LOCUS       NM_018372               3313 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ligand dependent nuclear receptor interacting factor 1
            (LRIF1), transcript variant 1, mRNA.
ACCESSION   NM_018372
VERSION     NM_018372.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3313)
  AUTHORS   Sikrova,D., Testa,A.M., Willemsen,I., van den Heuvel,A.,
            Tapscott,S.J., Daxinger,L., Balog,J. and van der Maarel,S.M.
  TITLE     SMCHD1 and LRIF1 converge at the FSHD-associated D4Z4 repeat and
            LRIF1 promoter yet display different modes of action
  JOURNAL   Commun Biol 6 (1), 677 (2023)
   PUBMED   37380887
  REMARK    GeneRIF: SMCHD1 and LRIF1 converge at the FSHD-associated D4Z4
            repeat and LRIF1 promoter yet display different modes of action.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3313)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3313)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3313)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3313)
  AUTHORS   Akram,S., Yang,F., Li,J., Adams,G., Liu,Y., Zhuang,X., Chu,L.,
            Liu,X., Emmett,N., Thompson,W., Mullen,M., Muthusamy,S., Wang,W.,
            Mo,F. and Liu,X.
  TITLE     LRIF1 interacts with HP1alpha to coordinate accurate chromosome
            segregation during mitosis
  JOURNAL   J Mol Cell Biol 10 (6), 527-538 (2018)
   PUBMED   30016453
  REMARK    GeneRIF: LRIF1 interacts directly with HP1 alpha chromoshadow
            domain via an evolutionarily conserved PXVXL motif within its
            C-terminus. Importantly, the LRIF1-HP1 alpha interaction is
            critical for Aurora B activity in the inner centromere.
REFERENCE   6  (bases 1 to 3313)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   7  (bases 1 to 3313)
  AUTHORS   Nozawa,R.S., Nagao,K., Masuda,H.T., Iwasaki,O., Hirota,T.,
            Nozaki,N., Kimura,H. and Obuse,C.
  TITLE     Human POGZ modulates dissociation of HP1alpha from mitotic
            chromosome arms through Aurora B activation
  JOURNAL   Nat Cell Biol 12 (7), 719-727 (2010)
   PUBMED   20562864
REFERENCE   8  (bases 1 to 3313)
  AUTHORS   Li,H.J., Haque,Z.K., Chen,A. and Mendelsohn,M.
  TITLE     RIF-1, a novel nuclear receptor corepressor that associates with
            the nuclear matrix
  JOURNAL   J Cell Biochem 102 (4), 1021-1035 (2007)
   PUBMED   17455211
  REMARK    GeneRIF: RIF1 is a novel nuclear matrix transcription repressor: a
            potential role of RIF1 regulation of nuclear receptor
            transcriptional activity.
REFERENCE   9  (bases 1 to 3313)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   10 (bases 1 to 3313)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY190122.1, BU192014.1 and BQ787643.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018372.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.115974.1,
                                           SRR1803612.119207.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369763.5/ ENSP00000358778.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AY190122.1         23-30
            9-864               BU192014.1         1-856
            865-3224            AY190122.1         877-3236
            3225-3313           BQ787643.1         15-103              c
FEATURES             Location/Qualifiers
     source          1..3313
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3313
                     /gene="LRIF1"
                     /gene_synonym="C1orf103; FSHD3; HBiX1; RIF1"
