LOCUS       NM_001305581            3662 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens leucine rich melanocyte differentiation associated
            (LRMDA), transcript variant 1, mRNA.
ACCESSION   NM_001305581 XM_005270212
VERSION     NM_001305581.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Yao,T.C., Du,G., Han,L., Sun,Y., Hu,D., Yang,J.J., Mathias,R.,
            Roth,L.A., Rafaels,N., Thompson,E.E., Loisel,D.A., Anderson,R.,
            Eng,C., Arruabarrena Orbegozo,M., Young,M., Klocksieben,J.M.,
            Anderson,E., Shanovich,K., Lester,L.A., Williams,L.K., Barnes,K.C.,
            Burchard,E.G., Nicolae,D.L., Abney,M. and Ober,C.
  TITLE     Genome-wide association study of lung function phenotypes in a
            founder population
  JOURNAL   J Allergy Clin Immunol 133 (1), 248-55 (2014)
   PUBMED   23932459
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Gronskov,K., Dooley,C.M., Ostergaard,E., Kelsh,R.N., Hansen,L.,
            Levesque,M.P., Vilhelmsen,K., Mollgard,K., Stemple,D.L. and
            Rosenberg,T.
  TITLE     Mutations in c10orf11, a melanocyte-differentiation gene, cause
            autosomal-recessive albinism
  JOURNAL   Am J Hum Genet 92 (3), 415-421 (2013)
   PUBMED   23395477
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Kiyotani,K., Mushiroda,T., Tsunoda,T., Morizono,T., Hosono,N.,
            Kubo,M., Tanigawara,Y., Imamura,C.K., Flockhart,D.A., Aki,F.,
            Hirata,K., Takatsuka,Y., Okazaki,M., Ohsumi,S., Yamakawa,T.,
            Sasa,M., Nakamura,Y. and Zembutsu,H.
  TITLE     A genome-wide association study identifies locus at 10q22
            associated with clinical outcomes of adjuvant tamoxifen therapy for
            breast cancer patients in Japanese
  JOURNAL   Hum Mol Genet 21 (7), 1665-1672 (2012)
   PUBMED   22180457
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Hancock,D.B., Soler Artigas,M., Gharib,S.A., Henry,A.,
            Manichaikul,A., Ramasamy,A., Loth,D.W., Imboden,M., Koch,B.,
            McArdle,W.L., Smith,A.V., Smolonska,J., Sood,A., Tang,W.,
            Wilk,J.B., Zhai,G., Zhao,J.H., Aschard,H., Burkart,K.M.,
            Curjuric,I., Eijgelsheim,M., Elliott,P., Gu,X., Harris,T.B.,
            Janson,C., Homuth,G., Hysi,P.G., Liu,J.Z., Loehr,L.R., Lohman,K.,
            Loos,R.J., Manning,A.K., Marciante,K.D., Obeidat,M., Postma,D.S.,
            Aldrich,M.C., Brusselle,G.G., Chen,T.H., Eiriksdottir,G.,
            Franceschini,N., Heinrich,J., Rotter,J.I., Wijmenga,C.,
            Williams,O.D., Bentley,A.R., Hofman,A., Laurie,C.C., Lumley,T.,
            Morrison,A.C., Joubert,B.R., Rivadeneira,F., Couper,D.J.,
            Kritchevsky,S.B., Liu,Y., Wjst,M., Wain,L.V., Vonk,J.M.,
            Uitterlinden,A.G., Rochat,T., Rich,S.S., Psaty,B.M., O'Connor,G.T.,
            North,K.E., Mirel,D.B., Meibohm,B., Launer,L.J., Khaw,K.T.,
            Hartikainen,A.L., Hammond,C.J., Glaser,S., Marchini,J., Kraft,P.,
            Wareham,N.J., Volzke,H., Stricker,B.H., Spector,T.D.,
            Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R., Heckbert,S.R.,
            Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A., Strachan,D.P.,
            Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and London,S.J.
