LOCUS       NM_013437               4378 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 12 (LRP12), transcript
            variant 1, mRNA.
ACCESSION   NM_013437 NM_024937
VERSION     NM_013437.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4378)
  AUTHORS   Kume,K., Kurashige,T., Muguruma,K., Morino,H., Tada,Y.,
            Kikumoto,M., Miyamoto,T., Akutsu,S.N., Matsuda,Y., Matsuura,S.,
            Nakamori,M., Nishiyama,A., Izumi,R., Niihori,T., Ogasawara,M.,
            Eura,N., Kato,T., Yokomura,M., Nakayama,Y., Ito,H., Nakamura,M.,
            Saito,K., Riku,Y., Iwasaki,Y., Maruyama,H., Aoki,Y., Nishino,I.,
            Izumi,Y., Aoki,M. and Kawakami,H.
  TITLE     CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis
  JOURNAL   Am J Hum Genet 110 (7), 1086-1097 (2023)
   PUBMED   37339631
  REMARK    GeneRIF: CGG repeat expansion in LRP12 in amyotrophic lateral
            sclerosis.
REFERENCE   2  (bases 1 to 4378)
  AUTHORS   Huang,M., Lu,L., Lin,C., Zheng,Y., Pan,X., Wang,S., Chen,S.,
            Zhang,Y., Liu,C., Ge,G., Zeng,Y.A. and Chen,J.
  TITLE     LRP12 is an endogenous transmembrane inactivator of alpha4
            integrins
  JOURNAL   Cell Rep 42 (6), 112667 (2023)
   PUBMED   37330909
  REMARK    GeneRIF: LRP12 is an endogenous transmembrane inactivator of alpha4
            integrins.
REFERENCE   3  (bases 1 to 4378)
  AUTHORS   Saito,R., Shimizu,H., Miura,T., Hara,N., Mezaki,N., Higuchi,Y.,
            Miyashita,A., Kawachi,I., Sanpei,K., Honma,Y., Onodera,O.,
            Ikeuchi,T. and Kakita,A.
  TITLE     Oculopharyngodistal myopathy with coexisting histology of systemic
            neuronal intranuclear inclusion disease: Clinicopathologic features
            of an autopsied patient harboring CGG repeat expansions in LRP12
  JOURNAL   Acta Neuropathol Commun 8 (1), 75 (2020)
   PUBMED   32493488
  REMARK    GeneRIF: Oculopharyngodistal myopathy with coexisting histology of
            systemic neuronal intranuclear inclusion disease: Clinicopathologic
            features of an autopsied patient harboring CGG repeat expansions in
            LRP12.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4378)
  AUTHORS   Ishiura,H., Shibata,S., Yoshimura,J., Suzuki,Y., Qu,W., Doi,K.,
            Almansour,M.A., Kikuchi,J.K., Taira,M., Mitsui,J., Takahashi,Y.,
            Ichikawa,Y., Mano,T., Iwata,A., Harigaya,Y., Matsukawa,M.K.,
            Matsukawa,T., Tanaka,M., Shirota,Y., Ohtomo,R., Kowa,H., Date,H.,
            Mitsue,A., Hatsuta,H., Morimoto,S., Murayama,S., Shiio,Y.,
            Saito,Y., Mitsutake,A., Kawai,M., Sasaki,T., Sugiyama,Y.,
            Hamada,M., Ohtomo,G., Terao,Y., Nakazato,Y., Takeda,A.,
            Sakiyama,Y., Umeda-Kameyama,Y., Shinmi,J., Ogata,K., Kohno,Y.,
            Lim,S.Y., Tan,A.H., Shimizu,J., Goto,J., Nishino,I., Toda,T.,
            Morishita,S. and Tsuji,S.
  TITLE     Noncoding CGG repeat expansions in neuronal intranuclear inclusion
            disease, oculopharyngodistal myopathy and an overlapping disease
  JOURNAL   Nat Genet 51 (8), 1222-1232 (2019)
   PUBMED   31332380
  REMARK    GeneRIF: GGC repeat expansions in LRP12 gene is associated with
            oculopharyngodistal myopathy.
REFERENCE   5  (bases 1 to 4378)
  AUTHORS   Grasse,S., Lienhard,M., Frese,S., Kerick,M., Steinbach,A.,
            Grimm,C., Hussong,M., Rolff,J., Becker,M., Dreher,F., Schirmer,U.,
            Boerno,S., Ramisch,A., Leschber,G., Timmermann,B., Grohe,C.,
            Luders,H., Vingron,M., Fichtner,I., Klein,S., Odenthal,M.,
            Buttner,R., Lehrach,H., Sultmann,H., Herwig,R. and Schweiger,M.R.
