LOCUS       NM_004525              15657 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens LDL receptor related protein 2 (LRP2), mRNA.
ACCESSION   NM_004525
VERSION     NM_004525.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15657)
  AUTHORS   Goto,S., Tsutsumi,A., Lee,Y., Hosojima,M., Kabasawa,H., Komochi,K.,
            Nagatoishi,S., Takemoto,K., Tsumoto,K., Nishizawa,T., Kikkawa,M.
            and Saito,A.
  TITLE     Cryo-EM structures elucidate the multiligand receptor nature of
            megalin
  JOURNAL   Proc Natl Acad Sci U S A 121 (22), e2318859121 (2024)
   PUBMED   38771880
  REMARK    GeneRIF: Cryo-EM structures elucidate the multiligand receptor
            nature of megalin.
REFERENCE   2  (bases 1 to 15657)
  AUTHORS   Anatolou,D., Steiropoulos,P., Zissimopoulos,A., Chadia,K.,
            Archontogeorgis,K., Kolios,G., Manolopoulos,V.G. and Ragia,G.
  TITLE     Polymorphisms in LRP2 and CUBN genes and their association with
            serum vitamin D levels and sleep apnea
  JOURNAL   Sleep Breath 28 (2), 959-966 (2024)
   PUBMED   38008818
  REMARK    GeneRIF: Polymorphisms in LRP2 and CUBN genes and their association
            with serum vitamin D levels and sleep apnea.
REFERENCE   3  (bases 1 to 15657)
  AUTHORS   Ceol,M., Gianesello,L., Trimarchi,H., Migliorini,A., Priante,G.,
            Radu,C.M., Naso,E., Angelini,A., Calo,L.A., Anglani,F. and Del
            Prete,D.
  TITLE     Human parietal epithelial cells (PECs) and proteinuria in lupus
            nephritis: a role for ClC-5, megalin, and cubilin?
  JOURNAL   J Nephrol 36 (9), 2499-2506 (2023)
   PUBMED   37594671
  REMARK    GeneRIF: Human parietal epithelial cells (PECs) and proteinuria in
            lupus nephritis: a role for ClC-5, megalin, and cubilin?
REFERENCE   4  (bases 1 to 15657)
  AUTHORS   Skeby,C.K., Hummelgaard,S., Gustafsen,C., Petrillo,F.,
            Frederiksen,K.P., Olsen,D., Kristensen,T., Ivarsen,P., Madsen,P.,
            Christensen,E.I., Nielsen,R., Birn,H., Glerup,S. and Weyer,K.
  TITLE     Proprotein convertase subtilisin/kexin type 9 targets megalin in
            the kidney proximal tubule and aggravates proteinuria in nephrotic
            syndrome
  JOURNAL   Kidney Int 104 (4), 754-768 (2023)
   PUBMED   37406929
  REMARK    GeneRIF: Proprotein convertase subtilisin/kexin type 9 targets
            megalin in the kidney proximal tubule and aggravates proteinuria in
            nephrotic syndrome.
REFERENCE   5  (bases 1 to 15657)
  AUTHORS   Farquhar,M.G., Saito,A., Kerjaschki,D. and Orlando,R.A.
  TITLE     The Heymann nephritis antigenic complex: megalin (gp330) and RAP
  JOURNAL   J Am Soc Nephrol 6 (1), 35-47 (1995)
   PUBMED   7579068
  REMARK    Review article
REFERENCE   6  (bases 1 to 15657)
  AUTHORS   Orlando,R.A. and Farquhar,M.G.
  TITLE     Functional domains of the receptor-associated protein (RAP)
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 3161-3165 (1994)
   PUBMED   7512726
REFERENCE   7  (bases 1 to 15657)
  AUTHORS   Longoni,M., Kantarci,S., Donnai,D. and Pober,B.R.
  TITLE     Donnai-Barrow Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301732
REFERENCE   8  (bases 1 to 15657)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   9  (bases 1 to 15657)
  AUTHORS   Christensen,E.I., Gliemann,J. and Moestrup,S.K.
  TITLE     Renal tubule gp330 is a calcium binding receptor for endocytic
            uptake of protein
  JOURNAL   J Histochem Cytochem 40 (10), 1481-1490 (1992)
   PUBMED   1382088
REFERENCE   10 (bases 1 to 15657)
  AUTHORS   Raychowdhury,R., Niles,J.L., McCluskey,R.T. and Smith,J.A.
  TITLE     Autoimmune target in Heymann nephritis is a glycoprotein with
            homology to the LDL receptor
  JOURNAL   Science 244 (4909), 1163-1165 (1989)
   PUBMED   2786251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA401915.1, U33837.1,
            DA339827.1, AY265358.1, DA200673.1, CD673312.1, AC007556.3 and
            AY265357.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 24, 2018 this sequence version replaced NM_004525.2.
