LOCUS       NM_001017924            3026 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens leucine rich repeat, Ig-like and transmembrane domains
            2 (LRIT2), transcript variant 2, mRNA.
ACCESSION   NM_001017924 XM_291697
VERSION     NM_001017924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC140765.1 and BX648524.1.
            
            On Jul 10, 2019 this sequence version replaced NM_001017924.4.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. This results
            in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648524.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148093
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372113.7/ ENSP00000361185.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BC140765.1         46-61
            17-1944             BX648524.1         2-1929
            1945-2192           BC140765.1         2020-2267
            2193-3026           BX648524.1         2178-3011
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..3026
                     /gene="LRIT2"
                     /gene_synonym="LRRC22"
                     /note="leucine rich repeat, Ig-like and transmembrane
                     domains 2"
                     /db_xref="GeneID:340745"
                     /db_xref="HGNC:HGNC:23443"
     exon            1..134
                     /gene="LRIT2"
                     /gene_synonym="LRRC22"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1677
                     /gene="LRIT2"
                     /gene_synonym="LRRC22"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; leucine rich repeat containing 22; leucine-rich
                     repeat, immunoglobulin-like and transmembrane domains 2;
                     leucine-rich repeat, immunoglobulin-like domain and
                     transmembrane domain-containing protein 2; leucine-rich
                     repeat-containing protein 22"
                     /codon_start=1
                     /product="leucine-rich repeat, immunoglobulin-like domain
                     and transmembrane domain-containing protein 2 isoform 2
                     precursor"
                     /protein_id="NP_001017924.1"
                     /db_xref="CCDS:CCDS31234.1"
                     /db_xref="GeneID:340745"
                     /db_xref="HGNC:HGNC:23443"
                     /translation="MASVFHYFLLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSV
                     SLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHL
                     PELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSS
                     NRLTVVSKSVFLNWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSI
                     TLPVILVNSYLICQGPLSKAGQLFHETELSACMKPQISTPSANITIRAGQNVTLRCLA
                     QASPSPSIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIG
                     KSNLVISLHVQPAQALHAPDSLSIPSEGNAYIDLRVVKQTVHGILLEWLAVADTSKEE
                     WFTLYIASDEAFRKEVVHIGPGINTYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVT
                     GRDAGGLEAREHLLHVTVVLCVVLLAVPVGAYAWAAQGPCSCSKWVLRGCLHRRKAPS
                     CTPAAPQSKDGSFREHPAVCDDGEGHIDTEGDKEKGGTEDNS"
     exon            135..916
                     /gene="LRIT2"
                     /gene_synonym="LRRC22"
                     /inference="alignment:Splign:2.1.0"
     exon            917..3026
                     /gene="LRIT2"
                     /gene_synonym="LRRC22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacgtattt tcttacagag aaatatggct tcagtttttc attacttcct gttagttctg
       61 gtctttctgg atacacacgc agctcagcct ttctgtctgc caggatgcac ttgctcagag
