LOCUS       NM_153377               4046 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens leucine rich repeats and immunoglobulin like domains 3
            (LRIG3), transcript variant 2, mRNA.
ACCESSION   NM_153377
VERSION     NM_153377.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4046)
  AUTHORS   Li,Y., Wang,W., Hou,X., Huang,W., Zhang,P., He,Y., Wang,B.,
            Duan,Q., Mao,F. and Guo,D.
  TITLE     Glioma-derived LRIG3 interacts with NETO2 in tumor-associated
            macrophages to modulate microenvironment and suppress tumor growth
  JOURNAL   Cell Death Dis 14 (1), 28 (2023)
   PUBMED   36639372
  REMARK    GeneRIF: Glioma-derived LRIG3 interacts with NETO2 in
            tumor-associated macrophages to modulate microenvironment and
            suppress tumor growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4046)
  AUTHORS   M Serag El-Dien,M., Fathy Mahmoud,S., Alhanafy,A.M., Mohamed
            Zanaty,F. and Shawky Holah,N.
  TITLE     Prognostic significance of LRIG2 and LRIG3 proteins in urothelial
            bladder carcinoma
  JOURNAL   J Immunoassay Immunochem 43 (3), 308-332 (2022)
   PUBMED   34839782
  REMARK    GeneRIF: Prognostic significance of LRIG2 and LRIG3 proteins in
            urothelial bladder carcinoma.
REFERENCE   3  (bases 1 to 4046)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4046)
  AUTHORS   Herdenberg,C., Mutie,P.M., Billing,O., Abdullah,A.,
            Strawbridge,R.J., Dahlman,I., Tuck,S., Holmlund,C., Arner,P.,
            Henriksson,R., Franks,P.W. and Hedman,H.
  TITLE     LRIG proteins regulate lipid metabolism via BMP signaling and
            affect the risk of type 2 diabetes
  JOURNAL   Commun Biol 4 (1), 90 (2021)
   PUBMED   33469151
  REMARK    GeneRIF: LRIG proteins regulate lipid metabolism via BMP signaling
            and affect the risk of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4046)
  AUTHORS   Qiu,Y., Han,Q., Lu,H. and Shi,C.
  TITLE     miR-196a targeting LRIG3 promotes the proliferation and migration
            of cervical cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 66 (7), 180-185 (2020)
   PUBMED   33287939
  REMARK    GeneRIF: miR-196a targeting LRIG3 promotes the proliferation and
            migration of cervical cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4046)
  AUTHORS   Karlsson,T., Mark,E.B., Henriksson,R. and Hedman,H.
  TITLE     Redistribution of LRIG proteins in psoriasis
  JOURNAL   J Invest Dermatol 128 (5), 1192-1195 (2008)
   PUBMED   18037903
  REMARK    GeneRIF: LRIG proteins may have a role in epidermal homeostasis and
            psoriasis
REFERENCE   7  (bases 1 to 4046)
  AUTHORS   Guo,D., Han,L., Shu,K., Chen,J. and Lei,T.
  TITLE     Down-regulation of leucine-rich repeats and immunoglobulin-like
            domain proteins (LRIG1-3) in HP75 pituitary adenoma cell line
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 27 (1), 91-94 (2007)
   PUBMED   17393120
  REMARK    GeneRIF: Down-regulation of LRIG3 in HP75 pituitary adenoma is
            reported.
REFERENCE   8  (bases 1 to 4046)
  AUTHORS   Guo,D., Nilsson,J., Haapasalo,H., Raheem,O., Bergenheim,T.,
            Hedman,H. and Henriksson,R.
  TITLE     Perinuclear leucine-rich repeats and immunoglobulin-like domain
            proteins (LRIG1-3) as prognostic indicators in astrocytic tumors
  JOURNAL   Acta Neuropathol 111 (3), 238-246 (2006)
   PUBMED   16532360
  REMARK    GeneRIF: These results indicate that expression and sub-cellular
            localization of LRIG1-3 might be of importance in the pathogenesis
            and prognosis of astrocytic tumors.
REFERENCE   9  (bases 1 to 4046)
  AUTHORS   Guo,D., Holmlund,C., Henriksson,R. and Hedman,H.
  TITLE     The LRIG gene family has three vertebrate paralogs widely expressed
            in human and mouse tissues and a homolog in Ascidiacea
  JOURNAL   Genomics 84 (1), 157-165 (2004)
   PUBMED   15203213
REFERENCE   10 (bases 1 to 4046)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292857.1 and AY358288.1.
