LOCUS       XM_047444340           15591 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens LDL receptor related protein 2 (LRP2),
            transcript variant X2, mRNA.
ACCESSION   XM_047444340
VERSION     XM_047444340.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..15591
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /note="LDL receptor related protein 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 51 ESTs, 302 long SRA reads, 2 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4036"
                     /db_xref="HGNC:HGNC:6694"
                     /db_xref="MIM:600073"
     CDS             994..14037
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     2 isoform X2"
                     /protein_id="XP_047300296.1"
                     /db_xref="GeneID:4036"
                     /db_xref="HGNC:HGNC:6694"
                     /db_xref="MIM:600073"
                     /translation="MTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDC
                     QIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIH
                     GRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVET
                     PENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFF
                     SDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETV
                     TYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQAS
                     LRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTD
                     ERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFS
                     DMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADK
                     TRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNG
                     LAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWR
                     LGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFP
                     VPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGV
                     DDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAP
                     ASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDL
                     SFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC
                     PTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDN
                     GNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDC
                     PNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDI
                     LGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQ
                     VHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTE
                     TIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFW
                     SDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYN
                     GHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWP
                     LGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDD
                     QPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGEIH
                     RVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL
                     IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNL
                     EHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYT
                     DEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICL
                     PVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAG
                     QGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGI
                     AVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWAD
                     YGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGE
                     NSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLR
                     DVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNC
                     AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLA
                     SGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGS
                     NRTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGL
                     TLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQR
                     IYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNG
                     AECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSD
                     EMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMC
                     NNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDN
                     DCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSER
                     TCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPD
                     RRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGD
                     YSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPH
                     EFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCS
                     CRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQN
                     SNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIE
                     RMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQH
                     CVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPN
                     GITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWN
                     TRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKP
                     GGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGS
                     DELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
                     CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDN
                     DCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEE
                     RTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPS
                     RWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC
                     PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFR
                     CDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCD
                     DADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCL
                     DINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRI
                     RKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPN
                     FESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLI
                     STDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDY
                     LNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWK
                     QNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACP
                     QGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEM
                     AFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKP
                     SENGNGVTFRSGADLNMDIGVSGFGPETAIDRSMAMSEDFVMEMGKQPIIFENPMYSA
                     RDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPTSPAADGTQVTKWNLFKRK
                     SKQTTNFENPIYAQMENEQKESVAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKD
                     TANLVKEDSEV"
ORIGIN      
        1 agtgatgtag tcaactagac ctgagaggac caagggccaa ggaagaccgc acagattgcc
       61 atttgaactg agtcttgaag gagttgggag agtggactgt ggaggatttt gtatgtcaag
      121 ctaagaagtt tggtgccttt gaagaaataa tgtgacagtg cgcattttcg ctgtggaagt
      181 gggcattgca tccctgcaga ctggaggtgt gatgggacca aagactgttc agatgacgcg
      241 gatgaaattg gctgcgctgt tgtgacctgc cagcagggct atttcaagtg ccagagtgag
      301 ggacaatgca tccccaactc ctgggtgtgt gaccaagatc aagactgtga tgatggctca
      361 gatgaacgtc aagattgctc acaaagtaca tgctcaagtc atcagataac atgctccaat
      421 ggtcagtgta tcccaagtga atacaggtgc gaccacgtca gagactgccc cgatggagct
      481 gatgagaatg actgccagta cccaacatgt gagcagctta cttgtgacaa tggggcctgc
      541 tataacacca gtcagaagtg tgattggaaa gttgattgca gggactcctc agatgaaatc
      601 aactgcactg agatatgctt gcacaatgag ttttcatgtg gcaatggaga gtgtatccct
      661 cgtgcttatg tctgtgacca tgacaatgat tgccaagacg gcagtgacga acatgcttgc
      721 aactatccga cctgcggtgg ttaccagttc acttgcccca gtggccgatg catttatcaa
      781 aactgggttt gtgatggaga agatgactgt aaagataatg gagatgaaga tggatgtgaa
      841 agcggtcctc atgatgttca taaatgttcc ccaagagaat ggtcttgccc agagtcggga
      901 cgatgcatct ccatttataa agtttgtgat gggattttag attgcccagg aagagaagat
      961 gaaaacaaca ctagtaccgg aaaatactgt agtatgactc tgtgctctgc cttgaactgc
     1021 cagtaccagt gccatgagac gccgtatgga ggagcgtgtt tttgtccccc aggttatatc
     1081 atcaaccaca atgacagccg tacctgtgtt gagtttgatg attgccagat atggggaatt
     1141 tgtgaccaga agtgtgaaag ccgacctggc cgtcacctgt gccactgtga agaagggtat
     1201 atcttggagc gtggacagta ttgcaaagct aatgattcct ttggcgaggc ctccattatc
     1261 ttctccaatg gtcgggattt gttaattggt gatattcatg gaaggagctt ccggatccta
     1321 gtggagtctc agaatcgtgg agtggccgtg ggtgtggctt tccactatca cctgcaaaga
     1381 gttttttgga cagacaccgt gcaaaataag gttttttcag ttgacattaa tggtttaaat
     1441 atccaagagg ttctcaatgt ttctgttgaa accccagaga acctggctgt ggactgggtt
     1501 aataataaaa tctatctagt ggaaaccaag gtcaaccgca tagatatggt aaatttggat
     1561 ggaagctatc gggttaccct tataactgaa aacttggggc atcctagagg aattgccgtg
     1621 gacccaactg ttggttattt atttttctca gattgggaga gcctttctgg ggaacctaag
     1681 ctggaaaggg cattcatgga tggcagcaac cgtaaagact tggtgaaaac aaagctggga
     1741 tggcctgctg gggtaactct ggatatgata tcgaagcgtg tttactgggt tgactctcgg
     1801 tttgattaca ttgaaactgt aacttatgat ggaattcaaa ggaagactgt agttcatgga
     1861 ggctccctca ttcctcatcc ctttggagta agcttatttg aaggtcaggt gttctttaca
     1921 gattggacaa agatggccgt gctgaaggca aacaagttca cagagaccaa cccacaagtg
     1981 tactaccagg cttccctgag gccctatgga gtgactgttt accattccct cagacagccc
     2041 tatgctacca atccgtgtaa agataacaat gggggctgtg agcaggtctg tgtcctcagc
     2101 cacagaacag ataatgatgg tttgggtttc cgttgcaagt gcacattcgg cttccaactg
     2161 gatacagatg agcgccactg cattgctgtt cagaatttcc tcattttttc atcccaagtt
     2221 gctattcgtg ggatcccgtt caccttgtct acccaggaag atgtcatggt tccagtttcg
     2281 gggaatcctt ctttctttgt cgggattgat tttgacgccc aggacagcac tatctttttt
     2341 tcagatatgt caaaacacat gatttttaag caaaagattg atggcacagg aagagaaatt
