LOCUS       NM_024509               4690 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat and fibronectin type III domain
            containing 3 (LRFN3), mRNA.
ACCESSION   NM_024509
VERSION     NM_024509.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4690)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
REFERENCE   2  (bases 1 to 4690)
  AUTHORS   Wang,C.Y., Chang,K., Petralia,R.S., Wang,Y.X., Seabold,G.K. and
            Wenthold,R.J.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
REFERENCE   3  (bases 1 to 4690)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF038458.1 and BC003578.1.
            
            On Jul 2, 2019 this sequence version replaced NM_024509.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003578.1, AY358127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246529.4/ ENSP00000246529.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               AF038458.1         22337-23082
            747-3261            BC003578.1         1-2515
            3262-4690           AF038458.1         31159-32587
FEATURES             Location/Qualifiers
     source          1..4690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4690
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 3"
                     /db_xref="GeneID:79414"
                     /db_xref="HGNC:HGNC:28370"
                     /db_xref="MIM:612809"
     exon            1..1182
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..2613
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1199..3085
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /note="fibronectin type III, immunoglobulin and leucine
                     rich repeat domains 1; leucine-rich repeat and fibronectin
                     type-III domain-containing protein 3; synaptic
                     adhesion-like molecule 4"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 3 precursor"
                     /protein_id="NP_078785.1"
                     /db_xref="CCDS:CCDS12483.1"
                     /db_xref="GeneID:79414"
                     /db_xref="HGNC:HGNC:28370"
                     /db_xref="MIM:612809"
                     /translation="MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVL
                     CPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGA
                     FADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLED
                     LDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTT
                     IPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPP
                     ALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQG
                     RLLGNSSRARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLA
                     NSTSCDPPRDGDPDALTPPSAASASAKVADTGPPTDRGVQVTEHGATAALVQWPDQRP
                     IPGIRMYQIQYNSSADDILVYRMIPAESRSFLLTDLASGRTYDLCVLAVYEDSATGLT
                     ATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALGGVIVASVLVFIFVLLMRYKVHG
                     GQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPAPEPAALRAHTVVQLDCEPWGPGHE
                     PVGP"
     exon            2614..4690
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3230..3235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /note="hexamer: AAGAAA"
     polyA_site      3250
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /note="major polyA site"
     regulatory      4667..4672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
                     /note="hexamer: AATAAA"
     polyA_site      4690
                     /gene="LRFN3"
                     /gene_synonym="FIGLER1; SALM4"
ORIGIN      
        1 aagcgccggt gcgcgcgctg ccctgggttg ccggcgagga ggccgcggga gcgcctggac
       61 ccggcccgcc cagcccggcc cccgcccggc ccccgcctcg gccccggcgg gggaggggtc
      121 tctgagcgcg gcccctcccc cctgcgcccc cgcctgcgct gcggtgcccc catcccgcgt
      181 gtcccagtct gtctgaccgt ccctccgctc ccaggcctcg ccccacccgg ccctggggct
      241 gcccggtcgc ccccctcccc accgcagccg gtcccctccc tcccagtcag cctccgccgc
      301 agcccaggaa gccagccggg acgccgccgc cccggacccc gcgccctaac ctccacctcg
