LOCUS       NM_001377440            5519 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LRP2 binding protein (LRP2BP), transcript variant 1,
            mRNA.
ACCESSION   NM_001377440 XM_006714260
VERSION     NM_001377440.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5519)
  AUTHORS   Pu,W., Wu,W., Liu,Q., Ma,Y., Tu,W., Zuo,X., Guo,G., Jiang,S.,
            Zhao,Y., Zuo,X., Wang,Q., Yang,L., Xiao,R., Chu,H., Wang,L.,
            Sun,L., Cui,J., Yu,L., Li,H., Li,Y., Shi,Y., Zhang,J., Zhang,H.,
            Liang,M., Chen,D., Ding,Y., Chen,X., Chen,Y., Zhang,R., Zhao,H.,
            Li,Y., Qi,Q., Bai,P., Zhao,L., Reveille,J.D., Mayes,M.D., Jin,L.,
            Lee,E.B., Zhang,X., Xu,J., Zhang,Z., Zhou,X., Zou,H. and Wang,J.
  TITLE     Exome-Wide Association Analysis Suggests LRP2BP as a Susceptibility
            Gene for Endothelial Injury in Systemic Sclerosis in the Han
            Chinese Population
  JOURNAL   J Invest Dermatol 141 (5), 1254-1263 (2021)
   PUBMED   33069728
  REMARK    GeneRIF: Exome-Wide Association Analysis Suggests LRP2BP as a
            Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in
            the Han Chinese Population.
REFERENCE   3  (bases 1 to 5519)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5519)
  AUTHORS   Zhang,Y., Zheng,L., Xu,B.M., Tang,W.H., Ye,Z.D., Huang,C., Ma,X.,
            Zhao,J.J., Guo,F.X., Kang,C.M., Lu,J.B., Xiu,J.C., Li,P., Xu,Y.J.,
            Xiao,L., Wu,Q., Hu,Y.W. and Wang,Q.
  TITLE     LncRNA-RP11-714G18.1 suppresses vascular cell migration via
            directly targeting LRP2BP
  JOURNAL   Immunol Cell Biol 96 (2), 175-189 (2018)
   PUBMED   29363163
  REMARK    GeneRIF: RP11-714G18.1 may play an athero-protective role by
            inhibiting vascular cell migration via RP11-714G18.1/LRP2BP/MMP1
            signaling pathway.
REFERENCE   5  (bases 1 to 5519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5519)
  AUTHORS   Stora,S., Conte,M., Chouery,E., Richa,S., Jalkh,N., Gillart,A.C.,
            Joannis,A.L. and Megarbane,A.
  TITLE     A 56-year-old female patient with facio-oculo-acoustico-renal
            syndrome (FOAR) syndrome. Report on the natural history and of a
            novel mutation
  JOURNAL   Eur J Med Genet 52 (5), 341-343 (2009)
   PUBMED   19577669
  REMARK    GeneRIF: A 56-year-old female patient with FOAR syndrome and a
            novel mutation is reported.
REFERENCE   7  (bases 1 to 5519)
  AUTHORS   Thrailkill,K.M., Nimmo,T., Bunn,R.C., Cockrell,G.E., Moreau,C.S.,
            Mackintosh,S., Edmondson,R.D. and Fowlkes,J.L.
  TITLE     Microalbuminuria in type 1 diabetes is associated with enhanced
            excretion of the endocytic multiligand receptors megalin and
            cubilin
  JOURNAL   Diabetes Care 32 (7), 1266-1268 (2009)
   PUBMED   19366958
  REMARK    GeneRIF: Aberrant shedding of megalin and cubilin may contribute to
            albuminuria in diabetes and to deficiency states of important
            vitamins and hormones.
REFERENCE   8  (bases 1 to 5519)
  AUTHORS   Li,J., Ji,C., Zheng,H., Fei,X., Zheng,M., Dai,J., Gu,S., Xie,Y. and
            Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human gene
            containing 4 ankyrin repeat domains
  JOURNAL   Cell Mol Biol Lett 10 (1), 185-193 (2005)
   PUBMED   15809689
  REMARK    GeneRIF: both in the cytoplasm and nucleus, 4 ankyrin repeats
REFERENCE   9  (bases 1 to 5519)
  AUTHORS   Petersen,H.H., Hilpert,J., Militz,D., Zandler,V., Jacobsen,C.,
            Roebroek,A.J. and Willnow,T.E.
