LOCUS       NM_018557              15850 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens LDL receptor related protein 1B (LRP1B), mRNA.
ACCESSION   NM_018557
VERSION     NM_018557.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15850)
  AUTHORS   Jiang,Z., Zhu,M., Zhang,L., Cui,H., Jiang,R. and Yang,Y.
  TITLE     Antitumor immunity and prognosis value elicited by FAT3 and LRP1B
            co-mutation in endometrial cancer
  JOURNAL   Gynecol Oncol 187, 1-11 (2024)
   PUBMED   38696842
  REMARK    GeneRIF: Antitumor immunity and prognosis value elicited by FAT3
            and LRP1B co-mutation in endometrial cancer.
REFERENCE   2  (bases 1 to 15850)
  AUTHORS   Chen,L.C., Lo,Y.S., Ho,H.Y., Lin,C.C., Chuang,Y.C., Chang,W.C. and
            Hsieh,M.J.
  TITLE     LDL Receptor-Related Protein 1B Polymorphisms Associated with
            Increased Risk of Lymph Node Metastasis in Oral Cancer Group with
            Diabetes Mellitus
  JOURNAL   Int J Mol Sci 25 (7), 3963 (2024)
   PUBMED   38612772
  REMARK    GeneRIF: LDL Receptor-Related Protein 1B Polymorphisms Associated
            with Increased Risk of Lymph Node Metastasis in Oral Cancer Group
            with Diabetes Mellitus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15850)
  AUTHORS   Shaikh,M.H., Dawson,A., Prokopec,S.D., Barrett,J.W., Y F Zeng,P.,
            Khan,M.I., Ryan,S.E.B., Cecchini,M., Palma,D.A., Mymryk,J.S.,
            Boutros,P.C. and Nichols,A.C.
  TITLE     Loss of LRP1B expression drives acquired chemo and radio-resistance
            in HPV-positive head and neck cancer
  JOURNAL   Oral Oncol 146, 106580 (2023)
   PUBMED   37778229
  REMARK    GeneRIF: Loss of LRP1B expression drives acquired chemo and
            radio-resistance in HPV-positive head and neck cancer.
REFERENCE   4  (bases 1 to 15850)
  AUTHORS   Kolb,S., Hoffmann,I., Monje,N., Dragomir,M.P., Jank,P.,
            Bischoff,P., Keunecke,C., Pohl,J., Kunze,C.A., Marchenko,S.,
            Schmitt,W.D., Kulbe,H., Sers,C., Sehouli,J., Braicu,E.I.,
            Denkert,C., Darb-Esfahani,S., Horst,D., Sinn,B.V. and Taube,E.T.
  TITLE     LRP1B-a prognostic marker in tubo-ovarian high-grade serous
            carcinoma
  JOURNAL   Hum Pathol 141, 158-168 (2023)
   PUBMED   37742945
  REMARK    GeneRIF: LRP1B-a prognostic marker in tubo-ovarian high-grade
            serous carcinoma.
REFERENCE   5  (bases 1 to 15850)
  AUTHORS   Sonoda,I., Imoto,I., Inoue,J., Shibata,T., Shimada,Y., Chin,K.,
            Imamura,M., Amagasa,T., Gray,J.W., Hirohashi,S. and Inazawa,J.
  TITLE     Frequent silencing of low density lipoprotein receptor-related
            protein 1B (LRP1B) expression by genetic and epigenetic mechanisms
            in esophageal squamous cell carcinoma
  JOURNAL   Cancer Res 64 (11), 3741-3747 (2004)
   PUBMED   15172977
  REMARK    GeneRIF: Loss of LRP1B function in esophageal carcinogenesis most
            often occurs either by homozygous deletion or by transcriptional
            silencing through hypermethylation of its CpG island.
REFERENCE   6  (bases 1 to 15850)
  AUTHORS   Li,Y., Knisely,J.M., Lu,W., McCormick,L.M., Wang,J., Henkin,J.,
            Schwartz,A.L. and Bu,G.
  TITLE     Low density lipoprotein (LDL) receptor-related protein 1B impairs
            urokinase receptor regeneration on the cell surface and inhibits
            cell migration
  JOURNAL   J Biol Chem 277 (44), 42366-42371 (2002)
   PUBMED   12194987
  REMARK    GeneRIF: LRP1B can function as a negative regulator of uPAR
            regeneration and cell migration.
REFERENCE   7  (bases 1 to 15850)
  AUTHORS   Langbein,S., Szakacs,O., Wilhelm,M., Sukosd,F., Weber,S., Jauch,A.,
            Lopez Beltran,A., Alken,P., Kalble,T. and Kovacs,G.
  TITLE     Alteration of the LRP1B gene region is associated with high grade
            of urothelial cancer
  JOURNAL   Lab Invest 82 (5), 639-643 (2002)
   PUBMED   12004004
  REMARK    GeneRIF: The LRP1B gene is a candidate tumor suppressor gene in
            urothelial cancer.
REFERENCE   8  (bases 1 to 15850)
  AUTHORS   Liu,C.X., Li,Y., Obermoeller-McCormick,L.M., Schwartz,A.L. and
            Bu,G.
  TITLE     The putative tumor suppressor LRP1B, a novel member of the low
            density lipoprotein (LDL) receptor family, exhibits both
            overlapping and distinct properties with the LDL receptor-related
            protein
  JOURNAL   J Biol Chem 276 (31), 28889-28896 (2001)
   PUBMED   11384978
REFERENCE   9  (bases 1 to 15850)
  AUTHORS   Liu,C.X., Musco,S., Lisitsina,N.M., Yaklichkin,S.Y. and
            Lisitsyn,N.A.