  TITLE     Epigenomic profiling of non-small cell lung cancer xenografts
            uncover LRP12 DNA methylation as predictive biomarker for
            carboplatin resistance
  JOURNAL   Genome Med 10 (1), 55 (2018)
   PUBMED   30029672
  REMARK    GeneRIF: LRP12 DNA methylation as a powerful predictive marker for
            carboplatin resistance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4378)
  AUTHORS   Debette,S., Visvikis-Siest,S., Chen,M.H., Ndiaye,N.C., Song,C.,
            Destefano,A., Safa,R., Azimi Nezhad,M., Sawyer,D., Marteau,J.B.,
            Xanthakis,V., Siest,G., Sullivan,L., Pfister,M., Smith,H.,
            Choi,S.H., Lamont,J., Lind,L., Yang,Q., Fitzgerald,P.,
            Ingelsson,E., Vasan,R.S. and Seshadri,S.
  TITLE     Identification of cis- and trans-acting genetic variants explaining
            up to half the variation in circulating vascular endothelial growth
            factor levels
  JOURNAL   Circ Res 109 (5), 554-563 (2011)
   PUBMED   21757650
REFERENCE   7  (bases 1 to 4378)
  AUTHORS   Schneider,S., Gulacsi,A. and Hatten,M.E.
  TITLE     Lrp12/Mig13a reveals changing patterns of preplate neuronal
            polarity during corticogenesis that are absent in reeler mutant
            mice
  JOURNAL   Cereb Cortex 21 (1), 134-144 (2011)
   PUBMED   20439316
  REMARK    GeneRIF: As the preplate separates, Lrp12/Mig13a-positive neurons
            polarize in the radial plane and form a pseudocolumnar pattern,
            prior to moving to a deeper position within the emerging subplate
            layer.
REFERENCE   8  (bases 1 to 4378)
  AUTHORS   Garnis,C., Coe,B.P., Zhang,L., Rosin,M.P. and Lam,W.L.
  TITLE     Overexpression of LRP12, a gene contained within an 8q22 amplicon
            identified by high-resolution array CGH analysis of oral squamous
            cell carcinomas
  JOURNAL   Oncogene 23 (14), 2582-2586 (2004)
   PUBMED   14676824
REFERENCE   9  (bases 1 to 4378)
  AUTHORS   Battle,M.A., Maher,V.M. and McCormick,J.J.
  TITLE     ST7 is a novel low-density lipoprotein receptor-related protein
            (LRP) with a cytoplasmic tail that interacts with proteins related
            to signal transduction pathways
  JOURNAL   Biochemistry 42 (24), 7270-7282 (2003)
   PUBMED   12809483
  REMARK    GeneRIF: ST7 is a novel low-density lipoprotein receptor-related
            protein (LRP) with a cytoplasmic tail that interacts with proteins
            related to signal transduction pathways.
REFERENCE   10 (bases 1 to 4378)
  AUTHORS   Qing,J., Wei,D., Maher,V.M. and McCormick,J.J.
  TITLE     Cloning and characterization of a novel gene encoding a putative
            transmembrane protein with altered expression in some human
            transformed and tumor-derived cell lines
  JOURNAL   Oncogene 18 (2), 335-342 (1999)
   PUBMED   9927190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090827.11, DC372924.1,
            BC032109.2, AB208957.1 and AI828757.1.
            
            On Aug 11, 2020 this sequence version replaced NM_013437.4.
