LOCUS       NM_002332              14923 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens LDL receptor related protein 1 (LRP1), mRNA.
ACCESSION   NM_002332
VERSION     NM_002332.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14923)
  AUTHORS   Zhou,J., Zhang,L., Peng,J., Zhang,X., Zhang,F., Wu,Y., Huang,A.,
            Du,F., Liao,Y., He,Y., Xie,Y., Gu,L., Kuang,C., Ou,W., Xie,M.,
            Tu,T., Pang,J., Zhang,D., Guo,K., Feng,Y., Yin,S., Cao,Y., Li,T.
            and Jiang,Y.
  TITLE     Astrocytic LRP1 enables mitochondria transfer to neurons and
            mitigates brain ischemic stroke by suppressing ARF1 lactylation
  JOURNAL   Cell Metab 36 (9), 2054-2068 (2024)
   PUBMED   38906140
  REMARK    GeneRIF: Astrocytic LRP1 enables mitochondria transfer to neurons
            and mitigates brain ischemic stroke by suppressing ARF1
            lactylation.
REFERENCE   2  (bases 1 to 14923)
  AUTHORS   Yamamoto,K., Scilabra,S.D., Bonelli,S., Jensen,A., Scavenius,C.,
            Enghild,J.J. and Strickland,D.K.
  TITLE     Novel insights into the multifaceted and tissue-specific roles of
            the endocytic receptor LRP1
  JOURNAL   J Biol Chem 300 (8), 107521 (2024)
   PUBMED   38950861
  REMARK    GeneRIF: Novel insights into the multifaceted and tissue-specific
            roles of the endocytic receptor LRP1.
            Review article
REFERENCE   3  (bases 1 to 14923)
  AUTHORS   Lin,H., Fu,L., Zhou,X., Yu,A., Chen,Y., Liao,W., Shu,G., Zhang,L.,
            Tan,L., Liang,H., Wang,Z., Deng,Q., Wang,J., Jin,M., Chen,Z.,
            Wei,J., Cao,J., Chen,W., Li,X., Li,P., Lu,J. and Luo,J.
  TITLE     LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer
  JOURNAL   Cancer Lett 593, 216807 (2024)
   PUBMED   38462037
  REMARK    GeneRIF: LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer.
REFERENCE   4  (bases 1 to 14923)
  AUTHORS   Akahane,S., Matsuura,H., Kaido,T., Usami,Y., Ishimine,N., Uehara,T.
            and Yamauchi,K.
  TITLE     Apolipoprotein E-containing lipoproteins and their extracellular
            interactions with LRP1 affect LPS-induced inflammation
  JOURNAL   Biol Chem 405 (6), 383-393 (2024)
   PUBMED   38488124
  REMARK    GeneRIF: Apolipoprotein E-containing lipoproteins and their
            extracellular interactions with LRP1 affect LPS-induced
            inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14923)
  AUTHORS   Lin,L. and Hu,K.
  TITLE     LRP-1: functions, signaling and implications in kidney and other
            diseases
  JOURNAL   Int J Mol Sci 15 (12), 22887-22901 (2014)
   PUBMED   25514242
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 14923)
  AUTHORS   Willnow,T.E., Moehring,J.M., Inocencio,N.M., Moehring,T.J. and
            Herz,J.
  TITLE     The low-density-lipoprotein receptor-related protein (LRP) is
            processed by furin in vivo and in vitro
  JOURNAL   Biochem J 313 (Pt 1) (Pt 1), 71-76 (1996)
   PUBMED   8546712
REFERENCE   7  (bases 1 to 14923)
  AUTHORS   Chappell,D.A., Fry,G.L., Waknitz,M.A., Iverius,P.H., Williams,S.E.
            and Strickland,D.K.
  TITLE     The low density lipoprotein receptor-related protein/alpha
            2-macroglobulin receptor binds and mediates catabolism of bovine
            milk lipoprotein lipase
  JOURNAL   J Biol Chem 267 (36), 25764-25767 (1992)
   PUBMED   1281473
REFERENCE   8  (bases 1 to 14923)
  AUTHORS   Hilliker,C., Van Leuven,F. and Van den Berghe,H.
  TITLE     Assignment of the gene coding for the alpha 2-macroglobulin
            receptor to mouse chromosome 15 and to human chromosome 12q13-q14
            by isotopic and nonisotopic in situ hybridization
  JOURNAL   Genomics 13 (2), 472-474 (1992)
   PUBMED   1377168
REFERENCE   9  (bases 1 to 14923)
  AUTHORS   Williams,S.E., Ashcom,J.D., Argraves,W.S. and Strickland,D.K.
  TITLE     A novel mechanism for controlling the activity of alpha
            2-macroglobulin receptor/low density lipoprotein receptor-related
            protein. Multiple regulatory sites for 39-kDa receptor-associated
            protein
  JOURNAL   J Biol Chem 267 (13), 9035-9040 (1992)
   PUBMED   1374383
REFERENCE   10 (bases 1 to 14923)
  AUTHORS   Herz,J., Hamann,U., Rogne,S., Myklebost,O., Gausepohl,H. and
            Stanley,K.K.
  TITLE     Surface location and high affinity for calcium of a 500-kd liver
            membrane protein closely related to the LDL-receptor suggest a
            physiological role as lipoprotein receptor
  JOURNAL   EMBO J 7 (13), 4119-4127 (1988)
   PUBMED   3266596
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023237.34, AC137628.3 and
            AC137834.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002332.2.