  TITLE     Functional interaction of megalin with the megalinbinding protein
            (MegBP), a novel tetratrico peptide repeat-containing adaptor
            molecule
  JOURNAL   J Cell Sci 116 (Pt 3), 453-461 (2003)
   PUBMED   12508107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106897.5 and AC073344.7.
            
            On Jan 13, 2020 this sequence version replaced XM_006714260.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126913.1, SRR1803617.43529.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505916.6/ ENSP00000426203.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1146              AC106897.5         2809-3954           c
            1147-1273           AC073344.7         188680-188806       c
            1274-1383           AC073344.7         187508-187617       c
            1384-1497           AC073344.7         186212-186325       c
            1498-1640           AC073344.7         184918-185060       c
            1641-1746           AC073344.7         184734-184839       c
            1747-1970           AC073344.7         183455-183678       c
            1971-2145           AC073344.7         181239-181413       c
            2146-5519           AC073344.7         174471-177844       c
FEATURES             Location/Qualifiers
     source          1..5519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..5519
                     /gene="LRP2BP"
                     /note="LRP2 binding protein"
                     /db_xref="GeneID:55805"
                     /db_xref="HGNC:HGNC:25434"
                     /db_xref="MIM:619020"
     exon            1..1146
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1273
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1168..2211
                     /gene="LRP2BP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     megalin-binding protein; megBP"
                     /codon_start=1
                     /product="LRP2-binding protein isoform 1"
                     /protein_id="NP_001364369.1"
                     /db_xref="CCDS:CCDS3840.1"
                     /db_xref="GeneID:55805"
                     /db_xref="HGNC:HGNC:25434"
                     /db_xref="MIM:619020"
                     /translation="MKLTSEKLPKNPFYASVSQYAAKNQKFFQWKKEKTDYTHANLVD
                     KALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYD
                     GLGTTLDAEKGVDYMKKILDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLW
                     LIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYL
                     YGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVH
                     DIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPAL
                     ADELHSLLIRQRI"
     exon            1274..1383
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1497
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1640
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1746
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1970
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2145
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..5519
                     /gene="LRP2BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AACAAA"
     polyA_site      2254
                     /gene="LRP2BP"
                     /note="major polyA site"
     regulatory      2468..2473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: ATTAAA"
     polyA_site      2490
                     /gene="LRP2BP"
                     /note="major polyA site"
     regulatory      3194..3199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AGTAAA"
     polyA_site      3219
                     /gene="LRP2BP"