            
            Summary: This gene encodes a member of the low-density lipoprotein
            receptor related protein family. The product of this gene is a
            transmembrane protein that is differentially expressed in many
            cancer cells. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032109.2, AK289752.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276654.10/ ENSP00000276654.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC090827.11        50902-51135         c
            235-288             DC372924.1         1-54
            289-291             AC090827.11        50845-50847         c
            292-358             DC372924.1         55-121
            359-3390            BC032109.2         1-3032
            3391-4364           AB208957.1         2832-3805
            4365-4378           AI828757.1         6-19                c
FEATURES             Location/Qualifiers
     source          1..4378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..4378
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /note="LDL receptor related protein 12"
                     /db_xref="GeneID:29967"
                     /db_xref="HGNC:HGNC:31708"
                     /db_xref="MIM:618299"
     exon            1..440
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..2941
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; low-density lipoprotein receptor-related
                     protein 12; LDLR-related protein 12; suppressor of
                     tumorigenicity 7 protein"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     12 isoform a precursor"
                     /protein_id="NP_038465.1"
                     /db_xref="CCDS:CCDS6303.1"
                     /db_xref="GeneID:29967"
                     /db_xref="HGNC:HGNC:31708"
                     /db_xref="MIM:618299"
                     /translation="MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVS
                     TACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRR
                     CNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK
                     SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN
                     QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYP
                     DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA
                     FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQ
                     QRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF
                     CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLL
                     VIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPV
                     CSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSAD
                     GDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKVPPT
                     TAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRWV
                     RFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDL
                     ASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEAL
                     LLC"
     exon            441..497
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /inference="alignment:Splign:2.1.0"
     exon            498..633
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /inference="alignment:Splign:2.1.0"
     exon            634..836
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1941
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2074
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..4378
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4338..4343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /note="hexamer: ATTAAA"
     polyA_site      4378
                     /gene="LRP12"
                     /gene_synonym="ALS28; MIG13A; ST7"
                     /note="major polyA site"
ORIGIN      
        1 agtctggcga gtggcggcgc cggctagccc gagcggcgcg aggccggagt ccggcgtccg
       61 ccaccctctc gtctcgcgct ggcgcgcgag ctccttgccc ttgcccccag gagggccgcc
      121 ccgcgtgggg ctctcgcacc gcccggggtg ggagcaggcg agccggaggg aggagggagg
      181 agggagcgcg cgcgggcggc ggcggcccct cccttccccc tcccgcagcc gcggagagcg
      241 cagggagcag ccggtggctc ggcggcggcg gcggcggcgg cggcggcgtc ggcgtcgtct
      301 acctccagct tctcctccct cctcctccgt ctcctcctct ctctctccat ctgctgtggt
      361 tatggcctgt cgctggagca caaaagagtc tccgcggtgg aggtctgcgt tgctcttgct
      421 tttcctcgct ggggtgtacg gaaatggtgc tcttgcagaa cattctgaaa atgtgcatat
      481 ttcaggagtg tcaactgctt gtggagagac tccagagcaa atacgagcac caagtggcat
      541 aatcacaagc ccaggctggc cttctgaata tcctgcaaaa atcaactgta gctggttcat
      601 aagggcaaac ccaggcgaaa tcattactat aagttttcag gattttgata ttcaaggatc
