LOCUS       NM_002334               8155 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens LDL receptor related protein 4 (LRP4), mRNA.
ACCESSION   NM_002334 XM_035037
VERSION     NM_002334.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8155)
  AUTHORS   Kantaputra,P., Panichkul,W., Sillapasorn,P., Adisornkanj,P.,
            Kitsadayurach,P., Kaewgaya,M., Intachai,W., Olsen,B., Ngamphiw,C.,
            Leethanakul,C., Jatooratthawichot,P., Ketudat Cairns,J.R. and
            Tongsima,S.
  TITLE     LRP4 mutations, dental anomalies, and oral exostoses
  JOURNAL   Int J Paediatr Dent 34 (4), 432-441 (2024)
   PUBMED   38013205
  REMARK    GeneRIF: LRP4 mutations, dental anomalies, and oral exostoses.
REFERENCE   2  (bases 1 to 8155)
  AUTHORS   Chen,B.H., Lin,Z.Y., Zeng,X.X., Jiang,Y.H. and Geng,F.
  TITLE     LRP4-related signalling pathways and their regulatory role in
            neurological diseases
  JOURNAL   Brain Res 1825, 148705 (2024)
   PUBMED   38065285
  REMARK    GeneRIF: LRP4-related signalling pathways and their regulatory role
            in neurological diseases.
            Review article
REFERENCE   3  (bases 1 to 8155)
  AUTHORS   Al Jabry,T., Al-Hashmi,N., Abdelhadi,B. and Al-Maawali,A.
  TITLE     LRP4 site-specific variants in the third beta-propeller domain
            causes congenital myasthenic syndrome type 17
  JOURNAL   Eur J Med Genet 67, 104903 (2024)
   PUBMED   38101565
  REMARK    GeneRIF: LRP4 site-specific variants in the third beta-propeller
            domain causes congenital myasthenic syndrome type 17.
            Review article
REFERENCE   4  (bases 1 to 8155)
  AUTHORS   Khan,H., Ullah,K., Jan,A., Ali,H., Ullah,I. and Ahmad,W.
  TITLE     A variant in the LDL receptor-related protein encoding gene LRP4
            underlying polydactyly and phalangeal synostosis in a family of
            Pakistani origin
  JOURNAL   Congenit Anom (Kyoto) 63 (6), 190-194 (2023)
   PUBMED   37563890
  REMARK    GeneRIF: A variant in the LDL receptor-related protein encoding
            gene LRP4 underlying polydactyly and phalangeal synostosis in a
            family of Pakistani origin.
REFERENCE   5  (bases 1 to 8155)
  AUTHORS   Jeong,Y.H., Sekiya,M., Hirata,M., Ye,M., Yamagishi,A., Lee,S.M.,
            Kang,M.J., Hosoda,A., Fukumura,T., Kim,D.H. and Saeki,S.
  TITLE     The low-density lipoprotein receptor-related protein 10 is a
            negative regulator of the canonical Wnt/beta-catenin signaling
            pathway
  JOURNAL   Biochem Biophys Res Commun 392 (4), 495-499 (2010)
   PUBMED   20093106
REFERENCE   6  (bases 1 to 8155)
  AUTHORS   Jeong,Y.H., Ishikawa,K., Someya,Y., Hosoda,A., Yoshimi,T.,
            Yokoyama,C., Kiryu-Seo,S., Kang,M.J., Tchibana,T., Kiyama,H.,
            Fukumura,T., Kim,D.H. and Saeki,S.
  TITLE     Molecular characterization and expression of the low-density
            lipoprotein receptor-related protein-10, a new member of the LDLR
            gene family
  JOURNAL   Biochem Biophys Res Commun 391 (1), 1110-1115 (2010)
   PUBMED   20005200
  REMARK    GeneRIF: The present studies suggest that LRP10 may play a
            significant role in the brain physiology other than lipoprotein
            metabolism.
REFERENCE   7  (bases 1 to 8155)
  AUTHORS   Styrkarsdottir,U., Halldorsson,B.V., Gretarsdottir,S.,
            Gudbjartsson,D.F., Walters,G.B., Ingvarsson,T., Jonsdottir,T.,
            Saemundsdottir,J., Snorradottir,S., Center,J.R., Nguyen,T.V.,
            Alexandersen,P., Gulcher,J.R., Eisman,J.A., Christiansen,C.,
            Sigurdsson,G., Kong,A., Thorsteinsdottir,U. and Stefansson,K.