                     /note="ligand dependent nuclear receptor interacting
                     factor 1"
                     /db_xref="GeneID:55791"
                     /db_xref="HGNC:HGNC:30299"
                     /db_xref="MIM:615354"
     exon            1..302
                     /gene="LRIF1"
                     /gene_synonym="C1orf103; FSHD3; HBiX1; RIF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2544
                     /gene="LRIF1"
                     /gene_synonym="C1orf103; FSHD3; HBiX1; RIF1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     receptor-interacting factor 1; HP1-binding protein
                     enriched in inactive X chromosome protein 1"
                     /codon_start=1
                     /product="ligand-dependent nuclear receptor-interacting
                     factor 1 isoform 1"
                     /protein_id="NP_060842.3"
                     /db_xref="CCDS:CCDS30800.1"
                     /db_xref="GeneID:55791"
                     /db_xref="HGNC:HGNC:30299"
                     /db_xref="MIM:615354"
                     /translation="MSNNLRRVFLKPAEENSGNASRCVSGCMYQVVQTIGSDGKNLLQ
                     LLPIPKSSGNLIPLVQSSVMSDALKGNTGKPVQVTFQTQISSSSTSASVQLPIFQPAS
                     SSNYFLTRTVDTSEKGRVTSVGTGNFSSSVSKVQSHGVKIDGLTMQTFAVPPSTQKDS
                     SFIVVNTQSLPVTVKSPVLPSGHHLQIPAHAEVKSVPASSLPPSVQQKILATATTSTS
                     GMVEASQMPTVIYVSPVNTVKNVVTKNFQNIYPKPVTEIAKPVILNTTQIPKNVATET
                     QLKGGQHSQAAPVKWIFQDNLQPFTPSLVPVKSSNNVASKILKTFVDRKNLGDNTINM
                     PPLSTIDPSGTRSKNMPIKDNALVMFNGKVYLLAKKGTDVLPSQIDQQNSVSPDTPVR
                     KDTLQTVSSSPVTEISREVVNIVLAKSKSSQMETKSLSNTQLASMANLRAEKNKVEKP
                     SPSTTNPHMNQSSNYLKQSKTLFTNPIFPVGFSTGHNAPRKVTAVIYARKGSVLQSIE
                     KISSSVDATTVTSQQCVFRDQEPKIHNEMASTSDKGAQGRNDKKDSQGRSNKALHLKS
                     DAEFKKIFGLTKDLRVCLTRIPDHLTSGEGFDSFSSLVKSGTYKETEFMVKEGERKQQ
                     NFDKKRKAKTNKKMDHIKKRKTENAYNAIINGEANVTGSQLLSSILPTSDVSQHNILT
                     SHSKTRQEKRTEMEYYTHEKQEKGTLNSNAAYEQSHFFNKNYTEDIFPVTPPELEETI
                     RDEKIRRLKQVLREKEAALEEMRKKMHQK"
     exon            303..1830
                     /gene="LRIF1"
                     /gene_synonym="C1orf103; FSHD3; HBiX1; RIF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2103
                     /gene="LRIF1"
                     /gene_synonym="C1orf103; FSHD3; HBiX1; RIF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..3313
                     /gene="LRIF1"
                     /gene_synonym="C1orf103; FSHD3; HBiX1; RIF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3313
                     /gene="LRIF1"
                     /gene_synonym="C1orf103; FSHD3; HBiX1; RIF1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtccacc gccaggagcc ttccggtttc tgcgcggtgc gcgacctcgt cccgaagcct
       61 ggggatacac cctctcgaga gcccgctgtc gccctccgtt aaggtcgaac ccctcacagt
      121 tgctgtgggc aactccagcc caacattccc tcgctctggt tctcgcccca ttgggaaact
      181 cggccccacg cttcccactt ttctggatga ggtgtcccct ttctccccac taaaatgtca
      241 aataacctac ggagggtctt cctgaaaccc gcagaggaaa attcaggcaa cgcctcgcgt
      301 tgtgtttcag gctgcatgta ccaagtagtt cagacgattg gctcggatgg aaaaaatctt
      361 ctgcaattac ttccaattcc taagtcttct ggaaatctta taccactagt tcaatcttca
      421 gtcatgtctg atgctttgaa agggaataca ggaaaaccag ttcaagttac ttttcagact
      481 cagatttcca gctcttccac aagtgcatca gttcaattgc ccatttttca gccagccagt