     regulatory      4449..4454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AATATA"
     polyA_site      4466
                     /gene="LRP2BP"
     polyA_site      5486
                     /gene="LRP2BP"
     regulatory      5490..5495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2BP"
                     /note="hexamer: AATAAA"
     polyA_site      5519
                     /gene="LRP2BP"
ORIGIN      
        1 agactctccc taagcgtctt tccagaagga tctgcttaga aaccaaagct ccagccgagt
       61 gtttcttttc ccctacattt ttagtgattc ccttctgttg atgcctttga aagctcggag
      121 aaataaatac gtttattgtt atgctgttag aaaacaagtt catgcttgtc ctctaaagat
      181 aagtggtctt ttcattctac tttttgtttt gtagtaagag ccataaaatt tgcaatcgca
      241 agtttatgtt gttatactta gttacccaag gggtagtttt aagcattttt attcatatga
      301 atatttgaat ataaatgtgt gttcaaatat atagaatcgt tcttatattc cacattttta
      361 atatttaaac tattcacaat atcttttaat gatgtttaaa gaacggcagt gtagagatac
      421 tgttgtcaga tttgtgaggt gagcacacgt tgatattgcc agtttcgctt ttgtttatca
      481 attcaataag cactgctttt taaaacacgt gttgaagctt caggtttgca cagaagttca
      541 ttttcaggaa ttcctaacta ataaagggta tcagacacgt tcttacagtt ttgaacataa
      601 atactgcagt tagcatatgt agtgggatat ttgtgtggtg aaagtgcctc catatttcat
      661 atcttttctt tgaaacaaga ttctgttcag tatgcattaa gtggtagtta ttttttaact
      721 tcctgttaca tacgtaaatt tcataaggaa aggaaatttg gggagtcgtt acagcttttc
      781 tccctttaat cacagcgtac ctgtccattg ctcacattgt tttcagaaaa aaaagttgta
      841 tctcagctgg atatctgact tgactttagt aatgggccta gaaactataa actgaacaaa
      901 gcttataatg cacaaaaaca ggataagtac atttggggga caatatctta ctggcaagta
      961 actggagttt caccaggcgt gtagcaggtg ggatcaattt tctaaaacgg aagatgatct
     1021 aagatgcata ttttataggc gttctcctaa gcagtgctaa ttctacatgt tttaattgct
     1081 ggtagatgcg tttccagaac gaggatgcca tttacagcga gtgttaaaaa aaacgttgga
     1141 tgatgaaata cacattgcag aaaaaggatg aagttgacca gtgaaaagtt gcccaagaac
     1201 cccttttatg cctctgtatc tcagtatgct gctaaaaacc aaaaattttt ccagtggaaa
     1261 aaggaaaaga ctgattacac ccatgctaat ttggtggata aggcattgca gctcttgaag
     1321 gaaagaatac tgaaaggaga cactctggca tatttcctac gaggtcaact atattttgaa
     1381 gagggatggt atgaagaagc attagaacag tttgaagaaa tcaaggagaa agaccatcaa
     1441 gcaacttacc agctaggagt gatgtactat gatgggctgg ggaccactct agacgctgag
     1501 aaaggggtgg actatatgaa gaaaattctt gattctccat gtcccaaagc aagacactta
     1561 aaatttgcag ctgcttacaa cctcggaaga gcttattatg aaggaaaagg tgttaaacga
     1621 tcaaatgagg aagctgaaag actgtggctt atcgcagcag acaatggaaa tcccaaagct
     1681 agtgtgaagg ctcaaagtat gctcgggctg tattactcaa ccaaggagcc caaggagtta
     1741 gaaaaggcat tttactggca ttccgaagca tgtggcaatg ggaatctgga gtcccagggt
     1801 gcacttgggc tcatgtactt gtatggacaa ggcatccggc aggatacgga agctgccctg
     1861 cagtgcttaa gagaagcagc agaacgcgga aacgtctatg ctcaagggaa tctcgtggag
     1921 tattactata agatgaaatt ttttacaaag tgtgttgcat tttccaaaag gatcgctgac
     1981 tatgatgagg ttcacgacat ccccatgatc gcccaggtca cagactgtct cccggagttc
     2041 atcggcagag gcatggcaat ggcatccttc taccacgcaa ggtgtcttca gcttggcttg
     2101 ggcatcacca gggatgaaac aaccgctaaa cactattatt ctaaagcttg tcgtctgaat
     2161 cccgcattgg cagatgaact tcactcctta cttattcgtc aaagaattta gaccacaatg
     2221 tatttcaaca aagatcatca atgctaacac ctcacaatgt gtgtattttt acagtagcta
     2281 tgtttggtta ttttgcacat cacaaattac actatcctgg gtattttaca ggtgacatgt
     2341 tacttcgttc ttgaattcgt acgctgttaa gttttgcaac ttgaaaccta gacacaaggt
     2401 caaattgctg gaagagtcct cagaggtcca cctcttaccc tacagactgg ccgagaccat
     2461 atcaagtatt aaaaccattc tatacagcaa gtatcgttta tcctttctta aacaccgagt
     2521 ctccaaaaat acttagttta gctttagttt agtaagttca gaagtagaaa caaacttatt