     2401 ctcgcagcta acagggtgga aaatgttgaa agtttggctt ttgattggat ttcaaagaat
     2461 ctctattgga cagactctca ttacaagagt atcagtgtca tgaggctagc tgataaaacg
     2521 agacgcacag tagttcagta tttaaataac ccacggtcgg tggtagttca tccttttgcc
     2581 gggtatctat tcttcactga ttggttccgt cctgctaaaa ttatgagagc atggagtgac
     2641 ggatctcacc tcttgcctgt aataaacact actcttggat ggcccaatgg cttggccatc
     2701 gattgggctg cttcacgatt gtactgggta gatgcctatt ttgataaaat tgagcacagc
     2761 acctttgatg gtttagacag aagaagactg ggccatatag agcagatgac acatccgttt
     2821 ggacttgcca tctttggaga gcatttattt tttactgact ggagactggg tgccattatt
     2881 cgagtcagga aagcagatgg tggagaaatg acagttatcc gaagtggcat tgcttacata
     2941 ctgcatttga aatcgtatga tgtcaacatc cagactggtt ctaacgcctg taatcaaccc
     3001 acgcatccta acggtgactg cagccacttc tgcttcccgg tgccaaattt ccagcgagtg
     3061 tgtgggtgcc cttatggaat gaggctggct tccaatcact tgacatgcga gggggaccca
     3121 accaatgaac cacccacaga gcagtgtggc ttattttcct tcccctgtaa aaatggcaga
     3181 tgtgtgccca attactatct ctgtgatgga gtcgatgatt gtcatgataa cagtgatgag
     3241 caactatgtg gcacacttaa taatacctgt tcatcttcgg cgttcacctg tggccatggg
     3301 gagtgcattc ctgcacactg gcgctgtgac aaacgcaacg actgtgtgga tggcagtgat
     3361 gagcacaact gccccaccca cgcacctgct tcctgccttg acacccaata cacctgtgat
     3421 aatcaccagt gtatctcaaa gaactgggtc tgtgacacag acaatgattg tggggatgga
     3481 tctgatgaaa agaactgcaa ttcgacagag acatgccaac ctagtcagtt taattgcccc
     3541 aatcatcgat gtattgacct atcgtttgtc tgtgatggtg acaaggattg tgttgatgga
     3601 tctgatgagg ttggttgtgt attaaactgt actgcttctc aattcaagtg tgccagtggg
     3661 gataaatgta ttggcgtcac aaatcgttgt gatggtgttt ttgattgcag tgacaactcg
     3721 gatgaagcag gctgtccaac caggcctcct ggtatgtgcc actcagatga atttcagtgc
     3781 caagaagatg gtatctgcat cccgaacttc tgggaatgtg atgggcatcc agactgcctc
     3841 tatggatctg atgagcacaa tgcctgtgtc cccaagactt gcccttcatc atatttccac
     3901 tgtgacaacg gaaactgcat ccacagggca tggctctgtg atcgggacaa tgactgcggg
     3961 gatatgagtg atgagaagga ctgccctact cagccctttc gctgtcctag ttggcaatgg
     4021 cagtgtcttg gccataacat ctgtgtgaat ctgagtgtag tgtgtgatgg catctttgac
     4081 tgccccaatg ggacagatga gtccccactt tgcaatggga acagctgctc agatttcaat
     4141 ggtggttgta ctcacgagtg tgttcaagag ccctttgggg ctaaatgcct atgtccattg
     4201 ggattcttac ttgccaatga ttctaagacc tgtgaagaca tagatgaatg tgatattcta
     4261 ggctcttgta gccagcactg ttacaatatg agaggttctt tccggtgctc gtgtgataca
     4321 ggctacatgt tagaaagtga tgggaggact tgcaaagtta cagcatctga gagtctgctg
     4381 ttacttgtgg caagtcagaa caaaattatt gccgacagtg tcacctccca ggtccacaat
     4441 atctattcat tggtcgagaa tggttcttac attgtagctg ttgattttga ttcaattagt
     4501 ggtcgtatct tttggtctga tgcaactcag ggtaaaacct ggagtgcgtt tcaaaatgga
     4561 acggacagaa gagtggtatt tgacagtagc atcatcttga ctgaaactat tgcaatagat
     4621 tgggtaggtc gtaatcttta ctggacagac tatgctctgg aaacaattga agtctccaaa
     4681 attgatggga gccacaggac tgtgctgatt agtaaaaacc taacaaatcc aagaggacta
     4741 gcattagatc ccagaatgaa tgagcatcta ctgttctggt ctgactgggg ccaccaccct
     4801 cgcatcgagc gagccagcat ggacggcagc atgcgcactg tcattgtcca ggacaagatc
     4861 ttctggccct gcggcttaac tattgactac cccaacagac tgctctactt catggactcc
     4921 tatcttgatt acatggactt ttgtgattat aatggacacc atcggagaca ggtgatagcc
     4981 agtgatttga ttatacggca cccctatgcc ctaactctct ttgaagactc tgtgtactgg