      661 cagaaggtgc aatttggact ggttgacaat agaaacatac aagaatattg aaagttacag
      721 agcttgtggt tccacaattc cacctccgta tatctcttca caagaccaca tctggattag
      781 gtttcattcg gatgacaaca tctctagaaa gggtttcaga ctggcatatt tttcagggaa
      841 atctgaggaa ccaaattgtg cttgtgatca gtttcgttgt ggtaatggaa agtgtatacc
      901 agaagcctgg aaatgtaata acatggatga atgtggagat agttccgatg aagagatctg
      961 tgccaaagaa gcaaatcctc caactgctgc tgcttttcaa ccctgtgctt acaaccagtt
     1021 ccagtgttta tcccgtttta ccaaagttta cacttgcctc cccgaatctt taaaatgtga
     1081 tgggaacatt gactgccttg acctaggaga tgagatagac tgtgatgtgc caacatgtgg
     1141 gcaatggcta aaatattttt atggtacttt taattctccc aattatccag acttttatcc
     1201 tcctggaagc aattgcacct ggttaataga cactggtgat caccgtaaag tcattttacg
     1261 cttcactgac tttaaacttg atggtactgg ttatggtgat tatgtcaaaa tatatgatgg
     1321 attagaggag aatccacaca agcttttgcg tgtgttgaca gcttttgatt ctcatgcacc
     1381 tcttacagtt gtttcttctt ctggacagat aagggtacat ttttgtgctg ataaagtgaa
     1441 tgctgcaagg ggatttaatg ctacttacca agtagatggg ttctgtttgc catgggaaat
     1501 accctgtgga ggtaactggg ggtgttatac tgagcagcag cgttgtgatg ggtattggca
     1561 ttgcccaaat ggaagggatg aaaccaattg taccatgtgc cagaaggaag aatttccatg
     1621 ttcccgaaat ggtgtctgtt atcctcgttc tgatcgctgc aactaccaga atcattgccc
     1681 aaatggctca gatgaaaaaa actgcttttt ttgccaacca ggaaatttcc attgtaaaaa
     1741 caatcgttgt gtgtttgaaa gttgggtgtg tgattctcaa gatgactgtg gtgatggcag
     1801 cgatgaagaa aattgcccag taatcgtgcc tacaagagtc atcactgctg ccgtcatagg
     1861 gagcctcatc tgtggcctgt tactcgtcat agcattggga tgtacttgta agctttattc
     1921 tctgagaatg tttgaaagaa gatcatttga aacacagttg tcaagagtgg aagcagaatt
     1981 gttaagaaga gaagctcctc cctcgtatgg acaattgatt gctcagggtt taattccacc
     2041 agttgaagat tttcctgttt gttcacctaa tcaggcttct gttttggaaa atctgaggct
     2101 agcggtacga tctcagcttg gatttacttc agtcaggctt cctatggcag gcagatcaag
     2161 caacatttgg aaccgtattt ttaattttgc aagatcacgt cattctgggt cattggcttt
     2221 ggtctcagca gatggagatg aggttgtccc tagtcagagt accagtagag aacctgagag
     2281 aaatcatact cacagaagtt tgttttccgt ggagtctgat gatacagaca cagaaaatga
     2341 gagaagagat atggcaggag catctggtgg ggttgcagct cctttgcctc aaaaagtccc
     2401 tcccacaacg gcagtagaag cgacagtagg agcatgtgca agttcctcaa ctcagagtac
     2461 ccgaggtggt catgcagata atggaaggga tgtgacaagt gtggaacccc caagtgtgag
     2521 tccagcacgt caccagctta caagtgcact cagtcgtatg actcaggggc tacgctgggt
     2581 acgttttaca ttaggacgat caagttccct aagtcagaac cagagtcctt tgagacaact
     2641 tgataatggg gtaagtggaa gagaagatga tgatgatgtt gaaatgctaa ttccaatttc
     2701 tgatggatct tcagactttg atgtgaatga ctgctccaga cctcttcttg atcttgcctc
     2761 agatcaagga caagggctta gacaaccata taatgcaaca aatcctggag taaggccaag
     2821 taatcgagat ggcccctgtg agcgctgtgg tattgtccac actgcccaga taccagacac
     2881 ttgcttagaa gtaacactga aaaacgaaac gagtgatgat gaggctttgt tactttgtta
     2941 ggtacgaatc acataaggga gattgtatac aagttggagc aatatccatt tattattttg
     3001 taactttaca gttaaactag ttttagttta aaaagaaaaa atgcagggtg atttcttatt
     3061 attatatgtt agcctgcatg gttaaattcg acaacttgta actctatgaa cttagagttt
     3121 actattttag cagctaaaaa tgcatcacat attcatattg ttcaataatg tcctttcatt
     3181 tgtttctgat tgttttcatc ctgatactgt agttcactgt agaaatgtgg ctgctgaaac
     3241 tcatttgatt gtcattttta tctatcctat gttaaatggt ttgtttttac aaaataatac
     3301 cttattttaa ttgaaacgtt tatgcttttg ccaacacatc ttgtaactta atatactaga
     3361 tgttaaggtt gttaatgtac aaaaaaaaaa cccttatact cacctgcgtt ttcatttgtt
     3421 tgacatttgt ctattattgg atttcattat catatgaact tgtcagtggg aaacaaactg
     3481 tctaaaaatt tttctcttac gtttaacata caatcatgtg aaatttaggc agagttcgat
     3541 aaattactgg caaaaacaaa actcttttat aaagattttc taatgttgac tttaatactc
     3601 taacatggta caaaccaaat ggtaaaatcc caagtcattt cttttttcat ctctatttag
     3661 caacagaatt aagtggatga agatattcta ctatgcatta aatcttgaac tttataaaac
     3721 atgtacaaaa attgtacaag ataagttcca cctggtaatg tctttcccta atacagggtt
     3781 gcgcttgcat tggaccctag ggatttgcac taaaattata tcaaggtctc agatgagctt
     3841 agtgcacaag cactatcact ttaaatacta ttatttgcta ccacagcaac tatatatttc
     3901 catagctttt ggctgggggc gggggacatt tttattacaa cttgaaattg ctttgctggt
     3961 ttcatattta tttgttgtat ttaaaaaata cattgttgta agagtgattt tttcaatata
     4021 ttttattcct gggggggatc atgctacact ctcaaaagaa aattaagaaa tcattcagat
     4081 catcccccct ttttaagtag tgtgaattgc aaaacccaac atattttttt tactgtcagt
     4141 tgcggtttat ttattcttta actgtctgtt ttagtagttt aatgattatg aaaaatgtat
     4201 ctgtgtgtga tttgctattt attaaatttt aagtactttg ctgaatgtca ttttaaagca
     4261 tgtttgaagt cttgtgtatt tgtctgtgtt aatgctgtca ggaggaactg actaagatgt
     4321 tttaatatgt atcaaaaatt aaaatgattt tttttattgc cttgaggtac tttttaaa
//