            
            Summary: This gene encodes a member of the low-density lipoprotein
            receptor family of proteins. The encoded preproprotein is
            proteolytically processed by furin to generate 515 kDa and 85 kDa
            subunits that form the mature receptor (PMID: 8546712). This
            receptor is involved in several cellular processes, including
            intracellular signaling, lipid homeostasis, and clearance of
            apoptotic cells. In addition, the encoded protein is necessary for
            the alpha 2-macroglobulin-mediated clearance of secreted amyloid
            precursor protein and beta-amyloid, the main component of amyloid
            plaques found in Alzheimer patients. Expression of this gene
            decreases with age and has been found to be lower than controls in
            brain tissue from Alzheimer's disease patients. [provided by
            RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13916.1, SRR18074969.1916331.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243077.8/ ENSP00000243077.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               AC023237.34        17325-17873         c
            550-672             AC023237.34        7775-7897           c
            673-810             AC023237.34        4845-4982           c
            811-930             AC023237.34        2558-2677           c
            931-1059            AC023237.34        1256-1384           c
            1060-1323           AC023237.34        866-1129            c
            1324-1486           AC137628.3         9853-10015
            1487-1709           AC137628.3         10124-10346
            1710-1899           AC137628.3         11739-11928
            1900-2043           AC137628.3         12422-12565
            2044-2280           AC137628.3         14047-14283
            2281-2461           AC137628.3         15470-15650
            2462-2684           AC137628.3         16538-16760
            2685-2886           AC137628.3         17962-18163
            2887-3012           AC137628.3         18503-18628
            3013-3153           AC137628.3         21450-21590
            3154-3279           AC137628.3         21729-21854
            3280-3396           AC137628.3         22575-22691
            3397-3477           AC137628.3         23089-23169
            3478-3645           AC137628.3         24785-24952
            3646-3828           AC137628.3         28813-28995
            3829-4029           AC137628.3         29425-29625
            4030-4275           AC137628.3         31105-31350
            4276-4473           AC137628.3         31554-31751
            4474-4678           AC137628.3         32686-32890
            4679-4843           AC137628.3         33072-33236
            4844-5088           AC137628.3         34004-34248
            5089-5220           AC137628.3         34535-34666
            5221-5448           AC137628.3         34974-35201
            5449-5623           AC137628.3         35427-35601
            5624-5718           AC137628.3         35692-35786
            5719-5868           AC137628.3         35975-36124
            5869-6009           AC137628.3         36312-36452
            6010-6144           AC137628.3         36802-36936
            6145-6276           AC137628.3         39024-39155
            6277-6411           AC137628.3         39420-39554
            6412-6541           AC137628.3         39730-39859
            6542-6668           AC137628.3         39971-40097
            6669-6719           AC137628.3         40484-40534
            6720-6820           AC137834.9         107419-107519       c
            6821-6945           AC137834.9         107204-107328       c
            6946-7323           AC137834.9         106501-106878       c
            7324-7513           AC137834.9         104953-105142       c
            7514-7718           AC137834.9         101400-101604       c
            7719-7911           AC137834.9         100897-101089       c
            7912-8037           AC137834.9         99439-99564         c
            8038-8166           AC137834.9         99105-99233         c
            8167-8286           AC137834.9         98724-98843         c
            8287-8400           AC137834.9         98397-98510         c
            8401-8550           AC137834.9         97906-98055         c
            8551-8673           AC137834.9         97710-97832         c
            8674-8790           AC137834.9         97308-97424         c
            8791-8919           AC137834.9         97010-97138         c
            8920-9042           AC137834.9         96629-96751         c
            9043-9183           AC137834.9         96406-96546         c
            9184-9374           AC137834.9         96132-96322         c
            9375-9558           AC137834.9         95244-95427         c
            9559-9644           AC137834.9         95025-95110         c
            9645-9764           AC137834.9         94745-94864         c
            9765-9952           AC137834.9         94066-94253         c
            9953-10158          AC137834.9         93739-93944         c
            10159-10347         AC137834.9         93009-93197         c
            10348-10496         AC137834.9         92384-92532         c
            10497-10590         AC137834.9         91874-91967         c
            10591-10707         AC137834.9         91594-91710         c
            10708-10827         AC137834.9         91256-91375         c
            10828-10950         AC137834.9         90790-90912         c
            10951-11076         AC137834.9         90504-90629         c