            
            Summary: The protein encoded by this gene, low density
            lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand
            endocytic receptor that is expressed in many different tissues but
            primarily in absorptive epithilial tissues such as the kidney. This
            glycoprotein has a large amino-terminal extracellular domain, a
            single transmembrane domain, and a short carboxy-terminal
            cytoplasmic tail. The extracellular ligand-binding-domains bind
            diverse macromolecules including albumin, apolipoproteins B and E,
            and lipoprotein lipase. The LRP2 protein is critical for the
            reuptake of numerous ligands, including lipoproteins, sterols,
            vitamin-binding proteins, and hormones. This protein also has a
            role in cell-signaling; extracellular ligands include parathyroid
            horomones and the morphogen sonic hedgehog while cytosolic ligands
            include MAP kinase scaffold proteins and JNK interacting proteins.
            Recycling of this membrane receptor is regulated by phosphorylation
            of its cytoplasmic domain. Mutations in this gene cause
            Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal
            syndrome (FOAR).[provided by RefSeq, Aug 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U33837.1, AY265358.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649046.1/ ENSP00000496870.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA401915.1         153-183
            32-382              U33837.1           1-351
            383-636             DA339827.1         339-592
            637-2159            AY265358.1         566-2088
            2160-2510           DA200673.1         91-441
            2511-3203           U33837.1           2480-3172
            3204-3344           CD673312.1         403-543
            3345-3794           U33837.1           3314-3763
            3795-3802           AC007556.3         150972-150979       c
            3803-10637          AY265358.1         3732-10566
            10638-12414         AY265357.1         10570-12346
            12415-14228         U33837.1           12384-14197
            14229-15657         AC007556.3         35125-36553         c
FEATURES             Location/Qualifiers
     source          1..15657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..15657
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /note="LDL receptor related protein 2"
                     /db_xref="GeneID:4036"
                     /db_xref="HGNC:HGNC:6694"
                     /db_xref="MIM:600073"
     exon            1..214
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..14103
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /note="megalin; glycoprotein 330; low-density lipoprotein
                     receptor-related protein 2; calcium sensor protein;
                     Heymann nephritis antigen homolog"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     2 precursor"
                     /protein_id="NP_004516.2"
                     /db_xref="CCDS:CCDS2232.1"
                     /db_xref="GeneID:4036"
                     /db_xref="HGNC:HGNC:6694"
                     /db_xref="MIM:600073"
                     /translation="MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPAD
                     WRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQD
                     CSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNT
                     SQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACN
                     YPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPES
                     GRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPP
                     GYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFG
                     EASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFS
                     VDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITEN
                     LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDM
                     ISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAV
                     LKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDN
                     DGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNP
                     SFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNL
                     YWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWS
                     DGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMT
                     HPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSN
                     ACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFS
                     FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDK
                     RNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNST
                     ETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVT
                     NRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDE
                     HNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL
                     GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLG
                     FLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESL
                     LLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAF
                     QNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLT
                     NPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNR
                     LLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRA
                     NKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCV
                     CPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVE
                     FDDAEQYIYWVENPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRT
                     QSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKI
                     ASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH
                     QLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAA
                     ESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIR
                     GFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGS
                     SLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVD
                     MPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYV
                     YWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKE
                     PENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLH
                     TPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVM
                     SLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRI
                     YYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLG
                     GNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAF
                     GLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNP
                     CEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRC
                     ISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGS
                     DEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTK
                     CHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQE
                     TDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQ
                     NQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGY
                     GLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG
                     SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPS
                     ISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYIC
                     KCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDF
                     DRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLD
                     GLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVG
                     MDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALP
                     HPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVS
                     NPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEK
                     CIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGS
                     DEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQF
                     RCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAV
                     CNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAP
                     RECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSE
                     LKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSD
                     EELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTE
                     YEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFI
                     CSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKR
                     CAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYT
                     VRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVK
                     NKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDR
                     NILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLD
                     IFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQ
                     ICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDET
                     DLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTG
                     SLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAIDRSMAMSEDF
                     VMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPT
                     SPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLPAKPKPP
                     SRRDPTPTYSATEDTFKDTANLVKEDSEV"
     exon            215..322
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..445
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..562
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..673
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..787
