LOCUS       NM_024036               2869 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens leucine rich repeat and fibronectin type III domain
            containing 4 (LRFN4), transcript variant 1, mRNA.
ACCESSION   NM_024036
VERSION     NM_024036.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2869)
  AUTHORS   Zheng,F., Zhai,X.L., Wang,W.J., Guo,K.P., Xiao,C.C. and Ni,Q.C.
  TITLE     [Expression and clinical significance of LRFN4 in colorectal cancer
            tissue]
  JOURNAL   Zhonghua Yi Xue Za Zhi 100 (22), 1745-1749 (2020)
   PUBMED   32536098
  REMARK    GeneRIF: [Expression and clinical significance of LRFN4 in
            colorectal cancer tissue].
REFERENCE   2  (bases 1 to 2869)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2869)
  AUTHORS   Liu,Y., Chen,X., Chen,X., Yang,X., Song,Q. and Wu,H.
  TITLE     High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated
            with Poor Prognosis in Gastric Cancer Patients
  JOURNAL   Dis Markers 2019, 8282414 (2019)
   PUBMED   31089399
  REMARK    GeneRIF: SALM3 is overexpressed in the tumor cells and fibroblasts
            of gastric cancer patients.  High SALM3 expression is associated
            with poor prognosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2869)
  AUTHORS   Li,Y., Zhang,P., Choi,T.Y., Park,S.K., Park,H., Lee,E.J., Lee,D.,
            Roh,J.D., Mah,W., Kim,R., Kim,Y., Kwon,H., Bae,Y.C., Choi,S.Y.,
            Craig,A.M. and Kim,E.
  TITLE     Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions
            Regulate Excitatory Synapse Development and Locomotion
  JOURNAL   Cell Rep 12 (10), 1618-1630 (2015)
   PUBMED   26321637
  REMARK    GeneRIF: SALM3 regulates excitatory synapse development and
            locomotion behavior.
REFERENCE   5  (bases 1 to 2869)
  AUTHORS   Konakahara,S., Suzuki,Y., Kawakami,T., Saitou,M., Kajikawa,M.,
            Masuho,Y. and Kohroki,J.
  TITLE     A neuronal transmembrane protein LRFN4 complexes with 14-3-3s and
            NCK1 to induce morphological change in monocytic cells via
            Rac1-mediated actin cytoskeleton reorganization
  JOURNAL   FEBS Lett 586 (16), 2251-2259 (2012)
   PUBMED   22677168
  REMARK    GeneRIF: LRFN4 complexed with 14-3-3s and NCK1 to mediate
            elongation in monocytic cells via Rac-1-mediated actin cytoskeleton
            reorganization
REFERENCE   6  (bases 1 to 2869)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2869)
  AUTHORS   Konakahara,S., Saitou,M., Hori,S., Nakane,T., Murai,K., Itoh,R.,
            Shinsaka,A., Kohroki,J., Kawakami,T., Kajikawa,M. and Masuho,Y.
  TITLE     A neuronal transmembrane protein LRFN4 induces monocyte/macrophage
            migration via actin cytoskeleton reorganization
  JOURNAL   FEBS Lett 585 (14), 2377-2384 (2011)
   PUBMED   21704618
  REMARK    GeneRIF: Data indicate that LRFN4 signaling plays an important role
            in the migration of monocytes/macrophages.
REFERENCE   8  (bases 1 to 2869)
  AUTHORS   Nam,J., Mah,W. and Kim,E.
  TITLE     The SALM/Lrfn family of leucine-rich repeat-containing cell
            adhesion molecules
  JOURNAL   Semin Cell Dev Biol 22 (5), 492-498 (2011)
   PUBMED   21736948
  REMARK    Review article
REFERENCE   9  (bases 1 to 2869)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
REFERENCE   10 (bases 1 to 2869)
  AUTHORS   Wang,C.Y., Chang,K., Petralia,R.S., Wang,Y.X., Seabold,G.K. and
            Wenthold,R.J.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003176.2, CN297399.1 and BC015581.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024036.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015581.2, SRR1163655.594494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309602.5/ ENSP00000312535.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AP003176.2         1164-1504
            342-438             CN297399.1         2-98
            439-2869            BC015581.2         1-2431
FEATURES             Location/Qualifiers
     source          1..2869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2869
                     /gene="LRFN4"
                     /gene_synonym="FIGLER6; SALM3; SALM3."