            
            On Feb 27, 2020 this sequence version replaced NM_153377.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region and represents the use of an alternate promoter,
            compared to variant 1, which results in a protein (isoform 2) with
            a shorter and distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358288.1, AY505340.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320743.8/ ENSP00000326759.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1650              AK292857.1         16-1665
            1651-4046           AY358288.1         1628-4023
FEATURES             Location/Qualifiers
     source          1..4046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     gene            1..4046
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /note="leucine rich repeats and immunoglobulin like
                     domains 3"
                     /db_xref="GeneID:121227"
                     /db_xref="HGNC:HGNC:30991"
                     /db_xref="MIM:608870"
     exon            1..505
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..3629
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; leucine-rich repeats and immunoglobulin-like
                     domains protein 3; LIG-3"
                     /codon_start=1
                     /product="leucine-rich repeats and immunoglobulin-like
                     domains protein 3 isoform 2 precursor"
                     /protein_id="NP_700356.2"
                     /db_xref="CCDS:CCDS8960.1"
                     /db_xref="GeneID:121227"
                     /db_xref="HGNC:HGNC:30991"
                     /db_xref="MIM:608870"
                     /translation="MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAE
                     RPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLRE
                     VKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL
                     QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQ
                     HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT
                     EITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL
                     SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLI
                     LQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDC
                     QLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQ
                     SAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTIL
                     RLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLEC
                     AAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA
                     GSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVT
                     ERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAP
                     SLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPS
                     YLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAA
                     TDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYP
                     CSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPAS
                     VASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKER
                     TDFQEENHICTFKQTLENYRTPNFQSYDLDT"
     exon            506..577
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..652
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            653..784
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..928
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1072
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1216
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1360
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1441
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1513
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1585
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1749
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2070
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2352
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2805
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2964
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3108
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3384
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..4046
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4027..4032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /note="hexamer: AATAAA"
     polyA_site      4046
                     /gene="LRIG3"
                     /gene_synonym="LIG3"
                     /note="major polyA site"
ORIGIN      
        1 gcagacaaga aggggcttcg gcgagccgac gctgctcaag ctgcaactct gttgcagttg
       61 gcagttcttt tcggtttccc tcctgctgtt tgggggcatg aaagggcttc gccgccggga
      121 gtaaaagaag gaattgaccg ggcagcgcga gggaggagcg cgcacgcgac cgcgagggcg
      181 ggcgtgcacc ctcggctgga agtttgtgcc gggccccgag cgcgcgccgg ctgggagctt
