LOCUS       NM_002333               4058 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens LDL receptor related protein 3 (LRP3), mRNA.
ACCESSION   NM_002333
VERSION     NM_002333.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4058)
  AUTHORS   Cuchillo-Ibanez,I., Lennol,M.P., Escamilla,S., Mata-Balaguer,T.,
            Valverde-Vozmediano,L., Lopez-Font,I., Ferrer,I. and Saez-Valero,J.
  TITLE     The apolipoprotein receptor LRP3 compromises APP levels
  JOURNAL   Alzheimers Res Ther 13 (1), 181 (2021)
   PUBMED   34727970
  REMARK    GeneRIF: The apolipoprotein receptor LRP3 compromises APP levels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4058)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   3  (bases 1 to 4058)
  AUTHORS   Elsafadi,M., Manikandan,M., Alajez,N.M., Hamam,R., Dawud,R.A.,
            Aldahmash,A., Iqbal,Z., Alfayez,M., Kassem,M. and Mahmood,A.
  TITLE     MicroRNA-4739 regulates osteogenic and adipocytic differentiation
            of immortalized human bone marrow stromal cells via targeting LRP3
  JOURNAL   Stem Cell Res 20, 94-104 (2017)
   PUBMED   28340487
  REMARK    GeneRIF: Low-density lipoprotein receptor-related protein 3
            (-deficient cells showed impaired osteoblastic and enhanced
            adipocytic differentiation.
REFERENCE   4  (bases 1 to 4058)
  AUTHORS   Takatsu,H., Katoh,Y., Shiba,Y. and Nakayama,K.
  TITLE     Golgi-localizing, gamma-adaptin ear homology domain,
            ADP-ribosylation factor-binding (GGA) proteins interact with acidic
            dileucine sequences within the cytoplasmic domains of sorting
            receptors through their Vps27p/Hrs/STAM (VHS) domains
  JOURNAL   J Biol Chem 276 (30), 28541-28545 (2001)
   PUBMED   11390366
REFERENCE   5  (bases 1 to 4058)
  AUTHORS   Ishii,H., Kim,D.H., Fujita,T., Endo,Y., Saeki,S. and Yamamoto,T.T.
  TITLE     cDNA cloning of a new low-density lipoprotein receptor-related
            protein and mapping of its gene (LRP3) to chromosome bands
            19q12-q13. 2
  JOURNAL   Genomics 51 (1), 132-135 (1998)
   PUBMED   9693042
REFERENCE   6  (bases 1 to 4058)
  AUTHORS   Korenberg,J.R., Argraves,K.M., Chen,X.N., Tran,H., Strickland,D.K.
            and Argraves,W.S.
  TITLE     Chromosomal localization of human genes for the LDL receptor family
            member glycoprotein 330 (LRP2) and its associated protein RAP
            (LRPAP1)
  JOURNAL   Genomics 22 (1), 88-93 (1994)
   PUBMED   7959795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008738.7, AB009462.1, BC007408.2, DA496540.1 and AK126750.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002333.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB009462.1, AK296536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253193.9/ ENSP00000253193.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               AC008738.7         63449-63811
            364-398             AB009462.1         110-144
            399-608             AB009462.1         169-378
            609-1487            BC007408.2         175-1053
            1488-2024           DA496540.1         32-568
            2025-2833           AK126750.1         2470-3278
            2834-4058           AC008738.7         76759-77983
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..4058
                     /gene="LRP3"
                     /note="LDL receptor related protein 3"
                     /db_xref="GeneID:4037"
                     /db_xref="HGNC:HGNC:6695"
                     /db_xref="MIM:603159"
     exon            1..529
                     /gene="LRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2769
                     /gene="LRP3"
                     /note="low-density lipoprotein receptor-related protein 3;
                     LRP-3; hLRp105; 105 kDa low-density lipoprotein
