LOCUS       NM_018409               5164 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LRP2 binding protein (LRP2BP), transcript variant 5,
            mRNA.
ACCESSION   NM_018409
VERSION     NM_018409.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5164)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5164)
  AUTHORS   Pu,W., Wu,W., Liu,Q., Ma,Y., Tu,W., Zuo,X., Guo,G., Jiang,S.,
            Zhao,Y., Zuo,X., Wang,Q., Yang,L., Xiao,R., Chu,H., Wang,L.,
            Sun,L., Cui,J., Yu,L., Li,H., Li,Y., Shi,Y., Zhang,J., Zhang,H.,
            Liang,M., Chen,D., Ding,Y., Chen,X., Chen,Y., Zhang,R., Zhao,H.,
            Li,Y., Qi,Q., Bai,P., Zhao,L., Reveille,J.D., Mayes,M.D., Jin,L.,
            Lee,E.B., Zhang,X., Xu,J., Zhang,Z., Zhou,X., Zou,H. and Wang,J.
  TITLE     Exome-Wide Association Analysis Suggests LRP2BP as a Susceptibility
            Gene for Endothelial Injury in Systemic Sclerosis in the Han
            Chinese Population
  JOURNAL   J Invest Dermatol 141 (5), 1254-1263 (2021)
   PUBMED   33069728
  REMARK    GeneRIF: Exome-Wide Association Analysis Suggests LRP2BP as a
            Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in
            the Han Chinese Population.
REFERENCE   3  (bases 1 to 5164)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5164)
  AUTHORS   Zhang,Y., Zheng,L., Xu,B.M., Tang,W.H., Ye,Z.D., Huang,C., Ma,X.,
            Zhao,J.J., Guo,F.X., Kang,C.M., Lu,J.B., Xiu,J.C., Li,P., Xu,Y.J.,
            Xiao,L., Wu,Q., Hu,Y.W. and Wang,Q.
  TITLE     LncRNA-RP11-714G18.1 suppresses vascular cell migration via
            directly targeting LRP2BP
  JOURNAL   Immunol Cell Biol 96 (2), 175-189 (2018)
   PUBMED   29363163
  REMARK    GeneRIF: RP11-714G18.1 may play an athero-protective role by
            inhibiting vascular cell migration via RP11-714G18.1/LRP2BP/MMP1
            signaling pathway.
REFERENCE   5  (bases 1 to 5164)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5164)
  AUTHORS   Stora,S., Conte,M., Chouery,E., Richa,S., Jalkh,N., Gillart,A.C.,
            Joannis,A.L. and Megarbane,A.
  TITLE     A 56-year-old female patient with facio-oculo-acoustico-renal
            syndrome (FOAR) syndrome. Report on the natural history and of a
            novel mutation
  JOURNAL   Eur J Med Genet 52 (5), 341-343 (2009)
   PUBMED   19577669
  REMARK    GeneRIF: A 56-year-old female patient with FOAR syndrome and a
            novel mutation is reported.
REFERENCE   7  (bases 1 to 5164)
  AUTHORS   Thrailkill,K.M., Nimmo,T., Bunn,R.C., Cockrell,G.E., Moreau,C.S.,
            Mackintosh,S., Edmondson,R.D. and Fowlkes,J.L.
  TITLE     Microalbuminuria in type 1 diabetes is associated with enhanced
            excretion of the endocytic multiligand receptors megalin and
            cubilin
  JOURNAL   Diabetes Care 32 (7), 1266-1268 (2009)
   PUBMED   19366958
  REMARK    GeneRIF: Aberrant shedding of megalin and cubilin may contribute to
            albuminuria in diabetes and to deficiency states of important
            vitamins and hormones.
REFERENCE   8  (bases 1 to 5164)
  AUTHORS   Li,J., Ji,C., Zheng,H., Fei,X., Zheng,M., Dai,J., Gu,S., Xie,Y. and
            Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human gene
            containing 4 ankyrin repeat domains
  JOURNAL   Cell Mol Biol Lett 10 (1), 185-193 (2005)
   PUBMED   15809689
  REMARK    GeneRIF: both in the cytoplasm and nucleus, 4 ankyrin repeats
REFERENCE   9  (bases 1 to 5164)
  AUTHORS   Petersen,H.H., Hilpert,J., Militz,D., Zandler,V., Jacobsen,C.,
            Roebroek,A.J. and Willnow,T.E.
