LOCUS       NM_152447               4417 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens leucine rich repeat and fibronectin type III domain
            containing 5 (LRFN5), transcript variant 1, mRNA.
ACCESSION   NM_152447
VERSION     NM_152447.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4417)
  AUTHORS   Xu,K., Zheng,P., Zhao,S., Wang,J., Feng,J., Ren,Y., Zhong,Q.,
            Zhang,H., Chen,X., Chen,J. and Xie,P.
  TITLE     LRFN5 and OLFM4 as novel potential biomarkers for major depressive
            disorder: a pilot study
  JOURNAL   Transl Psychiatry 13 (1), 188 (2023)
   PUBMED   37280213
  REMARK    GeneRIF: LRFN5 and OLFM4 as novel potential biomarkers for major
            depressive disorder: a pilot study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4417)
  AUTHORS   Jiang,Y., Zhao,J., Li,R., Liu,Y., Zhou,L., Wang,C., Lv,C., Gao,L.
            and Cui,D.
  TITLE     CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1
            mediated ferroptosis
  JOURNAL   J Exp Clin Cancer Res 41 (1), 307 (2022)
   PUBMED   36266731
  REMARK    GeneRIF: CircLRFN5 inhibits the progression of glioblastoma via
            PRRX2/GCH1 mediated ferroptosis.
            Erratum:[J Exp Clin Cancer Res. 2022 Nov 10;41(1):320. doi:
            10.1186/s13046-022-02527-7.. PMID: 36352462]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4417)
  AUTHORS   Lybaek,H., Robson,M., de Leeuw,N., Hehir-Kwa,J.Y., Jeffries,A.,
            Haukanes,B.I., Berland,S., de Bruijn,D., Mundlos,S., Spielmann,M.
            and Houge,G.
  TITLE     LRFN5 locus structure is associated with autism and influenced by
            the sex of the individual and locus conversions
  JOURNAL   Autism Res 15 (3), 421-433 (2022)
   PUBMED   35088940
  REMARK    GeneRIF: LRFN5 locus structure is associated with autism and
            influenced by the sex of the individual and locus conversions.
REFERENCE   4  (bases 1 to 4417)
  AUTHORS   Johnston,K.J.A., Adams,M.J., Nicholl,B.I., Ward,J.,
            Strawbridge,R.J., McIntosh,A.M., Smith,D.J. and Bailey,M.E.S.
  TITLE     Identification of novel common variants associated with chronic
            pain using conditional false discovery rate analysis with major
            depressive disorder and assessment of pleiotropic effects of LRFN5
  JOURNAL   Transl Psychiatry 9 (1), 310 (2019)
   PUBMED   31748543
  REMARK    GeneRIF: Identification of novel common variants associated with
            chronic pain using conditional false discovery rate analysis with
            major depressive disorder and assessment of pleiotropic effects of
            LRFN5.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4417)
  AUTHORS   Cappuccio,G., Attanasio,S., Alagia,M., Mutarelli,M., Borzone,R.,
            Karali,M., Genesio,R., Mormile,A., Nitsch,L., Imperati,F.,
            Esposito,A., Banfi,S., Del Giudice,E. and Brunetti-Pierri,N.
  TITLE     Microdeletion of pseudogene chr14.232.a affects LRFN5 expression in
            cells of a patient with autism spectrum disorder
  JOURNAL   Eur J Hum Genet 27 (9), 1475-1480 (2019)
   PUBMED   31152157
  REMARK    GeneRIF: we found that chr14.232.a increases expression of LRFN5 in
            his fibroblasts. Reduced expression of LRFN5 in fibroblasts should
            be interpreted with caution as these cells might not be
            representative of expression in brain cells, which are involved in
            the neurodevelopmental phenotype.
REFERENCE   6  (bases 1 to 4417)
  AUTHORS   Avery,C.L., Sitlani,C.M., Arking,D.E., Arnett,D.K., Bis,J.C.,
            Boerwinkle,E., Buckley,B.M., Ida Chen,Y.D., de Craen,A.J.,
            Eijgelsheim,M., Enquobahrie,D., Evans,D.S., Ford,I., Garcia,M.E.,
            Gudnason,V., Harris,T.B., Heckbert,S.R., Hochner,H., Hofman,A.,
            Hsueh,W.C., Isaacs,A., Jukema,J.W., Knekt,P., Kors,J.A.,
            Krijthe,B.P., Kristiansson,K., Laaksonen,M., Liu,Y., Li,X.,
            Macfarlane,P.W., Newton-Cheh,C., Nieminen,M.S., Oostra,B.A.,
            Peloso,G.M., Porthan,K., Rice,K., Rivadeneira,F.F., Rotter,J.I.,
            Salomaa,V., Sattar,N., Siscovick,D.S., Slagboom,P.E., Smith,A.V.,
            Sotoodehnia,N., Stott,D.J., Stricker,B.H., Sturmer,T., Trompet,S.,
            Uitterlinden,A.G., van Duijn,C., Westendorp,R.G., Witteman,J.C.,
            Whitsel,E.A. and Psaty,B.M.