                     receptor-related protein; CTD-2540B15.13"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     3 precursor"
                     /protein_id="NP_002324.2"
                     /db_xref="CCDS:CCDS12430.1"
                     /db_xref="GeneID:4037"
                     /db_xref="HGNC:HGNC:6695"
                     /db_xref="MIM:603159"
                     /translation="MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACS
                     GKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD
                     WLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK
                     LGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFP
                     CSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG
                     PSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPV
                     SLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCF
                     SEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK
                     NCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVC
                     GLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVE
                     DFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPL
                     LTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGP
                     PLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHPQVSTASSTLGPH
                     SPEPLGVCRNPPPPCSPMLEASDDEALLVC"
     exon            530..577
                     /gene="LRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..716
                     /gene="LRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            717..931
                     /gene="LRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            932..2048
                     /gene="LRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2181
                     /gene="LRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..4058
                     /gene="LRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP3"
                     /note="hexamer: AATACA"
     polyA_site      2839
                     /gene="LRP3"
                     /note="major polyA site"
     regulatory      4036..4041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP3"
                     /note="hexamer: AATAAA"
     polyA_site      4058
                     /gene="LRP3"
                     /note="major polyA site"
ORIGIN      
        1 gacagaccca cggacgctct accggcggca cccggccggg cgggctgggc gcagcgcggg
       61 gcggcccggg gacgccgggg ccgggcgggc tgcgcgccgc ggggcatggg cgcgccgggg
      121 gtccccgggc ccaggccggc cgcggcgggg ctcccggggc gcgggggcag cggcgggcgg
      181 gggtcttccc tggcggccgc cgctgagccc ccgcagggcc cgtgacgccg cggccgatgt
      241 ggccgcgcgc gccctacggg cctgcaccgc caccgcacaa agacgcctcg ggagccgccg
      301 cctgcacccg ggccgcagca gccacgccag ccggagcccg agccctagcc cgagcccgag
      361 cccgagccgc agccagagcc agagccggag ccgcagccgg aaccggagcc ggagccgcgg
      421 ggcaggaggc ggcgcccgcg ggcggccggg cccggcatgg agaagcgcgc ggccgcgggg
      481 ctggagggcg cgccgggcgc ccgggcgcag ctggccgtcg tctgtctggt gaacatcttt
      541 ctcaccggga gactcagcag tgcggttcct gccttagcgg cctgcagtgg gaagctggag
      601 cagcacacgg agcggcgtgg ggtcatctac agcccggcct ggcccctcaa ctacccgcca
      661 ggcaccaact gcagctggta catccagggc gaccgtggtg acatgattac catcagcttc
      721 cgcaactttg acgtggagga gtcccaccag tgctccctgg actggctcct gctgggccca
      781 gcagccccac cccgccagga ggccttccgc ctctgtggct ccgccatccc acctgccttc
      841 atctctgccc gcgaccatgt ctggattttc ttccactcag acgcctccag ctccggccag
      901 gcccagggct tccgtctgtc ttacatccga gggaagctgg gccaggcatc ctgccaggca
      961 gatgagttcc gctgtgacaa cggcaagtgc ctgcccggcc cgtggcagtg caacacggtg