            11077-11193         AC137834.9         89872-89988         c
            11194-11300         AC137834.9         89122-89228         c
            11301-11433         AC137834.9         88888-89020         c
            11434-11553         AC137834.9         87880-87999         c
            11554-11676         AC137834.9         87660-87782         c
            11677-11817         AC137834.9         87160-87300         c
            11818-11952         AC137834.9         86924-87058         c
            11953-12072         AC137834.9         86732-86851         c
            12073-12341         AC137834.9         85668-85936         c
            12342-12520         AC137834.9         84193-84371         c
            12521-12627         AC137834.9         83592-83698         c
            12628-12744         AC137834.9         83210-83326         c
            12745-12921         AC137834.9         82541-82717         c
            12922-13062         AC137834.9         82240-82380         c
            13063-13236         AC137834.9         81929-82102         c
            13237-13398         AC137834.9         81530-81691         c
            13399-13573         AC137834.9         81059-81233         c
            13574-13675         AC137834.9         80821-80922         c
            13676-13740         AC137834.9         80595-80659         c
            13741-13831         AC137834.9         80392-80482         c
            13832-13976         AC137834.9         80148-80292         c
            13977-14923         AC137834.9         79048-79994         c
FEATURES             Location/Qualifiers
     source          1..14923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..14923
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /note="LDL receptor related protein 1"
                     /db_xref="GeneID:4035"
                     /db_xref="HGNC:HGNC:6692"
                     /db_xref="MIM:107770"
     exon            1..549
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..14117
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /note="type V tgf-beta receptor; prolow-density
                     lipoprotein receptor-related protein 1;
                     TbetaR-V/LRP-1/IGFBP-3 receptor; alpha-2-macroglobulin
                     receptor; apolipoprotein E receptor; low density
                     lipoprotein receptor-related protein 1"
                     /codon_start=1
                     /product="prolow-density lipoprotein receptor-related
                     protein 1 preproprotein"
                     /protein_id="NP_002323.2"
                     /db_xref="CCDS:CCDS8932.1"
                     /db_xref="GeneID:4035"
                     /db_xref="HGNC:HGNC:6692"
                     /db_xref="MIM:107770"
                     /translation="MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKG
                     WRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGS
                     DEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTC
                     SQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQ
                     VSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINIS
                     LSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAM
                     GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIE
                     VVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEY
                     QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRS
                     GFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDF
                     HAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPK
                     KTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERA
                     WMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGP
                     ELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQ
                     QQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQP
                     GEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLC
                     DGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCA
                     YPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPE
                     HWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDC
                     MDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACR
                     PPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGI
                     VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCR
                     SLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK
                     IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLR
                     TTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWP
                     NGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWT
                     DWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHL
                     CLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFT
                     VPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWV
                     SRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISM
                     ANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRS
                     QLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQL
                     DHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEG
                     IRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRED
                     VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVH
                     PEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTD
                     KIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSV
                     PLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAED
                     GASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTS
                     PGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTST
                     ITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALS
                     GANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHP
                     FGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELS
                     PCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI
                     NFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSD
                     EIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKG
                     VLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMS
                     WTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE
                     GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNR
                     QCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHD
                     QSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINEC
                     LSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGS
                     YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV
                     ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYW
                     CDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMD
                     GSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHI
                     FALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNH
                     PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFW
                     WKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC
                     DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRC
                     IPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGS
                     DEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSC
                     ANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMD
                     GSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPN
                     RPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLS
                     SSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFH
                     TVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYI
                     ADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLP
                     PAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMK
                     GENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQW
                     PTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYG
                     VTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLL
                     SPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKC
                     RCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCAN
                     NSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEG
                     SRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMM
                     PECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAK
                     GFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATL
                     YMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA"
     exon            550..672
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            673..810
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            811..930
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1059
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1323
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1486
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1709
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1899
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2043
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2280
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2461
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2684
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2886
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3012
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3153
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3279
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3396
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3477
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3645
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3828
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..4029
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..4275
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4473
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4678
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4843
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..5088
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5089..5220
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5221..5448
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5449..5623
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5624..5718
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5719..5868
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5869..6009
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6010..6144
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6145..6276
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6277..6411
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..6541
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6542..6668
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6669..6820
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6821..6945
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6946..7323
