LOCUS       NP_001017924             550 aa            linear   PRI 29-APR-2025
DEFINITION  leucine-rich repeat, immunoglobulin-like domain and transmembrane
            domain-containing protein 2 isoform 2 precursor [Homo sapiens].
ACCESSION   NP_001017924 XP_291697
VERSION     NP_001017924.1
DBSOURCE    REFSEQ: accession NM_001017924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 550)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC140765.1 and BX648524.1.
            
            On May 1, 2005 this sequence version replaced XP_291697.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. This results
            in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648524.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148093
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372113.7/ ENSP00000361185.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     Protein         1..550
                     /product="leucine-rich repeat, immunoglobulin-like domain
                     and transmembrane domain-containing protein 2 isoform 2
                     precursor"
                     /note="leucine rich repeat containing 22; leucine-rich
                     repeat, immunoglobulin-like and transmembrane domains 2;
                     leucine-rich repeat, immunoglobulin-like domain and
                     transmembrane domain-containing protein 2; leucine-rich
                     repeat-containing protein 22"
                     /calculated_mol_wt=57963
     sig_peptide     1..19
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A6NDA9.1)"
                     /calculated_mol_wt=2224
     mat_peptide     20..550
                     /product="Leucine-rich repeat, immunoglobulin-like domain
                     and transmembrane domain-containing protein 2.
                     /id=PRO_0000309344"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NDA9.1)"
                     /calculated_mol_wt=57963
     Region          <37..>173
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          37..55
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            52
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A6NDA9.1)"
     Region          58..80
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          80..103
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NDA9.1)"
     Region          81..104
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          103..163
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          104..125
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NDA9.1)"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          128..149
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NDA9.1)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..173
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NDA9.1)"
     Region          153..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          193..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          200..243
                     /region_name="LRRCT"
                     /note="Leucine rich repeat C-terminal domain; smart00082"
                     /db_xref="CDD:214507"
     Region          252..331
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          367..430
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            466..486
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NDA9.1)"
     Region          508..550
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NDA9.1)"
     CDS             1..550
                     /gene="LRIT2"
                     /gene_synonym="LRRC22"
                     /coded_by="NM_001017924.5:25..1677"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS31234.1"
                     /db_xref="GeneID:340745"
                     /db_xref="HGNC:HGNC:23443"
ORIGIN      
        1 masvfhyfll vlvfldthaa qpfclpgctc seesfgrtlq ctsvslgkip gnlseefkqv
       61 riensplfem pqgsfinmst leylwlnfnn isvihlgale hlpelrelrl egnklcsvpw
      121 tafratpllr vldlkrnkid alpelalqfl vsltyldlss nrltvvsksv flnwpayqkc
      181 rqpdcgaeil sslvvalhdn pwvcdcrlrg lvqfvksitl pvilvnsyli cqgplskagq
      241 lfhetelsac mkpqistpsa nitiragqnv tlrclaqasp spsiawtypl smwrefdvlt
      301 sstgedtals elaipaahlv dsgnytcmas nsigksnlvi slhvqpaqal hapdslsips
      361 egnayidlrv vkqtvhgill ewlavadtsk eewftlyias deafrkevvh igpgintyav
      421 ddllpgtkye aclslegqpp hqgqcvafvt grdagglear ehllhvtvvl cvvllavpvg
      481 ayawaaqgpc scskwvlrgc lhrrkapsct paapqskdgs frehpavcdd geghidtegd
      541 kekggtedns
//