     1021 gacgagtgtg gagacggctc tgatgagggc aactgctcgg cgcccgcctc cgagcctcca
     1081 ggcagcctgt gccccggggg gaccttccca tgcagcgggg cgcgctccac gcgctgcctg
     1141 cctgtggagc ggcgctgtga cggcttgcag gactgcggcg acggctcgga tgaggcgggc
     1201 tgccccgacc tggcgtgcgg ccggcggctg ggcagcttct acggctcctt tgcctcccca
     1261 gacctgttcg gcgccgctcg cgggccctca gaccttcact gcacgtggct ggtggacaca
     1321 caggactccc ggcgggtgct gctgcagctg gaactgcggc tgggctatga cgactacgtg
     1381 caggtatacg agggcctggg cgagcgcggg gaccgcctgc tgcagacgct gtcctaccgc
     1441 agcaaccacc ggcccgtgag cctggaggcc gcccagggcc gcctcactgt ggcctaccac
     1501 gcgcgcgccc gcagcgccgg ccacggcttc aatgccacct accaggtgaa gggctattgc
     1561 ctcccctggg agcagccgtg cgggagcagt agtgacagtg acgggggcag cctgggcgac
     1621 cagggctgct tctcagagcc acagcgctgt gatggctggt ggcattgtgc cagcggccga
     1681 gacgagcagg gctgccctgc ctgcccgccc gaccagtacc cctgcgaggg tggcagtggt
     1741 ctgtgctaca cgcctgccga ccgctgcaac aaccagaaaa gctgtcccga cggcgccgac
     1801 gagaagaact gcttctcctg ccagcccggc accttccact gcggtaccaa cctgtgcatc
     1861 ttcgagacgt ggcgctgtga cggccaggaa gactgccagg acggcagcga tgagcatggg
     1921 tgcctggccg ccgtgccccg caaggtcatc acggcggcgc tcattggcag cctggtgtgt
     1981 ggcctgctgc tggtcatcgc gctgggctgc gccttcaagc tctactcact gcgcacgcag
     2041 gaatacaggg ccttcgagac ccagatgacg cgcctggagg ctgagttcgt gcggcgggag
     2101 gcacccccat cctatggtca gctcatcgcc cagggcctca ttccacccgt ggaggacttt
     2161 cctgtctaca gtgcgtccca ggcctctgtg ctgcagaatc ttcgcacagc catgcggaga
     2221 cagatgcgtc ggcacgcctc ccgccggggg ccctcccgcc gccgcctcgg ccgcctctgg
     2281 aaccggctct ttcaccggcc gcgggcgccc cgaggccaga tcccactgct gaccgcagca
     2341 cgcccctcac agaccgtgct gggcgatggc ttcctccagc ctgctccagg ggctgccccc
     2401 gaccccccag caccgctcat ggacacaggc agcaccaggg cggccggaga caggcccccc
     2461 agtgcccccg gccgtgcacc ggaggtggga ccttcagggc cacccttgcc ctcgggcctg
     2521 cgagacccag agtgcaggcc cgtggacaag gacagaaagg tctgcaggga gccactggta
     2581 gacggcccag ctcctgcaga tgcacctcgg gagccctgct cagcccagga cccgcacccc
     2641 caggtctcca ctgccagcag caccctgggc ccccactcgc cagagccact gggggtctgc
     2701 aggaaccccc cgcccccctg ctccccaatg ctggaggcca gcgatgatga ggccctgttg
     2761 gtctgttgac cgctgggctc gctggtgacc gccacagccc cgctttgtaa ccagggaata
     2821 cacagtcatt tctaccctgc ctctgcgtcc tttcttatgg agaggccctc cggggacccc
     2881 agcggagggg ctggccccta agccagctgg ctgcactggt gggcgggagc tgtgggactg
     2941 aacggcgggg gggagaagag tggagtggtg agcccgtctg cagggtccca ttgtacacaa
     3001 gcaccctggg gtctcacttc tctcccccca ctccattctg ggaacccatt tccagagaag
     3061 caggggacca gagccttttt gcttcatctg ccctgcagtg gcaacagctg cccctagagc
     3121 tgggagttgt catgaggatg gggccgggcc atggggacgc tgggtctcat ccgtggtgac
     3181 tattttgctc acgcctcacc ctcttcctgt ccagcaaggc ctctggagga cctgggttgg
     3241 gtggctcctg ccaaaccctc atgcccctgg ccaggcaggc gccctttgcc ctccctgaag
     3301 gtccaatctc ctgggcaccg tggaagggct ggggtgtgtg cctgctgtac atgaagcccc
     3361 tggagttccc tgcaggcctc aaagccccca ggacatgctg ctctgtgctt tctggggaca
     3421 gagaggccga ggcaccaaca gcagtggcca cgtctgttcc atcctatctc agggcctcgg
     3481 tttccccacc tgtaagccag ggtgagactg tgggctctga agtcctgacc ttcactctgt
     3541 ggtgatttac gggaagaaag acaatcccag cctggagccc ctgagctctc ctgggtggcc
     3601 gagctcagac tggcatcgag gggcctgggg taggggcgga ctgagctgct accccatcct
     3661 cgacatccct ttagggcagg gggactctgg gtgccatggt agggagcgcc tgtgtcaagc
     3721 agcaaagccc cctaatgtca agagcctcct ccagggcctg ccacggcatc ttcctggcca
     3781 gcaacatgtg tgcacccacc gaggtacgcc ccagccactc ccatctgtgc ccatcaggga
     3841 ctccccatag cacgagcgaa cagccagccc tgtttattta taggcctttt caggaagagc
     3901 tagcagggca gtgctaagac aggaaaccca gtccacattt tagggcttcc ttaaacaggc
     3961 ttctgagagt cgtatctttt ttcttttttt tccagaaaaa aacaaaacaa aacttttttg
     4021 ccaaaacacc tcctcaataa acaacatgta aacagaaa
//