  TITLE     Functional interaction of megalin with the megalinbinding protein
            (MegBP), a novel tetratrico peptide repeat-containing adaptor
            molecule
  JOURNAL   J Cell Sci 116 (Pt 3), 453-461 (2003)
   PUBMED   12508107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073344.7.
            
            On Jul 21, 2020 this sequence version replaced NM_018409.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152444.1, AB037746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-918               AC073344.7         188680-189597       c
            919-1028            AC073344.7         187508-187617       c
            1029-1142           AC073344.7         186212-186325       c
            1143-1285           AC073344.7         184918-185060       c
            1286-1391           AC073344.7         184734-184839       c
            1392-1615           AC073344.7         183455-183678       c
            1616-1790           AC073344.7         181239-181413       c
            1791-5164           AC073344.7         174471-177844       c
FEATURES             Location/Qualifiers
     source          1..5164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..5164
                     /gene="LRP2BP"
                     /note="LRP2 binding protein"
                     /db_xref="GeneID:55805"
                     /db_xref="HGNC:HGNC:25434"
                     /db_xref="MIM:619020"
     exon            1..918
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             813..1856
                     /gene="LRP2BP"
                     /note="isoform 1 is encoded by transcript variant 5;
                     megalin-binding protein; megBP"
                     /codon_start=1
                     /product="LRP2-binding protein isoform 1"
                     /protein_id="NP_060879.2"
                     /db_xref="CCDS:CCDS3840.1"
                     /db_xref="GeneID:55805"
                     /db_xref="HGNC:HGNC:25434"
                     /db_xref="MIM:619020"
                     /translation="MKLTSEKLPKNPFYASVSQYAAKNQKFFQWKKEKTDYTHANLVD
                     KALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYD
                     GLGTTLDAEKGVDYMKKILDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLW
                     LIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYL
                     YGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVH
                     DIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPAL
                     ADELHSLLIRQRI"
     exon            919..1028
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1142
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1285
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1391
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1615
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1790
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..5164
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AACAAA"
     polyA_site      1899
                     /gene="LRP2BP"
                     /note="major polyA site"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: ATTAAA"
     polyA_site      2135
                     /gene="LRP2BP"
                     /note="major polyA site"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AGTAAA"
     polyA_site      2864
                     /gene="LRP2BP"
