca tcgccttgga
      601 ccccgctcac gggtacatgt actggacaga ctggggtgag acgccccgga ttgagcgggc
      661 agggatggat ggcagcaccc ggaagatcat tgtggactcg gacatttact ggcccaatgg
      721 actgaccatc gacctggagg agcagaagct ctactgggct gacgccaagc tcagcttcat
      781 ccaccgtgcc aacctggacg gctcgttccg gcagaaggtg gtggagggca gcctgacgca
      841 ccccttcgcc ctgacgctct ccggggacac tctgtactgg acagactggc agacccgctc
      901 catccatgcc tgcaacaagc gcactggggg gaagaggaag gagatcctga gtgccctcta
      961 ctcacccatg gacatccagg tgctgagcca ggagcggcag cctttcttcc acactcgctg
     1021 tgaggaggac aatggcggct gctcccacct gtgcctgctg tccccaagcg agcctttcta
     1081 cacatgcgcc tgccccacgg gtgtgcagct gcaggacaac ggcaggacgt gtaaggcagg
     1141 agccgaggag gtgctgctgc tggcccggcg gacggaccta cggaggatct cgctggacac
     1201 gccggacttc accgacatcg tgctgcaggt ggacgacatc cggcacgcca ttgccatcga
     1261 ctacgacccg ctagagggct atgtctactg gacagatgac gaggtgcggg ccatccgcag
     1321 ggcgtacctg gacgggtctg gggcgcagac gctggtcaac accgagatca acgaccccga
     1381 tggcatcgcg gtcgactggg tggcccgaaa cctctactgg accgacacgg gcacggaccg
     1441 catcgaggtg acgcgcctca acggcacctc ccgcaagatc ctggtgtcgg aggacctgga
     1501 cgagccccga gccatcgcac tgcaccccgt gatgggcctc atgtactgga cagactgggg
     1561 agagaaccct aaaatcgagt gtgccaactt ggatgggcag gagcggcgtg tgctggtcaa
     1621 tgcctccctc gggtggccca acggcctggc cctggacctg caggagggga agctctactg
     1681 gggagacgcc aagacagaca agatcgaggt gatcaatgtt gatgggacga agaggcggac
     1741 cctcctggag gacaagctcc cgcacatttt tgggttcacg ctgctggggg acttcatcta
     1801 ctggactgac tggcagcgcc gcagcatcga gcgggtgcac aaggtcaagg ccagccggga
     1861 cgtcatcatt gaccagctgc ccgacctgat ggggctcaaa gctgtgaatg tggccaaggt
     1921 cgtcggaacc aacccgtgtg cggacaggaa cggggggtgc agccacctgt gcttcttcac
     1981 accccacgca acccggtgtg gctgccccat cggcctggag ctgctgagtg acatgaagac
     2041 ctgcatcgtg cctgaggcct tcttggtctt caccagcaga gccgccatcc acaggatctc
     2101 cctcgagacc aataacaacg acgtggccat cccgctcacg ggcgtcaagg aggcctcagc
     2161 cctggacttt gatgtgtcca acaaccacat ctactggaca gacgtcagcc tgaagaccat
     2221 cagccgcgcc ttcatgaacg ggagctcggt ggagcacgtg gtggagtttg gccttgacta
     2281 ccccgagggc atggccgttg actggatggg caagaacctc tactgggccg acactgggac
     2341 caacagaatc gaagtggcgc ggctggacgg gcagttccgg caagtcctcg tgtggaggga
     2401 cttggacaac ccgaggtcgc tggccctgga tcccaccaag ggctacatct actggaccga
     2461 gtggggcggc aagccgagga tcgtgcgggc cttcatggac gggaccaact gcatgacgct
     2521 ggtggacaag gtgggccggg ccaacgacct caccattgac tacgctgacc agcgcctcta
     2581 ctggaccgac ctggacacca acatgatcga gtcgtccaac atgctgggtc aggagcgggt
     2641 cgtgattgcc gacgatctcc cgcacccgtt cggtctgacg cagtacagcg attatatcta
     2701 ctggacagac tggaatctgc acagcattga gcgggccgac aagactagcg gccggaaccg
     2761 caccctcatc cagggccacc tggacttcgt gatggacatc ctggtgttcc actcctcccg
     2821 ccaggatggc ctcaatgact gtatgcacaa caacgggcag tgtgggcagc tgtgccttgc