  TITLE     New sequence variants associated with bone mineral density
  JOURNAL   Nat Genet 41 (1), 15-17 (2009)
   PUBMED   19079262
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 8155)
  AUTHORS   Nazer,B., Hong,S. and Selkoe,D.J.
  TITLE     LRP promotes endocytosis and degradation, but not transcytosis, of
            the amyloid-beta peptide in a blood-brain barrier in vitro model
  JOURNAL   Neurobiol Dis 30 (1), 94-102 (2008)
   PUBMED   18289866
REFERENCE   9  (bases 1 to 8155)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
REFERENCE   10 (bases 1 to 8155)
  AUTHORS   Abicht,A., Muller,J.S. and Lochmuller,H.
  TITLE     Congenital Myasthenic Syndromes Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021573.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002334.3.
            
            Summary: This gene encodes a member of the low-density lipoprotein
            receptor-related protein family. The encoded protein may be a
            regulator of Wnt signaling. Mutations in this gene are associated
            with Cenani-Lenz syndrome. [provided by RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB084910.1, AB231861.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378623.6/ ENSP00000367888.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC021573.10        97338-97560         c
            224-370             AC021573.10        81793-81939         c
            371-487             AC021573.10        79272-79388         c
            488-601             AC021573.10        78873-78986         c
            602-718             AC021573.10        78397-78513         c
            719-847             AC021573.10        77914-78042         c
            848-967             AC021573.10        77568-77687         c
            968-1093            AC021573.10        75879-76004         c
            1094-1219           AC021573.10        75220-75345         c
            1220-1354           AC021573.10        74894-75028         c
            1355-1480           AC021573.10        74176-74301         c
            1481-1711           AC021573.10        73599-73829         c
            1712-1868           AC021573.10        71983-72139         c
            1869-2086           AC021573.10        69287-69504         c
            2087-2263           AC021573.10        68954-69130         c
            2264-2386           AC021573.10        68421-68543         c
            2387-2595           AC021573.10        65335-65543         c
            2596-2677           AC021573.10        65101-65182         c
            2678-2783           AC021573.10        62881-62986         c
            2784-2985           AC021573.10        60712-60913         c
            2986-3175           AC021573.10        58136-58325         c
            3176-3307           AC021573.10        57917-58048         c
            3308-3448           AC021573.10        56209-56349         c
            3449-3535           AC021573.10        55754-55840         c
            3536-3707           AC021573.10        55476-55647         c
            3708-3870           AC021573.10        54814-54976         c
            3871-4096           AC021573.10        54466-54691         c
            4097-4400           AC021573.10        53810-54113         c
            4401-4619           AC021573.10        52385-52603         c
            4620-4754           AC021573.10        52110-52244         c
            4755-4863           AC021573.10        50535-50643         c
            4864-5008           AC021573.10        47998-48142         c
            5009-5122           AC021573.10        47610-47723         c
            5123-5258           AC021573.10        46989-47124         c
            5259-5326           AC021573.10        44129-44196         c
            5327-5414           AC021573.10        43458-43545         c
            5415-5556           AC021573.10        41616-41757         c
            5557-8155           AC021573.10        35727-38325         c
FEATURES             Location/Qualifiers
     source          1..8155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..8155