     regulatory      4094..4099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AATATA"
     polyA_site      4111
                     /gene="LRP2BP"
     polyA_site      5131
                     /gene="LRP2BP"
     regulatory      5135..5140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AATAAA"
     polyA_site      5164
                     /gene="LRP2BP"
ORIGIN      
        1 gcatcatgga atgatataaa aatgcagctt tccaatcaca ctaagggtct ctctatttct
       61 tctcttgacc accaatcagg aacctttgct ggaagcttgt ttctgattgg tgaaagtaag
      121 ccataacagt ggaatgccaa ggagtaaata caaaagtgta gcaacaactg agtttgctgt
      181 ctcactaccc tcagcctagg ccaacctgga ctccttcacc ccaaatgagg tgaccgctac
      241 attttatatg aagacactga tttaccattc aactgtgatc catcttataa catggcaatc
      301 caatacagac aggaagataa aactcaacaa cagctaaaat aaagtgtatt cccaggtaaa
      361 atagacaagt gctttaattt gaaatggatt cgtccgatga gtgtcagtta caagggcaga
      421 gaaggtacca gtgcagaaga gctctgactg tgggcagtgt caccaggtcc cactaagtgg
      481 caacacttgt gctgggtgac ttgacccatc ttgatgtata aacccatagc cagacaggac
      541 gtgcaaacag gtctcatggt gaatgcgatg ctgtggaaaa tgacatggag aatggctgtc
      601 tctcagctag ggaggagggt cttggtgtcc tagtaaagaa tgttcacgtc ctggagttgg
      661 tggttggtgt tctatctagg cgatgagaga aggatgcttt tcctaatgag cacctggtgg
      721 gaatagagtc tctctttgca cttcgctgga ggaagaaatt tctaccactt attttttctt
      781 cttgcttata gaatacacat tgcagaaaaa ggatgaagtt gaccagtgaa aagttgccca
      841 agaacccctt ttatgcctct gtatctcagt atgctgctaa aaaccaaaaa tttttccagt
      901 ggaaaaagga aaagactgat tacacccatg ctaatttggt ggataaggca ttgcagctct
      961 tgaaggaaag aatactgaaa ggagacactc tggcatattt cctacgaggt caactatatt
     1021 ttgaagaggg atggtatgaa gaagcattag aacagtttga agaaatcaag gagaaagacc
     1081 atcaagcaac ttaccagcta ggagtgatgt actatgatgg gctggggacc actctagacg
     1141 ctgagaaagg ggtggactat atgaagaaaa ttcttgattc tccatgtccc aaagcaagac
     1201 acttaaaatt tgcagctgct tacaacctcg gaagagctta ttatgaagga aaaggtgtta
     1261 aacgatcaaa tgaggaagct gaaagactgt ggcttatcgc agcagacaat ggaaatccca
     1321 aagctagtgt gaaggctcaa agtatgctcg ggctgtatta ctcaaccaag gagcccaagg
     1381 agttagaaaa ggcattttac tggcattccg aagcatgtgg caatgggaat ctggagtccc
     1441 agggtgcact tgggctcatg tacttgtatg gacaaggcat ccggcaggat acggaagctg
     1501 ccctgcagtg cttaagagaa gcagcagaac gcggaaacgt ctatgctcaa gggaatctcg
     1561 tggagtatta ctataagatg aaatttttta caaagtgtgt tgcattttcc aaaaggatcg
     1621 ctgactatga tgaggttcac gacatcccca tgatcgccca ggtcacagac tgtctcccgg
     1681 agttcatcgg cagaggcatg gcaatggcat ccttctacca cgcaaggtgt cttcagcttg
     1741 gcttgggcat caccagggat gaaacaaccg ctaaacacta ttattctaaa gcttgtcgtc
     1801 tgaatcccgc attggcagat gaacttcact ccttacttat tcgtcaaaga atttagacca
     1861 caatgtattt caacaaagat catcaatgct aacacctcac aatgtgtgta tttttacagt
     1921 agctatgttt ggttattttg cacatcacaa attacactat cctgggtatt ttacaggtga
     1981 catgttactt cgttcttgaa ttcgtacgct gttaagtttt gcaacttgaa acctagacac
     2041 aaggtcaaat tgctggaaga gtcctcagag gtccacctct taccctacag actggccgag
     2101 accatatcaa gtattaaaac cattctatac agcaagtatc gtttatcctt tcttaaacac
     2161 cgagtctcca aaaatactta gtttagcttt agtttagtaa gttcagaagt agaaacaaac
     2221 ttatttaaaa ccatcatttg aaagtttaat tctttaaatt tgtctcttag ttttgtgaat
     2281 tttgaataat aatgtttaaa ttttgtttca gtcatttaaa atttaaattt tcagtcattt
     2341 aaaattttaa aaatttaaaa tttcacaaaa ctaagggtaa aagacattta aagaattaaa
     2401 cttaaataag tgtgtgcagc atttctactt ctgaagttat taaagctaaa actgcactaa