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 4"
                     /db_xref="GeneID:78999"
                     /db_xref="HGNC:HGNC:28456"
                     /db_xref="MIM:612810"
     exon            1..2030
                     /gene="LRFN4"
                     /gene_synonym="FIGLER6; SALM3; SALM3."
                     /inference="alignment:Splign:2.1.0"
     CDS             682..2589
                     /gene="LRFN4"
                     /gene_synonym="FIGLER6; SALM3; SALM3."
                     /note="fibronectin type III, immunoglobulin and leucine
                     rich repeat domains 6; leucine-rich repeat and fibronectin
                     type-III domain-containing protein 4"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 4 precursor"
                     /protein_id="NP_076941.2"
                     /db_xref="CCDS:CCDS8153.1"
                     /db_xref="GeneID:78999"
                     /db_xref="HGNC:HGNC:28456"
                     /db_xref="MIM:612810"
                     /translation="MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPP
                     NVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLH
                     LDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQV
                     PWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGR
                     DAEASPAPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEF
                     SCEPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNG
                     TLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGRPGPSDIAAS
                     ARTAAEGEGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYNSSEDETLIYR
                     IVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPASPLCHA
                     LQAHVLGGTLTVAVGGVLVAALLVFTVALLVRGRGAGNGRLPLKLSHVQSQTNGGPSP
                     TPKAHPPRSPPPRPQRSCSLDLGDAGCYGYARRLGGAWARRSHSVHGGLLGAGCRGVG
                     GSAERLEESVV"
     exon            2031..2869
                     /gene="LRFN4"
                     /gene_synonym="FIGLER6; SALM3; SALM3."
                     /inference="alignment:Splign:2.1.0"
     regulatory      2846..2851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRFN4"
                     /gene_synonym="FIGLER6; SALM3; SALM3."
                     /note="hexamer: AATAAA"
     polyA_site      2869
                     /gene="LRFN4"
                     /gene_synonym="FIGLER6; SALM3; SALM3."
                     /note="major polyA site"
ORIGIN      
        1 gccggcgcgc acccgctcgc ctgtcgccgc cgccaccgct aaccgcgccg ggaaaaggtg
       61 ccgggaaccg agcgagccgg ggccgcgggc ccgagcgcca tgggcccgag ggtgggcggc
      121 gggcggccgg tcatccccgg gcctcgtccc cgcgggagag cggccaggag tcggcggggg
      181 ccggccgggc tcgcagggag gccggcccgc gccccctgag cgacggacac caggtgaggg
      241 ggccgccggg cgcagcgcgg gggccggcca gggaggggcc acggactcca cgggaggttc
      301 ggggggcgcc ttctctggcg ggggagggta tggcggggag tggggaggcg gctggcgatt
      361 cctggggacg cctgggaaag gaagttccgg gaccctccct gctctcggtc ctcctccgct