  TITLE     Genomic organization of a new candidate tumor suppressor gene,
            LRP1B
  JOURNAL   Genomics 69 (2), 271-274 (2000)
   PUBMED   11031110
REFERENCE   10 (bases 1 to 15850)
  AUTHORS   Liu,C.X., Musco,S., Lisitsina,N.M., Forgacs,E., Minna,J.D. and
            Lisitsyn,N.A.
  TITLE     LRP-DIT, a putative endocytic receptor gene, is frequently
            inactivated in non-small cell lung cancer cell lines
  JOURNAL   Cancer Res 60 (7), 1961-1967 (2000)
   PUBMED   10766186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092575.3, AC012353.6,
            AC087056.5, AC068287.5, AC073319.4, AC010740.7, AC110087.2,
            AC117947.3, AC108036.2, AC093039.3, AC068195.6 and AC092156.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 19, 2019 this sequence version replaced NM_018557.2.
            
            Summary: This gene encodes a member of the low density lipoprotein
            (LDL) receptor family. These receptors play a wide variety of roles
            in normal cell function and development due to their interactions
            with multiple ligands. Disruption of this gene has been reported in
            several types of cancer. [provided by RefSeq, Jun 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176832.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000389484.8/
                                                ENSP00000374135.3
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AC092575.3         118513-118881       c
            370-492             AC012353.6         195843-195965       c
            493-630             AC087056.5         23261-23398         c
            631-750             AC068287.5         105427-105546       c
            751-879             AC068287.5         98131-98259         c
            880-1137            AC068287.5         80088-80345         c
            1138-1300           AC068287.5         39326-39488         c
            1301-1523           AC073319.4         72772-72994         c
            1524-1695           AC073319.4         69604-69775         c
            1696-1839           AC073319.4         65837-65980         c
            1840-2076           AC073319.4         59707-59943         c
            2077-2257           AC073319.4         30643-30823         c
            2258-2477           AC073319.4         26417-26636         c
            2478-2667           AC073319.4         24277-24466         c
            2668-2790           AC073319.4         16056-16178         c
            2791-2931           AC073319.4         4716-4856           c
            2932-3057           AC073319.4         253-378             c
            3058-3174           AC010740.7         9004-9120
            3175-3255           AC010740.7         39340-39420
            3256-3423           AC010740.7         40878-41045
            3424-3606           AC010740.7         68133-68315
            3607-3807           AC010740.7         83203-83403
            3808-4053           AC010740.7         88115-88360
            4054-4251           AC010740.7         104945-105142
            4252-4456           AC010740.7         107259-107463
            4457-4621           AC010740.7         123017-123181
            4622-4866           AC010740.7         123446-123690
            4867-4998           AC010740.7         139497-139628
            4999-5226           AC010740.7         140951-141178
            5227-5401           AC010740.7         150188-150362
            5402-5496           AC010740.7         151195-151289
            5497-5646           AC010740.7         177474-177623
            5647-5787           AC110087.2         55933-56073         c
            5788-5913           AC110087.2         50716-50841         c
            5914-6045           AC110087.2         49048-49179         c
            6046-6180           AC117947.3         52462-52596         c
            6181-6310           AC117947.3         51753-51882         c
            6311-6437           AC117947.3         38207-38333         c
            6438-6589           AC117947.3         37921-38072         c
            6590-6714           AC117947.3         37501-37625         c
            6715-7086           AC117947.3         36030-36401         c
            7087-7276           AC108036.2         86549-86738         c
            7277-7481           AC108036.2         83730-83934         c
            7482-7674           AC108036.2         26878-27070         c
            7675-7800           AC108036.2         26072-26197         c
            7801-7929           AC108036.2         21680-21808         c
            7930-8049           AC108036.2         19120-19239         c
            8050-8163           AC108036.2         11336-11449         c
            8164-8313           AC108036.2         10943-11092         c
            8314-8436           AC108036.2         1988-2110           c
            8437-8556           AC093039.3         37032-37151         c
            8557-8685           AC093039.3         32307-32435         c
            8686-8808           AC093039.3         29175-29297         c
            8809-8949           AC093039.3         25342-25482         c
            8950-9137           AC093039.3         24066-24253         c
            9138-9321           AC093039.3         17944-18127         c
            9322-9407           AC093039.3         14987-15072         c
            9408-9530           AC093039.3         9996-10118          c
            9531-9712           AC093039.3         7722-7903           c
            9713-9912           AC068195.6         173664-173863       c
            9913-10101          AC068195.6         155989-156177       c
            10102-10250         AC068195.6         154981-155129       c
            10251-10344         AC068195.6         149094-149187       c
