LOCUS       NM_015613               2386 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat, Ig-like and transmembrane domains
            1 (LRIT1), mRNA.
ACCESSION   NM_015613
VERSION     NM_015613.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2386)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 2386)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2386)
  AUTHORS   Roni,V., Carpio,R. and Wissinger,B.
  TITLE     Mapping of transcription start sites of human retina expressed
            genes
  JOURNAL   BMC Genomics 8, 42 (2007)
   PUBMED   17286855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2386)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2386)
  AUTHORS   Gomi,F., Imaizumi,K., Yoneda,T., Taniguchi,M., Mori,Y., Miyoshi,K.,
            Hitomi,J., Fujikado,T., Tano,Y. and Tohyama,M.
  TITLE     Molecular cloning of a novel membrane glycoprotein, pal,
            specifically expressed in photoreceptor cells of the retina and
            containing leucine-rich repeat
  JOURNAL   J Neurosci 20 (9), 3206-3213 (2000)
   PUBMED   10777785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022389.9 and AB031547.1.
            
            On May 17, 2019 this sequence version replaced NM_015613.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031547.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372105.4/ ENSP00000361177.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC022389.9         99876-99960         c
            86-250              AB031547.1         1-165
            251-422             AC022389.9         95908-96079         c
            423-920             AB031547.1         338-835
            921-995             AC022389.9         92494-92568         c
            996-1150            AB031547.1         911-1065
            1151-2386           AC022389.9         89934-91169         c
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..2386
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /note="leucine rich repeat, Ig-like and transmembrane
                     domains 1"
                     /db_xref="GeneID:26103"
                     /db_xref="HGNC:HGNC:23404"
                     /db_xref="MIM:616103"
     exon            1..229
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1979
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /note="leucine rich repeat containing 21; fibronectin type
                     III, immunoglobulin and leucine rich repeat domains 9;
                     leucine-rich repeat, immunoglobulin-like domain and
                     transmembrane domain-containing protein 1; retina-specific
                     protein PAL; leucine-rich repeat-containing protein 21;
                     photoreceptor-associated LRR superfamily protein;
                     leucine-rich repeat, immunoglobulin-like and transmembrane
                     domains 1"
                     /codon_start=1
                     /product="leucine-rich repeat, immunoglobulin-like domain
                     and transmembrane domain-containing protein 1 precursor"
                     /protein_id="NP_056428.1"
                     /db_xref="CCDS:CCDS7373.1"
                     /db_xref="GeneID:26103"
                     /db_xref="HGNC:HGNC:23404"
                     /db_xref="MIM:616103"
                     /translation="MRVALGMLWLLALAWPPQARGFCPSQCSCSLHIMGDGSKARTVV
                     CNDPDMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALM
                     LRGLRRLRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFL
                     DLSSNQLMRLPQELIVSWAHLETGIFPPGHHPRRVLGLQDNPWACDCRLYDLVHLLDG
                     WAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCG
                     ATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFL
                     GASETVISLIVTEPPTSTEHSGSPGALWARTGGGGEAAAYNNKLVARHVPQIPKPAVL
                     ATGPSVPSTKEELTLEHFQMDALGELSDGRAGPSEARMVRSVKVVGDTYHSVSLVWKA
                     PQAKNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLVPRKE
                     QCVIFSTNEVVDAENTQQLINVVVISVAIVIALPLTLLVCCSALQKRCRKCFNKDSTE
                     ATVTYVNLERLGYSEDGLEELSRHSVSEADRLLSARSSVDFQAFGVKGGRRINEYFC"
     exon            230..696
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            697..1002
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..2386
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /note="hexamer: AATGAA"
     polyA_site      2317
                     /gene="LRIT1"
                     /gene_synonym="FIGLER9; LRRC21; PAL"
                     /note="major polyA site"
ORIGIN      
        1 gtgtaagggg ctggcgagca agtgggcagc tgctgagctt gctgggccgg tgggacggag
       61 cggtccaggg acaggcccct gcctgggcca gagaggagcc aggagccatg agggtggcat
      121 taggcatgct ctggctcttg gcccttgcgt ggccccccca ggcccggggc ttctgcccct
      181 ctcaatgcag ctgcagcctc catatcatgg gtgatggcag caaggccagg acagtagtgt
      241 gcaacgaccc cgacatgacc ctgcccccgg cgtccatccc cccggacacc tccagactgc
      301 gcctggagcg gacggccata cgcagggttc ctggcgaggc cttcaggccc ctgggccgcc
      361 tggagcagct gtggctgcct tacaacgccc tcagcgagct caacgccctc atgctgcggg
      421 gcctgcgacg cctgcgggag ctgcggctgc ccgggaaccg cctggccgcc ttcccctggg
      481 cggcgctcag ggacgccccc aagctgcggc tgctggacct gcaggccaac cgcctctcgg
      541 ctgtgcccgc tgaggccgcg cgcttcctgg agaacctcac cttcctcgac ctctccagca
      601 accagctgat gaggctcccg caggagctca tcgtctcctg ggctcacctg gagaccggta
      661 tctttcctcc cggccaccac cccaggcggg tcctagggct acaggacaac ccctgggcat
      721 gtgactgccg actctatgac ctggttcatc ttttggatgg ctgggcccca aacttggcct
      781 tcattgagac tgaactgaga tgtgccagcc cacgtagcct ggccggagtg gccttcagcc
      841 agcttgaact gaggaagtgc cagggcccag agctccatcc aggagtggcc agcatcaggt
      901 cccttttggg tggcacagca ctgctacgct gtggagctac tggagtccct gggcccgaga
      961 tgagctggag gagggccaat ggcaggcccc ttaatggtac agtgcaccag gaagtctcca
     1021 gtgacggcac gagctggact ctgctgggcc tgcctgcagt gtcccacctt gactccggag
     1081 actacatctg ccaagccaag aacttcctgg gagcctctga aactgttatc tccttgattg
     1141 tcactgagcc accgacttcc acagaacaca gtgggagccc aggagcacta tgggcaagga
     1201 caggtggcgg aggggaagct gctgcttaca acaacaagct ggtggccagg catgtccccc
     1261 agattcccaa acccgctgtc ctggccactg gaccctctgt gcccagcaca aaggaggagc
     1321 tgacccttga gcacttccag atggatgccc tgggagagct ctctgatggg cgggcaggac
     1381 cctcagaggc acgaatggtg aggtctgtga aggtggtggg ggacacttac cacagcgtgt
     1441 ccttggtgtg gaaggcaccc caggctaaga acacaactgc cttcagtgtc ctctacgcgg
     1501 tctttgggca gcacagcatg cggcgggtga ttgtgcagcc tgggaagacc agagtgacca
     1561 tcactgggct gttgcccaag accaagtatg tggcgtgtgt ctgtgtgcag ggcctggtgc
     1621 cccggaagga gcagtgtgtt attttctcca ccaatgaagt ggtggatgct gagaacactc
     1681 agcagcttat caatgtggtg gtgatcagtg tggccatcgt cattgccctg cctctcacgc
     1741 tgcttgtctg ctgcagtgct cttcagaagc gctgccgaaa gtgcttcaac aaggactcca
     1801 ctgaggccac agttacctac gtcaacctag agagactggg ctacagcgag gacggcttgg
     1861 aggagctgtc ccggcacagt gtcagcgagg ctgacaggct tctctcagct cgttccagtg
     1921 tggactttca ggcctttgga gtcaaagggg gcaggagaat caatgagtac ttctgctgag
     1981 ggatatgcct ccgcaactca cacacctgcc tgcccacgct ccttctttag ctctgacacc
     2041 tgagtacacg atcacccact cttacctgct cgggtacctg cttactcaga tacttacaca
     2101 caacaacagc agcagcagct gctactgcaa caaccgctaa cacttgttaa gcacttacta
     2161 cagactagaa agtgttctaa gtgctaaatt cttgtaacaa tcatttgcag caggcatcac
     2221 tattctctcc atttccctgg ggtggggggt taagaaactt gcctgtatca gtcagctttt
     2281 gctgtataac aaatgaaagc aaaatcttgg tgatgtatag cagtgaacac ttattttcac
     2341 actcacaggc ctgtgggttg attagggtgg ctctgctctg tgtgtt
//