     2461 gccttttgag acatccttta ttcttaaaaa gctcataaat aattggctta ttacatataa
     2521 acttcaaaaa agtgggttat aagacattgc tttagaatct tgcccctcca aatcttccct
     2581 caaagatctt aatgagtaaa acaactgcta catacatatg cagaatgtgt aataaaacaa
     2641 aaagcaattg ctatatgaaa atattcgtaa gaaaagtaaa gcaaattgtt tctttgtgct
     2701 tcagctcatt ttccatattt ttaaaaccct gtggtaaaag cctcaatgaa atcatttaca
     2761 agaactacaa ttaaatattg ttaaaattag caaaaggctt tccgtatata gatgacatct
     2821 atgaaggcaa aaggtgacag taaaaacagt aagatccata tgcataagat tgtacaaggc
     2881 tattcatttg tgaaacaaat atacatatcg aagacaggtc tcagagatac cttaactatt
     2941 ccttttttta taaacatatt aaaggatgtg gctttatttt ataaatcaca accatcccaa
     3001 cagtggattt aaacaagatt tctttttagt aatgggaaaa tgcaattaat atggaggtga
     3061 tagtcactaa gaactgttga atggcagaaa agtatttgct ctcgttttat gttctggctt
     3121 gtctgtattg cctgaacttc attttgtctt tgtgtaaggg aagaaatttc aacagactcg
     3181 ggtttgagat atcctcaaat ggtcatgtat ttctgtctca aatctcttaa taccacccat
     3241 gtaacattcc ttcaaccact tgaagatcca aattcccaac tagtattctc ttctccacac
     3301 ttaatccagt tcctaaagat tattattatt attattatta ttattttttt ttttttgaga
     3361 cggagtctcc tgacctaatc ttagcccggc gcagtggctc acgtctgtaa tcccagcact
     3421 ttgggaggct gaggcgggca gatcatgagg tcaggagttt gagaccaggc tggccaacgt
     3481 ggtgaaaccc cgtctctact aaaaatacaa aaattagccg ggcgtgatgg cggacgcctg
     3541 tagtcccagc tactcgggag gctgagacag aagaactgct tgaaaccagg aggcagaggt
     3601 tgcagtgagc tgagatcgcg caaattgcac tccagcctcg gtgacaagag cgagactcca
     3661 tctcaaaaaa aaataaaaag aatcttaaaa taggaacata ataaaagatc ggccctaagt
     3721 aaagagcact ttttaaactg ccattaaaga tgggtttcag aaatcataaa ctttgacgtg
     3781 tgccatacat ggtaacatgc tatgcttata tgtcttctat aaatccaatg cagaatttaa
     3841 aatttcagtt tactctagtt accataaagc taatgctctg gcacaagcga gtccctgcaa
     3901 actaccactg ctgaggacag tagtaaaccc cttgacctga gactgcggtg agtctgtaac
     3961 tcgagtgcat tgagacttcc agatcattac tcttacacac acacacacac acacacatac
     4021 acacacacac actccttctc taagattcct tgtagctgat atctcatgga aaaatgacat
     4081 tttatcataa ataaatatag agacaaaata atagtgatct ttctcattcg caatgtaaac
     4141 ttaacagcta cagtttaaat gatagcatag aattatgcct aaaatagaca tttcccataa
     4201 ttgtattgtg ataagttctt caggcttgac aacttcacat tgcctctctt ccttgaatgt
     4261 attttatctg gtcttttcta tatagtcttt tgaaggataa tttttatcaa tagccaactt
     4321 tgggtatttt tttaagtgtc aaatatcatc atggtttgaa aaaaggataa aaaagctata
     4381 actaaaaaaa tcttaaggat aacatttggt ttactaattt ttaatcattt atctttcaga
     4441 acttgtttct tatcaagaag ttagcaggta tgatatgtat atcatacgta tataaactgg
     4501 cataggttac atcctagggc atgaggggag tatctttcag ggattcaaat ggaattttta
     4561 cctgttactt gtttaattgt tttgttttca atattcttgg ggattagaca ggggaaggta
     4621 ttttattact gcataataga tggtgaaacc caggaaaatt aagtacttgt gcatggcccc
     4681 actatcaata acacaaagtc tgtactctgg atctccccta atgtccctgt ggtctaaacg
     4741 gcttgataat acaaccgagc ccctgaagta gctgccctcc tctttccgct cccccatctc
     4801 ggccctgccc atactccaag ggtcagctcc catctctcct ccctaatgcc tcacttcaag
     4861 cactaatttg gctctttctg ctcactaaaa atcatatatt ttacagattt attttgtttc
     4921 tggagaaggc agcaaacttt tacttccctg cagaagtagt taagtacata gtgttttctc
     4981 taaaaaggca tttgataaat atttgaacag cctgtagagt ttcaacctct ttgagatata
     5041 agtatcttaa atatcataga gcactgtgat tcatttttat attttattgc tttgaatgct
     5101 caaactatgg gaaatctttg gtaaaaataa agacaataaa atcttcacaa taactttaca
     5161 caaa
//