     2881 catccccggc ggccaccgct gcggctgcgc ctcacactac accctggacc ccagcagccg
     2941 caactgcagc ccgcccacca ccttcttgct gttcagccag aaatctgcca tcagtcggat
     3001 gatcccggac gaccagcaca gcccggatct catcctgccc ctgcatggac tgaggaacgt
     3061 caaagccatc gactatgacc cactggacaa gttcatctac tgggtggatg ggcgccagaa
     3121 catcaagcga gccaaggacg acgggaccca gccctttgtt ttgacctctc tgagccaagg
     3181 ccaaaaccca gacaggcagc cccacgacct cagcatcgac atctacagcc ggacactgtt
     3241 ctggacgtgc gaggccacca ataccatcaa cgtccacagg ctgagcgggg aagccatggg
     3301 ggtggtgctg cgtggggacc gcgacaagcc cagggccatc gtcgtcaacg cggagcgagg
     3361 gtacctgtac ttcaccaaca tgcaggaccg ggcagccaag atcgaacgcg cagccctgga
     3421 cggcaccgag cgcgaggtcc tcttcaccac cggcctcatc cgccctgtgg ccctggtggt
     3481 ggacaacaca ctgggcaagc tgttctgggt ggacgcggac ctgaagcgca ttgagagctg
     3541 tgacctgtca ggggccaacc gcctgaccct ggaggacgcc aacatcgtgc agcctctggg
     3601 cctgaccatc cttggcaagc atctctactg gatcgaccgc cagcagcaga tgatcgagcg
     3661 tgtggagaag accaccgggg acaagcggac tcgcatccag ggccgtgtcg cccacctcac
     3721 tggcatccat gcagtggagg aagtcagcct ggaggagttc tcagcccacc catgtgcccg
     3781 tgacaatggt ggctgctccc acatctgtat tgccaagggt gatgggacac cacggtgctc
     3841 atgcccagtc cacctcgtgc tcctgcagaa cctgctgacc tgtggagagc cgcccacctg
     3901 ctccccggac cagtttgcat gtgccacagg ggagatcgac tgtatccccg gggcctggcg
     3961 ctgtgacggc tttcccgagt gcgatgacca gagcgacgag gagggctgcc ccgtgtgctc
     4021 cgccgcccag ttcccctgcg cgcggggtca gtgtgtggac ctgcgcctgc gctgcgacgg
     4081 cgaggcagac tgtcaggacc gctcagacga ggcggactgt gacgccatct gcctgcccaa
     4141 ccagttccgg tgtgcgagcg gccagtgtgt cctcatcaaa cagcagtgcg actccttccc
     4201 cgactgtatc gacggctccg acgagctcat gtgtgaaatc accaagccgc cctcagacga
     4261 cagcccggcc cacagcagtg ccatcgggcc cgtcattggc atcatcctct ctctcttcgt
     4321 catgggtggt gtctattttg tgtgccagcg cgtggtgtgc cagcgctatg cgggggccaa
     4381 cgggcccttc ccgcacgagt atgtcagcgg gaccccgcac gtgcccctca atttcatagc
     4441 cccgggcggt tcccagcatg gccccttcac aggcatcgca tgcggaaagt ccatgatgag
     4501 ctccgtgagc ctgatggggg gccggggcgg ggtgcccctc tacgaccgga accacgtcac
     4561 aggggcctcg tccagcagct cgtccagcac gaaggccacg ctgtacccgc cgatcctgaa
     4621 cccgccgccc tccccggcca cggacccctc cctgtacaac atggacatgt tctactcttc
     4681 aaacattccg gccactgcga gaccgtacag gccctacatc attcgaggaa tggcgccccc
     4741 gacgacgccc tgcagcaccg acgtgtgtga cagcgactac agcgccagcc gctggaaggc
     4801 cagcaagtac tacctggatt tgaactcgga ctcagacccc tatccacccc cacccacgcc
     4861 ccacagccag tacctgtcgg cggaggacag ctgcccgccc tcgcccgcca ccgagaggag
     4921 ctacttccat ctcttcccgc cccctccgtc cccctgcacg gactcatcct gacctcggcc
     4981 gggccactct ggcttctctg tgcccctgta aatagtttta aatatgaaca aagaaaaaaa
     5041 tatattttat gatttaaaaa ataaatataa ttgggatttt aaaaacatga gaaatgtgaa
     5101 ctgtgatggg gtgggcaggg ctgggagaac tttgtacagt ggagaaatat ttataaactt
     5161 aattttgtaa aacagaa
//