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..904
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1057
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1177
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1306
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1476
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1700
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1907
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2110
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2251
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2455
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2648
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2774
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2905
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3043
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3325
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3565
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3685
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..3802
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..4180
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..4429
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..4641
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..4826
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..5055
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5056..5233
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5234..5362
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5363..5529
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5530..5673
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5674..5783
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5784..5961
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5962..6175
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6176..6415
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6416..6604
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6605..7525
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7526..7691
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7692..7850
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7851..8140
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8141..8344
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8345..8587
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8588..8713
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8714..8833
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8834..8965
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8966..9167
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9168..9463
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9464..9980
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9981..10133
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10134..10304
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10305..10528
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10529..10706
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10707..10903
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10904..11149
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11150..11278
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11279..11398
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11399..11515
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11516..11632
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11633..11770
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11771..11893
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11894..12022
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12023..12154
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12155..12286
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12287..12430
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12431..12596
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12597..12725
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12726..12946
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12947..13123
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13124..13243
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13244..13334
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13335..13402
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13403..13523
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13524..13653
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13654..13755
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13756..13863
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13864..13935
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13936..15657
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14399..14404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /note="hexamer: AATAAA"
     polyA_site      14416
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
     regulatory      15636..15641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /note="hexamer: AATAAA"
     polyA_site      15657