            10345-10461         AC068195.6         143089-143205       c
            10462-10581         AC068195.6         142856-142975       c
            10582-10701         AC068195.6         141030-141149       c
            10702-10818         AC068195.6         84419-84535         c
            10819-10925         AC068195.6         76706-76812         c
            10926-11055         AC068195.6         71534-71663         c
            11056-11162         AC068195.6         69705-69811         c
            11163-11295         AC068195.6         69236-69368         c
            11296-11418         AC068195.6         63187-63309         c
            11419-11544         AC068195.6         57347-57472         c
            11545-11682         AC068195.6         56505-56642         c
            11683-11817         AC068195.6         54868-55002         c
            11818-11937         AC068195.6         51479-51598         c
            11938-12179         AC068195.6         49323-49564         c
            12180-12403         AC068195.6         34141-34364         c
            12404-12510         AC068195.6         32979-33085         c
            12511-12627         AC068195.6         24288-24404         c
            12628-12801         AC068195.6         22419-22592         c
            12802-12927         AC068195.6         20489-20614         c
            12928-13092         AC068195.6         13461-13625         c
            13093-13254         AC092156.2         162963-163124       c
            13255-13429         AC092156.2         139579-139753       c
            13430-13534         AC092156.2         135397-135501       c
            13535-13611         AC092156.2         112241-112317       c
            13612-13702         AC092156.2         104597-104687       c
            13703-13847         AC092156.2         103307-103451       c
            13848-13946         AC092156.2         99941-100039        c
            13947-15850         AC092156.2         96578-98481         c
FEATURES             Location/Qualifiers
     source          1..15850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.1-q22.2"
     gene            1..15850
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /note="LDL receptor related protein 1B"
                     /db_xref="GeneID:53353"
                     /db_xref="HGNC:HGNC:6693"
                     /db_xref="MIM:608766"
     exon            1..369
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..14087
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /note="LRP-deleted in tumors; low density
                     lipoprotein-related protein 1B (deleted in tumors); low
                     density lipoprotein receptor related protein-deleted in
                     tumor; low density lipoprotein receptor-related protein
                     1B"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     1B precursor"
                     /protein_id="NP_061027.2"
                     /db_xref="CCDS:CCDS2182.1"
                     /db_xref="GeneID:53353"
                     /db_xref="HGNC:HGNC:6693"
                     /db_xref="MIM:608766"
                     /translation="MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVT
                     CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLD
                     CPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECA
                     VYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFY
                     LNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTI
                     NILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVD
                     PIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLD
                     YVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSL
                     IKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFN
                     LGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAE
                     TNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTI
                     NVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMD
                     GFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNH
                     PFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMC
                     RVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRH
                     CIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSN
                     EDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQ
                     FVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDND
                     CGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGC
                     NGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCAND
                     TSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQ
                     LNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFI
                     IFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES
                     GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAME
                     HPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFE
                     KRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSK
                     ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSA
                     ACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTV
                     IDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISS
                     EFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSK
                     ILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALT
                     IMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNN
                     GGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKM
                     DALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGI
                     AVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWG
                     QMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGN
                     REMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKE
                     VKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLL
                     YSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHF
                     GNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAF
                     DREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILT
                     PNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSD
                     WGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCL
                     LTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKD
                     KSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF
                     RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVL
                     PTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRD
                     EFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQG
                     SRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDD
                     DCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKS
                     AEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQD
                     LPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPD
                     NPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWI
                     DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNG
                     LYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRP
                     MALTIDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKT
                     KSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAP
                     GKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPD
                     DCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQK
                     CIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADAS
                     DEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCAN
                     GDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGE
                     DEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCK
                     NKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDD
                     CGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLT
                     YKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGD
                     DAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQN
                     FQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYY
                     QRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDH
                     SRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVV
                     GDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSN
                     SVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVL
                     ISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLT
                     CENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALG
                     FTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCT
                     IGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLC
                     DGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVL
                     LVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLL
                     DPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMD
                     GQNCRNSLGSVDERKELLPKKIEIGIRETVA"
     exon            370..492
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            493..630
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            631..750
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            751..879
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1137
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1300
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1523
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1695
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1839
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2076
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2257
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2477
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2667
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2790
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2931
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3057
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3174
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3255
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3423
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3606
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3807
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..4053
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4251
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4456
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4621
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4866
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4867..4998
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5226
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5227..5401
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5402..5496
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5497..5646
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5647..5787
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..5913
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5914..6045
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6046..6180
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6181..6310
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6311..6437
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6438..6589
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6590..6714
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6715..7086