      241 cgggtagaga cctaggccgc tggaccgcga tgagcgcgcc gagcctccgt gcgcgcgccg
      301 cggggttggg gctgctgctg tgcgcggtgc tggggcgcgc tggccggtca gacagcggcg
      361 gtcgcgggga actcgggcag ccctctgggg tagccgccga gcgcccatgc cccactacct
      421 gccgctgcct cggggacctg ctggactgca gtcgtaagcg gctagcgcgt cttcccgagc
      481 cactcccgtc ctgggtcgct cggctggact taagtcacaa cagattatct ttcatcaagg
      541 caagttccat gagccacctt caaagccttc gagaagtgaa actgaacaac aatgaattgg
      601 agaccattcc aaatctggga ccagtctcgg caaatattac acttctctcc ttggctggaa
      661 acaggattgt tgaaatactc cctgaacatc tgaaagagtt tcagtccctt gaaactttgg
      721 accttagcag caacaatatt tcagagctcc aaactgcatt tccagcccta cagctcaaat
      781 atctgtatct caacagcaac cgagtcacat caatggaacc tgggtatttt gacaatttgg
      841 ccaacacact ccttgtgtta aagctgaaca ggaaccgaat ctcagctatc ccacccaaga
      901 tgtttaaact gccccaactg caacatctcg aattgaaccg aaacaagatt aaaaatgtag
      961 atggactgac attccaaggc cttggtgctc tgaagtctct gaaaatgcaa agaaatggag
     1021 taacgaaact tatggatgga gctttttggg ggctgagcaa catggaaatt ttgcagctgg
     1081 accataacaa cctaacagag attaccaaag gctggcttta cggcttgctg atgctgcagg
     1141 aacttcatct cagccaaaat gccatcaaca ggatcagccc tgatgcctgg gagttctgcc
     1201 agaagctcag tgagctggac ctaactttca atcacttatc aaggttagat gattcaagct
     1261 tccttggcct aagcttacta aatacactgc acattgggaa caacagagtc agctacattg
     1321 ctgattgtgc cttccggggg ctttccagtt taaagacttt ggatctgaag aacaatgaaa
     1381 tttcctggac tattgaagac atgaatggtg ctttctctgg gcttgacaaa ctgaggcgac
     1441 tgatactcca aggaaatcgg atccgttcta ttactaaaaa agccttcact ggtttggatg
     1501 cattggagca tctagacctg agtgacaacg caatcatgtc tttacaaggc aatgcatttt
     1561 cacaaatgaa gaaactgcaa caattgcatt taaatacatc aagccttttg tgcgattgcc
     1621 agctaaaatg gctcccacag tgggtggcgg aaaacaactt tcagagcttt gtaaatgcca
     1681 gttgtgccca tcctcagctg ctaaaaggaa gaagcatttt tgctgttagc ccagatggct
     1741 ttgtgtgtga tgattttccc aaaccccaga tcacggttca gccagaaaca cagtcggcaa
     1801 taaaaggttc caatttgagt ttcatctgct cagctgccag cagcagtgat tccccaatga
     1861 cttttgcttg gaaaaaagac aatgaactac tgcatgatgc tgaaatggaa aattatgcac
     1921 acctccgggc ccaaggtggc gaggtgatgg agtataccac catccttcgg ctgcgcgagg
     1981 tggaatttgc cagtgagggg aaatatcagt gtgtcatctc caatcacttt ggttcatcct
     2041 actctgtcaa agccaagctt acagtaaata tgcttccctc attcaccaag acccccatgg
     2101 atctcaccat ccgagctggg gccatggcac gcttggagtg tgctgctgtg gggcacccag
     2161 ccccccagat agcctggcag aaggatgggg gcacagactt cccagctgca cgggagagac
     2221 gcatgcatgt gatgcccgag gatgacgtgt tctttatcgt ggatgtgaag atagaggaca
     2281 ttggggtata cagctgcaca gctcagaaca gtgcaggaag tatttcagca aatgcaactc
     2341 tgactgtcct agaaacacca tcatttttgc ggccactgtt ggaccgaact gtaaccaagg
     2401 gagaaacagc cgtcctacag tgcattgctg gaggaagccc tccccctaaa ctgaactgga
     2461 ccaaagatga tagcccattg gtggtaaccg agaggcactt ttttgcagca ggcaatcagc
     2521 ttctgattat tgtggactca gatgtcagtg atgctgggaa atacacatgt gagatgtcta
     2581 acacccttgg cactgagaga ggaaacgtgc gcctcagtgt gatccccact ccaacctgcg
     2641 actcccctca gatgacagcc ccatcgttag acgatgacgg atgggccact gtgggtgtcg
     2701 tgatcatagc cgtggtttgc tgtgtggtgg gcacgtcact cgtgtgggtg gtcatcatat
     2761 accacacaag gcggaggaat gaagattgca gcattaccaa cacagatgag accaacttgc
     2821 cagcagatat tcctagttat ttgtcatctc agggaacgtt agctgacagg caggatgggt
     2881 acgtgtcttc agaaagtgga agccaccacc agtttgtcac atcttcaggt gctggatttt
     2941 tcttaccaca acatgacagt agtgggacct gccatattga caatagcagt gaagctgatg
     3001 tggaagctgc cacagatctg ttcctttgtc cgtttttggg atccacaggc cctatgtatt
     3061 tgaagggaaa tgtgtatggc tcagatcctt ttgaaacata tcatacaggt tgcagtcctg
     3121 acccaagaac agttttaatg gaccactatg agcccagtta cataaagaaa aaggagtgct
     3181 acccatgttc tcatccttca gaagaatcct gcgaacggag cttcagtaat atatcgtggc
     3241 cttcacatgt gaggaagcta cttaacacta gttactctca caatgaagga cctggaatga
     3301 aaaatctgtg tctaaacaag tcctctttag attttagtgc aaatccagag ccagcgtcgg
     3361 ttgcctcgag taattctttc atgggtacct ttggaaaagc tctcaggaga cctcacctag
     3421 atgcctattc aagctttgga cagccatcag attgtcagcc aagagccttt tatttgaaag
     3481 ctcattcttc cccagacttg gactctgggt cagaggaaga tgggaaagaa aggacagatt
     3541 ttcaggaaga aaatcacatt tgtaccttta aacagacttt agaaaactac aggactccaa
     3601 attttcagtc ttatgacttg gacacataga ctgaatgaga ccaaaggaaa agcttaacat
     3661 actacctcaa gtgaactttt atttaaaaga gagagaatct tatgtttttt aaatggagtt
     3721 atgaatttta aaaggataaa aatgctttat ttatacagat gaaccaaaat tacaaaaagt
     3781 tatgaaaatt tttatactgg gaatgatgct catataagaa taccttttta aactattttt
     3841 taactttgtt ttatgcaaaa aagtatctta cgtaaattaa tgatataaat catgattatt
     3901 ttatgtattt ttataatgcc agatttcttt ttatggaaaa tgagttacta aagcatttta
     3961 aataatacct gccttgtacc attttttaaa tagaagttac ttcattatat tttgcacatt
     4021 atatttaata aaatgtgtca atttga
//
