LOCUS       XM_005258945            4103 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens LDL receptor related protein 3 (LRP3),
            transcript variant X1, mRNA.
ACCESSION   XM_005258945
VERSION     XM_005258945.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000019.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005258945.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
     gene            1..4103
                     /gene="LRP3"
                     /note="LDL receptor related protein 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 48 ESTs, 226 long SRA reads, and 98% coverage
                     of the annotated genomic feature by RNAseq alignments,
                     including 91 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:4037"
                     /db_xref="HGNC:HGNC:6695"
                     /db_xref="MIM:603159"
     CDS             457..2814
                     /gene="LRP3"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     3 isoform X1"
                     /protein_id="XP_005259002.1"
                     /db_xref="GeneID:4037"
                     /db_xref="HGNC:HGNC:6695"
                     /db_xref="MIM:603159"
                     /translation="MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACS
                     GKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD
                     WLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK
                     LGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFP
                     CSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG
                     PSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPV
                     SLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCF
                     SEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK
                     NCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVC
                     GLLLVIALGCAFKLYSLRTQEYRSRAAQSCRPPPTASRAFETQMTRLEAEFVRREAPP
                     SYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWN
                     RLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRP
                     PSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQD
                     PHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC"
ORIGIN      
        1 gacagaccca cggacgctct accggcggca cccggccggg cgggctgggc gcagcgcggg
       61 gcggcccggg gacgccgggg ccgggcgggc tgcgcgccgc ggggcatggg cgcgccgggg
      121 gtccccgggc ccaggccggc cgcggcgggg ctcccggggc gcgggggcag cggcgggcgg
      181 gggtcttccc tggcggccgc cgctgagccc ccgcagggcc cgtgacgccg cggccgatgt
      241 ggccgcgcgc gccctacggg cctgcaccgc caccgcacaa agacgcctcg ggagccgccg
      301 cctgcacccg ggccgcagca gccacgccag ccggagcccg agccctagcc cgagcccgag
      361 cccgagccgc agccagagcc agagccggag ccgcagccgg aaccggagcc ggagccgcgg
      421 ggcaggaggc ggcgcccgcg ggcggccggg cccggcatgg agaagcgcgc ggccgcgggg
      481 ctggagggcg cgccgggcgc ccgggcgcag ctggccgtcg tctgtctggt gaacatcttt
      541 ctcaccggga gactcagcag tgcggttcct gccttagcgg cctgcagtgg gaagctggag
      601 cagcacacgg agcggcgtgg ggtcatctac agcccggcct ggcccctcaa ctacccgcca
      661 ggcaccaact gcagctggta catccagggc gaccgtggtg acatgattac catcagcttc
      721 cgcaactttg acgtggagga gtcccaccag tgctccctgg actggctcct gctgggccca
      781 gcagccccac cccgccagga ggccttccgc ctctgtggct ccgccatccc acctgccttc
      841 atctctgccc gcgaccatgt ctggattttc ttccactcag acgcctccag ctccggccag
      901 gcccagggct tccgtctgtc ttacatccga gggaagctgg gccaggcatc ctgccaggca
      961 gatgagttcc gctgtgacaa cggcaagtgc ctgcccggcc cgtggcagtg caacacggtg
     1021 gacgagtgtg gagacggctc tgatgagggc aactgctcgg cgcccgcctc cgagcctcca
     1081 ggcagcctgt gccccggggg gaccttccca tgcagcgggg cgcgctccac gcgctgcctg