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7087..7276
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7277..7481
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7482..7674
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7675..7800
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7801..7929
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7930..8049
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8050..8163
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8164..8313
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8314..8436
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8437..8556
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8557..8685
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8686..8808
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8809..8949
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8950..9137
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9138..9321
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9322..9407
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9408..9530
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9531..9712
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9713..9912
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9913..10101
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10102..10250
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10251..10344
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10345..10461
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10462..10581
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10582..10701
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10702..10818
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10819..10925
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10926..11055
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11056..11162
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11163..11295
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11296..11418
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11419..11544
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11545..11682
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11683..11817
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11818..11937
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11938..12179
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12180..12403
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12404..12510
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12511..12627
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12628..12801
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12802..12927
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12928..13092
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13093..13254
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13255..13429
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13430..13534
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13535..13611
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13612..13702
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13703..13847
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13848..13946
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13947..15850
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15830..15835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /note="hexamer: AATGAA"
     polyA_site      15850
                     /gene="LRP1B"
                     /gene_synonym="LRP-1B; LRP-DIT; LRPDIT"
                     /note="major polyA site"
ORIGIN      
        1 agacgtaccc tgcattgaaa agtcaagaca cacgggcgtc tcgctcgcgc tcacacacgc
       61 tctgcctcct ctctcccgca cgcgcgcatc cctccacctt ccacatcctg ctccaggcag
      121 gagaaggctg actggctgga ctcattgagc tgaagaattt ccagtgacat ttgtaaatga
      181 cgccgctcga ttccaggctc caagcggccc ctgccgccgc cgccgccgcc gggccgaagg
      241 tgccgccgag cagtctccag cgcaggcttc cttaccgggc gaccacaatg tccgagtttc
      301 tcctcgcctt actcactctc tcgggattat tgccgattgc cagggtgctg accgtgggag
      361 ccgaccgaga tcagcagttg tgtgatcctg gtgaatttct ttgccacgat cacgtgactt
      421 gtgtctccca gagctggctg tgtgatgggg accctgactg ccctgatgat tcagacgagt
      481 ctttagatac ctgtcccgag gaggtagaaa tcaagtgccc cttgaatcac attgcttgcc
      541 ttggtaccaa caaatgtgtt catttatccc agctgtgcaa tggtgtcttg gactgcccag
      601 atgggtatga cgaaggagta cattgtcagg aactgttatc caattgccaa cagctgaatt
      661 gtcagtataa atgtacaatg gtcagaaata gtacaagatg ttactgtgag gatggattcg
      721 aaataacaga agatgggaga agctgtaaag atcaagatga atgtgctgtt tatggtacat
      781 gcagccagac ctgcagaaac acacatggat cctacacttg cagttgtgtg gaaggctacc
      841 taatgcagcc agacaacaga tcttgcaagg ctaaaattga acctacagat agaccaccta
      901 tactattaat tgcaaatttt gaaacaattg aggttttcta tcttaatgga agtaaaatgg
      961 caactctaag ctcagtcaat ggaaatgaaa ttcatactct ggattttatt tataatgaag
     1021 atatgatttg ttggattgaa tcaagagaat cttcaaatca actcaaatgt atccagataa
     1081 caaaagcagg aggattaaca gatgaatgga caatcaatat tcttcaatcc ttccacaatg
     1141 tgcaacaaat ggcgattgac tggctcactc gaaatctcta ttttgtggac catgtcggtg
     1201 accggatctt tgtttgtaat tccaacggtt ctgtatgtgt caccctgatt gatctggagc
     1261 ttcacaatcc taaagcaata gcagtagatc caatagcagg aaaacttttc tttactgact
     1321 acgggaatgt cgccaaagtg gagagatgtg acatggatgg gatgaaccga acaaggataa
     1381 ttgattcaaa gacagagcag ccagctgcac tggcactaga cctagtcaac aaattggttt
     1441 actgggtaga tctttacttg gactatgtgg gagtagtgga ctatcaagga aaaaatagac
     1501 acactgtcat tcaaggcaga caagttagac atctttatgg tataactgtg tttgaagatt
     1561 atttgtatgc aaccaattct gataactaca atatcgtaag gataaaccga tttaatggga
     1621 ctgatattca ctcattaatt aaaattgaga atgcttgggg aatccgaatt tatcaaaaaa
     1681 gaactcaacc aacagtcaga agccatgcat gtgaagtcga tccatatgga atgccagggg
     1741 gctgttcaca catctgtcta ctcagcagca gttacaaaac tcggacttgt cgctgcagga