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            7324..7513
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            7514..7718
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            7719..7911
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            7912..8037
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8038..8166
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8167..8286
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8287..8400
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8401..8550
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8551..8673
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8674..8790
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8791..8919
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            8920..9042
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            9043..9183
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            9184..9374
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            9375..9558
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            9559..9644
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            9645..9764
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            9765..9952
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            9953..10158
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            10159..10347
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            10348..10496
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            10497..10590
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            10591..10707
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            10708..10827
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            10828..10950
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            10951..11076
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11077..11193
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11194..11300
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11301..11433
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11434..11553
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11554..11676
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11677..11817
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11818..11952
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            11953..12072
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            12073..12341
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            12342..12520
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            12521..12627
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            12628..12744
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            12745..12921
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            12922..13062
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13063..13236
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13237..13398
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13399..13573
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13574..13675
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13676..13740
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13741..13831
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13832..13976
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     exon            13977..14923
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14243..14248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /note="hexamer: ATTACA"
     polyA_site      14268
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /note="major polyA site"
     regulatory      14841..14846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
                     /note="hexamer: AATAAT"
     polyA_site      14877
                     /gene="LRP1"
                     /gene_synonym="A2MR; APOER; APR; CD91; DDH3; IGFBP-3R;
                     IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5"
ORIGIN      
        1 acttcagtcc ggggaacagc ggtgcgagct ccaggcccat gcactgagga ggcggaaaca
       61 aggggagccc ccagagctcc atcaagcccc ctccaaaggc tcccctaccc ggtccacgcc
      121 ccccaccccc cctccccgcc tcctcccaat tgtgcatttt tgcagccgga ggcggctccg
      181 agatggggct gtgagcttcg cccggggagg gggaaagagc agcgaggagt gaagcggggg
      241 ggtggggtga agggtttgga tttcggggca gggggcgcac ccccgtcagc aggccctccc
      301 caaggggctc ggaactctac ctcttcaccc acgcccctgg tgcgctttgc cgaaggaaag
      361 aataagaaca gagaaggagg agggggaaag gaggaaaagg gggacccccc aactgggggg
      421 ggtgaaggag agaagtagca ggaccagagg ggaaggggct gctgcttgca tcagcccaca
      481 ccatgctgac cccgccgttg ctcctgctgc tgcccctgct ctcagctctg gtcgcggcgg
      541 ctatcgacgc ccctaagact tgcagcccca agcagtttgc ctgcagagat caaataacct
      601 gtatctcaaa gggctggcgg tgcgacggtg agagggactg cccagacgga tctgacgagg
      661 cccctgagat ttgtccacag agtaaggccc agcgatgcca gccaaacgag cataactgcc
      721 tgggtactga gctgtgtgtt cccatgtccc gcctctgcaa tggggtccag gactgcatgg
      781 acggctcaga tgaggggccc cactgccgag agctccaagg caactgctct cgcctgggct
      841 gccagcacca ttgtgtcccc acactcgatg ggcccacctg ctactgcaac agcagctttc
      901 agcttcaggc agatggcaag acctgcaaag attttgatga gtgctcagtg tacggcacct
      961 gcagccagct atgcaccaac acagacggct ccttcatatg tggctgtgtt gaaggatacc
     1021 tcctgcagcc ggataaccgc tcctgcaagg ccaagaacga gccagtagac cggccccctg
     1081 tgctgttgat agccaactcc cagaacatct tggccacgta cctgagtggg gcccaggtgt
     1141 ctaccatcac acctacgagc acgcggcaga ccacagccat ggacttcagc tatgccaacg
     1201 agaccgtatg ctgggtgcat gttggggaca gtgctgctca gacgcagctc aagtgtgccc
     1261 gcatgcctgg cctaaagggc ttcgtggatg agcacaccat caacatctcc ctcagtctgc