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /note="LDL receptor related protein 4"
                     /db_xref="GeneID:4038"
                     /db_xref="HGNC:HGNC:6696"
                     /db_xref="MIM:604270"
     exon            1..223
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..5889
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /note="multiple epidermal growth factor-like domains 7;
                     low-density lipoprotein receptor-related protein 4;
                     multiple EGF like domains 7"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     4 precursor"
                     /protein_id="NP_002325.2"
                     /db_xref="CCDS:CCDS31478.1"
                     /db_xref="GeneID:4038"
                     /db_xref="HGNC:HGNC:6696"
                     /db_xref="MIM:604270"
                     /translation="MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTC
                     IPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE
                     QDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSC
                     IAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGD
                     WSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFR
                     CHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGV
                     NDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHT
                     CQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDI
                     RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVST
                     GLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEG
                     TIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIER
                     ANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLH
                     FPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSL
                     DKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTIS
                     RAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWE
                     NLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGS
                     QRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSAD
                     RLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTC
                     PTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGV
                     DPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTN
                     RIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAV
                     LINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLD
                     SYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC
                     SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVH
                     VPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVD
                     WVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIA
                     KIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVL
                     VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQR
                     QTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKS
                     PVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISY
                     AIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKP
                     AMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVC
                     MKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLS
                     SESQV"
     exon            224..370
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..487
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..601
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..718
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..847
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..967
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1093
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1219
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1354
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1480
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1711
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1868
