LOCUS       NM_052972               2605 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens leucine rich alpha-2-glycoprotein 1 (LRG1), mRNA.
ACCESSION   NM_052972
VERSION     NM_052972.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2605)
  AUTHORS   Randen-Brady,R., Carpen,T., Hautala,L.C., Tolvanen,T., Haglund,C.,
            Joenvaara,S., Mattila,P., Makitie,A., Lehtonen,S., Hagstrom,J. and
            Silen,S.
  TITLE     LRG1 and SDR16C5 protein expressions differ according to HPV status
            in oropharyngeal squamous cell carcinoma
  JOURNAL   Sci Rep 14 (1), 14148 (2024)
   PUBMED   38898137
  REMARK    GeneRIF: LRG1 and SDR16C5 protein expressions differ according to
            HPV status in oropharyngeal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2605)
  AUTHORS   Gobel,A., Rachner,T.D., Hoffmann,O., Klotz,D.M., Kasimir-Bauer,S.,
            Kimmig,R., Hofbauer,L.C. and Bittner,A.K.
  TITLE     High serum levels of leucine-rich alpha-2 glycoprotein 1 (LRG-1)
            are associated with poor survival in patients with early breast
            cancer
  JOURNAL   Arch Gynecol Obstet 309 (6), 2789-2798 (2024)
   PUBMED   38413424
  REMARK    GeneRIF: High serum levels of leucine-rich alpha-2 glycoprotein 1
            (LRG-1) are associated with poor survival in patients with early
            breast cancer.
REFERENCE   3  (bases 1 to 2605)
  AUTHORS   Chen,J., Zhang,Z., Feng,L., Liu,W., Wang,X., Chen,H. and Zou,H.
  TITLE     Lrg1 silencing attenuates ischemia-reperfusion renal injury by
            regulating autophagy and apoptosis through the TGFbeta1- Smad1/5
            signaling pathway
  JOURNAL   Arch Biochem Biophys 753, 109892 (2024)
   PUBMED   38246328
  REMARK    GeneRIF: Lrg1 silencing attenuates ischemia-reperfusion renal
            injury by regulating autophagy and apoptosis through the TGFbeta1-
            Smad1/5 signaling pathway.
REFERENCE   4  (bases 1 to 2605)
  AUTHORS   Cheng,X., Wei,H., Liu,Y., Sun,Y., Ye,J., Lu,P. and Han,B.
  TITLE     Relation between LRG1 and CD4+ T cells, cognitive impairment and
            neurological function in patients with acute ischemic stroke
  JOURNAL   Biomark Med 18 (1), 5-14 (2024)
   PUBMED   38380988
  REMARK    GeneRIF: Relation between LRG1 and CD4[+] T cells, cognitive
            impairment and neurological function in patients with acute
            ischemic stroke.
REFERENCE   5  (bases 1 to 2605)
  AUTHORS   Wang,D., Pei,W., Liu,Y., Mo,R., Li,X., Gu,W., Su,Y., Ye,J., Xu,J.
            and Zhao,D.
  TITLE     Leucine rich alpha2 glycoprotein 1 derived from malignant pleural
            mesothelioma cells facilitates macrophage M2 phenotypes
  JOURNAL   Exp Lung Res 50 (1), 136-145 (2024)
   PUBMED   39033404
  REMARK    GeneRIF: Leucine rich alpha2 glycoprotein 1 derived from malignant
            pleural mesothelioma cells facilitates macrophage M2 phenotypes.
REFERENCE   6  (bases 1 to 2605)
  AUTHORS   Anderson,N.L., Polanski,M., Pieper,R., Gatlin,T., Tirumalai,R.S.,
            Conrads,T.P., Veenstra,T.D., Adkins,J.N., Pounds,J.G., Fagan,R. and
            Lobley,A.
  TITLE     The human plasma proteome: a nonredundant list developed by
            combination of four separate sources
  JOURNAL   Mol Cell Proteomics 3 (4), 311-326 (2004)
   PUBMED   14718574
REFERENCE   7  (bases 1 to 2605)
  AUTHORS   Bunkenborg,J., Pilch,B.J., Podtelejnikov,A.V. and Wisniewski,J.R.
  TITLE     Screening for N-glycosylated proteins by liquid chromatography mass
            spectrometry
  JOURNAL   Proteomics 4 (2), 454-465 (2004)
   PUBMED   14760718
REFERENCE   8  (bases 1 to 2605)
  AUTHORS   O'Donnell,L.C., Druhan,L.J. and Avalos,B.R.