     1321 accacgtgga acagatggcc atcgactggc tgacaggcaa cttctacttt gtggatgaca
     1381 tcgatgatag gatctttgtc tgcaacagaa atggggacac atgtgtcaca ttgctagacc
     1441 tggaactcta caaccccaag ggcattgccc tggaccctgc catggggaag gtgtttttca
     1501 ctgactatgg gcagatccca aaggtggaac gctgtgacat ggatgggcag aaccgcacca
     1561 agctcgtcga cagcaagatt gtgtttcctc atggcatcac gctggacctg gtcagccgcc
     1621 ttgtctactg ggcagatgcc tatctggact atattgaagt ggtggactat gagggcaagg
     1681 gccgccagac catcatccag ggcatcctga ttgagcacct gtacggcctg actgtgtttg
     1741 agaattatct ctatgccacc aactcggaca atgccaatgc ccagcagaag acgagtgtga
     1801 tccgtgtgaa ccgctttaac agcaccgagt accaggttgt cacccgggtg gacaagggtg
     1861 gtgccctcca catctaccac cagaggcgtc agccccgagt gaggagccat gcctgtgaaa
     1921 acgaccagta tgggaagccg ggtggctgct ctgacatctg cctgctggcc aacagccaca
     1981 aggcgcggac ctgccgctgc cgttccggct tcagcctggg cagtgacggg aagtcatgca
     2041 agaagccgga gcatgagctg ttcctcgtgt atggcaaggg ccggccaggc atcatccggg
     2101 gcatggatat gggggccaag gtcccggatg agcacatgat ccccattgaa aacctcatga
     2161 acccccgagc cctggacttc cacgctgaga ccggcttcat ctactttgcc gacaccacca
     2221 gctacctcat tggccgccag aagattgatg gcactgagcg ggagaccatc ctgaaggacg
     2281 gcatccacaa tgtggagggt gtggccgtgg actggatggg agacaatctg tactggacgg
     2341 acgatgggcc caaaaagaca atcagcgtgg ccaggctgga gaaagctgct cagacccgca
     2401 agactttaat cgagggcaaa atgacacacc ccagggctat tgtggtggat ccactcaatg
     2461 ggtggatgta ctggacagac tgggaggagg accccaagga cagtcggcgt gggcggctgg
     2521 agagggcgtg gatggatggc tcacaccgag acatctttgt cacctccaag acagtgcttt
     2581 ggcccaatgg gctaagcctg gacatcccgg ctgggcgcct ctactgggtg gatgccttct
     2641 acgaccgcat cgagacgata ctgctcaatg gcacagaccg gaagattgtg tatgaaggtc
     2701 ctgagctgaa ccacgccttt ggcctgtgtc accatggcaa ctacctcttc tggactgagt
     2761 atcggagtgg cagtgtctac cgcttggaac ggggtgtagg aggcgcaccc cccactgtga
     2821 cccttctgcg cagtgagcgg ccccccatct ttgagatccg aatgtatgat gcccagcagc
     2881 agcaagttgg caccaacaaa tgccgggtga acaatggcgg ctgcagcagc ctgtgcttgg
     2941 ccacccctgg gagccgccag tgcgcctgtg ctgaggacca ggtgttggac gcagacggcg
     3001 tcacttgctt ggcgaaccca tcctacgtgc ctccacccca gtgccagcca ggcgagtttg
     3061 cctgtgccaa cagccgctgc atccaggagc gctggaagtg tgacggagac aacgattgcc
     3121 tggacaacag tgatgaggcc ccagccctct gccatcagca cacctgcccc tcggaccgat
     3181 tcaagtgcga gaacaaccgg tgcatcccca accgctggct ctgcgacggg gacaatgact
     3241 gtgggaacag tgaagatgag tccaatgcca cttgttcagc ccgcacctgc ccccccaacc
     3301 agttctcctg tgccagtggc cgctgcatcc ccatctcctg gacgtgtgat ctggatgacg
     3361 actgtgggga ccgctctgat gagtctgctt cgtgtgccta tcccacctgc ttccccctga
     3421 ctcagtttac ctgcaacaat ggcagatgta tcaacatcaa ctggagatgc gacaatgaca
     3481 atgactgtgg ggacaacagt gacgaagccg gctgcagcca ctcctgttct agcacccagt
     3541 tcaagtgcaa cagcgggcgt tgcatccccg agcactggac ctgcgatggg gacaatgact
     3601 gcggagacta cagtgatgag acacacgcca actgcaccaa ccaggccacg aggccccctg
     3661 gtggctgcca cactgatgag ttccagtgcc ggctggatgg actatgcatc cccctgcggt
     3721 ggcgctgcga tggggacact gactgcatgg actccagcga tgagaagagc tgtgagggag
     3781 tgacccacgt ctgcgatccc agtgtcaagt ttggctgcaa ggactcagct cggtgcatca
     3841 gcaaagcgtg ggtgtgtgat ggcgacaatg actgtgagga taactcggac gaggagaact
     3901 gcgagtccct ggcctgcagg ccaccctcgc acccttgtgc caacaacacc tcagtctgcc
     3961 tgccccctga caagctgtgt gatggcaacg acgactgtgg cgacggctca gatgagggcg
     4021 agctctgcga ccagtgctct ctgaataacg gtggctgcag ccacaactgc tcagtggcac
     4081 ctggcgaagg cattgtgtgt tcctgccctc tgggcatgga gctggggccc gacaaccaca
     4141 cctgccagat ccagagctac tgtgccaagc atctcaaatg cagccaaaag tgcgaccaga
     4201 acaagttcag cgtgaagtgc tcctgctacg agggctgggt cctggaacct gacggcgaga
     4261 gctgccgcag cctggacccc ttcaagccgt tcatcatttt ctccaaccgc catgaaatcc
     4321 ggcgcatcga tcttcacaaa ggagactaca gcgtcctggt gcccggcctg cgcaacacca
     4381 tcgccctgga cttccacctc agccagagcg ccctctactg gaccgacgtg gtggaggaca
     4441 agatctaccg cgggaagctg ctggacaacg gagccctgac tagtttcgag gtggtgattc
     4501 agtatggcct ggccacaccc gagggcctgg ctgtagactg gattgcaggc aacatctact
     4561 gggtggagag taacctggat cagatcgagg tggccaagct ggatgggacc ctccggacca
     4621 ccctgctggc cggtgacatt gagcacccaa gggcaatcgc actggatccc cgggatggga
     4681 tcctgttttg gacagactgg gatgccagcc tgccccgcat tgaggcagcc tccatgagtg
     4741 gggctgggcg ccgcaccgtg caccgggaga ccggctctgg gggctggccc aacgggctca
     4801 ccgtggacta cctggagaag cgcatccttt ggattgacgc caggtcagat gccatttact
     4861 cagcccgtta cgacggctct ggccacatgg aggtgcttcg gggacacgag ttcctgtcgc
     4921 acccgtttgc agtgacgctg tacggggggg aggtctactg gactgactgg cgaacaaaca
     4981 cactggctaa ggccaacaag tggaccggcc acaatgtcac cgtggtacag aggaccaaca
     5041 cccagccctt tgacctgcag gtgtaccacc cctcccgcca gcccatggct cccaatccct
     5101 gtgaggccaa tgggggccag ggcccctgct cccacctgtg tctcatcaac tacaaccgga
     5161 ccgtgtcctg cgcctgcccc cacctcatga agctccacaa ggacaacacc acctgctatg
     5221 agtttaagaa gttcctgctg tacgcacgtc agatggagat ccgaggtgtg gacctggatg
     5281 ctccctacta caactacatc atctccttca cggtgcccga catcgacaac gtcacagtgc
     5341 tagactacga tgcccgcgag cagcgtgtgt actggtctga cgtgcggaca caggccatca
     5401 agcgggcctt catcaacggc acaggcgtgg agacagtcgt ctctgcagac ttgccaaatg
     5461 cccacgggct ggctgtggac tgggtctccc gaaacctgtt ctggacaagc tatgacacca
     5521 ataagaagca gatcaatgtg gcccggctgg atggctcctt caagaacgca gtggtgcagg
     5581 gcctggagca gccccatggc cttgtcgtcc accctctgcg tgggaagctc tactggaccg
     5641 atggtgacaa catcagcatg gccaacatgg atggcagcaa tcgcaccctg ctcttcagtg
     5701 gccagaaggg ccccgtgggc ctggctattg acttccctga aagcaaactc tactggatca
     5761 gctccgggaa ccataccatc aaccgctgca acctggatgg gagtgggctg gaggtcatcg
     5821 atgccatgcg gagccagctg ggcaaggcca ccgccctggc catcatgggg gacaagctgt