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2086
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2263
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2386
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2595
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2677
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2783
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2985
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3175
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3307
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3448
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3535
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3707
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3870
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4096
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            4097..4400
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4619
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            4620..4754
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            4755..4863
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            4864..5008
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            5009..5122
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            5123..5258
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5326
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            5327..5414
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            5415..5556
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     exon            5557..8155
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7982..7987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /note="hexamer: TATAAA"
     polyA_site      8005
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /note="major polyA site"
     regulatory      8129..8134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
                     /note="hexamer: AATAAA"
     polyA_site      8155
                     /gene="LRP4"
                     /gene_synonym="CLSS; CMS17; LRP-4; LRP10; MEGF7; SOST2"
ORIGIN      
        1 agcgtcggct ctggcagcac tggaggcggc ggcggcccga gggcgacttg cggggcgcgc
       61 aggccgccgt gcacccggga cgcttccccc tcggggaccc tccgcgggct tctccgccgc
      121 gccgtccggc gggagccggc gggaccccgg gcgagcggcg cgggcggcac catgaggcgg
      181 cagtggggcg cgctgctgct tggcgccctg ctctgcgcac acggcctggc cagcagcccc
      241 gagtgtgctt gtggtcggag ccacttcaca tgtgcagtga gtgctcttgg agagtgtacc
      301 tgcatccctg cccagtggca gtgtgatgga gacaatgact gcggggacca cagcgatgag
      361 gatggatgta tactacctac ctgttcccct cttgactttc actgtgacaa tggcaagtgc
      421 atccgccgct cctgggtgtg tgacggggac aacgactgtg aggatgactc ggatgagcag
      481 gactgtcccc cccgggagtg tgaggaggac gagtttccct gccagaatgg ctactgcatc
      541 cggagtctgt ggcactgcga tggtgacaat gactgtggcg acaacagcga tgagcagtgt
      601 gacatgcgca agtgctccga caaggagttc cgctgtagtg acggaagctg cattgctgag
      661 cattggtact gcgacggtga caccgactgc aaagatggct ccgatgagga gaactgtccc
      721 tcagcagtgc cagcgccccc ctgcaacctg gaggagttcc agtgtgccta tggacgctgc
      781 atcctcgaca tctaccactg cgatggcgac gatgactgtg gagactggtc agacgagtct
      841 gactgctcct cccaccagcc ctgccgctct ggggagttca tgtgtgacag tggcctgtgc
      901 atcaatgcag gctggcgctg cgatggtgac gcggactgtg atgaccagtc tgatgagcgc
      961 aactgcacca cctccatgtg tacggcagaa cagttccgct gtcactcagg ccgctgtgtc
     1021 cgcctgtcct ggcgctgtga tggggaggac gactgtgcag acaacagcga tgaagagaac
     1081 tgtgagaata caggaagccc ccaatgtgcc ttggaccagt tcctgtgttg gaatgggcgc
     1141 tgcattgggc agaggaagct gtgcaacggg gtcaacgact gtggtgacaa cagcgacgaa
     1201 agcccacagc agaattgccg gccccggacg ggtgaggaga actgcaatgt taacaacggt
     1261 ggctgtgccc agaagtgcca gatggtgcgg ggggcagtgc agtgtacctg ccacacaggc
     1321 taccggctca cagaggatgg gcacacgtgc caagatgtga atgaatgtgc cgaggagggg
     1381 tattgcagcc agggctgcac caacagcgaa ggggctttcc aatgctggtg tgaaacaggc
     1441 tatgaactac ggcccgaccg gcgcagctgc aaggctctgg ggccagagcc tgtgctgctg
     1501 ttcgccaatc gcatcgacat ccggcaggtg ctgccacacc gctctgagta cacactgctg