     1801 ctggcttcaa cttgggaagt gatggcaggt catgcaaaag accaaagaat gagttgttcc
     1861 tcttttatgg gaaaggacgc ccaggaattg ttagaggaat ggacttgaat accaagatag
     1921 ctgatgaata catgatcccc atagaaaatc tggtaaaccc tcgtgcttta gactttcacg
     1981 cagaaaccaa ttacatctac tttgctgaca ccaccagttt cctaattggc cggcagaaga
     2041 tagatggcac agagagagaa accatcctga aagatgatct ggataatgta gagggcattg
     2101 ctgtggactg gattggaaat aatctttact ggaccaatga tggccatagg aaaaccatta
     2161 atgtggccag gctggaaaaa gcttctcaga gtcggaagac tcttttagag ggtgaaatgt
     2221 ctcatcccag aggaattgtg gtggatccag ttaatggttg gatgtattgg acagactggg
     2281 aggaagatga aatagatgac agcgtgggaa ggattgagaa ggcctggatg gatggattca
     2341 atcggcagat ttttgtgact tcaaagatgc tgtggccaaa cggtttaact ctggactttc
     2401 acaccaacac attatactgg tgtgatgcct attacgatca tattgaaaaa gtatttttga
     2461 atgggactca caggaagatt gtttacagtg ggagagagtt gaaccaccct ttcggactgt
     2521 cgcatcatgg aaattatgtg ttctggactg attatatgaa tggttccatt tttcaactag
     2581 atttgataac aagtgaggtg acattgctga ggcatgaaag accaccccta tttgggcttc
     2641 agatttatga tccacgaaag caacaaggtg acaatatgtg ccgagtaaat aatgggggct
     2701 gtagtacact ttgcttggct atcccaggag gccgggtgtg tgcttgtgcc gataatcaac
     2761 ttttggatga aaatgggaca acttgcacat ttaatcctgg agaagcacta cctcacatat
     2821 gtaaagctgg agagtttcgc tgcaaaaaca gacactgtat ccaagctcgg tggaaatgtg
     2881 atggcgacga tgactgccta gacggaagcg atgaggattc agtaaactgc ttcaatcata
     2941 gctgtcctga tgatcagttt aaatgccaga ataatcgctg catccccaag agatggcttt
     3001 gtgatggagc taatgactgt gggagcaatg aagatgaatc caatcaaact tgcacagcca
     3061 gaacatgcca ggtagaccag ttttcttgcg gaaatgggcg ttgcattccc agagcatggc
     3121 tgtgtgacag ggaagacgac tgtggtgacc agacagatga aatggcatct tgtgaattcc
     3181 caacttgtga gccactaacc caattcgtat gcaaaagtgg aagatgcatt agcagcaaat
     3241 ggcactgcga ctctgatgac gactgtgggg acgggagtga tgaggtgggc tgtgttcact
     3301 cttgctttga taatcagttc agatgttcca gtggcagatg catcccaggc cactgggcct
     3361 gtgatggtga caatgactgt ggggacttca gtgatgaagc ccagatcaat tgtactaaag
     3421 aagagattca ttctcctgct ggttgtaacg gaaatgaatt tcagtgccac cctgatggta
     3481 attgcgttcc tgatttgtgg cgctgtgatg gagaaaaaga ctgtgaagat ggtagtgatg
     3541 aaaaaggttg caatggtacc atacgattgt gtgaccacaa aaccaagttt tcctgttgga
     3601 gtacagggag atgcatcaac aaagcatggg tgtgtgatgg agatattgat tgcgaagatc
     3661 agtcagatga agatgactgt gacagtttct tgtgtggacc acccaagcat ccttgtgcta
     3721 atgacacctc agtctgcctg cagccagaga aactctgcaa tgggaaaaag gattgtcctg
     3781 atggctctga tgaaggctat ctctgtgatg agtgttcgct gaacaatgga ggctgtagca
     3841 accactgttc tgttgttcct ggaagaggaa ttgtctgttc ctgccctgaa ggacttcaac
     3901 tcaacaaaga caataaaaca tgtgaaattg tggattattg tagcaatcat ctaaagtgca
     3961 gccaagtatg tgagcagcac aagcacacag tcaagtgctc atgttatgaa ggttggaagc
     4021 tggatgtaga cggtgaaagt tgtacaagtg ttgatccttt tgaagcattc atcatctttt
     4081 ctattcgtca tgagatcaga aggattgatc ttcacaaaag agactatagt ctacttgttc
     4141 ctggattgag aaacacaata gcacttgatt ttcacttcaa tcaaagttta ctttattgga
     4201 cagatgttgt agaagacaga atataccggg gaaagctttc tgaaagtgga ggtgtcagtg
     4261 ccattgaagt ggttgtggag catggcctgg ctactccaga aggcctgaca gtcgactgga
     4321 tagcaggaaa catatactgg atagacagca atctggacca aatcgaagtg gccaaactag
     4381 atggctccct aagaactaca ctaatagcag gagccatgga acaccccagg gccattgctt
     4441 tggacccaag atatggaatt cttttctgga cagactggga tgcaaatttt cctcgcattg
     4501 aatctgcctc tatgagtggt gctgggagaa aaaccatcta taaagacatg aaaactgggg
     4561 cttggcctaa tggactaact gtggaccact ttgagaaaag gatagtgtgg acagacgcca
     4621 ggtcagatgc tatttattca gccctctatg atggaacaaa catgatagaa atcatccgag
     4681 gtcatgaata cctttcccat ccctttgctg tgtctctata tgggagtgaa gtctactgga
     4741 cagactggag gaccaacaca ttgtccaaag ccaataagtg gacagggcag aatgtcagtg
     4801 tgattcagaa aaccagtgca cagccatttg accttcagat ataccatccc agtcgccagc
     4861 cacaggctcc caatccttgt gcagctaatg atggcaaagg cccctgctct cacatgtgtc
     4921 taatcaatca caataggagt gctgcctgtg cgtgccccca cttgatgaag ctttcttcag
     4981 acaagaagac ctgctatgaa atgaaaaaat ttcttcttta tgcaagacgt tctgaaatca
     5041 gaggagtgga tattgacaat ccatacttta acttcatcac ggcatttaca gtccctgata
     5101 ttgatgacgt tactgtgata gacttcgatg catctgagga acgtttatac tggacagata
     5161 ttaaaacaca aaccattaaa cgagctttta ttaacggaac tgggttagaa actgttattt
     5221 caagagatat tcagagtatc agagggctag cagtggattg ggtgtcacgt aatttatact
     5281 ggattagctc agaatttgat gaaacgcaaa ttaatgtggc aaggctagat ggctctttga
     5341 aaacctcaat tatccatgga atcgataagc cacagtgtct tgcagctcac ccagtcaggg
     5401 gaaaactcta ctggaccgat ggaaacacaa ttaacatggc aaatatggat ggcagtaata
     5461 gcaagattct gtttcagaat cagaaggagc cagttggtct atcgatagac tatgtggaaa
     5521 acaagcttta ttggatcagt tcagggaatg gaaccataaa tagatgcaac ctggatggtg
     5581 gtaatttaga agtaatcgag tcaatgaaag aagaattaac aaaagctaca gccctaacca
     5641 tcatggataa gaaactgtgg tgggcagacc aaaacttagc ccagctagga acctgcagca
     5701 aaagagacgg aagaaacccc accatcctac ggaataagac ttctggggta gttcatatga
     5761 aagtctatga taaagaagca cagcaaggca gcaattcctg ccaactaaac aatggtggat
     5821 gctctcaact ttgtttacca acatctgaaa ctacaaggac ttgtatgtgt acagtgggat
     5881 attatctcca aaagaaccgt atgtcatgtc aaggtataga atcatttctt atgtactctg
     5941 ttcatgaagg aatcagggga atacctcttg aaccaagtga caaaatggat gctttgatgc
     6001 ctatatcagg aacttcattt gccgtgggaa tagatttcca tgcagaaaat gataccatct
     6061 actggacaga catgggcttc aataaaatta gcagagctaa aagagatcag acttggaaag
     6121 aagatatcat taccaatggc ttgggaagag tggaagggat agctgttgac tggattgctg
     6181 gtaacatata ttggacagat catggtttca acttaattga agttgcaaga ctcaatggtt
     6241 ctttccgtta tgtaattatt tcccaaggcc tggatcaacc aagatctata gctgtgcacc
     6301 cagagaaagg cctcttgttc tggactgaat ggggacaaat gccctgtatt ggaaaggctc
     6361 gcttggatgg ctcagagaag gttgtccttg taagcatggg aatagcatgg ccgaatggca
     6421 tctccatcga ctatgaggaa aataaattgt actggtgtga tgctcgcaca gacaagatag