     5881 ggtgggctga tcaggtgtcg gaaaagatgg gcacatgcag caaggctgac ggctcgggct
     5941 ccgtggtcct tcggaacagc accaccctgg tgatgcacat gaaggtctat gacgagagca
     6001 tccagctgga ccataagggc accaacccct gcagtgtcaa caacggtgac tgctcccagc
     6061 tctgcctgcc cacgtcagag acgacccgct cctgcatgtg cacagccggc tatagcctcc
     6121 ggagtggcca gcaggcctgc gagggcgtag gttcctttct cctgtactct gtgcatgagg
     6181 gaatcagggg aattcccctg gatcccaatg acaagtcaga tgccctggtc ccagtgtccg
     6241 ggacctcgct ggctgtcggc atcgacttcc acgctgaaaa tgacaccatc tactgggtgg
     6301 acatgggcct gagcacgatc agccgggcca agcgggacca gacgtggcgt gaagacgtgg
     6361 tgaccaatgg cattggccgt gtggagggca ttgcagtgga ctggatcgca ggcaacatct
     6421 actggacaga ccagggcttt gatgtcatcg aggtcgcccg gctcaatggc tccttccgct
     6481 acgtggtgat ctcccagggt ctagacaagc cccgggccat caccgtccac ccggagaaag
     6541 ggtacttgtt ctggactgag tggggtcagt atccgcgtat tgagcggtct cggctagatg
     6601 gcacggagcg tgtggtgctg gtcaacgtca gcatcagctg gcccaacggc atctcagtgg
     6661 actaccagga tgggaagctg tactggtgcg atgcacggac agacaagatt gaacggatcg
     6721 acctggagac aggtgagaac cgcgaggtgg ttctgtccag caacaacatg gacatgtttt
     6781 cagtgtctgt gtttgaggat ttcatctact ggagtgacag gactcatgcc aacggctcta
     6841 tcaagcgcgg gagcaaagac aatgccacag actccgtgcc cctgcgaacc ggcatcggcg
     6901 tccagcttaa agacatcaaa gtcttcaacc gggaccggca gaaaggcacc aacgtgtgcg
     6961 cggtggccaa tggcgggtgc cagcagctgt gcctgtaccg gggccgtggg cagcgggcct
     7021 gcgcctgtgc ccacgggatg ctggctgaag acggagcatc gtgccgcgag tatgccggct
     7081 acctgctcta ctcagagcgc accattctca agagtatcca cctgtcggat gagcgcaacc
     7141 tcaatgcgcc cgtgcagccc ttcgaggacc ctgagcacat gaagaacgtc atcgccctgg
     7201 cctttgacta ccgggcaggc acctctccgg gcacccccaa tcgcatcttc ttcagcgaca
     7261 tccactttgg gaacatccaa cagatcaacg acgatggctc caggaggatc accattgtgg
     7321 aaaacgtggg ctccgtggaa ggcctggcct atcaccgtgg ctgggacact ctctattgga
     7381 caagctacac gacatccacc atcacgcgcc acacagtgga ccagacccgc ccaggggcct
     7441 tcgagcgtga gaccgtcatc actatgtctg gagatgacca cccacgggcc ttcgttttgg
     7501 acgagtgcca gaacctcatg ttctggacca actggaatga gcagcatccc agcatcatgc
     7561 gggcggcgct ctcgggagcc aatgtcctga cccttatcga gaaggacatc cgtaccccca
     7621 atggcctggc catcgaccac cgtgccgaga agctctactt ctctgacgcc accctggaca
     7681 agatcgagcg gtgcgagtat gacggctccc accgctatgt gatcctaaag tcagagcctg
     7741 tccacccctt cgggctggcc gtgtatgggg agcacatttt ctggactgac tgggtgcggc
     7801 gggcagtgca gcgggccaac aagcacgtgg gcagcaacat gaagctgctg cgcgtggaca
     7861 tcccccagca gcccatgggc atcatcgccg tggccaacga caccaacagc tgtgaactct
     7921 ctccatgccg aatcaacaac ggtggctgcc aggacctgtg tctgctcact caccagggcc
     7981 atgtcaactg ctcatgccga gggggccgaa tcctccagga tgacctcacc tgccgagcgg
     8041 tgaattcctc ttgccgagca caagatgagt ttgagtgtgc caatggcgag tgcatcaact
     8101 tcagcctgac ctgcgacggc gtcccccact gcaaggacaa gtccgatgag aagccatcct
     8161 actgcaactc ccgccgctgc aagaagactt tccggcagtg cagcaatggg cgctgtgtgt
     8221 ccaacatgct gtggtgcaac ggggccgacg actgtgggga tggctctgac gagatccctt
     8281 gcaacaagac agcctgtggt gtgggcgagt tccgctgccg ggacgggacc tgcatcggga
     8341 actccagccg ctgcaaccag tttgtggatt gtgaggacgc ctcagatgag atgaactgca
     8401 gtgccaccga ctgcagcagc tacttccgcc tgggcgtgaa gggcgtgctc ttccagccct
     8461 gcgagcggac ctcactctgc tacgcaccca gctgggtgtg tgatggcgcc aatgactgtg
     8521 gggactacag tgatgagcgc gactgcccag gtgtgaaacg ccccagatgc cctctgaatt
     8581 acttcgcctg ccctagtggg cgctgcatcc ccatgagctg gacgtgtgac aaagaggatg
     8641 actgtgaaca tggcgaggac gagacccact gcaacaagtt ctgctcagag gcccagtttg
     8701 agtgccagaa ccatcgctgc atctccaagc agtggctgtg tgacggcagc gatgactgtg
     8761 gggatggctc agacgaggct gctcactgtg aaggcaagac gtgcggcccc tcctccttct
     8821 cctgccctgg cacccacgtg tgcgtccccg agcgctggct ctgtgacggt gacaaagact
     8881 gtgctgatgg tgcagacgag agcatcgcag ctggttgctt gtacaacagc acttgtgacg
     8941 accgtgagtt catgtgccag aaccgccagt gcatccccaa gcacttcgtg tgtgaccacg
     9001 accgtgactg tgcagatggc tctgatgagt cccccgagtg tgagtacccg acctgcggcc
     9061 ccagtgagtt ccgctgtgcc aatgggcgct gtctgagctc ccgccagtgg gagtgtgatg
     9121 gcgagaatga ctgccacgac cagagtgacg aggctcccaa gaacccacac tgcaccagcc
     9181 aagagcacaa gtgcaatgcc tcgtcacagt tcctgtgcag cagtgggcgc tgtgtggctg
     9241 aggcactgct ctgcaacggc caggatgact gtggcgacag ctcggacgag cgtggctgcc
     9301 acatcaatga gtgtctcagc cgcaagctca gtggctgcag ccaggactgt gaggacctca
     9361 agatcggctt caagtgccgc tgtcgccctg gcttccggct gaaggacgac ggccggacgt
     9421 gtgctgatgt ggacgagtgc agcaccacct tcccctgcag ccagcgctgc atcaacactc
     9481 atggcagcta taagtgtctg tgtgtggagg gctatgcacc ccgcggcggc gacccccaca
     9541 gctgcaaggc tgtgactgac gaggaaccgt ttctgatctt cgccaaccgg tactacctgc
     9601 gcaagctcaa cctggacggg tccaactaca cgttacttaa gcagggcctg aacaacgccg
     9661 ttgccttgga ttttgactac cgagagcaga tgatctactg gacagatgtg accacccagg
     9721 gcagcatgat ccgaaggatg caccttaacg ggagcaatgt gcaggtccta caccgtacag
     9781 gcctcagcaa ccccgatggg ctggctgtgg actgggtggg tggcaacctg tactggtgcg
     9841 acaaaggccg ggacaccatc gaggtgtcca agctcaatgg ggcctatcgg acggtgctgg
     9901 tcagctctgg cctccgtgag cccagggctc tggtggtgga tgtgcagaat gggtacctgt
     9961 actggacaga ctggggtgac cattcactga tcggccgcat cggcatggat gggtccagcc
    10021 gcagcgtcat cgtggacacc aagatcacat ggcccaatgg cctgacgctg gactatgtca
    10081 ctgagcgcat ctactgggcc gacgcccgcg aggactacat tgaatttgcc agcctggatg
    10141 gctccaatcg ccacgttgtg ctgagccagg acatcccgca catctttgca ctgaccctgt
    10201 ttgaggacta cgtctactgg accgactggg aaacaaagtc cattaaccga gcccacaaga
    10261 ccacgggcac caacaaaacg ctcctcatca gcacgctgca ccggcccatg gacctgcatg
    10321 tcttccatgc cctgcgccag ccagacgtgc ccaatcaccc ctgcaaggtc aacaatggtg