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330; LRP-2"
                     /note="major polyA site"
ORIGIN      
        1 aggcttttgg ccactaggag ctggcggagg tgcagaccta aaggagcgtt cgctagcaga
       61 ggcgctgccg gtgcggtgtg ctacgcgcgc ccacctcccg gggaaggaac ggcgaggccg
      121 gggaccgtcg cggagatgga tcgcgggccg gcagcagtgg cgtgcacgct gctcctggct
      181 ctcgtcgcct gcctagcgcc ggccagtggc caagaatgtg acagtgcgca ttttcgctgt
      241 ggaagtgggc attgcatccc tgcagactgg aggtgtgatg ggaccaaaga ctgttcagat
      301 gacgcggatg aaattggctg cgctgttgtg acctgccagc agggctattt caagtgccag
      361 agtgagggac aatgcatccc caactcctgg gtgtgtgacc aagatcaaga ctgtgatgat
      421 ggctcagatg aacgtcaaga ttgctcacaa agtacatgct caagtcatca gataacatgc
      481 tccaatggtc agtgtatccc aagtgaatac aggtgcgacc acgtcagaga ctgccccgat
      541 ggagctgatg agaatgactg ccagtaccca acatgtgagc agcttacttg tgacaatggg
      601 gcctgctata acaccagtca gaagtgtgat tggaaagttg attgcaggga ctcctcagat
      661 gaaatcaact gcactgagat atgcttgcac aatgagtttt catgtggcaa tggagagtgt
      721 atccctcgtg cttatgtctg tgaccatgac aatgattgcc aagacggcag tgacgaacat
      781 gcttgcaact atccgacctg cggtggttac cagttcactt gccccagtgg ccgatgcatt
      841 tatcaaaact gggtttgtga tggagaagat gactgtaaag ataatggaga tgaagatgga
      901 tgtgaaagcg gtcctcatga tgttcataaa tgttccccaa gagaatggtc ttgcccagag
      961 tcgggacgat gcatctccat ttataaagtt tgtgatggga ttttagattg cccaggaaga
     1021 gaagatgaaa acaacactag taccggaaaa tactgtagta tgactctgtg ctctgccttg
     1081 aactgccagt accagtgcca tgagacgccg tatggaggag cgtgtttttg tcccccaggt
     1141 tatatcatca accacaatga cagccgtacc tgtgttgagt ttgatgattg ccagatatgg
     1201 ggaatttgtg accagaagtg tgaaagccga cctggccgtc acctgtgcca ctgtgaagaa
     1261 gggtatatct tggagcgtgg acagtattgc aaagctaatg attcctttgg cgaggcctcc
     1321 attatcttct ccaatggtcg ggatttgtta attggtgata ttcatggaag gagcttccgg
     1381 atcctagtgg agtctcagaa tcgtggagtg gccgtgggtg tggctttcca ctatcacctg
     1441 caaagagttt tttggacaga caccgtgcaa aataaggttt tttcagttga cattaatggt
     1501 ttaaatatcc aagaggttct caatgtttct gttgaaaccc cagagaacct ggctgtggac
     1561 tgggttaata ataaaatcta tctagtggaa accaaggtca accgcataga tatggtaaat
     1621 ttggatggaa gctatcgggt tacccttata actgaaaact tggggcatcc tagaggaatt
     1681 gccgtggacc caactgttgg ttatttattt ttctcagatt gggagagcct ttctggggaa
     1741 cctaagctgg aaagggcatt catggatggc agcaaccgta aagacttggt gaaaacaaag
     1801 ctgggatggc ctgctggggt aactctggat atgatatcga agcgtgttta ctgggttgac
     1861 tctcggtttg attacattga aactgtaact tatgatggaa ttcaaaggaa gactgtagtt
     1921 catggaggct ccctcattcc tcatcccttt ggagtaagct tatttgaagg tcaggtgttc
     1981 tttacagatt ggacaaagat ggccgtgctg aaggcaaaca agttcacaga gaccaaccca
     2041 caagtgtact accaggcttc cctgaggccc tatggagtga ctgtttacca ttccctcaga
     2101 cagccctatg ctaccaatcc gtgtaaagat aacaatgggg gctgtgagca ggtctgtgtc
     2161 ctcagccaca gaacagataa tgatggtttg ggtttccgtt gcaagtgcac attcggcttc
     2221 caactggata cagatgagcg ccactgcatt gctgttcaga atttcctcat tttttcatcc
     2281 caagttgcta ttcgtgggat cccgttcacc ttgtctaccc aggaagatgt catggttcca
     2341 gtttcgggga atccttcttt ctttgtcggg attgattttg acgcccagga cagcactatc
     2401 tttttttcag atatgtcaaa acacatgatt tttaagcaaa agattgatgg cacaggaaga
     2461 gaaattctcg cagctaacag ggtggaaaat gttgaaagtt tggcttttga ttggatttca
     2521 aagaatctct attggacaga ctctcattac aagagtatca gtgtcatgag gctagctgat
     2581 aaaacgagac gcacagtagt tcagtattta aataacccac ggtcggtggt agttcatcct
     2641 tttgccgggt atctattctt cactgattgg ttccgtcctg ctaaaattat gagagcatgg
     2701 agtgacggat ctcacctctt gcctgtaata aacactactc ttggatggcc caatggcttg
     2761 gccatcgatt gggctgcttc acgattgtac tgggtagatg cctattttga taaaattgag
     2821 cacagcacct ttgatggttt agacagaaga agactgggcc atatagagca gatgacacat
     2881 ccgtttggac ttgccatctt tggagagcat ttatttttta ctgactggag actgggtgcc
     2941 attattcgag tcaggaaagc agatggtgga gaaatgacag ttatccgaag tggcattgct
     3001 tacatactgc atttgaaatc gtatgatgtc aacatccaga ctggttctaa cgcctgtaat
     3061 caacccacgc atcctaacgg tgactgcagc cacttctgct tcccggtgcc aaatttccag
     3121 cgagtgtgtg ggtgccctta tggaatgagg ctggcttcca atcacttgac atgcgagggg
     3181 gacccaacca atgaaccacc cacagagcag tgtggcttat tttccttccc ctgtaaaaat
     3241 ggcagatgtg tgcccaatta ctatctctgt gatggagtcg atgattgtca tgataacagt
     3301 gatgagcaac tatgtggcac acttaataat acctgttcat cttcggcgtt cacctgtggc
     3361 catggggagt gcattcctgc acactggcgc tgtgacaaac gcaacgactg tgtggatggc
     3421 agtgatgagc acaactgccc cacccacgca cctgcttcct gccttgacac ccaatacacc
     3481 tgtgataatc accagtgtat ctcaaagaac tgggtctgtg acacagacaa tgattgtggg
     3541 gatggatctg atgaaaagaa ctgcaattcg acagagacat gccaacctag tcagtttaat
     3601 tgccccaatc atcgatgtat tgacctatcg tttgtctgtg atggtgacaa ggattgtgtt
     3661 gatggatctg atgaggttgg ttgtgtatta aactgtactg cttctcaatt caagtgtgcc
     3721 agtggggata aatgtattgg cgtcacaaat cgttgtgatg gtgtttttga ttgcagtgac
     3781 aactcggatg aagcaggctg tccaaccagg cctcctggta tgtgccactc agatgaattt
