LOCUS       NM_001410946            3491 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens LDL receptor related protein 11 (LRP11), transcript
            variant 2, mRNA.
ACCESSION   NM_001410946 XM_017011380
VERSION     NM_001410946.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3491)
  AUTHORS   Xiao,K., McClatchy,D.B., Shukla,A.K., Zhao,Y., Chen,M.,
            Shenoy,S.K., Yates,J.R. 3rd and Lefkowitz,R.J.
  TITLE     Functional specialization of beta-arrestin interactions revealed by
            proteomic analysis
  JOURNAL   Proc Natl Acad Sci U S A 104 (29), 12011-12016 (2007)
   PUBMED   17620599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355312.24.
            
            On Aug 18, 2022 this sequence version replaced XM_017011380.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3559016.1,
                                           SRR14038197.2616183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-952               AL355312.24        144947-145898       c
            953-1110            AL355312.24        134542-134699       c
            1111-1252           AL355312.24        124522-124663       c
            1253-3491           AL355312.24        121977-124215       c
FEATURES             Location/Qualifiers
     source          1..3491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..3491
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="LDL receptor related protein 11"
                     /db_xref="GeneID:84918"
                     /db_xref="HGNC:HGNC:16936"
     exon            1..952
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1317
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; low-density lipoprotein receptor-related
                     protein 11; LRP-11"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     11 isoform 2 precursor"
                     /protein_id="NP_001397875.1"
                     /db_xref="CCDS:CCDS94018.1"
                     /db_xref="GeneID:84918"
                     /db_xref="HGNC:HGNC:16936"
                     /translation="MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAP
                     LSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPD
                     AIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGC
                     YLFNCTARGRNVCKFALHSGYSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDV
                     VLHLPTDGVVLDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTF
                     QLTVTDTAGQRSSDNVSVTVLRAAYSTGDGWSICCICSKREAKEFSETS"
     exon            953..1110
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1252
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..3491
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3472..3477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="hexamer: AATAAA"
     polyA_site      3491
                     /gene="LRP11"
                     /gene_synonym="bA350J20.3; MANSC3"
                     /note="major polyA site"
ORIGIN      
        1 actgttcgca cacacctggt gctgatcaac gccgaggccg actcgtcgcc acccagcgcg
       61 ccgcaggccg gggcggagag gcgcagggcg ctgggcagtc tccggcgagg gcaaggagcg
      121 gtgcccggct gggccggcta tgtctcccgc tactgcggtt cccgccggcg cccgcgacct
      181 cgggggagca gccgggttcg ggggcgccgc gctgtgaggc cggggcctag agccagccgc
      241 ggccgcgcag gaggggccca gggcccgcgc tcgcccgcgt ccccgccttc ctcccgcgct
      301 cagccccgcc tcggctcgct gcccttggct ctcgtcgcca tggcctccgt cgcccaggag
      361 agcgcgggct cgcagcgccg gctaccgccg cgtcacgggg cgctgcgcgg gctgctactg
      421 ctctgcctgt ggctgccaag cggccgtgcg gccttgccgc ccgcggcgcc gctgtccgaa
      481 ctgcacgcgc agctgtcggg cgtggagcag ctgctggagg agttccgccg gcaactgcag