  TITLE     Genome-wide joint meta-analysis of SNP and SNP-by-smoking
            interaction identifies novel loci for pulmonary function
  JOURNAL   PLoS Genet 8 (12), e1003098 (2012)
   PUBMED   23284291
REFERENCE   5  (bases 1 to 3662)
  AUTHORS   Soler Artigas,M., Loth,D.W., Wain,L.V., Gharib,S.A., Obeidat,M.,
            Tang,W., Zhai,G., Zhao,J.H., Smith,A.V., Huffman,J.E., Albrecht,E.,
            Jackson,C.M., Evans,D.M., Cadby,G., Fornage,M., Manichaikul,A.,
            Lopez,L.M., Johnson,T., Aldrich,M.C., Aspelund,T., Barroso,I.,
            Campbell,H., Cassano,P.A., Couper,D.J., Eiriksdottir,G.,
            Franceschini,N., Garcia,M., Gieger,C., Gislason,G.K., Grkovic,I.,
            Hammond,C.J., Hancock,D.B., Harris,T.B., Ramasamy,A.,
            Heckbert,S.R., Heliovaara,M., Homuth,G., Hysi,P.G., James,A.L.,
            Jankovic,S., Joubert,B.R., Karrasch,S., Klopp,N., Koch,B.,
            Kritchevsky,S.B., Launer,L.J., Liu,Y., Loehr,L.R., Lohman,K.,
            Loos,R.J., Lumley,T., Al Balushi,K.A., Ang,W.Q., Barr,R.G.,
            Beilby,J., Blakey,J.D., Boban,M., Boraska,V., Brisman,J.,
            Britton,J.R., Brusselle,G.G., Cooper,C., Curjuric,I., Dahgam,S.,
            Deary,I.J., Ebrahim,S., Eijgelsheim,M., Francks,C., Gaysina,D.,
            Granell,R., Gu,X., Hankinson,J.L., Hardy,R., Harris,S.E.,
            Henderson,J., Henry,A., Hingorani,A.D., Hofman,A., Holt,P.G.,
            Hui,J., Hunter,M.L., Imboden,M., Jameson,K.A., Kerr,S.M.,
            Kolcic,I., Kronenberg,F., Liu,J.Z., Marchini,J., McKeever,T.,
            Morris,A.D., Olin,A.C., Porteous,D.J., Postma,D.S., Rich,S.S.,
            Ring,S.M., Rivadeneira,F., Rochat,T., Sayer,A.A., Sayers,I.,
            Sly,P.D., Smith,G.D., Sood,A., Starr,J.M., Uitterlinden,A.G.,
            Vonk,J.M., Wannamethee,S.G., Whincup,P.H., Wijmenga,C.,
            Williams,O.D., Wong,A., Mangino,M., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., North,K.E., Omenaas,E., Palmer,L.J.,
            Pietilainen,K.H., Pin,I., Pola Sbreve Ek,O., Pouta,A., Psaty,B.M.,
            Hartikainen,A.L., Rantanen,T., Ripatti,S., Rotter,J.I., Rudan,I.,
            Rudnicka,A.R., Schulz,H., Shin,S.Y., Spector,T.D., Surakka,I.,
            Vitart,V., Volzke,H., Wareham,N.J., Warrington,N.M., Wichmann,H.E.,
            Wild,S.H., Wilk,J.B., Wjst,M., Wright,A.F., Zgaga,L., Zemunik,T.,
            Pennell,C.E., Nyberg,F., Kuh,D., Holloway,J.W., Boezen,H.M.,
            Lawlor,D.A., Morris,R.W., Probst-Hensch,N., Kaprio,J., Wilson,J.F.,
            Hayward,C., Kahonen,M., Heinrich,J., Musk,A.W., Jarvis,D.L.,
            Glaser,S., Jarvelin,M.R., Ch Stricker,B.H., Elliott,P.,
            O'Connor,G.T., Strachan,D.P., London,S.J., Hall,I.P., Gudnason,V.
            and Tobin,M.D.