     3841 cagtgccaag aagatggtat ctgcatcccg aacttctggg aatgtgatgg gcatccagac
     3901 tgcctctatg gatctgatga gcacaatgcc tgtgtcccca agacttgccc ttcatcatat
     3961 ttccactgtg acaacggaaa ctgcatccac agggcatggc tctgtgatcg ggacaatgac
     4021 tgcggggata tgagtgatga gaaggactgc cctactcagc cctttcgctg tcctagttgg
     4081 caatggcagt gtcttggcca taacatctgt gtgaatctga gtgtagtgtg tgatggcatc
     4141 tttgactgcc ccaatgggac agatgagtcc ccactttgca atgggaacag ctgctcagat
     4201 ttcaatggtg gttgtactca cgagtgtgtt caagagccct ttggggctaa atgcctatgt
     4261 ccattgggat tcttacttgc caatgattct aagacctgtg aagacataga tgaatgtgat
     4321 attctaggct cttgtagcca gcactgttac aatatgagag gttctttccg gtgctcgtgt
     4381 gatacaggct acatgttaga aagtgatggg aggacttgca aagttacagc atctgagagt
     4441 ctgctgttac ttgtggcaag tcagaacaaa attattgccg acagtgtcac ctcccaggtc
     4501 cacaatatct attcattggt cgagaatggt tcttacattg tagctgttga ttttgattca
     4561 attagtggtc gtatcttttg gtctgatgca actcagggta aaacctggag tgcgtttcaa
     4621 aatggaacgg acagaagagt ggtatttgac agtagcatca tcttgactga aactattgca
     4681 atagattggg taggtcgtaa tctttactgg acagactatg ctctggaaac aattgaagtc
     4741 tccaaaattg atgggagcca caggactgtg ctgattagta aaaacctaac aaatccaaga
     4801 ggactagcat tagatcccag aatgaatgag catctactgt tctggtctga ctggggccac
     4861 caccctcgca tcgagcgagc cagcatggac ggcagcatgc gcactgtcat tgtccaggac
     4921 aagatcttct ggccctgcgg cttaactatt gactacccca acagactgct ctacttcatg
     4981 gactcctatc ttgattacat ggacttttgt gattataatg gacaccatcg gagacaggtg
     5041 atagccagtg atttgattat acggcacccc tatgccctaa ctctctttga agactctgtg
     5101 tactggactg accgtgctac tcgtcgggtt atgcgagcca acaagtggca tggagggaac
     5161 cagtcagttg taatgtataa tattcaatgg ccccttggga ttgttgcggt tcatccttcg
     5221 aaacaaccaa attccgtgaa tccatgtgcc ttttcccgct gcagccatct ctgcctgctt
     5281 tcctcacagg ggcctcattt ttactcctgt gtttgtcctt caggatggag tctgtctcct
     5341 gatctcctga attgcttgag agatgatcaa cctttcttaa taactgtaag gcaacatata
     5401 atttttggaa tctcccttaa tcctgaggtg aagagcaatg atgctatggt ccccatagca
     5461 gggatacaga atggtttaga tgttgaattt gatgatgctg agcaatacat ctattgggtt
     5521 gaaaatccag gtgaaattca cagagtgaag acagatggca ccaacaggac agtatttgct
     5581 tctatatcta tggtggggcc ttctatgaac ctggccttag attggatttc aagaaacctt
     5641 tattctacca atcctagaac tcagtcaatc gaggttttga cactccacgg agatatcaga
     5701 tacagaaaaa cattgattgc caatgatggg acagctcttg gagttggctt tccaattggc
     5761 ataactgttg atcctgctcg tgggaagctg tactggtcag accaaggaac tgacagtggg
     5821 gttcctgcca agatcgccag tgctaacatg gatggcacat ctgtgaaaac tctctttact
     5881 gggaacctcg aacacctgga gtgtgtcact cttgacatcg aagagcagaa actctactgg
     5941 gcagtcactg gaagaggagt gattgaaaga ggaaacgtgg atggaacaga tcgaatgatc
     6001 ctggtacacc agctttccca cccctgggga attgcagtcc atgattcttt cctttattat
     6061 actgatgaac agtatgaggt cattgaaaga gttgataagg ccactggggc caacaaaata
     6121 gtcttgagag ataatgttcc aaatctgagg ggtcttcaag tttatcacag acgcaatgcc
     6181 gccgaatcct caaatggctg tagcaacaac atgaatgcct gtcagcagat ttgcctgcct
     6241 gtaccaggag gattgttttc ctgcgcctgt gccactggat ttaaactcaa tcctgataat
     6301 cggtcctgct ctccatataa ctctttcatt gttgtttcaa tgctgtctgc aatcagaggc
     6361 tttagcttgg aattgtcaga tcattcagaa accatggtgc cggtggcagg ccaaggacga
     6421 aacgcactgc atgtggatgt ggatgtgtcc tctggcttta tttattggtg tgattttagc
     6481 agctcagtgg catctgataa tgcgatccgt agaattaaac cagatggatc ttctctgatg
     6541 aacattgtga cacatggaat aggagaaaat ggagtccggg gtattgcagt ggattgggta
     6601 gcaggaaatc tttatttcac caatgccttt gtttctgaaa cactgataga agttctgcgg
     6661 atcaatacta cttaccgccg tgttcttctt aaagtcacag tggacatgcc taggcatatt
     6721 gttgtagatc ccaagaacag atacctcttc tgggctgact atgggcagag accaaagatt
     6781 gagcgttctt tccttgactg taccaatcga acagtgcttg tgtcagaggg cattgtcaca
     6841 ccacggggct tggcagtgga ccgaagtgat ggctacgttt attgggttga tgattcttta
     6901 gatataattg caaggattcg tatcaatgga gagaactctg aagtgattcg ttatggcagt
     6961 cgttacccaa ctccttatgg catcactgtt tttgaaaatt ctatcatatg ggtagatagg
     7021 aatttgaaaa agatcttcca agccagcaag gaaccagaga acacagagcc acccacagtg
     7081 ataagagaca atatcaactg gctaagagat gtgaccatct ttgacaagca agtccagccc
     7141 cggtcaccag cagaggtcaa caacaaccct tgcttggaaa acaatggtgg gtgctctcat
     7201 ctctgctttg ctctgcctgg attgcacacc ccaaaatgtg actgtgcctt tgggaccctg
     7261 caaagtgatg gcaagaattg tgccatttca acagaaaatt tcctcatctt tgccttgtct
     7321 aattccttga gaagcttaca cttggaccct gaaaaccata gcccaccttt ccaaacaata
     7381 aatgtggaaa gaactgtcat gtctctagac tatgacagtg taagtgatag aatctacttc
     7441 acacaaaatt tagcctctgg agttggacag atttcctatg ccaccctgtc ttcagggatc
     7501 catactccaa ctgtcattgc ttcaggtata gggactgctg atggcattgc ctttgactgg
     7561 attactagaa gaatttatta cagtgactac ctcaaccaga tgattaattc catggctgaa
     7621 gatgggtcta accgcactgt gatagcccgc gttccaaaac caagagcaat tgtgttagat
     7681 ccctgccaag ggtacctgta ctgggctgac tgggatacac atgccaaaat cgagagagcc
     7741 acattgggag gaaacttccg cgtacccatt gtgaacagca gtctggtcat gcccagtggg