     1561 cttaacaacc tggagaatgc cattgccctt gatttccacc accgccgcga gcttgtcttc
     1621 tggtcagatg tcaccctgga ccggatcctc cgtgccaacc tcaacggcag caacgtggag
     1681 gaggttgtgt ctactgggct ggagagccca gggggcctgg ctgtggattg ggtccatgac
     1741 aaactctact ggaccgactc aggcacctcg aggattgagg tggccaatct ggatggggcc
     1801 caccggaaag tgttgctgtg gcagaacctg gagaagcccc gggccattgc cttgcatccc
     1861 atggagggta ccatttactg gacagactgg ggcaacaccc cccgtattga ggcctccagc
     1921 atggatggct ctggacgccg catcattgcc gatacccatc tcttctggcc caatggcctc
     1981 accatcgact atgccgggcg ccgtatgtac tgggtggatg ctaagcacca tgtcatcgag
     2041 agggccaatc tggatgggag tcaccgtaag gctgtcatta gccagggcct cccgcatccc
     2101 ttcgccatca cagtgtttga agacagcctg tactggacag actggcacac caagagcatc
     2161 aatagcgcta acaaatttac ggggaagaac caggaaatca ttcgcaacaa actccacttc
     2221 cctatggaca tccacacctt gcacccccag cgccaacctg cagggaaaaa ccgctgtggg
     2281 gacaacaacg gaggctgcac gcacctgtgt ctgcccagtg gccagaacta cacctgtgcc
     2341 tgccccactg gcttccgcaa gatcagcagc cacgcctgtg cccagagtct tgacaagttc
     2401 ctgctttttg cccgaaggat ggacatccgt cgaatcagct ttgacacaga ggacctgtct
     2461 gatgatgtca tcccactggc tgacgtgcgc agtgctgtgg cccttgactg ggactcccgg
     2521 gatgaccacg tgtactggac agatgtcagc actgatacca tcagcagggc caagtgggat
     2581 ggaacaggac aggaggtggt agtggatacc agtttggaga gcccagctgg cctggccatt
     2641 gattgggtca ccaacaaact gtactggaca gatgcaggta cagaccggat tgaagtagcc
     2701 aacacagatg gcagcatgag aacagtactc atctgggaga accttgatcg tcctcgggac
     2761 atcgtggtgg aacccatggg cgggtacatg tattggactg actggggtgc gagccccaag
     2821 attgaacgag ctggcatgga tgcctcaggc cgccaagtca ttatctcttc taatctgacc
     2881 tggcctaatg ggttagctat tgattatggg tcccagcgtc tatactgggc tgacgccggc
     2941 atgaagacaa ttgaatttgc tggactggat ggcagtaaga ggaaggtgct gattggaagc
     3001 cagctccccc acccatttgg gctgaccctc tatggagagc gcatctattg gactgactgg
     3061 cagaccaaga gcatacagag cgctgaccgg ctgacagggc tggaccggga gactctgcag
     3121 gagaacctgg aaaacctaat ggacatccat gtcttccacc gccgccggcc cccagtgtct
     3181 acaccatgtg ctatggagaa tggcggctgt agccacctgt gtcttaggtc cccaaatcca
     3241 agcggattca gctgtacctg ccccacaggc atcaacctgc tgtctgatgg caagacctgc
     3301 tcaccaggca tgaacagttt cctcatcttc gccaggagga tagacattcg catggtctcc
     3361 ctggacatcc cttattttgc tgatgtggtg gtaccaatca acattaccat gaagaacacc
     3421 attgccattg gagtagaccc ccaggaagga aaggtgtact ggtctgacag cacactgcac
     3481 aggatcagtc gtgccaatct ggatggctca cagcatgagg acatcatcac cacagggcta
     3541 cagaccacag atgggctcgc ggttgatgcc attggccgga aagtatactg gacagacacg
     3601 ggaacaaacc ggattgaagt gggcaacctg gacgggtcca tgcggaaagt gttggtgtgg
     3661 cagaaccttg acagtccccg ggccatcgta ctgtaccatg agatggggtt tatgtactgg
     3721 acagactggg gggagaatgc caagttagag cggtccggaa tggatggctc agaccgcgcg
     3781 gtgctcatca acaacaacct aggatggccc aatggactga ctgtggacaa ggccagctcc
     3841 caactgctat gggccgatgc ccacaccgag cgaattgagg ctgctgacct gaatggtgcc
     3901 aatcggcata cattggtgtc accggtgcag cacccatatg gcctcaccct gctcgactcc
     3961 tatatctact ggactgactg gcagactcgg agcatccacc gtgctgacaa gggtactggc
     4021 agcaatgtca tcctcgtgag gtccaacctg ccaggcctca tggacatgca ggctgtggac
     4081 cgggcacagc cactaggttt taacaagtgc ggctcgagaa atggcggctg ctcccacctc
     4141 tgcttgcctc ggccttctgg cttctcctgt gcctgcccca ctggcatcca gctgaaggga
     4201 gatgggaaga cctgtgatcc ctctcctgag acctacctgc tcttctccag ccgtggctcc
     4261 atccggcgta tctcactgga caccagtgac cacaccgatg tgcatgtccc tgttcctgag
     4321 ctcaacaatg tcatctccct ggactatgac agcgtggatg gaaaggtcta ttacacagat
     4381 gtgttcctgg atgttatcag gcgagcagac ctgaacggca gcaacatgga gacagtgatc
     4441 gggcgagggc tgaagaccac tgacgggctg gcagtggact gggtggccag gaacctgtac
     4501 tggacagaca caggtcgaaa taccattgag gcgtccaggc tggatggttc ctgccgcaaa
     4561 gtactgatca acaatagcct ggatgagccc cgggccattg ctgttttccc caggaagggg
     4621 tacctcttct ggacagactg gggccacatt gccaagatcg aacgggcaaa cttggatggt
     4681 tctgagcgga aggtcctcat caacacagac ctgggttggc ccaatggcct taccctggac
     4741 tatgataccc gcaggatcta ctgggtggat gcgcatctgg accggatcga gagtgctgac
     4801 ctcaatggga aactgcggca ggtcttggtc agccatgtgt cccacccctt tgccctcaca