     1141 cctgtggagc ggcgctgtga cggcttgcag gactgcggcg acggctcgga tgaggcgggc
     1201 tgccccgacc tggcgtgcgg ccggcggctg ggcagcttct acggctcctt tgcctcccca
     1261 gacctgttcg gcgccgctcg cgggccctca gaccttcact gcacgtggct ggtggacaca
     1321 caggactccc ggcgggtgct gctgcagctg gaactgcggc tgggctatga cgactacgtg
     1381 caggtatacg agggcctggg cgagcgcggg gaccgcctgc tgcagacgct gtcctaccgc
     1441 agcaaccacc ggcccgtgag cctggaggcc gcccagggcc gcctcactgt ggcctaccac
     1501 gcgcgcgccc gcagcgccgg ccacggcttc aatgccacct accaggtgaa gggctattgc
     1561 ctcccctggg agcagccgtg cgggagcagt agtgacagtg acgggggcag cctgggcgac
     1621 cagggctgct tctcagagcc acagcgctgt gatggctggt ggcattgtgc cagcggccga
     1681 gacgagcagg gctgccctgc ctgcccgccc gaccagtacc cctgcgaggg tggcagtggt
     1741 ctgtgctaca cgcctgccga ccgctgcaac aaccagaaaa gctgtcccga cggcgccgac
     1801 gagaagaact gcttctcctg ccagcccggc accttccact gcggtaccaa cctgtgcatc
     1861 ttcgagacgt ggcgctgtga cggccaggaa gactgccagg acggcagcga tgagcatggg
     1921 tgcctggccg ccgtgccccg caaggtcatc acggcggcgc tcattggcag cctggtgtgt
     1981 ggcctgctgc tggtcatcgc gctgggctgc gccttcaagc tctactcact gcgcacgcag
     2041 gaatacaggt cccgggcagc ccagtcatgt cgccctccgc ccactgcttc tagggccttc
     2101 gagacccaga tgacgcgcct ggaggctgag ttcgtgcggc gggaggcacc cccatcctat
     2161 ggtcagctca tcgcccaggg cctcattcca cccgtggagg actttcctgt ctacagtgcg
     2221 tcccaggcct ctgtgctgca gaatcttcgc acagccatgc ggagacagat gcgtcggcac
     2281 gcctcccgcc gggggccctc ccgccgccgc ctcggccgcc tctggaaccg gctctttcac
     2341 cggccgcggg cgccccgagg ccagatccca ctgctgaccg cagcacgccc ctcacagacc
     2401 gtgctgggcg atggcttcct ccagcctgct ccaggggctg cccccgaccc cccagcaccg
     2461 ctcatggaca caggcagcac cagggcggcc ggagacaggc cccccagtgc ccccggccgt
     2521 gcaccggagg tgggaccttc agggccaccc ttgccctcgg gcctgcgaga cccagagtgc
     2581 aggcccgtgg acaaggacag aaaggtctgc agggagccac tggtagacgg cccagctcct
     2641 gcagatgcac ctcgggagcc ctgctcagcc caggacccgc acccccaggt ctccactgcc
     2701 agcagcaccc tgggccccca ctcgccagag ccactggggg tctgcaggaa ccccccgccc
     2761 ccctgctccc caatgctgga ggccagcgat gatgaggccc tgttggtctg ttgaccgctg
     2821 ggctcgctgg tgaccgccac agccccgctt tgtaaccagg gaatacacag tcatttctac
     2881 cctgcctctg cgtcctttct tatggagagg ccctccgggg accccagcgg aggggctggc
     2941 ccctaagcca gctggctgca ctggtgggcg ggagctgtgg gactgaacgg cgggggggag
     3001 aagagtggag tggtgagccc gtctgcaggg tcccattgta cacaagcacc ctggggtctc
     3061 acttctctcc ccccactcca ttctgggaac ccatttccag agaagcaggg gaccagagcc
     3121 tttttgcttc atctgccctg cagtggcaac agctgcccct agagctggga gttgtcatga
     3181 ggatggggcc gggccatggg gacgctgggt ctcatccgtg gtgactattt tgctcacgcc
     3241 tcaccctctt cctgtccagc aaggcctctg gaggacctgg gttgggtggc tcctgccaaa
     3301 ccctcatgcc cctggccagg caggcgccct ttgccctccc tgaaggtcca atctcctggg
     3361 caccgtggaa gggctggggt gtgtgcctgc tgtacatgaa gcccctggag ttccctgcag
     3421 gcctcaaagc ccccaggaca tgctgctctg tgctttctgg ggacagagag gccgaggcac
     3481 caacagcagt ggccacgtct gttccatcct atctcagggc ctcggtttcc ccacctgtaa
     3541 gccagggtga gactgtgggc tctgaagtcc tgaccttcac tctgtggtga tttacgggaa
     3601 gaaagacaat cccagcctgg agcccctgag ctctcctggg tggccgagct cagactggca
     3661 tcgaggggcc tggggtaggg gcggactgag ctgctacccc atcctcgaca tccctttagg
     3721 gcagggggac tctgggtgcc atggtaggga gcgcctgtgt caagcagcaa agccccctaa
     3781 tgtcaagagc ctcctccagg gcctgccacg gcatcttcct ggccagcaac atgtgtgcac
     3841 ccaccgaggt acgccccagc cactcccatc tgtgcccatc agggactccc catagcacga
     3901 gcgaacagcc agccctgttt atttataggc cttttcagga agagctagca gggcagtgct
     3961 aagacaggaa acccagtcca cattttaggg cttccttaaa caggcttctg agagtcgtat
     4021 cttttttctt ttttttccag aaaaaaacaa aacaaaactt ttttgccaaa acacctcctc
     4081 aataaacaac atgtaaacag aaa
//
