LOCUS       NM_032832               3634 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 11 (LRP11), transcript
            variant 1, mRNA.
ACCESSION   NM_032832
VERSION     NM_032832.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3634)
  AUTHORS   Xiao,K., McClatchy,D.B., Shukla,A.K., Zhao,Y., Chen,M.,
            Shenoy,S.K., Yates,J.R. 3rd and Lefkowitz,R.J.
  TITLE     Functional specialization of beta-arrestin interactions revealed by
            proteomic analysis
  JOURNAL   Proc Natl Acad Sci U S A 104 (29), 12011-12016 (2007)
   PUBMED   17620599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355312.24, BC043141.2, BC025239.1, AK027641.1, AK299599.1 and
            N91459.1.
            
            On May 17, 2019 this sequence version replaced NM_032832.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043141.2, AK027641.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239367.7/ ENSP00000239367.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL355312.24        145884-145898       c
            16-305              BC043141.2         2-291
            306-306             BC025239.1         283-283
            307-608             BC043141.2         293-594
            609-614             AK027641.1         276-281
            615-1390            BC043141.2         601-1376
            1391-1391           AK299599.1         619-619
            1392-2612           BC043141.2         1378-2598
            2613-2613           AK027641.1         2280-2280
            2614-3456           BC043141.2         2600-3442
            3457-3457           AK027641.1         3124-3124
            3458-3595           BC043141.2         3444-3581
            3596-3633           N91459.1           1-38                c
            3634-3634           AL355312.24        100296-100296       c
FEATURES             Location/Qualifiers
     source          1..3634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..3634
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="LDL receptor related protein 11"
                     /db_xref="GeneID:84918"
                     /db_xref="HGNC:HGNC:16936"
     exon            1..952
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1842
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; low-density lipoprotein receptor-related
                     protein 11; LRP-11"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     11 isoform 1 precursor"
                     /protein_id="NP_116221.3"
                     /db_xref="CCDS:CCDS5220.1"
                     /db_xref="GeneID:84918"
                     /db_xref="HGNC:HGNC:16936"
                     /translation="MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAP
                     LSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPD
                     AIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGC
                     YLFNCTARGRNVCKFALHSGYSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDV
                     VLHLPTDGVVLDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTF
                     QLTVTDTAGQRSSDNVSVTVLRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQ
                     CPDGSDEDFCQNLGLDRKMVTHTAASPALPRTTGPSEDAGGDSLVEKSQKATAPNKPP
                     ALSNTEKRNHSAFWGPESQIIPVMPDSSSSGKNRKEESYIFESKGDGGGGEHPAPETG
                     AVLPLALGLAITALLLLMVACRLRLVKQKLKKARPITSEESDYLINGMYL"
     exon            953..1110
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1252
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1378
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1591
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1687
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..3634
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="hexamer: AATAAA"
     polyA_site      3595
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="major polyA site"
     regulatory      3612..3617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="hexamer: AATATA"
     polyA_site      3634
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
ORIGIN      
        1 actgttcgca cacacctggt gctgatcaac gccgaggccg actcgtcgcc acccagcgcg
       61 ccgcaggccg gggcggagag gcgcagggcg ctgggcagtc tccggcgagg gcaaggagcg
      121 gtgcccggct gggccggcta tgtctcccgc tactgcggtt cccgccggcg cccgcgacct