  TITLE     Molecular characterization and expression analysis of leucine-rich
            alpha2-glycoprotein, a novel marker of granulocytic differentiation
  JOURNAL   J Leukoc Biol 72 (3), 478-485 (2002)
   PUBMED   12223515
  REMARK    GeneRIF: cDNA clones for human leucine-rich alpha2-glycoprotein
            were isolated. LRG expression was up-regulated during neutrophil
            differentiation but down-regulated during monocytic
            differentiation. The hLRG gene was localized to chromosome 19p13.3.
REFERENCE   9  (bases 1 to 2605)
  AUTHORS   Saito,K., Tanaka,T., Kanda,H., Ebisuno,Y., Izawa,D., Kawamoto,S.,
            Okubo,K. and Miyasaka,M.
  TITLE     Gene expression profiling of mucosal addressin cell adhesion
            molecule-1+ high endothelial venule cells (HEV) and identification
            of a leucine-rich HEV glycoprotein as a HEV marker
  JOURNAL   J Immunol 168 (3), 1050-1059 (2002)
   PUBMED   11801638
REFERENCE   10 (bases 1 to 2605)
  AUTHORS   Takahashi,N., Takahashi,Y. and Putnam,F.W.
  TITLE     Periodicity of leucine and tandem repetition of a 24-amino acid
            segment in the primary structure of leucine-rich alpha
            2-glycoprotein of human serum
  JOURNAL   Proc Natl Acad Sci U S A 82 (7), 1906-1910 (1985)
   PUBMED   3856868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011498.7, AF403428.1 and AK027382.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052972.2.
            
            Summary: The leucine-rich repeat (LRR) family of proteins,
            including LRG1, have been shown to be involved in protein-protein
            interaction, signal transduction, and cell adhesion and
            development. LRG1 is expressed during granulocyte differentiation
            (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027382.1, SRR5189664.113946.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306390.7/ ENSP00000302621.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC011498.7         171678-171689       c
            13-1206             AF403428.1         1-1194
            1207-1792           AK027382.1         1207-1792
            1793-2605           AC011498.7         168055-168867       c
FEATURES             Location/Qualifiers
     source          1..2605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2605
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /note="leucine rich alpha-2-glycoprotein 1"
                     /db_xref="GeneID:116844"
                     /db_xref="HGNC:HGNC:29480"
                     /db_xref="MIM:611289"
     exon            1..55
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1067
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /note="2310031E04Rik; 1300008B03Rik; leucine rich alpha 2
                     glycoprotein"
                     /codon_start=1
                     /product="leucine-rich alpha-2-glycoprotein precursor"
                     /protein_id="NP_443204.1"
                     /db_xref="CCDS:CCDS12130.1"
                     /db_xref="GeneID:116844"
                     /db_xref="HGNC:HGNC:29480"
                     /db_xref="MIM:611289"
                     /translation="MSSWSRQRPKSPGGIQPHVSRTLFLLLLLAASAWGVTLSPKDCQ
                     VFRSDHGSSISCQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSN
                     GLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWL
                     HGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLH
                     LEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVP
                     EGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEA
                     VKGQTLLAVAKSQ"
     exon            56..2605
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /note="hexamer: AATAAA"
     polyA_site      1792