     6481 agagaatcga ccttgagact ggagggaatc gcgagatggt gctgtcagga agcaatgtgg
     6541 atatgttttc agttgcagtc tttggggctt acatctactg gtctgacaga gcacatgcaa
     6601 acgggtctgt cagaaggggc cacaagaatg atgccacaga aacgataacc atgagaaccg
     6661 gccttggagt caacctgaag gaggttaaaa tatttaaccg agtaagagag aaagggacca
     6721 atgtttgtgc cagggacaat ggtggctgta agcaactctg tctttatcga ggaaattccc
     6781 ggagaacttg tgcttgtgcc catggatatt tggcagaaga tggagttact tgcctgaggc
     6841 atgaaggcta tttactgtat tcaggaagaa caatattaaa aagtatacat ctttctgatg
     6901 aaaccaattt aaattcccca ataaggccat atgagaatcc acgttatttc aagaatgtca
     6961 tagccttggc ttttgactat aatcaaagaa gaaaaggtac caaccgaatc ttttacagtg
     7021 atgcacactt tggaaatata cagcttatta aagacaactg ggaagacaga caagtaattg
     7081 ttgaaaatgt gggttctgtg gaaggacttg cctatcacag agcctgggat acactgtact
     7141 ggacaagctc taccacctca tccatcacca gacacactgt ggaccagact cggcctggag
     7201 catttgacag ggaagctgtc atcaccatgt cagaagatga ccatccacat gtgctagcct
     7261 tggatgaatg tcaaaattta atgttttgga ccaactggaa tgaacaacat ccaagtatca
     7321 tgagatctac tctgactggg aaaaatgctc aagtggtggt cagtacagac atactcactc
     7381 caaatggact tactatcgac taccgtgcag agaagctgta tttctcagat ggcagtctag
     7441 gaaaaattga aaggtgtgaa tacgatggat cccagagaca tgtgatagtt aaatctgggc
     7501 cagggacttt cctcagtttg gctgtttatg acaattatat attctggtcg gactggggaa
     7561 gaagagctat actgcggtcc aacaagtaca caggaggaga tacaaaaatt cttcgttccg
     7621 atattccaca tcagccaatg ggaatcatag ctgttgccaa tgacaccaat agctgtgaac
     7681 tttctccatg tgcattattg aatggaggct gccatgactt gtgcctttta actcccaatg
     7741 ggagagtgaa ttgttcctgc agaggggacc gaatattgct agaggacaac agatgtgtga
     7801 ctaaaaattc ctcctgcaac gcttattcgg agtttgaatg tggaaatggt gagtgcattg
     7861 actaccagct cacctgtgat ggcattcctc actgtaaaga taaatcagat gaaaaactgc
     7921 tctactgtga aaacagaagc tgtcgaagag gcttcaagcc atgctataat cgccgctgca
     7981 ttcctcatgg caagttatgt gatggagaaa atgactgcgg agacaactct gatgaattag
     8041 attgtaaagt ttcaacctgt gccacggttg agttccgctg tgcagatggg acttgtattc
     8101 caagatcagc acgatgcaac cagaacatag attgtgcaga tgcttcagat gaaaagaact
     8161 gcaataacac agactgcaca catttctata agcttggagt gaaaaccaca gggttcataa
     8221 gatgtaattc tacctcactg tgtgttctgc caacctggat atgcgacggg tctaatgact
     8281 gtggagacta ttcagatgaa ttaaagtgcc cagttcaaaa caaacacaaa tgtgaagaaa
     8341 attattttag ttgtcctagt ggaagatgca ttttgaatac ctggatatgc gatggtcaga
     8401 aagattgtga ggatggacgt gatgaattcc actgtgattc ttcttgctct tggaaccaat
     8461 ttgcttgttc cgcacaaaaa tgtatttcta agcattggat ttgtgatgga gaagatgact
     8521 gtggggatgg gttagatgaa agtgacagca tttgtggtgc cataacctgt gctgctgaca
     8581 tgttcagctg ccagggctct cgtgcctgcg tgccccgaca ttggctttgt gatggtgaaa
     8641 gggactgtcc agatggaagc gatgagcttt ccacagcagg ctgcgctccc aataatacat
     8701 gtgatgaaaa tgctttcatg tgccataata aagtatgcat tcccaagcaa tttgtttgtg
     8761 accatgatga cgactgtgga gatggctctg atgagtcacc gcagtgtgga tatcgacagt
     8821 gtggtacaga agaatttagt tgtgctgatg ggcggtgtct tctaaatact caatggcagt
     8881 gtgatggaga ctttgactgt cctgaccatt ctgatgaagc acctttaaac ccaaagtgta
     8941 aaagtgcaga acagtcatgc aacagttcat tttttatgtg caaaaatggc aggtgcattc
     9001 ccagtggagg tctttgcgac aataaggatg actgtggcga tggttcagat gagagaaact
     9061 gccatataaa tgaatgtttg agtaagaaag tcagtggatg ttctcaagac tgtcaagacc
     9121 ttccggtcag ttataagtgc aaatgctggc ctggattcca actgaaggat gacggcaaaa
     9181 catgtgtaga cattgatgaa tgctcttcag gctttccctg tagccagcaa tgcatcaata
     9241 catacgggac ttacaagtgc ctctgtacag atgggtatga aatacaacct gataacccaa
     9301 atggctgcaa atcgctctca gatgaagaac cttttttaat tcttgctgat catcatgaga
     9361 taaggaaaat tagcactgat ggctccaact acacactttt aaaacaggga ttaaacaatg
     9421 ttattgctat agactttgat tacagagaag aattcatcta ttggatcgat tctagccgac
     9481 ccaatggcag tcgcataaat agaatgtgtt taaatggaag tgacattaag gtagttcata
     9541 acacagcggt ccccaatgca cttgctgtcg attggattgg aaaaaacctc tattggtctg
     9601 acacagaaaa aagaatcatt gaagtatcca aactcaatgg cttgtaccct actatactcg
     9661 ttagcaaaag gctgaagttt cccagagact tgtctttaga tcctcaagct ggatatttgt
     9721 attggattga ctgctgcgag tatcctcata ttggccgtgt tggaatggat ggaaccaatc
     9781 agagtgttgt catagaaacc aagatttcta gacctatggc actaacaata gattatgtta
     9841 atcgtagact ctactgggcc gatgaaaatc acattgaatt tagcaacatg gatggatctc
     9901 atagacacaa agtccctaat caagatattc caggggtgat tgcactaaca ttgtttgaag
     9961 actacatcta ctggactgat gggaaaacca agtcactcag ccgtgcccat aaaacatcgg
    10021 gagcagacag actctcactg atttactcat ggcatgccat cacagatatc caggtgtatc
    10081 attcttatag acaacctgat gtctccaaac atctctgcat gataaataat ggtggttgca
    10141 gtcatttgtg ccttttagcc cctggaaaaa cccacacttg tgcatgtccc actaacttct
    10201 atctggcagc tgataatagg acttgcttat ccaactgcac agccagccag tttcgttgca
    10261 aaactgacaa atgtattcca ttctggtgga aatgtgacac cgtggatgac tgtggtgatg
    10321 gatctgatga acctgatgac tgtcctgaat ttagatgtca gccaggccga tttcagtgtg
    10381 ggactggact ctgtgctcta ccagctttca tctgtgatgg agagaatgat tgtggagaca
    10441 attctgatga actcaactgt gacacacatg tctgcctgtc aggtcaattc aaatgtacca
    10501 agaaccagaa atgtatccca gtaaacttaa gatgtaatgg gcaagatgac tgtggtgatg
    10561 aggaagatga aagagactgt cctgaaaaca gctgttctcc agactatttc cagtgtaaga
    10621 ctacgaagca ttgcatttcc aagctgtggg tttgtgacga ggatccagac tgtgcagatg
    10681 catcagacga ggccaactgc gataaaaaga cttgtggacc tcatgaattc cagtgtaaaa
    10741 acaacaactg tattcccgat cactggcggt gtgatagcca aaatgactgc agtgataatt
    10801 cagatgaaga aaactgtaag ccacagacat gtacattgaa agatttcctc tgtgccaatg
    10861 gggactgtgt ttcttcaagg ttttggtgtg atggagattt tgactgtgca gatggctctg
    10921 atgagagaaa ttgtgagaca agttgttcca aagatcagtt ccggtgttcc aatggtcagt
    10981 gtataccagc aaaatggaaa tgtgatggcc atgaagactg caaatatggg gaagatgaga
    11041 aaagctgtga gccagcttct cctacttgct catcacgtga atatatatgt gccagtgatg
    11101 gatgtatttc agcatctttg aaatgtaatg gagaatatga ttgtgctgat ggttcagatg