  CONSRTM   International Lung Cancer Consortium; GIANT consortium
  TITLE     Genome-wide association and large-scale follow up identifies 16 new
            loci influencing lung function
  JOURNAL   Nat Genet 43 (11), 1082-1090 (2011)
   PUBMED   21946350
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3662)
  AUTHORS   Tzschach,A., Bisgaard,A.M., Kirchhoff,M., Graul-Neumann,L.M.,
            Neitzel,H., Page,S., Ahmed,A., Muller,I., Erdogan,F., Ropers,H.H.,
            Kalscheuer,V.M. and Ullmann,R.
  TITLE     Chromosome aberrations involving 10q22: report of three overlapping
            interstitial deletions and a balanced translocation disrupting
            C10orf11
  JOURNAL   Eur J Hum Genet 18 (3), 291-295 (2010)
   PUBMED   19844253
  REMARK    GeneRIF: This finding suggests that haploinsufficiency of C10orf11
            contributes to the cognitive defects in 10q22 deletion patients.
REFERENCE   7  (bases 1 to 3662)
  AUTHORS   Trevino,L.R., Shimasaki,N., Yang,W., Panetta,J.C., Cheng,C.,
            Pei,D., Chan,D., Sparreboom,A., Giacomini,K.M., Pui,C.H.,
            Evans,W.E. and Relling,M.V.
  TITLE     Germline genetic variation in an organic anion transporter
            polypeptide associated with methotrexate pharmacokinetics and
            clinical effects
  JOURNAL   J Clin Oncol 27 (35), 5972-5978 (2009)
   PUBMED   19901119
REFERENCE   8  (bases 1 to 3662)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 3662)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3662)
  AUTHORS   Thomas,M.G., Zippin,J. and Brooks,B.P.
  TITLE     Oculocutaneous Albinism and Ocular Albinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37053367
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010997.12, BM720401.1,
            HY006640.1, BX105111.1, AC012047.8, AC024603.7 and CR933639.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001305581.1.
            
            Summary: This gene encodes a leucine-rich repeat protein. The
            encoded protein is thought to play a role in melanocyte
            differentiation. Mutations in this gene have been associated with
            autosomal recessive oculocutaneous albinism 7 (OCA7). Alternatively
            spliced transcript variants have been identified. [provided by
            RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.1879.1, ERR279827.560.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611255.5/ ENSP00000480240.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC010997.12        21155-21176         c
            23-59               BM720401.1         1-37
            60-60               HY006640.1         29-29
            61-131              BM720401.1         39-109
            132-416             BX105111.1         3-287
            417-418             AC012047.8         101399-101400       c
            419-628             BX105111.1         290-499
            629-823             BX105111.1         501-695
            824-824             AC024603.7         105954-105954
            825-842             BX105111.1         697-714
            843-843             AC024603.7         105973-105973
            844-856             BX105111.1         716-728
            857-866             CR933639.1         1110-1119
            867-867             AC024603.7         105997-105997
            868-869             CR933639.1         1121-1122
            870-3662            AC024603.7         106000-108792
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2-q22.3"
     gene            1..3662