  TITLE     Drug-gene interactions and the search for missing heritability: a
            cross-sectional pharmacogenomics study of the QT interval
  JOURNAL   Pharmacogenomics J 14 (1), 6-13 (2014)
   PUBMED   23459443
REFERENCE   7  (bases 1 to 4417)
  AUTHORS   Oudot-Mellakh,T., Cohen,W., Germain,M., Saut,N., Kallel,C.,
            Zelenika,D., Lathrop,M., Tregouet,D.A. and Morange,P.E.
  TITLE     Genome wide association study for plasma levels of natural
            anticoagulant inhibitors and protein C anticoagulant pathway: the
            MARTHA project
  JOURNAL   Br J Haematol 157 (2), 230-239 (2012)
   PUBMED   22443383
REFERENCE   8  (bases 1 to 4417)
  AUTHORS   Nam,J., Mah,W. and Kim,E.
  TITLE     The SALM/Lrfn family of leucine-rich repeat-containing cell
            adhesion molecules
  JOURNAL   Semin Cell Dev Biol 22 (5), 492-498 (2011)
   PUBMED   21736948
  REMARK    GeneRIF: SALM5/Lrfn5, has recently been implicated in severe
            progressive autism and familial schizophrenia, pointing to the
            clinical importance of SALMs.[review]
            Review article
REFERENCE   9  (bases 1 to 4417)
  AUTHORS   Mah,W., Ko,J., Nam,J., Han,K., Chung,W.S. and Kim,E.
  TITLE     Selected SALM (synaptic adhesion-like molecule) family proteins
            regulate synapse formation
  JOURNAL   J Neurosci 30 (16), 5559-5568 (2010)
   PUBMED   20410109
  REMARK    GeneRIF: Expression of SALM family proteins SALM3 and SALM5 in
            nonneural and neural cells induces both excitatory and inhibitory
            presynaptic differentiation in contacting axons.
REFERENCE   10 (bases 1 to 4417)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121821.7, DA096504.1,
            AK096627.1, BC043165.1, AL138498.5 and AW013887.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_152447.4.
            
            Summary: This gene encodes a protein that belongs to the
            leucine-rich repeat and fibronectin type III domain-containing
            family of proteins. A similar protein in mouse, a glycosylated
            transmembrane protein, is thought to function in presynaptic
            differentiation. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096627.1, BC043165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298119.9/ ENSP00000298119.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-685               AL121821.7         84901-85585
            686-833             DA096504.1         1-148
            834-1386            AK096627.1         122-674
            1387-2605           BC043165.1         127-1345
            2606-3268           AK096627.1         1894-2556
            3269-3981           AL138498.5         69378-70090         c
            3982-4166           AK096627.1         3270-3454
            4167-4417           AW013887.1         16-266              c
FEATURES             Location/Qualifiers
     source          1..4417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..4417
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 5"
                     /db_xref="GeneID:145581"
                     /db_xref="HGNC:HGNC:20360"
                     /db_xref="MIM:612811"
     exon            1..1687
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1863
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..3268
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             1884..4043
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fibronectin type III, immunoglobulin and
                     leucine rich repeat domains 8; leucine-rich repeat and
                     fibronectin type-III domain-containing protein 5"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 5 isoform 1 precursor"