     5041 actgaccgtg ctactcgtcg ggttatgcga gccaacaagt ggcatggagg gaaccagtca
     5101 gttgtaatgt ataatattca atggcccctt gggattgttg cggttcatcc ttcgaaacaa
     5161 ccaaattccg tgaatccatg tgccttttcc cgctgcagcc atctctgcct gctttcctca
     5221 caggggcctc atttttactc ctgtgtttgt ccttcaggat ggagtctgtc tcctgatctc
     5281 ctgaattgct tgagagatga tcaacctttc ttaataactg taaggcaaca tataattttt
     5341 ggaatctccc ttaatcctga ggtgaagagc aatgatgcta tggtccccat agcagggata
     5401 cagaatggtt tagatgttga atttgatgat gctgagcaat acatctattg ggttgaaaat
     5461 ccaggtgaaa ttcacagagt gaagacagat ggcaccaaca ggacagtatt tgcttctata
     5521 tctatggtgg ggccttctat gaacctggcc ttagattgga tttcaagaaa cctttattct
     5581 accaatccta gaactcagtc aatcgaggtt ttgacactcc acggagatat cagatacaga
     5641 aaaacattga ttgccaatga tgggacagct cttggagttg gctttccaat tggcataact
     5701 gttgatcctg ctcgtgggaa gctgtactgg tcagaccaag gaactgacag tggggttcct
     5761 gccaagatcg ccagtgctaa catggatggc acatctgtga aaactctctt tactgggaac
     5821 ctcgaacacc tggagtgtgt cactcttgac atcgaagagc agaaactcta ctgggcagtc
     5881 actggaagag gagtgattga aagaggaaac gtggatggaa cagatcgaat gatcctggta
     5941 caccagcttt cccacccctg gggaattgca gtccatgatt ctttccttta ttatactgat
     6001 gaacagtatg aggtcattga aagagttgat aaggccactg gggccaacaa aatagtcttg
     6061 agagataatg ttccaaatct gaggggtctt caagtttatc acagacgcaa tgccgccgaa
     6121 tcctcaaatg gctgtagcaa caacatgaat gcctgtcagc agatttgcct gcctgtacca
     6181 ggaggattgt tttcctgcgc ctgtgccact ggatttaaac tcaatcctga taatcggtcc
     6241 tgctctccat ataactcttt cattgttgtt tcaatgctgt ctgcaatcag aggctttagc
     6301 ttggaattgt cagatcattc agaaaccatg gtgccggtgg caggccaagg acgaaacgca
     6361 ctgcatgtgg atgtggatgt gtcctctggc tttatttatt ggtgtgattt tagcagctca
     6421 gtggcatctg ataatgcgat ccgtagaatt aaaccagatg gatcttctct gatgaacatt
     6481 gtgacacatg gaataggaga aaatggagtc cggggtattg cagtggattg ggtagcagga
     6541 aatctttatt tcaccaatgc ctttgtttct gaaacactga tagaagttct gcggatcaat
     6601 actacttacc gccgtgttct tcttaaagtc acagtggaca tgcctaggca tattgttgta
     6661 gatcccaaga acagatacct cttctgggct gactatgggc agagaccaaa gattgagcgt
     6721 tctttccttg actgtaccaa tcgaacagtg cttgtgtcag agggcattgt cacaccacgg
     6781 ggcttggcag tggaccgaag tgatggctac gtttattggg ttgatgattc tttagatata
     6841 attgcaagga ttcgtatcaa tggagagaac tctgaagtga ttcgttatgg cagtcgttac
     6901 ccaactcctt atggcatcac tgtttttgaa aattctatca tatgggtaga taggaatttg
     6961 aaaaagatct tccaagccag caaggaacca gagaacacag agccacccac agtgataaga
     7021 gacaatatca actggctaag agatgtgacc atctttgaca agcaagtcca gccccggtca
     7081 ccagcagagg tcaacaacaa cccttgcttg gaaaacaatg gtgggtgctc tcatctctgc
     7141 tttgctctgc ctggattgca caccccaaaa tgtgactgtg cctttgggac cctgcaaagt
     7201 gatggcaaga attgtgccat ttcaacagaa aatttcctca tctttgcctt gtctaattcc
     7261 ttgagaagct tacacttgga ccctgaaaac catagcccac ctttccaaac aataaatgtg
     7321 gaaagaactg tcatgtctct agactatgac agtgtaagtg atagaatcta cttcacacaa
     7381 aatttagcct ctggagttgg acagatttcc tatgccaccc tgtcttcagg gatccatact
     7441 ccaactgtca ttgcttcagg tatagggact gctgatggca ttgcctttga ctggattact
     7501 agaagaattt attacagtga ctacctcaac cagatgatta attccatggc tgaagatggg
     7561 tctaaccgca ctgtgatagc ccgcgttcca aaaccaagag caattgtgtt agatccctgc
     7621 caagggtacc tgtactgggc tgactgggat acacatgcca aaatcgagag agccacattg