     7801 ctgactctgg actatgaaga ggaccttctc tactgggtgg atgctagtct gcagaggatt
     7861 gaacgcagca ctctgacggg cgtggatcgt gaagtcattg tcaatgcagc cgttcatgct
     7921 tttggcttga ctctctatgg ccagtatatt tactggactg acttgtacac acaaagaatt
     7981 taccgagcta acaaatatga cgggtcaggt cagattgcaa tgaccacaaa tttgctctcc
     8041 cagcccaggg gaatcaacac tgttgtgaag aaccagaaac aacagtgtaa caatccttgt
     8101 gaacagttta atgggggctg cagccatatc tgtgcaccag gtccaaatgg tgccgagtgc
     8161 cagtgtccac atgagggcaa ctggtatttg gccaacaaca ggaagcactg cattgtggac
     8221 aatggtgaac gatgtggtgc atcttccttc acctgctcca atgggcgctg catctcggaa
     8281 gagtggaagt gtgataatga caacgactgt ggggatggca gtgatgagat ggaaagtgtc
     8341 tgtgcacttc acacctgctc accgacagcc ttcacctgtg ccaatgggcg atgtgtccaa
     8401 tactcttacc gctgtgatta ctacaatgac tgtggtgatg gcagtgatga ggcagggtgc
     8461 ctgttcaggg actgcaatgc caccacggag tttatgtgca ataacagaag gtgcatacct
     8521 cgtgagttta tctgcaatgg tgtagacaac tgccatgata ataacacttc agatgagaaa
     8581 aattgccctg atcgcacttg ccagtctgga tacacaaaat gtcataattc aaatatttgt
     8641 attcctcgcg tttatttgtg tgacggagac aatgactgtg gagataacag tgatgaaaac
     8701 cctacttatt gcaccactca cacgtgcagc agcagtgagt tccaatgcgc atctgggcgc
     8761 tgtattcctc aacattggta ttgtgatcaa gaaacagatt gttttgatgc ctctgatgaa
     8821 cctgcctctt gtggtcactc tgagcgaaca tgcctagctg atgagttcaa gtgtgatggt
     8881 gggaggtgca tcccaagcga atggatctgt gacggtgata atgactgtgg ggatatgagt
     8941 gacgaggata aaaggcacca gtgtcagaat caaaactgct cggattccga gtttctctgt
     9001 gtaaatgaca gacctccgga caggaggtgc attccccagt cttgggtctg tgatggcgat
     9061 gtggattgta ctgacggcta cgatgagaat cagaattgca ccaggagaac ttgctctgaa
     9121 aatgaattca cctgtggtta cggactgtgt atcccaaaga tattcaggtg tgaccggcac
     9181 aatgactgtg gtgactatag cgacgagagg ggctgcttat accagacttg ccaacagaat
     9241 cagtttacct gtcagaacgg gcgctgcatt agtaaaacct tcgtctgtga tgaggataat
     9301 gactgtggag acggatctga tgagctgatg cacctgtgcc acaccccaga acccacgtgt
     9361 ccacctcacg agttcaagtg tgacaatggg cgctgcatcg agatgatgaa actctgcaac
     9421 cacctagatg actgtttgga caacagcgat gagaaaggct gtggcattaa tgaatgccat
     9481 gacccttcaa tcagtggctg cgatcacaac tgcacagaca ccttaaccag tttctattgt
     9541 tcctgtcgtc ctggttacaa gctcatgtct gacaagcgga cttgtgttga tattgatgaa
     9601 tgcacagaga tgccttttgt ctgtagccag aagtgtgaga atgtaatagg ctcctacatc
     9661 tgtaagtgtg ccccaggcta cctccgagaa ccagatggaa agacctgccg gcaaaacagt
     9721 aacatcgaac cctatctcat ttttagcaac cgttactatt tgagaaattt aactatagat
     9781 ggctattttt actccctcat cttggaagga ctggacaatg ttgtggcatt agattttgac
     9841 cgagtagaga agagattgta ttggattgat acacagaggc aagtcattga gagaatgttt
     9901 ctgaataaga caaacaagga gacaatcata aaccacagac taccagctgc agaaagtctg
     9961 gctgtagact gggtttccag aaagctctac tggttggatg cccgcctgga tggcctcttt
    10021 gtctctgacc tcaatggtgg acaccgccgc atgctggccc agcactgtgt ggatgccaac
    10081 aacaccttct gctttgataa tcccagagga cttgcccttc accctcaata tgggtacctc
    10141 tactgggcag actggggtca ccgcgcatac attgggagag taggcatgga tggaaccaac
    10201 aagtctgtga taatctccac caagttagag tggcctaatg gcatcaccat tgattacacc
    10261 aatgatctac tctactgggc agatgcccac ctgggttaca tagagtactc tgatttggag
    10321 ggccaccatc gacacacggt gtatgatggg gcactgcctc accctttcgc tattaccatt
    10381 tttgaagaca ctatttattg gacagattgg aatacaagga cagtggaaaa gggaaacaaa
    10441 tatgatggat caaatagaca gacactggtg aacacaacac acagaccatt tgacatccat
    10501 gtgtaccatc catataggca gcccattgtg agcaatccct gtggtaccaa caatggtggc
    10561 tgttctcatc tctgcctcat caagccagga ggaaaagggt tcacttgcga gtgtccagat
    10621 gacttccgca cccttcagct gagtggcagc acctactgca tgcccatgtg ctccagcacc
    10681 cagttcctgt gcgctaacaa tgaaaagtgc attcctatct ggtggaaatg tgatggacag
    10741 aaagactgct cagatggctc tgatgaactg gccctttgcc cgcagcgctt ctgccgactg
    10801 ggacagttcc agtgcagtga cggcaactgc accagcccgc agactttatg caatgctcac
    10861 caaaattgcc ctgatgggtc tgatgaagac cgtcttcttt gtgagaatca ccactgtgac
    10921 tccaatgaat ggcagtgcgc caacaaacgt tgcatcccag aatcctggca gtgtgacaca
    10981 tttaacgact gtgaggataa ctcagatgaa gacagttccc actgtgccag caggacctgc
    11041 cggccgggcc agtttcggtg tgctaatggc cgctgcatcc cgcaggcctg gaagtgtgat
    11101 gtggataatg attgtggaga ccactcggat gagcccattg aagaatgcat gagctctgcc
    11161 catctctgtg acaacttcac agaattcagc tgcaaaacaa attaccgctg catcccaaag
    11221 tgggccgtgt gcaatggtgt agatgactgc agggacaaca gtgatgagca aggctgtgag
    11281 gagaggacat gccatcctgt gggggatttc cgctgtaaaa atcaccactg catccctctt
    11341 cgttggcagt gtgatgggca aaatgactgt ggagataact cagatgagga aaactgtgct
    11401 ccccgggagt gcacagagag cgagtttcga tgtgtcaatc agcagtgcat tccctcgcga
    11461 tggatctgtg accattacaa cgactgtggg gacaactcag atgaacggga ctgtgagatg
    11521 aggacctgcc atcctgaata ttttcagtgt acaagtggac attgtgtaca cagtgaactg
    11581 aaatgcgatg gatccgctga ctgtttggat gcgtctgatg aagctgattg tcccacacgc
    11641 tttcctgatg gtgcatactg ccaggctact atgttcgaat gcaaaaacca tgtttgtatc