    10381 gctgcagcaa cctgtgcctg ctgtcccccg ggggagggca caaatgtgcc tgccccacca
    10441 acttctacct gggcagcgat gggcgcacct gtgtgtccaa ctgcacggct agccagtttg
    10501 tatgcaagaa cgacaagtgc atccccttct ggtggaagtg tgacaccgag gacgactgcg
    10561 gggaccactc agacgagccc ccggactgcc ctgagttcaa gtgccggccc ggacagttcc
    10621 agtgctccac aggtatctgc acaaaccctg ccttcatctg cgatggcgac aatgactgcc
    10681 aggacaacag tgacgaggcc aactgtgaca tccacgtctg cttgcccagt cagttcaaat
    10741 gcaccaacac caaccgctgt attcccggca tcttccgctg caatgggcag gacaactgcg
    10801 gagatgggga ggatgagagg gactgccccg aggtgacctg cgcccccaac cagttccagt
    10861 gctccattac caaacggtgc atcccccggg tctgggtctg cgaccgggac aatgactgtg
    10921 tggatggcag tgatgagccc gccaactgca cccagatgac ctgtggtgtg gacgagttcc
    10981 gctgcaagga ttcgggccgc tgcatcccag cgcgttggaa gtgtgacgga gaggatgact
    11041 gtggggatgg ctcggatgag cccaaggaag agtgtgatga acgcacctgt gagccatacc
    11101 agttccgctg caagaacaac cgctgcgtgc ccggccgctg gcagtgcgac tacgacaacg
    11161 attgcggtga caactccgat gaagagagct gcacccctcg gccctgctcc gagagtgagt
    11221 tctcctgtgc caacggccgc tgcatcgcgg ggcgctggaa atgcgatgga gaccacgact
    11281 gcgcggacgg ctcggacgag aaagactgca ccccccgctg tgacatggac cagttccagt
    11341 gcaagagcgg ccactgcatc cccctgcgct ggcgctgtga cgcagacgcc gactgcatgg
    11401 acggcagcga cgaggaggcc tgcggcactg gcgtgcggac ctgccccctg gacgagttcc
    11461 agtgcaacaa caccttgtgc aagccgctgg cctggaagtg cgatggcgag gatgactgtg
    11521 gggacaactc agatgagaac cccgaggagt gtgcccggtt cgtgtgccct cccaaccggc
    11581 ccttccgttg caagaatgac cgcgtctgtc tgtggatcgg gcgccaatgc gatggcacgg
    11641 acaactgtgg ggatgggact gatgaagagg actgtgagcc ccccacagcc cacaccaccc
    11701 actgcaaaga caagaaggag tttctgtgcc ggaaccagcg ctgcctctcc tcctccctgc
    11761 gctgcaacat gttcgatgac tgcggggacg gctctgacga ggaggactgc agcatcgacc
    11821 ccaagctgac cagctgcgcc accaatgcca gcatctgtgg ggacgaggca cgctgcgtgc
    11881 gcaccgagaa agcggcctac tgtgcctgcc gctcgggctt ccacaccgtg cccggccagc
    11941 ccggatgcca agacatcaac gagtgcctgc gcttcggcac ctgctcccag ctctgcaaca
    12001 acaccaaggg cggccacctc tgcagctgcg ctcggaactt catgaagacg cacaacacct
    12061 gcaaggccga aggctctgag taccaggtcc tgtacatcgc tgatgacaat gagatccgca
    12121 gcctgttccc cggccacccc cattcggctt acgagcaggc attccagggt gacgagagtg
    12181 tccgcattga tgctatggat gtccatgtca aggctggccg tgtctattgg accaactggc
    12241 acacgggcac catctcctac cgcagcctgc cacctgctgc gcctcctacc acttccaacc
    12301 gccaccggcg acagattgac cggggtgtca cccacctcaa catttcaggg ctgaagatgc
    12361 ccagaggcat cgccatcgac tgggtggccg gaaacgtgta ctggaccgac tcgggccgag
    12421 atgtgattga ggtggcgcag atgaagggcg agaaccgcaa gacgctcatc tcgggcatga
    12481 ttgacgagcc ccacgccatt gtggtggacc cactgagggg gaccatgtac tggtcagact
    12541 ggggcaacca ccccaagatt gagacggcag cgatggatgg gacgcttcgg gagacactgg
    12601 tgcaggacaa cattcagtgg cccacaggcc tggccgtgga ttatcacaat gagcggctgt
    12661 actgggcaga cgccaagctt tcagtcatcg gcagcatccg gctcaatggc acggacccca
    12721 ttgtggctgc tgacagcaaa cgaggcctaa gtcacccctt cagcatcgac gtctttgagg
    12781 attacatcta tggtgtcacc tacatcaata atcgtgtctt caagatccat aagtttggcc
    12841 acagcccctt ggtcaacctg acagggggcc tgagccacgc ctctgacgtg gtcctttacc
    12901 atcagcacaa gcagcccgaa gtgaccaacc catgtgaccg caagaaatgc gagtggctct
    12961 gcctgctgag ccccagtggg cctgtctgca cctgtcccaa tgggaagcgg ctggacaacg
    13021 gcacatgcgt gcctgtgccc tctccaacgc cccccccaga tgctccccgg cctggaacct
    13081 gtaacctgca gtgcttcaac ggtggcagct gtttcctcaa tgcacggagg cagcccaagt
    13141 gccgctgcca accccgctac acgggtgaca agtgtgaact ggaccagtgc tgggagcact
    13201 gtcgcaatgg gggcacctgt gctgcctccc cctctggcat gcccacgtgc cggtgcccca
    13261 cgggcttcac gggccccaaa tgcacccagc aggtgtgtgc gggctactgt gccaacaaca
    13321 gcacctgcac tgtcaaccag ggcaaccagc cccagtgccg atgcctaccc ggcttcctgg
    13381 gcgaccgctg ccagtaccgg cagtgctctg gctactgtga gaactttggc acatgccaga
    13441 tggctgctga tggctcccga caatgccgct gcactgccta ctttgaggga tcgaggtgtg
    13501 aggtgaacaa gtgcagccgc tgtctcgaag gggcctgtgt ggtcaacaag cagagtgggg
    13561 atgtcacctg caactgcacg gatggccggg tggcccccag ctgtctgacc tgcgtcggcc
    13621 actgcagcaa tggcggctcc tgtaccatga acagcaaaat gatgcctgag tgccagtgcc
    13681 caccccacat gacagggccc cggtgtgagg agcacgtctt cagccagcag cagccaggac
    13741 atatagcctc catcctaatc cctctgctgt tgctgctgct gctggttctg gtggccggag
    13801 tggtattctg gtataagcgg cgagtccaag gggctaaggg cttccagcac caacggatga
    13861 ccaacggggc catgaacgtg gagattggaa accccaccta caagatgtac gaaggcggag
    13921 agcctgatga tgtgggaggc ctactggacg ctgactttgc cctggaccct gacaagccca
    13981 ccaacttcac caaccccgtg tatgccacac tctacatggg gggccatggc agtcgccact
    14041 ccctggccag cacggacgag aagcgagaac tcctgggccg gggccctgag gacgagatag
    14101 gggacccctt ggcatagggc cctgccccgt cggactgccc ccagaaagcc tcctgccccc
    14161 tgccagtgaa gtccttcagt gagcccctcc ccagccagcc cttccctggc cccgccggat
    14221 gtataaatgt aaaaatgaag gaattacatt ttatatgtga gcgagcaagc cggcaagcga
    14281 gcacagtatt atttctccat cccctccctg cctgctcctt ggcaccccca tgctgccttc
    14341 agggagacag gcagggaggg cttggggctg cacctcctac cctcccacca gaacgcaccc
    14401 cactgggaga gctggtggtg cagccttccc ctccctgtat aagacacttt gccaaggctc
    14461 tcccctctcg ccccatccct gcttgcccgc tcccacagct tcctgagggc taattctggg
    14521 aagggagagt tctttgctgc ccctgtctgg aagacgtggc tctgggtgag gtaggcggga
    14581 aaggatggag tgttttagtt cttgggggag gccaccccaa accccagccc caactccagg
    14641 ggcacctatg agatggccat gctcaacccc cctcccagac aggccctccc tgtctccagg
    14701 gcccccaccg aggttcccag ggctggagac ttcctctggt aaacattcct ccagcctccc
    14761 ctcccctggg gacgccaagg aggtgggcca cacccaggaa gggaaagcgg gcagccccgt
    14821 tttggggacg tgaacgtttt aataattttt gctgaattcc tttacaacta aataacacag
    14881 atattgttat aaataaaatt gtaaaaaaaa aaaaaaaaaa aaa
//