     7681 ggaggaaact tccgcgtacc cattgtgaac agcagtctgg tcatgcccag tgggctgact
     7741 ctggactatg aagaggacct tctctactgg gtggatgcta gtctgcagag gattgaacgc
     7801 agcactctga cgggcgtgga tcgtgaagtc attgtcaatg cagccgttca tgcttttggc
     7861 ttgactctct atggccagta tatttactgg actgacttgt acacacaaag aatttaccga
     7921 gctaacaaat atgacgggtc aggtcagatt gcaatgacca caaatttgct ctcccagccc
     7981 aggggaatca acactgttgt gaagaaccag aaacaacagt gtaacaatcc ttgtgaacag
     8041 tttaatgggg gctgcagcca tatctgtgca ccaggtccaa atggtgccga gtgccagtgt
     8101 ccacatgagg gcaactggta tttggccaac aacaggaagc actgcattgt ggacaatggt
     8161 gaacgatgtg gtgcatcttc cttcacctgc tccaatgggc gctgcatctc ggaagagtgg
     8221 aagtgtgata atgacaacga ctgtggggat ggcagtgatg agatggaaag tgtctgtgca
     8281 cttcacacct gctcaccgac agccttcacc tgtgccaatg ggcgatgtgt ccaatactct
     8341 taccgctgtg attactacaa tgactgtggt gatggcagtg atgaggcagg gtgcctgttc
     8401 agggactgca atgccaccac ggagtttatg tgcaataaca gaaggtgcat acctcgtgag
     8461 tttatctgca atggtgtaga caactgccat gataataaca cttcagatga gaaaaattgc
     8521 cctgatcgca cttgccagtc tggatacaca aaatgtcata attcaaatat ttgtattcct
     8581 cgcgtttatt tgtgtgacgg agacaatgac tgtggagata acagtgatga aaaccctact
     8641 tattgcacca ctcacacgtg cagcagcagt gagttccaat gcgcatctgg gcgctgtatt
     8701 cctcaacatt ggtattgtga tcaagaaaca gattgttttg atgcctctga tgaacctgcc
     8761 tcttgtggtc actctgagcg aacatgccta gctgatgagt tcaagtgtga tggtgggagg
     8821 tgcatcccaa gcgaatggat ctgtgacggt gataatgact gtggggatat gagtgacgag
     8881 gataaaaggc accagtgtca gaatcaaaac tgctcggatt ccgagtttct ctgtgtaaat
     8941 gacagacctc cggacaggag gtgcattccc cagtcttggg tctgtgatgg cgatgtggat
     9001 tgtactgacg gctacgatga gaatcagaat tgcaccagga gaacttgctc tgaaaatgaa
     9061 ttcacctgtg gttacggact gtgtatccca aagatattca ggtgtgaccg gcacaatgac
     9121 tgtggtgact atagcgacga gaggggctgc ttataccaga cttgccaaca gaatcagttt
     9181 acctgtcaga acgggcgctg cattagtaaa accttcgtct gtgatgagga taatgactgt
     9241 ggagacggat ctgatgagct gatgcacctg tgccacaccc cagaacccac gtgtccacct
     9301 cacgagttca agtgtgacaa tgggcgctgc atcgagatga tgaaactctg caaccaccta
     9361 gatgactgtt tggacaacag cgatgagaaa ggctgtggca ttaatgaatg ccatgaccct
     9421 tcaatcagtg gctgcgatca caactgcaca gacaccttaa ccagtttcta ttgttcctgt
     9481 cgtcctggtt acaagctcat gtctgacaag cggacttgtg ttgatattga tgaatgcaca
     9541 gagatgcctt ttgtctgtag ccagaagtgt gagaatgtaa taggctccta catctgtaag
     9601 tgtgccccag gctacctccg agaaccagat ggaaagacct gccggcaaaa cagtaacatc
     9661 gaaccctatc tcatttttag caaccgttac tatttgagaa atttaactat agatggctat
     9721 ttttactccc tcatcttgga aggactggac aatgttgtgg cattagattt tgaccgagta
     9781 gagaagagat tgtattggat tgatacacag aggcaagtca ttgagagaat gtttctgaat
     9841 aagacaaaca aggagacaat cataaaccac agactaccag ctgcagaaag tctggctgta
     9901 gactgggttt ccagaaagct ctactggttg gatgcccgcc tggatggcct ctttgtctct
     9961 gacctcaatg gtggacaccg ccgcatgctg gcccagcact gtgtggatgc caacaacacc
    10021 ttctgctttg ataatcccag aggacttgcc cttcaccctc aatatgggta cctctactgg
    10081 gcagactggg gtcaccgcgc atacattggg agagtaggca tggatggaac caacaagtct
    10141 gtgataatct ccaccaagtt agagtggcct aatggcatca ccattgatta caccaatgat
    10201 ctactctact gggcagatgc ccacctgggt tacatagagt actctgattt ggagggccac
    10261 catcgacaca cggtgtatga tggggcactg cctcaccctt tcgctattac catttttgaa