    11701 ccgccatatt ggaaatgtga tggcgatgat gactgtggcg atggttcaga tgaagaactt
    11761 cacctgtgct tggatgttcc ctgtaattca ccaaaccgtt tccggtgtga caacaatcgc
    11821 tgcatttata gtcatgaggt gtgcaatggt gtggatgact gtggagatgg aactgatgag
    11881 acagaggagc actgtagaaa accgacccct aaaccttgta cagaatatga atataagtgt
    11941 ggcaatgggc attgcattcc acatgacaat gtgtgtgatg atgccgatga ctgtggtgac
    12001 tggtccgatg aactgggttg caataaagga aaagaaagaa catgtgctga aaatatatgc
    12061 gagcaaaatt gtacccaatt aaatgaagga ggatttatct gctcctgtac agctgggttc
    12121 gaaaccaatg tttttgacag aacctcctgt ctagatatca atgaatgtga acaatttggg
    12181 acttgtcccc agcactgcag aaataccaaa ggaagttatg agtgtgtctg tgctgatggc
    12241 ttcacgtcta tgagtgaccg ccctggaaaa cgatgtgcag ctgagggtag ctctcctttg
    12301 ttgctactgc ctgacaatgt ccgaattcga aaatataatc tctcatctga gaggttctca
    12361 gagtatcttc aagatgagga atatatccaa gctgttgatt atgattggga tcccaaggac
    12421 ataggcctca gtgttgtgta ttacactgtg cgaggggagg gctctaggtt tggtgctatc
    12481 aaacgtgcct acatccccaa ctttgaatcc ggccgcaata atcttgtgca ggaagttgac
    12541 ctgaaactga aatacgtaat gcagccagat ggaatagcag tggactgggt tggaaggcat
    12601 atttactggt cagatgtcaa gaataaacgc attgaggtgg ctaaacttga tggaaggtac
    12661 agaaagtggc tgatttccac tgacctggac caaccagctg ctattgctgt gaatcccaaa
    12721 ctagggctta tgttctggac tgactgggga aaggaaccta aaatcgagtc tgcctggatg
    12781 aatggagagg accgcaacat cctggttttc gaggaccttg gttggccaac tggcctttct
    12841 atcgattatt tgaacaatga ccgaatctac tggagtgact tcaaggagga cgttattgaa
    12901 accataaaat atgatgggac tgataggaga gtcattgcaa aggaagcaat gaacccttac
    12961 agcctggaca tctttgaaga ccagttatac tggatatcta aggaaaaggg agaagtatgg
    13021 aaacaaaata aatttgggca aggaaagaaa gagaaaacgc tggtagtgaa cccttggctc
    13081 actcaagttc gaatctttca tcaactcaga tacaataagt cagtgcccaa cctttgcaaa
    13141 cagatctgca gccacctctg ccttctgaga cctggaggat acagctgtgc ctgtccccaa
    13201 ggctccagct ttatagaggg gagcaccact gagtgtgatg cagccatcga actgcctatc
    13261 aacctgcccc ccccatgcag gtgcatgcac ggaggaaatt gctattttga tgagactgac
    13321 ctccccaaat gcaagtgtcc tagcggctac accggaaaat attgtgaaat ggcgttttca
    13381 aaaggcatct ctccaggaac aaccgcagta gctgtgctgt tgacaatcct cttgatcgtc
    13441 gtaattggag ctctggcaat tgcaggattc ttccactata gaaggaccgg ctcccttttg
    13501 cctgctctgc ccaagctgcc aagcttaagc agtctcgtca agccctctga aaatgggaat
    13561 ggggtgacct tcagatcagg ggcagatctt aacatggata ttggagtgtc tggttttgga
    13621 cctgagactg ctattgacag gtcaatggca atgagtgaag actttgtcat ggaaatgggg
    13681 aagcagccca taatatttga aaacccaatg tactcagcca gagacagtgc tgtcaaagtg
    13741 gttcagccaa tccaggtgac tgtatctgaa aatgtggata ataagaatta tggaagtccc
    13801 ataaaccctt ctgagatagt tccagagaca aacccaactt caccagctgc tgatggaact
    13861 caggtgacaa aatggaatct cttcaaacga aaatctaaac aaactaccaa ctttgaaaat
    13921 ccaatctatg cacagatgga gaacgagcaa aaggaaagtg ttgctgcgac accacctcca
    13981 tcaccttcgc tccctgctaa gcctaagcct ccttcgagaa gagacccaac tccaacctat
    14041 tctgcaacag aagacacttt taaagacacc gcaaatcttg ttaaagaaga ctctgaagta
    14101 tagctatacc agctatttag ggaataatta gaaacacact tttgcacata tattttttac
    14161 aaacagatga aaaaagttaa cattcagtac tttatgaaaa aaatatattt ttccctgttt
    14221 gcctatagtt ggaggtatcc tgtgtgtctt tttttactta tgccgtctca tatttttaca
    14281 aataattatc acaatgtact atatgtatat ctttgcactg aagttgtctg aaggtaatac
    14341 tataaatata ttgtatattt gtaaattttg gaaagattat cctgttactg aatttgctaa
    14401 taaagatgtc tgctgatttg gttggtgatc attatagtaa atgatccaac aagaaaagga
    14461 attgactggg gacctttagc cgtgtctaaa gaagaggcac cactcatatt tcctataaaa
    14521 ttatctagga aaggaatcca ggccccgctc ttgggtccat ttttacacat tagcacttaa
    14581 ttaatgttca atattacatg tcaatttgat taatggctat gttgataggg gccactatgt
    14641 gttgtataga catctggact tgactgtaga ctcctcagat aatacagaag gtaggaaaag
    14701 caattcagtt tggcccttct gtgtgttggc attgtctaac cagaactctc tgtttcatgt
    14761 gtgttctctc actagctgcc aagacaacat ttttatttgt gatgtctatg aggaaatccc
    14821 atatcattaa gtgccagtgt cctgcattga gtttgtggtt aattaaatga gctcttctgc
    14881 tgatggaccc tggagcaatt tctcccctca cctgacattc aaggtggtca cctgccctag
    14941 tagttggagc tcagtagctg aatttctgaa accaaatctg tgtcttcata aaataaggtg
    15001 caaaaaaaaa aaataccagt taagtaaagc ctcaactggg tttttgtttc tatgaaaata
    15061 tcattataat cactatttat ttcctaagtt gaacctgaat agaaagggaa accattctta
    15121 ttaagctttt tattaggccc tgtggctaaa tgtgtacatt tatattagaa tgtactgtac
    15181 agtccagatc ttttctttaa ttcttattgg tttttttttt tttttttttt ttagagatgg
    15241 agtcttgcta tattgccaag gctgatcttg aagtcctggg ctcaagtgat cctcccacct
    15301 cagcctcctg agtggttggg gttacgggcg tgagccactg tgcctggctt ccagctctcc
    15361 tcttaaatag tgggtatagt ctgcacaaca ggaaccatgg caggaatata cactttccca
    15421 tagcaaatag catacctgac tctctgtgct aatattgcac atttgttaaa caatgaatga
    15481 atggatggat ggatggatgg atgaatgaat gaaacatata ctactgatta ttttattcca
    15541 gagttctcaa aatatttgtt gctgatattt tgagtgctga ctgtaattac tttgattaga
    15601 taaacaactg gaaataatgc tgctgaaaaa gttctaataa atgtgtattt tatcaga
//