    11161 agatggactg tgtgactgaa tgtaaggaag atcagtttcg gtgcaaaaat aaagcccact
    11221 gtattccaat tagatggctg tgtgatggaa ttcatgactg tgtggatggc agtgatgaag
    11281 agaactgtga aagaggagga aatatatgta gagctgatga gttcctttgc aataattctc
    11341 tctgcaaact acatttctgg gtgtgtgatg gagaggacga ctgtggagac aactctgatg
    11401 aagcccctga tatgtgtgtc aaatttcttt gtccatccac gagacctcac agatgcagaa
    11461 ataacagaat atgcctacag tcggagcaaa tgtgcaatgg gattgatgaa tgcggtgaca
    11521 attcagatga agatcactgt ggtggtaagc tgacatataa agcaaggcct tgtaaaaagg
    11581 atgagtttgc ttgtagtaat aaaaaatgca tccctatgga tctccagtgt gatcgacttg
    11641 atgactgcgg agatggttca gatgagcaag gatgcagaat agctcctact gaatatacct
    11701 gtgaagataa tgtgaatcca tgtggagatg atgcatattg taatcaaata aaaacatctg
    11761 ttttctgtcg ctgtaagcct ggatttcaga gaaacatgaa aaacagacaa tgtgaagacc
    11821 ttaatgaatg tttggtgttt ggcacatgtt cccatcaatg tataaatgtg gaaggatcat
    11881 ataaatgtgt gtgtgaccag aattttcaag aaagaaataa cacctgcata gcagaaggct
    11941 ctgaagatca agttctctac attgctaatg acactgatat cctgggtttt atatatccat
    12001 tcaactacag tggcgatcat caacaaattt ctcatattga acataattca agaataacag
    12061 ggatggatgt atattatcaa agagatatga ttatttggag tactcagttt aatccaggcg
    12121 gaattttcta caaaaggatc catggcagag aaaaaaggca agcaaacagt ggcttgattt
    12181 gtcctgaatt taaaaggccc agggacattg cagttgactg ggtggctgga aacatttact
    12241 ggactgatca ttctagaatg cattggttca gttactacac tactcactgg accagtctga
    12301 ggtactctat caacgtaggg cagctgaatg gccccaactg caccagactc ttaacaaata
    12361 tggctggaga accctatgct attgcagtaa atcctaaaag agggatgatg tactggactg
    12421 ttgttgggga tcattcccat atagaagaag cagccatgga tggtacactg agaaggattt
    12481 tagtacaaaa gaacttacag agacccacag gtttggctgt ggattatttt agtgaacgca
    12541 tatattgggc tgactttgag ctctccatca ttggcagtgt tctgtatgat ggctctaatt
    12601 cagtagtctc tgtcagcagc aaacaaggtt tattacatcc acataggatc gatatctttg
    12661 aagattatat atatggagca ggacctaaaa atggtgtatt tcgagttcaa aaatttggcc
    12721 atggttcagt agagtactta gctttaaata ttgataaaac aaaaggtgtt ttgatatctc
    12781 atcgttataa acaactagat ttacccaatc catgcttgga tttagcatgc gaatttcttt
    12841 gcttgctaaa tccttctggg gccacttgtg tgtgtccaga aggaaaatat ttgattaatg
    12901 gcacctgcaa tgatgacagc ctgttagatg attcatgtaa gttaacttgt gaaaatggag
    12961 gaagatgcat tttaaatgag aaaggtgatt tgaggtgtca ctgttggccc agttattcag
    13021 gagaaagatg tgaagtcaac cactgtagca actactgcca gaatggagga acttgcgtac
    13081 catcagttct agggagaccc acctgcagct gtgcactggg tttcactggg ccaaactgtg
    13141 gtaagacagt ctgtgaggat ttttgtcaaa atggaggaac ctgcattgtg actgctggaa
    13201 accagcctta ctgccactgc cagccggaat acaccggaga cagatgtcag tactacgtgt
    13261 gccaccacta ttgtgtgaat tctgaatcat gtaccattgg ggatgatgga agtgttgaat
    13321 gtgtctgtcc aacgcgctat gaaggaccaa aatgtgaggt tgacaagtgt gtaaggtgcc
    13381 atggggggca ctgcattata aataaagaca gtgaagatat attttgcaac tgcactaatg
    13441 gaaagattgc ctctagctgt cagttatgtg atggctactg ttacaatggt ggcacatgcc
    13501 agctggaccc cgagacaaat gtacctgtgt gtctatgctc caccaactgg tcaggcacac
    13561 agtgtgaaag gccagcccca aagagcagca agtctgatca tatcagcaca agaagcattg
    13621 ccatcattgt gcctctcgtc ctcttggtga ctttgataac caccttagta attggtttag
    13681 tgctttgtaa aagaaaaaga aggacaaaaa caattagaag acaacctatt atcaatggag
    13741 gaataaatgt agaaattggc aatccatctt ataacatgta tgaggtagat catgatcaca
    13801 acgatggagg tcttttagat cctggcttta tgatagaccc aacaaaggcc aggtacatag
    13861 ggggaggacc cagtgctttc aagcttccac acacagcgcc gcccatctac ctaaactctg
    13921 atttgaaagg accactaact gctgggccaa caaattactc caatccggta tatgcaaaat
    13981 tatatatgga tgggcaaaac tgtcgaaact ccttaggaag tgttgatgaa aggaaagaac
    14041 tgcttccaaa gaaaatagaa attggtataa gagagacagt ggcataatca gtgatatctt
    14101 ttatatgctg tataaatgta taaaatataa ggattacttt tgtatgttcc aacagtatta
    14161 tacttgtttt ggcatcagca ttacctcttt ctttatcttt ttcctggtta attgttttct
    14221 gagttttttg ggttttattt tttgctgatg actattgatt gaccatttgt atggtatttt
    14281 tatgaaaaag aactgcacta cagtacaatt tacaacaatg ctgctgatat gacacacctt
    14341 tgaatttgtt aaaattaaaa acaacgtatt cctttgtagt gtgaatatga gcaatctatt
    14401 ttatatgaac ttttttggtt gtacttaatc aacgaggaga atctctgcac ttttccatta
    14461 tacggtttga aggctgtaat acagtgtcat attatttttc tgtttaaatt gatggaaaaa
    14521 tgattgaatg gtcaactctc ttctttgtgc ccataaagat cgattcagac tctgctgaaa
    14581 atatatagct ctcacaagtt cagcatcacc tgctttgaaa ttagccttag attgccaacc
    14641 aatagatgag aattttgagg aaaaaaatta aaaatatgta aaattaataa tttgcatgaa
    14701 cacagatgac tacattttcc aaaacttagt ggactctatg tgatgtacta aatgtataca
    14761 ccttgtaagc aatagttata tttaggtggt agaacatagc aaaaatataa ccgaaagttg
    14821 gccgactgca cttgctatgg aataagacct tttattctcc ctcagtctcg agataaatag
    14881 ccagcctaga gcacaacagg gcattgggta cttgcatctt aggtatttct tcccagtcac
    14941 atccattttg tggaagatta acccaacccc ttacactaca ctgaacacta aagaataata
    15001 tataagcaca caaattggtg acagaatttc aattacgtga acgcatcctc tttgctaggt
    15061 caaaaaacaa agggcaaagc agacatttta gtatacagag tgattggcaa atattttcaa
    15121 gatttaatat gagcaaccca ttatttgccc tatccaaaat atattcaagg gccttccaag
    15181 ttgtagaaga acaatgatct tcccataatc aaaagtggag agtcgaaatg ctgtgccagt
    15241 tgctctggta ttcaggtttc tctgggtttt acagaacgca tggaccccat tcacgtttgg
    15301 tttgtttatc ttcaaatttg agttgaaacg agtgcgattt atttaagttg tatataaaaa
    15361 taaaaggata gcatttttat acaaatatct ttaaaggcac aaaagattta ttcacaagtt
    15421 ttggagggct ttttgttcct ctgatagaca tgactgactt ttagctgtca taatgtatta
    15481 acctaacaga tgaaatatgt taaatatgtg gttgctcttt atccctttgt acaagcatta
    15541 aaaaaactgc tgttttataa gaagactttt tgttgtacta tgtgcatgca tactacctat
    15601 ttctaaactt tgccatattg aggcctttat aaactattga tttatgtaat actagtgcaa
    15661 ttttgcttga acaatgttat gcatatcata aactttttca ggttcttgtt taagtacatt
    15721 ttttaaattg aacagtattt ttcattttgg ttataatata gtcattttgc ctatgtttct
    15781 acaatgaagt gttaaatact ttataaaaaa ttgttgactg acttatttaa atgaaattct
    15841 acatatttaa
//