    10321 gacactattt attggacaga ttggaataca aggacagtgg aaaagggaaa caaatatgat
    10381 ggatcaaata gacagacact ggtgaacaca acacacagac catttgacat ccatgtgtac
    10441 catccatata ggcagcccat tgtgagcaat ccctgtggta ccaacaatgg tggctgttct
    10501 catctctgcc tcatcaagcc aggaggaaaa gggttcactt gcgagtgtcc agatgacttc
    10561 cgcacccttc agctgagtgg cagcacctac tgcatgccca tgtgctccag cacccagttc
    10621 ctgtgcgcta acaatgaaaa gtgcattcct atctggtgga aatgtgatgg acagaaagac
    10681 tgctcagatg gctctgatga actggccctt tgcccgcagc gcttctgccg actgggacag
    10741 ttccagtgca gtgacggcaa ctgcaccagc ccgcagactt tatgcaatgc tcaccaaaat
    10801 tgccctgatg ggtctgatga agaccgtctt ctttgtgaga atcaccactg tgactccaat
    10861 gaatggcagt gcgccaacaa acgttgcatc ccagaatcct ggcagtgtga cacatttaac
    10921 gactgtgagg ataactcaga tgaagacagt tcccactgtg ccagcaggac ctgccggccg
    10981 ggccagtttc ggtgtgctaa tggccgctgc atcccgcagg cctggaagtg tgatgtggat
    11041 aatgattgtg gagaccactc ggatgagccc attgaagaat gcatgagctc tgcccatctc
    11101 tgtgacaact tcacagaatt cagctgcaaa acaaattacc gctgcatccc aaagtgggcc
    11161 gtgtgcaatg gtgtagatga ctgcagggac aacagtgatg agcaaggctg tgaggagagg
    11221 acatgccatc ctgtggggga tttccgctgt aaaaatcacc actgcatccc tcttcgttgg
    11281 cagtgtgatg ggcaaaatga ctgtggagat aactcagatg aggaaaactg tgctccccgg
    11341 gagtgcacag agagcgagtt tcgatgtgtc aatcagcagt gcattccctc gcgatggatc
    11401 tgtgaccatt acaacgactg tggggacaac tcagatgaac gggactgtga gatgaggacc
    11461 tgccatcctg aatattttca gtgtacaagt ggacattgtg tacacagtga actgaaatgc
    11521 gatggatccg ctgactgttt ggatgcgtct gatgaagctg attgtcccac acgctttcct
    11581 gatggtgcat actgccaggc tactatgttc gaatgcaaaa accatgtttg tatcccgcca
    11641 tattggaaat gtgatggcga tgatgactgt ggcgatggtt cagatgaaga acttcacctg
    11701 tgcttggatg ttccctgtaa ttcaccaaac cgtttccggt gtgacaacaa tcgctgcatt
    11761 tatagtcatg aggtgtgcaa tggtgtggat gactgtggag atggaactga tgagacagag
    11821 gagcactgta gaaaaccgac ccctaaacct tgtacagaat atgaatataa gtgtggcaat
    11881 gggcattgca ttccacatga caatgtgtgt gatgatgccg atgactgtgg tgactggtcc
    11941 gatgaactgg gttgcaataa aggaaaagaa agaacatgtg ctgaaaatat atgcgagcaa
    12001 aattgtaccc aattaaatga aggaggattt atctgctcct gtacagctgg gttcgaaacc
    12061 aatgtttttg acagaacctc ctgtctagat atcaatgaat gtgaacaatt tgggacttgt
    12121 ccccagcact gcagaaatac caaaggaagt tatgagtgtg tctgtgctga tggcttcacg
    12181 tctatgagtg accgccctgg aaaacgatgt gcagctgagg gtagctctcc tttgttgcta
    12241 ctgcctgaca atgtccgaat tcgaaaatat aatctctcat ctgagaggtt ctcagagtat
    12301 cttcaagatg aggaatatat ccaagctgtt gattatgatt gggatcccaa ggacataggc
    12361 ctcagtgttg tgtattacac tgtgcgaggg gagggctcta ggtttggtgc tatcaaacgt
    12421 gcctacatcc ccaactttga atccggccgc aataatcttg tgcaggaagt tgacctgaaa
    12481 ctgaaatacg taatgcagcc agatggaata gcagtggact gggttggaag gcatatttac
    12541 tggtcagatg tcaagaataa acgcattgag gtggctaaac ttgatggaag gtacagaaag
    12601 tggctgattt ccactgacct ggaccaacca gctgctattg ctgtgaatcc caaactaggg
    12661 cttatgttct ggactgactg gggaaaggaa cctaaaatcg agtctgcctg gatgaatgga
    12721 gaggaccgca acatcctggt tttcgaggac cttggttggc caactggcct ttctatcgat
    12781 tatttgaaca atgaccgaat ctactggagt gacttcaagg aggacgttat tgaaaccata
    12841 aaatatgatg ggactgatag gagagtcatt gcaaaggaag caatgaaccc ttacagcctg
    12901 gacatctttg aagaccagtt atactggata tctaaggaaa agggagaagt atggaaacaa