      421 tcctgcctca tgcctcacct tgtccccagc gcctggactc ccccttaact gcttgggaaa
      481 tgtgaccttt gctctggggg gcctggccct gcaggcccca accttccctc atctctggcg
      541 gccctcttgg gcctctgacc cagcccctcc ccgggccagg ctcacagaag ctggcttctg
      601 ggactgtcct gggcccaagt gggcacctgc gccagcccca cctgtgcctg ggctgtggcc
      661 ccttcctaca gggcgctcac catggccccg ccgctcctgc tgctgctgct ggccagtgga
      721 gcggccgcct gcccgctgcc ctgcgtctgc cagaacctgt ccgagtcgct cagcaccctc
      781 tgtgcccacc gaggcctgct gtttgtgccg cccaacgtgg accggcgcac agtggagctg
      841 cggctggctg acaacttcat ccaggccctg gggccccctg acttccgcaa catgacggga
      901 ctggtggacc tgacactgtc tcgcaatgcc atcacccgca ttggggcccg cgcctttggg
      961 gacctcgaga gcctgcgttc cctccacctt gacggcaaca ggctggtgga gctgggcacc
     1021 gggagcctcc ggggccccgt caatctgcag cacctcatcc tcagcggcaa ccagctgggc
     1081 cgcatcgcgc cgggagcctt cgacgacttc ctagagagcc tggaggacct ggacctgtcc
     1141 tacaacaacc tccggcaggt gccctgggcc ggcatcggcg ccatgcctgc cctgcacacc
     1201 ctcaacctgg accataacct tattgacgca ctgcccccag gcgccttcgc ccagctcggt
     1261 cagctctccc gcctggacct cacctccaac cgcctggcca cgctggctcc ggacccgctt
     1321 ttctctcgtg ggcgtgatgc agaggcctct cccgcccccc tggtgctgag ctttagcggg
     1381 aaccccctgc actgcaactg tgagctgctg tggctgcggc ggctggcgcg gccggacgac
     1441 ctggaaacgt gcgcctcccc gcccggcctg gccggccgct acttctgggc agtgcccgag
     1501 ggcgagttct cctgtgagcc gcccctcatt gcccgccaca cgcagcgcct ctgggtgctg
     1561 gaaggccagc gggccacgct gcggtgccgg gccctgggtg accccgcgcc taccatgcac
     1621 tgggtcggtc ctgacgaccg gttggttggc aactcctccc gagcccgggc tttccccaac
     1681 gggaccttag agattggggt gaccggcgct ggggacgctg ggggctacac ctgcatcgcc
     1741 accaaccctg ctggtgaggc cacagcccga gtagaactgc gggtgctggc cttgccccat
     1801 ggtgggaaca gcagtgccga ggggggccgc cccgggccct cggacatcgc cgcctccgct
     1861 cgcactgctg ccgagggtga ggggacgctg gagtctgagc cagccgtgca ggtgacggag
     1921 gtgaccgcca cctcagggct ggtgagctgg ggtcccgggc ggccagccga cccagtgtgg
     1981 atgttccaaa tccagtacaa cagcagcgaa gatgagaccc tcatctaccg gattgtccca
     2041 gcctccagcc accacttcct gctgaagcac ctcgtccccg gcgctgacta tgacctctgc
     2101 ctgctggcct tgtcaccggc cgctgggccc tctgacctca cggccaccag gctgctgggc
     2161 tgtgcccatt tctccacgct gccggcctcg cccctgtgcc acgccctgca ggcccacgtg
     2221 ctgggcggga ccctgaccgt ggccgtgggg ggtgtgctgg tggctgcctt actggtcttc
     2281 actgtggcct tgctggttcg gggccggggg gccggaaatg gccgcctccc cctcaagctc
     2341 agccacgtcc agtcccagac caatggaggc cccagcccca cacccaaggc ccacccgccg
     2401 cggagccccc cgccccggcc gcagcgcagc tgctctctgg acctgggaga tgccgggtgc
     2461 tacggttatg ccaggcgcct gggaggagct tgggcccgac ggagccactc tgtgcatggg
     2521 gggctgctcg gggcagggtg ccggggggta ggaggcagcg ccgagcggct ggaagagagt
     2581 gtggtgtgat ggacgggcag cttcctgtgt gctccaaggg atgagcctcg tggggcagag
     2641 ggcccggggc cgccgcctgg cctgggagtc cctccctggt ttttattctc agtacctcag
     2701 gctcccctgt gtacttggag gggcagggag ccctttcctc ggttctggcc tccagaccag
     2761 ggtaagggca ggcccctcca acaggtgctc acagccaccg aggcaggggc tgcagccacc
     2821 cactgggagt cttgttttta tttataataa aattgttggg gacacctca
//