      121 gagagttttg gcaggactct gcagtgcaca tctgtctcct tgggaaagat ccctgggaac
      181 ctttctgaag agttcaagca agtgagaatt gaaaattcac ccttatttga gatgccccaa
      241 gggtctttca tcaacatgag caccttggaa tacctctggc tcaattttaa caatatcagt
      301 gtgatccacc taggagccct ggaacacctg ccagaactga gggagctgag actggagggg
      361 aacaagctct gctcagtacc atggacagcg ttccgtgcca cccctctcct gagggtcttg
      421 gatctcaaac gcaacaagat tgatgcactc cctgagctgg ctcttcaatt cttggtcagc
      481 ctgacctacc ttgacctatc ctccaatagg cttacagttg tatccaagag tgtcttcctg
      541 aactggccag cctaccagaa atgccggcag cctgactgtg gggctgagat tctctccagc
      601 ctggtggtgg ccctgcatga caacccctgg gtatgtgact gtcgcctaag ggggcttgtc
      661 cagtttgtca agtccattac cctcccagtc atcctggtga attcctacct gatatgtcag
      721 ggccctctgt ccaaggcagg gcagcttttt catgaaactg agcttagtgc ttgcatgaag
      781 ccacagatct caacccccag tgccaatatc accatccggg caggacagaa tgtgaccctg
      841 cgatgcttgg cacaggccag cccctcacca tccattgcat ggacttatcc cctgagtatg
      901 tggagagaat ttgatgtgtt gacatcttct actggagaag acactgctct gtcagagctg
      961 gccatacctg ctgcccacct ggtagacagt ggtaattaca cctgcatggc ctccaactcc
     1021 attggcaaga gcaaccttgt aatctctctc catgtccagc ctgcccaggc cctacatgca
     1081 cctgattctc tttccatccc ctcggagggc aatgcctaca ttgacctgcg ggttgtcaag
     1141 cagacagtgc atgggatttt gctggagtgg cttgcagtgg ctgacacctc taaggaggag
     1201 tggttcaccc tctacattgc atcggatgaa gccttcagga aggaggtggt tcacattggc
     1261 cccggaatca atacttatgc tgtggatgac ctccttcctg gcacaaaata tgaggcctgc
     1321 ctcagcctag agggccagcc tccacaccag ggccagtgtg tagcttttgt aacaggcaga
     1381 gatgctggtg ggctagaggc acgtgagcac ctcctgcatg tcacagtggt cctgtgtgtg
     1441 gtgctgcttg cagtgcctgt gggcgcctat gcctgggcag cccagggccc ctgcagctgc
     1501 agcaagtggg tcctgcgcgg ctgtcttcat cgcaggaaag cccccagctg cacccctgca
     1561 gccccgcagt ccaaggatgg ctcctttaga gaacatccag ctgtctgtga tgacggtgaa
     1621 gggcacatag acactgaggg ggacaaggag aaaggaggaa cggaagacaa cagctgaaca
     1681 acccaggcca tggggtggaa acggcttggg cttcaagcct ctgaaaccaa ccctctgcag
     1741 cagctccatc catttatcca gcaagtatat attgagcacc cactgtgttc caagcactga
     1801 acttgacaca gggggttcaa gagtaaaaag ggaaacagag tctttatctt catgataaag
     1861 gggacatagt cattatcttc gtaaagttaa agtcaatgaa gatttgtcca tcaaattaat
     1921 cattttatta tacatggtga ttagaaatca ctaaatatta ctctttgcat atacttagcc
     1981 tataacattt acatgcttat acgtaatgtc tacgtataat attttacata tattatcctg
     2041 taaacgaagg tagacttcta cccacttttt ataggtgaaa aactgcagcc tggacagttc
     2101 aatgatacac ccagagtcca catctggcag gaggcagaag ccccattcaa aagaggttcc
     2161 agttccatcg tttccttgaa tgcctgtttt gcggtattct tgtgtctttc attgtttata
     2221 aagtgtgacc ctctctcttc atgacaaact cctaatgaga tcacataaat gtgatgttcc
     2281 aaagagctgc ccatcagggt gatgagagct gttgggtaat gtgagtctct ttttgtaggt
     2341 gtctgttccc ctgtgagcac agcccttggt gctgctgggc aggctggagc catcagcacc
     2401 aaggaagagt aggggattgg ctgcagccct gggtctggca gagagcagac tctgcagggc
     2461 catacccaga aggaagagca cccatacgtc cgctgctttc ccctagtcaa tgtctaaagc
     2521 cctcctatga aatccatgag aggtggtcat ttcctcttag ccggacccat gtggaatgga
     2581 ggggccccaa gaatcccaac atcagctcat catcccactg aacagccctt ctaggggaga
     2641 ccattcccag gatttaattc acatctgtct ccctgccgtt tccctcactg gccacatgca
     2701 aacctttcta agagtgtaaa catgaactag actcattgtg acatctccac acgtttcctc
     2761 cttcccacct tttttaccca ttcctaatca tccttttagg cctctctcaa gtgtgtacat
     2821 tacgtcttcc acagagcttt ccttgacttc acacctctgg ggaaaaggac agtatgcaca
     2881 ttgtgtccat tggttgtgag acatttgcag gcaaagactg accttcctca cggtggccac
     2941 tgcactcgtc taatacctgg attgtgttca taatcaatgt tagttaacaa taaattttaa
     3001 aaaattgaag atggctctca ttttca
//