      541 tcttcaaact attttcttac aagaacagta gatacatcag aaaaaggtag agttacttct
      601 gtgggaactg gaaatttttc ttcatcagtt tctaaagttc agagtcatgg tgtgaaaatt
      661 gatggactca ccatgcaaac atttgctgtt cctccctcaa cacaaaaaga ctcatctttt
      721 attgtagtta atacccagag tcttccagtg actgtgaagt ctccagtttt gccttctggg
      781 catcatttac agattccagc ccatgctgaa gtgaaatctg taccagcgtc atcattgcct
      841 ccttcagtgc agcaaaagat acttgcaact gccaccacca gtacctcagg aatggttgag
      901 gcctcccaaa tgccaaccgt tatttatgta tctcctgtaa atacagtgaa aaatgtagtt
      961 accaagaact ttcaaaacat ttacccaaaa cctgttacag aaatagcaaa gccagtaata
     1021 ctaaatacca cacaaattcc aaagaatgtt gctacagaga cacaattgaa aggtggtcag
     1081 cattctcaag ctgctccagt gaaatggatt ttccaagata atctacagcc ttttacgcca
     1141 tctcttgttc ctgttaagtc ttcaaataat gtggcttcaa agattttaaa aacttttgta
     1201 gataggaaaa atttgggaga taatactata aatatgccac cattgagtac catcgatcct
     1261 agtgggacgc gatccaaaaa tatgcctatt aaagataatg ctttggttat gtttaatggg
     1321 aaagtctatc tgttggctaa aaaggggaca gatgttctgc catcacaaat tgaccaacag
     1381 aattctgttt ctcctgatac tccagtaaga aaagacacgt tacagacagt gagttcaagt
     1441 ccagtcacag aaatatccag agaggttgta aatattgttt tggctaaaag taaatcttcc
     1501 cagatggaga caaaatcact ttccaatacc cagcttgctt ccatggccaa tctaagggca
     1561 gagaagaata aagtggagaa accatctcct tctaccacaa atccacatat gaaccaatcc
     1621 agtaactact taaaacagag taagacttta ttcacaaatc caatctttcc agttggattt
     1681 agtacaggac acaatgcccc cagaaaagta acagccgtca tttatgctag aaaaggaagt
     1741 gtcctccaga gcatagagaa aataagttcc tctgttgatg caacaactgt tacttcacaa
     1801 cagtgtgttt tcagagacca agaaccaaag atccataatg agatggcatc aacatcagat
     1861 aaaggtgccc aaggaagaaa tgacaagaaa gattctcaag gaagaagtaa taaggcatta
     1921 catctgaaga gtgatgctga atttaaaaag atatttggcc ttactaagga tttgagagtg
     1981 tgccttactc gaattcctga ccatttgacc tctggagaag gtttcgattc ctttagcagt
     2041 ttggtaaaga gtggtactta caaagagaca gagtttatgg tgaaggaagg agagagaaaa
     2101 cagcagaatt ttgataagaa aagaaaagca aaaactaata agaagatgga tcacataaag
     2161 aagagaaaaa cagagaatgc ttataacgca atcataaatg gggaagctaa tgtcaccggt
     2221 tcccaactcc taagcagtat tttaccaact tcagatgtgt cacaacataa cattctcacg
     2281 agtcacagca aaaccagaca agaaaagaga actgagatgg aatactatac ccatgagaag
     2341 caagagaaag gcactttgaa ttcaaatgca gcttatgaac aaagtcattt cttcaataaa
     2401 aattataccg aagatatttt cccagtgaca ccaccggagt tagaagaaac cattcgagat
     2461 gaaaaaataa gaagacttaa gcaggtgctg agagagaaag aagcagctct tgaagaaatg
     2521 cgtaagaaga tgcaccaaaa ataaaatctc ctgtaaagac ttcagtgaaa tagctgtttt
     2581 ttaaaatata cttcagcatt aataagttaa ttgtaggtgt gttctgaaag tgtctttgaa
     2641 tatgaagctt gttttttcat cagtcgattg tacaacttta aggaatacag aaaaggttga
     2701 ttcacatatg acttgtgaat aatttacatg gggtatctat acctttgtct tagatacctt
     2761 tttttggaag gataaatttt atatttttct attattttaa ctagaattct ccaagtttga
     2821 atatttgggc agggtttttg ttattgtttg tatctttacc taaattgctc aggcattatt
     2881 ccagcagtag atagtgactg tgtattactg aaattttaca attcaagaga ggaaatcagc
     2941 tccaaactta gcttttccag tggatttgta tatgtacttg ctttatctct ttacccttaa
     3001 aatgatgata ccttgtattc accattgttt tttttaatgt cgtgaaataa tatgtattat
     3061 ggcaacatta tttaaacatt caaacatttc tcaagaatga gcaacatttg taactttaca
     3121 atgtaatttt atataatcca aaggtatttt agaattcagg ccatttgatg ttttgtttgc
     3181 ttatagtgat gtgttcccag gcaaatgctg cttttttttt ttttgggact atgtacatac
     3241 gttactgaga ttgtgtaaaa agtagatcct gaacagttat cacatttaat atttcttaaa
     3301 ctgtaaaagt gta
//