     2581 taaaaccatc atttgaaagt ttaattcttt aaatttgtct cttagttttg tgaattttga
     2641 ataataatgt ttaaattttg tttcagtcat ttaaaattta aattttcagt catttaaaat
     2701 tttaaaaatt taaaatttca caaaactaag ggtaaaagac atttaaagaa ttaaacttaa
     2761 ataagtgtgt gcagcatttc tacttctgaa gttattaaag ctaaaactgc actaagcctt
     2821 ttgagacatc ctttattctt aaaaagctca taaataattg gcttattaca tataaacttc
     2881 aaaaaagtgg gttataagac attgctttag aatcttgccc ctccaaatct tccctcaaag
     2941 atcttaatga gtaaaacaac tgctacatac atatgcagaa tgtgtaataa aacaaaaagc
     3001 aattgctata tgaaaatatt cgtaagaaaa gtaaagcaaa ttgtttcttt gtgcttcagc
     3061 tcattttcca tatttttaaa accctgtggt aaaagcctca atgaaatcat ttacaagaac
     3121 tacaattaaa tattgttaaa attagcaaaa ggctttccgt atatagatga catctatgaa
     3181 ggcaaaaggt gacagtaaaa acagtaagat ccatatgcat aagattgtac aaggctattc
     3241 atttgtgaaa caaatataca tatcgaagac aggtctcaga gataccttaa ctattccttt
     3301 ttttataaac atattaaagg atgtggcttt attttataaa tcacaaccat cccaacagtg
     3361 gatttaaaca agatttcttt ttagtaatgg gaaaatgcaa ttaatatgga ggtgatagtc
     3421 actaagaact gttgaatggc agaaaagtat ttgctctcgt tttatgttct ggcttgtctg
     3481 tattgcctga acttcatttt gtctttgtgt aagggaagaa atttcaacag actcgggttt
     3541 gagatatcct caaatggtca tgtatttctg tctcaaatct cttaatacca cccatgtaac
     3601 attccttcaa ccacttgaag atccaaattc ccaactagta ttctcttctc cacacttaat
     3661 ccagttccta aagattatta ttattattat tattattatt tttttttttt tgagacggag
     3721 tctcctgacc taatcttagc ccggcgcagt ggctcacgtc tgtaatccca gcactttggg
     3781 aggctgaggc gggcagatca tgaggtcagg agtttgagac caggctggcc aacgtggtga
     3841 aaccccgtct ctactaaaaa tacaaaaatt agccgggcgt gatggcggac gcctgtagtc
     3901 ccagctactc gggaggctga gacagaagaa ctgcttgaaa ccaggaggca gaggttgcag
     3961 tgagctgaga tcgcgcaaat tgcactccag cctcggtgac aagagcgaga ctccatctca
     4021 aaaaaaaata aaaagaatct taaaatagga acataataaa agatcggccc taagtaaaga
     4081 gcacttttta aactgccatt aaagatgggt ttcagaaatc ataaactttg acgtgtgcca
     4141 tacatggtaa catgctatgc ttatatgtct tctataaatc caatgcagaa tttaaaattt
     4201 cagtttactc tagttaccat aaagctaatg ctctggcaca agcgagtccc tgcaaactac
     4261 cactgctgag gacagtagta aaccccttga cctgagactg cggtgagtct gtaactcgag
     4321 tgcattgaga cttccagatc attactctta cacacacaca cacacacaca catacacaca
     4381 cacacactcc ttctctaaga ttccttgtag ctgatatctc atggaaaaat gacattttat
     4441 cataaataaa tatagagaca aaataatagt gatctttctc attcgcaatg taaacttaac
     4501 agctacagtt taaatgatag catagaatta tgcctaaaat agacatttcc cataattgta
     4561 ttgtgataag ttcttcaggc ttgacaactt cacattgcct ctcttccttg aatgtatttt
     4621 atctggtctt ttctatatag tcttttgaag gataattttt atcaatagcc aactttgggt
     4681 atttttttaa gtgtcaaata tcatcatggt ttgaaaaaag gataaaaaag ctataactaa
     4741 aaaaatctta aggataacat ttggtttact aatttttaat catttatctt tcagaacttg
     4801 tttcttatca agaagttagc aggtatgata tgtatatcat acgtatataa actggcatag
     4861 gttacatcct agggcatgag gggagtatct ttcagggatt caaatggaat ttttacctgt
     4921 tacttgttta attgttttgt tttcaatatt cttggggatt agacagggga aggtatttta
     4981 ttactgcata atagatggtg aaacccagga aaattaagta cttgtgcatg gccccactat
     5041 caataacaca aagtctgtac tctggatctc ccctaatgtc cctgtggtct aaacggcttg
     5101 ataatacaac cgagcccctg aagtagctgc cctcctcttt ccgctccccc atctcggccc
     5161 tgcccatact ccaagggtca gctcccatct ctcctcccta atgcctcact tcaagcacta
     5221 atttggctct ttctgctcac taaaaatcat atattttaca gatttatttt gtttctggag
     5281 aaggcagcaa acttttactt ccctgcagaa gtagttaagt acatagtgtt ttctctaaaa
     5341 aggcatttga taaatatttg aacagcctgt agagtttcaa cctctttgag atataagtat
     5401 cttaaatatc atagagcact gtgattcatt tttatatttt attgctttga atgctcaaac
     5461 tatgggaaat ctttggtaaa aataaagaca ataaaatctt cacaataact ttacacaaa
//