                     /protein_id="NP_689660.2"
                     /db_xref="CCDS:CCDS9678.1"
                     /db_xref="GeneID:145581"
                     /db_xref="HGNC:HGNC:20360"
                     /db_xref="MIM:612811"
                     /translation="MEKILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLF
                     VPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLR
                     ALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLE
                     TIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQR
                     AQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWS
                     IPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRS
                     LVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIHEPDP
                     GSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEATSSTALLKFNFQRNIPGIRMFQIQ
                     YNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCVLAIYDDGITSLTATRVVGCIQF
                     TTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNGQHKVTKV
                     SNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENAQCCKATSDNVIQSSETCSSQDSST
                     TTSALPPSWTSSTSVSQKQKRKTGTKPSTEPQNEAVTNVESQNTNRNNSTALQLASRP
                     PDSVTEGPTSKRAHIKPNALLTNVDQIVQETQRLELI"
     exon            3269..3981
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /inference="alignment:Splign:2.1.0"
     exon            3982..4025
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4417
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4394..4399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /note="hexamer: AATAAA"
     polyA_site      4417
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgccg ccgccttcat gctgcagcgc agggctcagt tccacgcggc caggaggccg
       61 ccgttgccca cacgcgacgc tttgggaagc ccagctcccg ggtccgcccc ggccgcggcc
      121 gcagccccgg acctcggctg cttgcctcgc gcctgaactg cggactcgcc ccagcgcggt
      181 ggccagcggg cggggcgctg tgttccgcgg cgcgcaggga ggcggtgagc gtgtgcagag
      241 ctgcccgaac ggaggactat gtatgtgtgt gcgcgtgttt gcgtgtgttt gagcgtgttt
      301 ttccttcttc ccttgaggat gtgaattgtt tagcagctgg ctgctccctt aggatccttg
      361 actttgggga gctctggctg tgaacacagc ccacccatat aatccatttt gcacggtccg
      421 ttatatcaga aaaaaaaagc gcaactggac gggggtgggg cagaccaacg aaacctagac
      481 agacacacac acactcagag gagagaggaa gaattgaaag acttgagaag actttgataa
      541 cctccctgct ggcccttctg tgttccggaa agatcctgga tgttggctac cttttcaagt
      601 catcttggca tgtctctagt gttttgtaag ccgctttcca gctagctgcg tgtgtgtgtg
      661 cgcgcgcgtg tgtacgcgcg cgcctatctg atgcatttga ctgtctttta tccaactgcc
      721 cagaagcaaa tgtgttaact cggcgatgcc ccttcatgcc cgggttcttg cagagctctg
      781 aggacgccca gacccatttt cctggctgga tttggagcgg ctgctgggct gtggacccag
      841 gtgtgtggat cgctttaccc agaagcttgg aaagcgccaa tattaacctg cttccaggta
      901 catcacaagg tcaagagagt gtcttgcagc cctcttgttt ccgtgtatct acaccttctt
      961 ctcttggcca gaaggatatt tacgttttgg ttcacagcat ttgaagccaa aagttcagcc
     1021 cttcgaactg gtttgctata caaaacaaaa caaaacaaat aaggtaatga ggattgctta
     1081 ttaaactgct taacaaaatc cccgactctt cctcagccct ttctcggctc cctcctcccc
     1141 accaaaatgt caccagctct tgaattacgt ggattcgggt tggaggagaa cttgaaggaa
     1201 acgtgattaa agggctatgc gagaacgctc tctttgctgc ccgcggtccg gtgggcttcg
     1261 aagccaatcg tgagaaggac cggttccctc cgtgctgctt cctccccgtg cagtgctggg
     1321 tgtgcgtgtg cgagtgtgag tgcaagtgcg cgcgcgcccg ggtgcgagtg tgtgtgagtg
     1381 tgagcgtgtg tctgtgtgtg cgtgcgcggc cgccctgcct ctgcccgctc cccgggcgcg
     1441 gagccgcggg tttcatgggg cgattgcagc gattccccca cccagagcga cctgcgggca