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /note="major polyA site"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /note="hexamer: AATAAA"
     polyA_site      2008
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
     regulatory      2584..2589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
                     /note="hexamer: AATAAA"
     polyA_site      2605
                     /gene="LRG1"
                     /gene_synonym="HMFT1766; LRG"
ORIGIN      
        1 agaagcaaaa gagcagagct accatgtcct cttggagcag acagcgacca aaaagcccag
       61 ggggcattca accccatgtt tctagaactc tgttcctgct gctgctgttg gcagcctcag
      121 cctggggggt caccctgagc cccaaagact gccaggtgtt ccgctcagac catggcagct
      181 ccatctcctg tcaaccacct gccgaaatcc ccggctacct gccagccgac accgtgcacc
      241 tggccgtgga attcttcaac ctgacccacc tgccagccaa cctcctccag ggcgcctcta
      301 agctccaaga attgcacctc tccagcaatg ggctggaaag cctctcgccc gaattcctgc
      361 ggccagtgcc gcagctgagg gtgctggatc taacccgaaa cgccctgacc gggctgcccc
      421 cgggcctctt ccaggcctca gccaccctgg acaccctggt attgaaagaa aaccagctgg
      481 aggtcctgga ggtctcgtgg ctacacggcc tgaaagctct ggggcatctg gacctgtctg
      541 ggaaccgcct ccggaaactg ccccccgggc tgctggccaa cttcaccctc ctgcgcaccc
      601 ttgaccttgg ggagaaccag ttggagacct tgccacctga cctcctgagg ggtccgctgc
      661 aattagaacg gctacatcta gaaggcaaca aattgcaagt actgggaaaa gatctcctct
      721 tgccgcagcc ggacctgcgc tacctcttcc tgaacggcaa caagctggcc agggtggcag
      781 ccggtgcctt ccagggcctg cggcagctgg acatgctgga cctctccaat aactcactgg
      841 ccagcgtgcc cgaggggctc tgggcatccc tagggcagcc aaactgggac atgcgggatg
      901 gcttcgacat ctccggcaac ccctggatct gtgaccagaa cctgagcgac ctctatcgtt
      961 ggcttcaggc ccaaaaagac aagatgtttt cccagaatga cacgcgctgt gctgggcctg
     1021 aagccgtgaa gggccagacg ctcctggcag tggccaagtc ccagtgagac caggggcttg
     1081 ggttgagggt ggggggtctg gtagaacact gcaacccgct taacaaataa tcctgccttt
     1141 ggccgggtgc gggggctcac gcctgtaatc ccagcacttt gggaggccca ggtgggcgga
     1201 tcacgaggtc aggagatcga gaccatcttg gctaacatgg tgaaaccctg tctctactaa
     1261 aaatataaaa aattagccag gcgtggtggt gggcacctgt agtcccagca actcgggagg
     1321 ctgaggcagg agaatggcgt gaacttggga ggcggagctt gcggtgagcc aagatcgtgc
     1381 cactgcactc tagcctgggc gacagagcaa gactgtctca aaaaaattaa aattaaaatt
     1441 aaaaacaaat aatcctgcct tttacaggtg aaactcgggg ctgtccatag cggctgggac
     1501 cccgtttcat ccatccatgc ttcctagaac acacgatggg ctttccttac ccatgcccaa
     1561 ggtgtgccct ccgtctggaa tgccgttccc tgtttcccag atctcttgaa ctctgggttc
     1621 tcccagcccc ttgtccttcc ttccagctga gccctggcca cactggggct gcctttctct
     1681 gactctgtct tccccaagtc agggggctct ctgagtgcag ggtctgatgc tgagtcccac
     1741 ttagcttggg gtcagaacca aggggtttaa taaataaccc ttgaaaactg gatcggatga
     1801 attggctttc attgtgttcc tagcatcttc tcaaatcaac ttcccaggac tccagggtga
     1861 aggaggaaaa gaggcatggc ccaggccctg gggtgtggga tatggtctcc ctaggggatg
     1921 acagttggga tcaatggcct gtgacttctc ctctcccttc ccccatcctg ggacctaact
     1981 ggaaataaaa ccttgactgt tgcccgggtg tcattttacc agtggatttc tgccagggct
     2041 tgtgtcctag gagaaggttt aagttaaacc agattgccca ggtctccaaa cgatttgtca
     2101 tgctgacctg agatcatcga agggggcacc tgcccccggg caaggttgca ggggcaggat
     2161 ggggctgaag ggatgagcag ggtcccgggc ccacctgctg atacagcatt ggccatgtgg
     2221 gggctgcaat cggatttgga agaccctggg gcttgggggc atgtccagtt ttcccagctc
     2281 cctaaaaaat gaccatgcag cctggcgccg tggctcatgc ctgtaatcca aacactttgg
     2341 gaggctgagg caggcagatc accggaggtc aggagttcga gaccagactg gccaacatgg
     2401 caaaaccctg tctctactaa aaatacaaaa attagccagg cacagtggca cgtgcctgta
     2461 ataccagcta cttgggaggg tcaggcagga gaatcacttg aacctgggag gcggaggttg
     2521 cagtgagcca agatcacgcc actgcactcc aggctgggcg acagagtgaa actgtgtctc
     2581 aaaaataaaa ataaaaataa aaaga
//