      541 caggagcggc ctcaggagga gctggagctg gagctgcgcg cgggcggcgg cccccaggag
      601 gactgcccgg gcccgggcag cggcggctac agcgcaatgc ctgacgccat catccgcacc
      661 aaggactccc tggcggcggg tgccagcttc ctgcgggcgc cggcggccgt gcggggctgg
      721 cggcaatgcg tggcggcctg ctgctccgag ccgcgctgct ccgtggccgt ggtggagctg
      781 ccccggcgcc ccgcgccccc ggcagccgtg ctcggctgct acctcttcaa ctgcacggcg
      841 cgcggccgca acgtctgcaa gttcgcgctg cacagcggct acagcagcta cagcctcagc
      901 cgcgcgccgg acggcgccgc cctggccacc gcgcgcgcct cgccccggca ggaaaaggat
      961 gcgcctccac ttagcaaggc tgggcaggat gtggttctgc atctgcccac agacggggtg
     1021 gttctagacg gccgcgagag cacagatgac cacgccatcg tccagtatga gtgggcactg
     1081 ctgcaggggg acccgtcagt ggacatgaag gtgcctcaat caggaaccct gaagctgtcc
     1141 cacctacagg agggaaccta caccttccag ctgaccgtga cggacactgc cgggcagaga
     1201 agctctgaca acgtgtcagt gacagtgctt cgcgcagcct actccacagg agatggatgg
     1261 tccatttgct gcatctgttc caagagggaa gctaaggagt ttagtgaaac cagttgaact
     1321 cgtggaagca gagagtggaa tggcggttac tggaggctgt gcgggggacg gactgggaaa
     1381 ggagagacgc tggtcaaagg gtacaaagtg tcactgagac cggaggaaca ggttctggtg
     1441 atctgttgca cagcatggtg actatagtta atgataatgt attgtctgtt tcaaaattgc
     1501 taaaacagta ggttttaaat gttgtcatca caaaaagatt acaagtaggg gagatgatag
     1561 atatgtcagt tagcttgatg taatcattcc acaatgcaaa catatatcaa aacatcacat
     1621 tgtgcctcat aaatatatac tctcctcttt tgtcaattaa aaatacatat taaaaaaaca
     1681 aggaaaaggc ataccacagg attgaagaaa gacttggctc ttgggtgtaa tcaattgctg
     1741 atataataag tcacttcaaa aattttagaa agagaaaaag agtgcagcta aggagtacgg
     1801 ttaaaattaa ttgaaatacg caaaggaccc atcaatttga aagtgctacc tacacatttt
     1861 catagacact ttacgcagat gcagttatat taataatata actttaaata catatgatgg
     1921 ttctcacatt ctgttgtaca atgtaacaat gtaaaactta tttcattcat ctatgtttct
     1981 tacttttcta aacatctaca tttttttttt gagagggagt tttgctcttg ttgcctaggc
     2041 tggagtggga gtgcagtggt gcagtctcgg ctcactgcag cctctgcctc ctgggttcaa
     2101 gtgattctcc tgcctcagcc tcccaagtag ctgggactac aggtgtgcac caccacgccc
     2161 tgctaatttt gtatttttag tagagacagg gtttcaccat gttggccaac ctggtctcga
     2221 attcctgacc tcaggtgatc cacccgcctc agcctcccga agcacttaga ctacaggcgt
     2281 gaaccaccgc gcccagccca acgtctacat gtctaagaaa gattaggtca tcaaattttt
     2341 taaaatatcc attgcatgga acttagcgac actaaagata ttgtagtatt gtagagggaa
     2401 cccctcacca cacacacaat tcacttctgg agaggtgcta aggtcttgta catttaaata
     2461 tcctgttact cggtcatcgt gtattttctt agtgtatgca gtgtgcaggg tccttgccag
     2521 gcactgggga tagagtggtg cactggtggt ccctgactct ggtaaacttg cagtaagtct
     2581 gtgacatttt tgaattctca gtattcaata ctcaggatcc agatggtaat taagccagca
     2641 gagtgcagaa tgaggataaa agagttggaa caggactgtg atttacttgt actatattgg
     2701 atctagcctt ctatcaaaaa ctgaggttag tatgcatact ggaaatgaaa ttttctaagg
     2761 agttagagat tttaggatcc taaggacttg tcaactttga taattttcat aggcggcatt
     2821 aaaaatttgt ttggctgatg acaacctgtc cagccagggg ttaagcttac tgtaaggaag
     2881 cagggtaacc attcacagac aggacaggca ccaaactcca gcccgtgcca gcactgtgag
     2941 gtcaccagtg atagcgagta aacagtctgt ccagctcagc ccggattcca tcagccctgc
     3001 taattcattg cagctggaca ggagagccag ccagctactc aaaacattgt tgagtccctt
     3061 tgctgggcag ctactcaaaa catcattggt cccttggcca ccaggaccag tggagacatg
     3121 acattgtctc cagcagggat ggctcacttc tgtagatctg ggcgccctct agagggcttt
     3181 ccccctgggt accgggactc acctggacag ggtctgagtc aagtgctgac tctgggagga
     3241 agggactctt gggaaaaaga cacagatacc ctgtcatccc cacagaaatc agaaaaggat
     3301 tgctcttgta cagctgaagt gcctgggagg gaggaagggc ctgcactgat atgagcagat
     3361 ggccagcacc tcaccggcca cttgtttgtc ctggtttatt tcctcaggca gctttccggg
     3421 ctccagaggt aaattgccag ctgtaaattt ctggcccttc tccaagatga taataaactg
     3481 tatttgaagt a
//