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /note="leucine rich melanocyte differentiation associated"
                     /db_xref="GeneID:83938"
                     /db_xref="HGNC:HGNC:23405"
                     /db_xref="MIM:614537"
     exon            1..131
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..782
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein C10orf11;
                     leucine-rich melanocyte differentiation-associated
                     protein"
                     /codon_start=1
                     /product="leucine-rich melanocyte
                     differentiation-associated protein isoform 1"
                     /protein_id="NP_001292510.1"
                     /db_xref="CCDS:CCDS76319.1"
                     /db_xref="GeneID:83938"
                     /db_xref="HGNC:HGNC:23405"
                     /db_xref="MIM:614537"
                     /translation="MAGLVVRGTQVSYIGQDCREIPEHLGRDCGHFAKRLDLSFNLLR
                     SLEGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENLLDHLAEVTP
                     ALEYLSLLGNVACPNELVSLEKDEEDYKRYRCFVLYKLPNLKFLDAQKVTRQEREEAL
                     VRGVFMKVVKPKASSEDVASSPERHYTPLPSASRELTSHQGVLGKCRYVYYGKNSEGN
                     RFIRDDQL"
     exon            132..232
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /inference="alignment:Splign:2.1.0"
     exon            233..359
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /inference="alignment:Splign:2.1.0"
     exon            360..499
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /inference="alignment:Splign:2.1.0"
     exon            500..617
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /inference="alignment:Splign:2.1.0"
     exon            618..702
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /inference="alignment:Splign:2.1.0"
     exon            703..3662
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /inference="alignment:Splign:2.1.0"
     regulatory      818..823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /note="hexamer: AATAAA"
     polyA_site      843
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /note="major polyA site"
     regulatory      846..851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /note="hexamer: AAGAAA"
     polyA_site      866
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /note="major polyA site"
     regulatory      3642..3647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
                     /note="hexamer: AATAAA"
     polyA_site      3662
                     /gene="LRMDA"
                     /gene_synonym="C10orf11; CDA017"
ORIGIN      
        1 agtgcggaac tgtgcgcccg ccgcgctccc ctgccgcgct ccccgctgct gccgccgcgc
       61 ccccgcgctc cgtcccgcgc gcccgcagcg tcctggccgc catggccggg ctcgtggtgc
      121 gtggaactca agtgtcctac ataggccagg actgcagaga aattccagag caccttggca
      181 gggactgtgg acatttcgca aagaggcttg atctgagctt taaccttctg aggtcactgg
      241 aaggactgag cgcattcagg agcctggagg aactcatctt ggacaacaat cagctggggg
      301 acgaccttgt gttgccaggg ttacccagac tgcatacctt aaccctcaac aagaaccgaa
      361 tcactgattt ggagaacctg ctggatcact tggcagaagt gacaccagct ctggagtacc
      421 tcagtctgct gggcaacgtg gcctgtccca acgagctggt cagcttggaa aaggatgagg
      481 aagactacaa gagatacaga tgctttgttc tgtacaagct gcccaacttg aaatttctgg
      541 atgcccagaa agtaaccaga caagaacgag aggaggcgtt ggtcagagga gtcttcatga
      601 aggtggtgaa gcccaaggct tctagtgagg acgttgccag ctccccggag cgccactaca
      661 cgcccttgcc ttctgcttcc agggaactca ccagtcacca aggtgtcctg gggaagtgtc
      721 gctacgttta ctatgggaaa aactcagagg gcaacaggtt tatccgagat gaccagctct
      781 gaagccaact tctgtatacc ttcacccatt tcatgaaaat aaaatcaaaa gggaaatcaa