      181 cgggggagca gccgggttcg ggggcgccgc gctgtgaggc cggggcctag agccagccgc
      241 ggccgcgcag gaggggccca gggcccgcgc tcgcccgcgt ccccgccttc ctcccgcgct
      301 cagccccgcc tcggctcgct gcccttggct ctcgtcgcca tggcctccgt cgcccaggag
      361 agcgcgggct cgcagcgccg gctaccgccg cgtcacgggg cgctgcgcgg gctgctactg
      421 ctctgcctgt ggctgccaag cggccgtgcg gccttgccgc ccgcggcgcc gctgtccgaa
      481 ctgcacgcgc agctgtcggg cgtggagcag ctgctggagg agttccgccg gcaactgcag
      541 caggagcggc ctcaggagga gctggagctg gagctgcgcg cgggcggcgg cccccaggag
      601 gactgcccgg gcccgggcag cggcggctac agcgcaatgc ctgacgccat catccgcacc
      661 aaggactccc tggcggcggg tgccagcttc ctgcgggcgc cggcggccgt gcggggctgg
      721 cggcaatgcg tggcggcctg ctgctccgag ccgcgctgct ccgtggccgt ggtggagctg
      781 ccccggcgcc ccgcgccccc ggcagccgtg ctcggctgct acctcttcaa ctgcacggcg
      841 cgcggccgca acgtctgcaa gttcgcgctg cacagcggct acagcagcta cagcctcagc
      901 cgcgcgccgg acggcgccgc cctggccacc gcgcgcgcct cgccccggca ggaaaaggat
      961 gcgcctccac ttagcaaggc tgggcaggat gtggttctgc atctgcccac agacggggtg
     1021 gttctagacg gccgcgagag cacagatgac cacgccatcg tccagtatga gtgggcactg
     1081 ctgcaggggg acccgtcagt ggacatgaag gtgcctcaat caggaaccct gaagctgtcc
     1141 cacctacagg agggaaccta caccttccag ctgaccgtga cggacactgc cgggcagaga
     1201 agctctgaca acgtgtcagt gacagtgctt cgcgcagcct actccacagg aggatgtttg
     1261 cacacttgct cacgctacca cttcttctgt gacgatggct gctgcattga catcacgctc
     1321 gcctgcgatg gagtgcagca gtgtcctgat gggtctgatg aagacttctg ccagaatctg
     1381 ggcctggacc gcaagatggt aacccacacg gcagctagtc ctgccctgcc aagaaccaca
     1441 gggccgagtg aagatgcagg gggtgactcc ttggtggaaa agtctcagaa agccactgcc
     1501 ccaaacaagc cacctgcatt atcaaacaca gagaagagga atcattccgc cttttgggga
     1561 ccagagagtc aaatcattcc tgtgatgcca gatagtagtt cctcagggaa gaacagaaaa
     1621 gaggaaagtt atatatttga gtcaaagggt gatggaggag gaggggaaca cccagcccca
     1681 gaaacaggtg cagtgctacc cctggcgctg ggtttggcta tcactgctct gctgcttctc
     1741 atggttgcat gccgactacg actggtgaaa cagaaactga aaaaagctcg tcccattaca
     1801 tctgaggaat cggactacct cataaatggg atgtatctat agtaatgtaa tttcaatacc
     1861 ttggggcagg gacatgtttt gtttataatt tatacatcta ttaagttctg gatatttaca
     1921 gcttcttttg tttttaattg ggccagaaga ttctgcaaat cccaaatctt tctttattat
     1981 ttattgtaaa aaaagtttcc ttagaagtca taaaatattt tgaaatttag agaggaattc
     2041 atgattaaag attcctaaaa atataattct gatttatgta agctgtccct gaaaatagaa
     2101 atgtgtactt agctgagaga aaattcagca tctcaggagg tggtattagg atgactgtgt
     2161 taacccatta ccttttagaa gccaactgtt ggccccttac catgctggac tgctataggc
     2221 ccagcttccc cttgttctgt ggcccttttc ttcctccttg aagctcccag tattcttttt
     2281 cttttcccct ctaaacctgt ttctgagagt ggatctcaag caagttcatg ccttcaatca
     2341 gatgttactt agggtgggta tacctaaatt ataaacctta tgtacaagtc agtaagcctt
     2401 agggaaggtg agtgtgggtc cttcctaatc cctctgacgt catgtcatat aggtggctgc
     2461 ctccttagac tgacctttgg gagaaaaaaa ccccagactt tgaattagta acagctctaa
     2521 gatggtcatg cagtgagata ggaaatcaag atggaagcag agaatctggc atgccaaaaa
     2581 ctaacagaaa cttagttgaa ggcaaagaga gcaaggagaa cgtttaatac ttcattacat
     2641 caaatcaaca ctgctccatg gtgagagcac agcaactcat ttatatatat atatataggc
     2701 tttgttgatg aaaaacgaca attgaagaga ggacgttgag tggattcctg ggtacagctt
     2761 ttgtaaaaat gtcaccatgg ctttcatcca atggaatgag tcgatgtttt ttaatgctat
     2821 aaaatgttag aatgtgccat cagctaatgc caggcttacg tatttctaga ccataaagca
     2881 gtttttcaca aattcatctt tacagaaaac cagcatctag cttagcatct ttcccctttt
     2941 aatttgtagg cttttaaagg caaatcattc ccaccatcac ttaacgccgg gattatacac
     3001 attctagaaa tgattctgag aggagtgtat agtatggtgc ctatctacac tcacatgata
     3061 ttcttattca cgtttttttt aaccataagt ggcaaatatt ttaaaatatt tgaaaaacac
     3121 tccagaatct agtacgcttt atttttagac tgaacctaaa gtaggttgtt cttttaacaa
     3181 agggtttaat tcgggtgggg aatataacat atcaaaatac atgaacaaat ggaaagttac
     3241 ttctagaaaa gcaaagaaat tgggtatcat ttttgtttct tgggaagcta attttgttga
     3301 atgtttagaa ttgagcaaag atgtaaattt ttgaagggca gtttagaaaa attaactttg
     3361 tgaatgaact taagatgtct gtactctata tgtgatgctg tgcagtttgt ttttatatgg
     3421 aaagatgtca actatagcca taaccaataa aataaaaact gatgaggcat gcagctttca
     3481 gcacatcttt tatacatgaa gaaattaatt ttgtgttgct atggtgttga aatatccaag
     3541 atgttctgta tctatgtaaa catgattcct ttaataaatt gtattttatt attaagcctt
     3601 tttttccttt taatataatc ataagttgct atta
//