     1501 gcggcggcag tggcaggagc cgcctttccg attccctacg atgcgggtgc tgagctatgg
     1561 caaagggcag cgaagtgacg agcgagaccc gcgtacgact gtgaaagcca cctggagcca
     1621 ccttgccggg attgtacctg caggcagaaa gtcttcctac gaccgtcttt tcccttagag
     1681 gcaccagaat ccctgtaacc attcatccag gtgttgagaa gatatgtagc agccgagcac
     1741 ccatcttttg acaccgtcct ctgaaatcag ctttggagat gctttcactc tgtccgtctt
     1801 ctgcagcagc caggcagagt gccgactcct tcacagccgt gaggaactct tcaggctcca
     1861 gaagctctta aacctgatct acaatggaaa aaattctttt ttatctgttt ctcattggca
     1921 tagcagtgaa agctcagatc tgtccaaagc gttgtgtctg tcagattttg tctcctaatc
     1981 ttgcaaccct ttgtgccaag aaagggcttt tatttgttcc accaaacatt gacagaagaa
     2041 ctgtggaact gcggttggca gacaattttg ttacaaatat taaaaggaaa gattttgcca
     2101 atatgaccag cttggtggac ctgactctat ccaggaatac aataagtttt attacacctc
     2161 atgctttcgc tgacctacga aatttgaggg ctttgcattt gaatagcaac agattgacta
     2221 aaattacaaa tgatatgttc agtggtcttt ccaatcttca tcatttgata ctgaacaaca
     2281 atcagctgac tttaatttcc tctacagcgt ttgatgatgt cttcgccctt gaggagctgg
     2341 atctgtccta taataatcta gaaaccattc cttgggatgc tgttgagaag atggttagct
     2401 tgcataccct tagtttggat cacaatatga ttgataacat tcctaagggg accttctccc
     2461 atttgcacaa gatgactcgg ttagatgtga catcaaataa attgcagaag ctaccacctg
     2521 accctctctt tcagcgagct caggtactag caacctcagg aatcataagc ccatctactt
     2581 ttgcattaag ttttggtgga aaccccttgc attgcaattg tgaattgttg tggttgaggc
     2641 gtctgtccag agaagatgac ttagagacct gtgcttctcc tccactttta actggccgct
     2701 acttttggtc aattcctgaa gaagagtttt tgtgtgagcc tcctctcatt actcgtcata
     2761 cacatgagat gagagtcctg gagggacaaa gggcaacact gaggtgcaaa gccaggggag
     2821 accctgagcc tgcaattcac tggatttctc ctgaagggaa gcttatttca aatgcaacaa
     2881 gatctctggt gtatgataac ggaacacttg acattcttat cacaactgta aaggatacag
     2941 gtgcttttac ctgcattgct tccaatcctg ctggggaagc aacacaaata gtggatcttc
     3001 atataattaa gctccctcac ttactaaata gtacaaacca tatccatgag cctgatcctg
     3061 gttcttcaga tatctcaact tctaccaagt caggttctaa tacaagcagt agtaatggtg
     3121 atactaaatt gagtcaagat aaaattgtgg tggcagaagc tacatcatca acggcactac
     3181 ttaaatttaa ttttcaaaga aatatccctg gaatacgtat gtttcaaatc cagtacaatg
     3241 gtacttatga tgacaccctt gtttacagaa tgatacctcc tacgagcaaa acttttctgg
     3301 tcaataatct ggctgctgga actatgtatg acttgtgtgt cttggccata tatgatgatg
     3361 gcatcacttc cctcactgcc acaagagtcg tgggttgcat ccagtttact acggaacagg
     3421 attatgtgcg ttgccatttc atgcagtctc agtttttggg aggcaccatg attattatta
     3481 ttggtggaat cattgtagca tctgtgctgg tattcatcat tattctgatg atccggtata
     3541 aggtttgcaa caataatggg caacacaagg tcaccaaggt tagcaatgtt tattcccaaa
     3601 ctaacggggc tcaaatacaa ggctgtagtg taacgctgcc ccagtccgtg tccaaacaag
     3661 ctgtgggaca cgaagagaat gcccagtgtt gtaaagctac cagtgacaat gtgattcaat
     3721 cttcagaaac ttgttcgagt caggactcct ctaccactac ctctgctttg cctccttcct
     3781 ggacttcaag cacttctgtg tcccaaaagc agaaaagaaa gactggcaca aagccaagta
     3841 cagaaccaca gaatgaagcc gtcacaaatg ttgaatccca aaacactaac aggaacaact
     3901 caactgcctt gcagttagct agccgtcctc ccgattctgt cacagagggg cccacgtcta
     3961 aaagagcaca tataaagcca aatgctttgc tgactaatgt tgaccagatt gtccaggaaa
     4021 cacagaggct ggagttaatc tgaagagcac cacttctcct ctctctcctg aaaaaatttg
     4081 ccactgatat ttttactgga taaaattcaa aaatgtttca attcacaaag gctaattgtt
     4141 gaactggtgt cgtagaagaa attgtctaca ggagccaagg tgaaagtctc tgatgacggc
     4201 ggaactggct ccattagacc atggttcatc ctcttttaaa accaaatttt tttttcttct
     4261 ggcctacaag tatttttttt ttaaaaaaga aaaaaagcct acattggcat caagttctgt
     4321 atcaatccat cttacattgc catccatgat ttaacagact gtagaatctt gaataatcta
     4381 tatcacttta acaaataaat gttttactat gacagaa
//