      841 aaataaagaa aacgctaaag aaaaaacaat agcccacatt gcctctcttt gggaaaagct
      901 atgacttcag cttttggtac cttccgctga ctttgccagg cctgtcaaga tgatccttct
      961 gccttagact gagtggtcac atagagattg acatgattgc ccttaagcag gtctcatcca
     1021 ccagggtgac agacagcggt ggcaaagcaa cagggctgac agcatgaaca ccatgataga
     1081 ttgcctggtc ctgccactgc tcacagggga gcagaggtca cacctggggc ctccctggac
     1141 atgctcagtg gctgcagtca agtgagaaag actgtcctca gctcgcctat tgaattgaaa
     1201 tccctctgat accatcgtgc tgtgggctta tttttagtga aatagtcaca gtttagggga
     1261 tggccattct ccctcactcc ttttaaatct taacgtcctg tattctgcat atacatagct
     1321 cccgtctctt cccctccacc ttcctttagc atcgatttta tgacaggtgg tgcatttcag
     1381 tttgcagttt ttcggagaac aaggtataac ttcccagcca ggtcatacat ttatggctgg
     1441 cttcatgttg ctacaatccc tttattggcg taaatagctt tccctaaatc cctgactaca
     1501 aaagcgtgga cttttatctt gtttcattca actctaaatc cacttcttgc cctgaatatg
     1561 atgcagtgta aggcataagg catctttctc agcatgaggg tttggttgca ccagggactc
     1621 ttatttatta atttattttt aaccgtacac acttccagtg atgcctgtgg ccatacttgt
     1681 gcgtggggct ggcttgctcc tttgggtgct atttaaaggg agtgaggtga tgaaagatag
     1741 agtgaagggt caggaggtta aaaaacaaaa ttaagactgt tgaaaacacc caccagacca
     1801 aagagttttt atagaaggca caaacctttt ggattttgca tctttgtcat gacctctcag
     1861 aaatcaaatc cacaggttgt gagacagtgc tctgtcttcc tgtatgcttg gctgtgcact
     1921 agcactaatg tcacaaggaa cataagtgtg atcattgcta gttgggtgac tcaaagttta
     1981 tctaacttgc tggtgcacca gtcaaatcac tctagaagat gttcaaaagg ttgattgatt
     2041 gttcttgaca cgatagtgtt tatttttctg cttcttccat ttagaccaag tgttcattgt
     2101 cctcccagta ttaggtcagt ttgatgacag caaaacctga aagagaatcc ctccaagtta
     2161 tagatactga gggactagga gctgctattg taaaactatg gggactcaga atccctaagc
     2221 tgcccaagga gaacctactt tctcagctct agcccgttta catagcctct ggcccactga
     2281 gtcaacacag gccttgaatg acatgtattg aggctggcag gagtccctgt ttgagattac
     2341 acaacctttg ttaatcagtt ctttagacaa gttaacatta aaatcctcaa aaccatgaaa
     2401 aattggagaa tgttgaatgt ttgcatttat ctctcaaatc cattagtaac tggatttgag
     2461 taccttttct ctgtttgatc tacaaaacag cactggaaaa atgctttaaa ttatctgcat
     2521 ttggtcccac cctgggtcat tgtttagaag catcaacaca tgttttctcc ctggcataat
     2581 atgggcagcc agaattctgt gcaagggcag ctagacgagt cagatgtcat atccaatcta
     2641 gccacacata tatccttgtc tttataaaag gctttaaccc tgcctcaaac aataaaaaag
     2701 cacttgtgaa ctgaccacag aatttttcca tctttatttt tcttacttgt ttactttttt
     2761 taatgtcaga accatttgta tcatgcgcag gaatgtctcc ctcaatgtga gctttggagg
     2821 caaaacatat ttttggagtg agttattgac cacattgttt ccctctcttt gggttgttta
     2881 ttttcttcca gaatggtgta ataactttaa ttaagattag ctttaattat aaattaccta
     2941 aaggccatca ctaaggtata ttcatcttat tgatagaatt atagtcagct ttgtttctct
     3001 taagcaggga tagtgataat gaagtgctgg gttggttaca gttccactgt gtgttaacca
     3061 aaatttgctg tgctagagct agactttggt ctgaattggc agaggtagaa cccatgttgc
     3121 atgtttatcc taaatctgta ggaatttccc aaaccttgtt tttcaaagtt gagaagtaga
     3181 aagtaataaa ttcaatcagg gcccagacat gttttgtacc ccctttaccc tttggtcttt
     3241 cttcctttta tcctattcca ctgagcttgt tctttgggga ttgtggtgcc tgacatcact
     3301 gtctttcctc ccctaggaca ctgacttgag tggagagacc tcggcaattc aaggctgtcc
     3361 tgcagctctc tgttgcctca gcaatgtcag gacgactgtc tctttcctaa gtaacataat
     3421 tttaaagaac aatttgttcc tcagggaata atgtcttgga ttgtggggaa tcctattaaa
     3481 agtacaacta ttgcagtcat ttgcttttac ttttaccagc ctcactcata aaccctccat
     3541 ctgtttgttg ctttaaatag aagcacatta taagagatta tcacttgatc aggctgcatg
     3601 tctgagtgtt gtgtgttttc acatactcat gtatactaag gaataaaaga aagcaaacca
     3661 ca
//