     4861 cagcaagaca ggtggatcta ctggacagac tggcagacca agtcaatcca gcgtgttgac
     4921 aaatactcag gccggaacaa ggagacagtg ctggcaaatg tggaaggact catggatatc
     4981 atcgtggttt cccctcagcg gcagacaggg accaatgcct gtggtgtgaa caatggtggc
     5041 tgcacccacc tctgctttgc cagagcctcg gacttcgtat gtgcctgtcc tgacgaacct
     5101 gatagccggc cctgctccct tgtgcctggc ctggtaccac cagctcctag ggctactggc
     5161 atgagtgaaa agagcccagt gctacccaac acaccaccta ccaccttgta ttcttcaacc
     5221 acccggaccc gcacgtctct ggaggaggtg gaaggaagat gctctgaaag ggatgccagg
     5281 ctgggcctct gtgcacgttc caatgacgct gttcctgctg ctccagggga aggacttcat
     5341 atcagctacg ccattggtgg actcctcagt attctgctga ttttggtggt gattgcagct
     5401 ttgatgctgt acagacacaa aaaatccaag ttcactgatc ctggaatggg gaacctcacc
     5461 tacagcaacc cctcctaccg aacatccaca caggaagtga agattgaagc aatccccaaa
     5521 ccagccatgt acaaccagct gtgctataag aaagagggag ggcctgacca taactacacc
     5581 aaggagaaga tcaagatcgt agagggaatc tgcctcctgt ctggggatga tgctgagtgg
     5641 gatgacctca agcaactgcg aagctcacgg gggggcctcc tccgggatca tgtatgcatg
     5701 aagacagaca cggtgtccat ccaggccagc tctggctccc tggatgacac agagacggag
     5761 cagctgttac aggaagagca gtctgagtgt agcagcgtcc atactgcagc cactccagaa
     5821 agacgaggct ctctgccaga cacgggctgg aaacatgaac gcaagctctc ctcagagagc
     5881 caggtctaaa tgcccacatt ctcttccctg cctgcctgtt ccttctcctt tatggacgtc
     5941 tagtccttgt gctcgcttac accgcaggcc ccgcttctgt gtgcttgtcc tcctcctcct
     6001 cccaccccat aactgttcct aagccttcac cggagctgtt taccacgtga gtccataact
     6061 acctgtgcac aagaaatgat ggcacatcac gagaatttag acctggattt taccatgaac
     6121 ctcacatctt gtactccatc ctgggccccc tgaaactgct tattcgtgat tcctcaccag
     6181 cgtagagctc cacctcccct ttccccagta ccctcagtgc ctgcttctca gtgctgatgc
     6241 agctgatgac ccaggactgc gctctgcccc atcacagcca gcatgactgc ttctctgaga
     6301 gaacttgccc atcaggggct gggacatggg ggtgtgggta aagacaggga tgaaggatag
     6361 aggctgagag aagaaggaag aatcagccca gcaggtatgg gcatctggga aacctccagc
     6421 ctcaagtgtg ttagtaacat gaaaaagctt tggggggtag ttggatctgg gtgtctggtc
     6481 cattgctggc agtggacatt attcttgccc taagagacac tgccttttca gcagcagata
     6541 ctggtgagat gggggtggct caggctgttc ttcctcctcc tagaatgtct ggagctgttt
     6601 ctacattcag ataactgggt cccctatcac aaggctactg gctaatagga attccctcct
     6661 ggtgccacca ctggccagta cctttcctaa gtctttgctc aaattaacca ggttgtgagc
     6721 cagtggcttg agtgaatgtt aggccttggg ggctgagtct ctgaaaagtc taagaagctc
     6781 tgcctagacc aaatatggta tacctcctga cccctctctc cctcatgtcc tgggattctg
     6841 gggaagagac ctagaaacaa gctttcaaag aaaaaccaga agttgtcata aatggtcaga
     6901 aagaacgatc aggttggaga cttgggaaac ccagggccta aagagaagta tccatgaggg
     6961 tcaaacttcc tgttgaactt cctatgttct ttctcaagtg ctcagggatc taagttagtg
     7021 gacagcaagc ctgtggctac ggggtggtga tgttcctctt ccagctgtcc cctcagctaa
     7081 ggggcttagt ttccatgtgg gatgccatca cttggttcat gctcattcac acaaagggca
     7141 cgtgtctcag cctggtatca gggaaattga gacttatttt tgccctaaaa cgtctcccta
     7201 gctgttcttc gtggggtttt tttgtttgtt tttttgccta atttgctttt tctgaccaag
     7261 ccttgtggca ccagcaatct ccaaagtcct gtggtgggag ggctgaataa ataaaaatac
     7321 aaagaggtgg gtaaggagta ggaaggtaga gagcaccact gatgaggccc tcctagccca
     7381 tggcagaccc agacctcttc tcccccagga attagaagtg gcaggagaga acaacagggg
     7441 ctgggaatgg aggggagaat ttctagggga agtttcctga gttgaaactt ctcctgtggt
     7501 tactggtatt gagaaatcag ctaccaaagt gaaaaaggac aagatcaatt cttttctagt
     7561 cagttctaag actgctagag agagatacca ggcccttagc cttgctctca gtagcgtcag
     7621 ccccagttct gagcctcccc acattacact taacaagcag taaaggagtg agcactttgg
     7681 gtccttagac tcacgtctgg ggaggaagag caagtagaaa agtggcattt tcttgattgg
     7741 aaagggggaa ggatcttatt gcacttgggc tgttcagaat gtagaaagga catatttgag
     7801 gaagtatcta tttgagcact gatttactct gtaaaaagca aaatctctct gtcctaaact
     7861 aatggaagcg attctcccat gctcatgtgt aatggtttta acgttactca ctggagagat
     7921 tggactttct ggagttattt aaccactatg ttcagtattt taggacttta tgataattta
     7981 atataaattt agcttttctt aatcaccttg cctggcttgg agtcatgact aatcctgcac
     8041 ctgctctgtc tggcagaccc atgctgtgga aaacctgctt acagacatca cttttaagtc
     8101 ctttgtggat gtgggcacag tgaagagcaa taaagagtgt gaggttcctg ctgga
//