    12961 aataaatttg ggcaaggaaa gaaagagaaa acgctggtag tgaacccttg gctcactcaa
    13021 gttcgaatct ttcatcaact cagatacaat aagtcagtgc ccaacctttg caaacagatc
    13081 tgcagccacc tctgccttct gagacctgga ggatacagct gtgcctgtcc ccaaggctcc
    13141 agctttatag aggggagcac cactgagtgt gatgcagcca tcgaactgcc tatcaacctg
    13201 ccccccccat gcaggtgcat gcacggagga aattgctatt ttgatgagac tgacctcccc
    13261 aaatgcaagt gtcctagcgg ctacaccgga aaatattgtg aaatggcgtt ttcaaaaggc
    13321 atctctccag gaacaaccgc agtagctgtg ctgttgacaa tcctcttgat cgtcgtaatt
    13381 ggagctctgg caattgcagg attcttccac tatagaagga ccggctccct tttgcctgct
    13441 ctgcccaagc tgccaagctt aagcagtctc gtcaagccct ctgaaaatgg gaatggggtg
    13501 accttcagat caggggcaga tcttaacatg gatattggag tgtctggttt tggacctgag
    13561 actgctattg acaggtcaat ggcaatgagt gaagactttg tcatggaaat ggggaagcag
    13621 cccataatat ttgaaaaccc aatgtactca gccagagaca gtgctgtcaa agtggttcag
    13681 ccaatccagg tgactgtatc tgaaaatgtg gataataaga attatggaag tcccataaac
    13741 ccttctgaga tagttccaga gacaaaccca acttcaccag ctgctgatgg aactcaggtg
    13801 acaaaatgga atctcttcaa acgaaaatct aaacaaacta ccaactttga aaatccaatc
    13861 tatgcacaga tggagaacga gcaaaaggaa agtgttgctg cgacaccacc tccatcacct
    13921 tcgctccctg ctaagcctaa gcctccttcg agaagagacc caactccaac ctattctgca
    13981 acagaagaca cttttaaaga caccgcaaat cttgttaaag aagactctga agtatagcta
    14041 taccagctat ttagggaata attagaaaca cacttttgca catatatttt ttacaaacag
    14101 atgaaaaaag ttaacattca gtactttatg aaaaaaatat atttttccct gtttgcctat
    14161 agttggaggt atcctgtgtg tcttttttta cttatgccgt ctcatatttt tacaaataat
    14221 tatcacaatg tactatatgt atatctttgc actgaagttg tctgaaggta atactataaa
    14281 tatattgtat atttgtaaat tttggaaaga ttatcctgtt actgaatttg ctaataaaga
    14341 tgtctgctga tttggttggt gatcattata gtaaatgatc caacaagaaa aggaattgac
    14401 tggggacctt tagccgtgtc taaagaagag gcaccactca tatttcctat aaaattatct
    14461 aggaaaggaa tccaggcccc gctcttgggt ccatttttac acattagcac ttaattaatg
    14521 ttcaatatta catgtcaatt tgattaatgg ctatgttgat aggggccact atgtgttgta
    14581 tagacatctg gacttgactg tagactcctc agataataca gaaggtagga aaagcaattc
    14641 agtttggccc ttctgtgtgt tggcattgtc taaccagaac tctctgtttc atgtgtgttc
    14701 tctcactagc tgccaagaca acatttttat ttgtgatgtc tatgaggaaa tcccatatca
    14761 ttaagtgcca gtgtcctgca ttgagtttgt ggttaattaa atgagctctt ctgctgatgg
    14821 accctggagc aatttctccc ctcacctgac attcaaggtg gtcacctgcc ctagtagttg
    14881 gagctcagta gctgaatttc tgaaaccaaa tctgtgtctt cataaaataa ggtgcaaaaa
    14941 aaaaaaatac cagttaagta aagcctcaac tgggtttttg tttctatgaa aatatcatta
    15001 taatcactat ttatttccta agttgaacct gaatagaaag ggaaaccatt cttattaagc
    15061 tttttattag gccctgtggc taaatgtgta catttatatt agaatgtact gtacagtcca
    15121 gatcttttct ttaattctta ttggtttttt tttttttttt ttttttagag atggagtctt
    15181 gctatattgc caaggctgat cttgaagtcc tgggctcaag tgatcctccc acctcagcct
    15241 cctgagtggt tggggttacg ggcgtgagcc actgtgcctg gcttccagct ctcctcttaa
    15301 atagtgggta tagtctgcac aacaggaacc atggcaggaa tatacacttt cccatagcaa
    15361 atagcatacc tgactctctg tgctaatatt gcacatttgt taaacaatga atgaatggat
    15421 ggatggatgg atggatgaat gaatgaaaca tatactactg attattttat tccagagttc
    15481 tcaaaatatt tgttgctgat attttgagtg ctgactgtaa ttactttgat tagataaaca
    15541 actggaaata atgctgctga aaaagttcta ataaatgtgt attttatcag a
//