      361 ggggcctgca cccccagatt gaatcgggaa ttccggaaac ccgagcctgg aaccctgatc
      421 tgggaccagc accccgagat ccggccgtgg aaccccaaga tctggagcct gaaccccagt
      481 atatggggct ggaatctcaa catcggtcac tgggacctca atatttggag ccggaacccc
      541 acaatttgga acacagaccc caatatttgg agcagaaccc caagatttga catctaaaac
      601 ctcaagcctg gagctgaact ctgaattctg ggcctgggac cttgaaatct gggactggat
      661 ttccagtact gtaccctgga acccactctt ggggacctga accctgggat tcaggcctca
      721 aattccaaga tctggactgt gggattccaa ggggcctgaa cccgagtttg ggcctgaagt
      781 ccttgctgca gacctgagtg cttaaatctg gggcttgaga cctcccaatc ttgactcagc
      841 accccaatat ctgaatgcag aaccccggga tcggatctca gactctaaac cccaccgttt
      901 ggctgcttag catcccaaga ctggacctgg gagaccctga ccctgaacaa cccaaactgg
      961 acccgtaaaa ctggacccta gaggcccaat atttaggggt ctggaacccc gagtattaag
     1021 gtctggagac tccgttgcca cagatttgag ccgagtcagg acacagtccc tctacagaag
     1081 ccttggggac aggaaaagca tgaccagatg ctccctccag agccctgacc tctgactccc
     1141 ctggagctag gactctgctc cctggggctg cttctagctc aggacacccc tgcccgcgat
     1201 ggccatcctc ccgttgctcc tgtgcctgct gccgctggcc cctgcctcat ccccacccca
     1261 gtcagccaca cccagcccat gtccccgccg ctgccgctgc cagacacagt cgctgcccct
     1321 aagcgtgctg tgcccagggg caggcctcct gttcgtgcca ccctcgctgg accgccgggc
     1381 agccgagctg cggctggcag acaacttcat cgcctccgtg cgccgccgcg acctggccaa
     1441 catgacaggc ctgctgcatc tgagcctgtc gcggaacacc atccgccacg tggctgccgg
     1501 cgccttcgcc gacctgcggg ccctgcgtgc cctgcacctg gatggcaacc ggctgacctc
     1561 actgggcgag ggccagctgc gcggcctggt caacttgcgc cacctcatcc tcagcaacaa
     1621 ccagctggca gcgctggcgg ccggcgccct ggatgattgt gccgagacac tggaggacct
     1681 cgacctctcc tacaacaacc tcgagcagct gccctgggag gccctgggcc gcctgggcaa
     1741 cgtcaacacg ttgggcctcg accacaacct gctggcttct gtgcccgccg gcgctttttc
     1801 ccgcctgcac aagctggccc ggctggacat gacctccaac cgcctgacca caatcccacc
     1861 cgacccactc ttctcccgcc tgcccctgct cgccaggccc cggggctcgc ccgcctctgc
     1921 cctggtgctg gcctttggcg ggaaccccct gcactgcaac tgcgagctgg tgtggctgcg
     1981 tcgcctggcg cgggaggacg acctcgaggc ctgcgcgtcc ccacctgctc tgggcggccg
     2041 ctacttctgg gcggtgggcg aggaggagtt tgtctgcgag ccgcccgtgg tgactcaccg
     2101 ctcaccacct ctggctgtgc ccgcaggtcg gccggctgcc ctgcgctgcc gggcagtggg
     2161 ggacccagag ccccgtgtgc gttgggtgtc accccagggc cggctgctag gcaactcaag
     2221 ccgtgcccgc gccttcccca atgggacgct ggagctgctg gtcaccgagc cgggtgatgg
     2281 tggcatcttc acctgcattg cggccaatgc agctggcgag gccacagctg ctgtggagct
     2341 gactgtgggt cccccaccac ctcctcagct agccaacagc accagctgtg accccccgcg
     2401 ggacggggat cctgatgctc tcaccccacc ctccgctgcc tctgcttctg ccaaggtggc
     2461 cgacactggg ccccctaccg accgtggcgt ccaggtgact gagcacgggg ccacagctgc
     2521 tcttgtccag tggccggatc agcggcctat cccgggcatc cgcatgtacc agatccagta
     2581 caacagctcg gctgatgaca tcctcgtcta caggatgatc ccggcggaga gccgctcgtt
     2641 cctgctgacg gacctggcgt caggccggac ctacgatctg tgcgtgctcg ccgtgtatga
     2701 ggacagcgcc acggggctca cggccacgcg gcctgtgggc tgcgcccgct tctccaccga
     2761 acctgcgctg cggccatgcg gggcgccgca cgctcccttc ctgggcggca cgatgatcat
     2821 cgcgctgggc ggcgtcatcg tagcctcggt actggtcttc atcttcgtgc tgctaatgcg
     2881 ctacaaggtg cacggcggcc agccccccgg caaggccaag attcccgcgc ctgttagcag
     2941 cgtttgctcc cagaccaacg gcgccctggg ccccacgccc acgcccgccc cgcccgcccc
     3001 ggagcccgcg gcgctcaggg cccacaccgt ggtccagctg gactgcgagc cctgggggcc
     3061 cggccacgaa cctgtgggac cctagccagg cgcccccccc tctaagggtc ctctggcccc
     3121 acggacagca ggacccggac accctgtggg acctggcctc aaactcacca aatcgctcat
     3181 ggtttttaaa actctgatgg ggagggtgtc ggggacaccg gggcaaaaca agaaagtcct
     3241 atttttccaa gcttgggcga agacccttgc cctcgtctct gtctatgggg gttgggggac
     3301 ggagcagggg tctggagctg gggaatgcct cctttgggga gacaccccct ccccgcccag
     3361 ttcagtctga ggaccccgga ggaggctgag gatggcgatc cattcagaca atagatgttc
     3421 cctgcgtgtc ggctctgagc atgccctggg ttgggggatg ctgtggtgat ccagatagcc
     3481 ctgagccctg cccgcagggg cctaaagtca aatgggagac agacacatcc ccagacagtg
     3541 atagcacaga gtgaccaggg atgtggggat gagggaagcc tgggggattg tgacagtcca
     3601 gaagaggtac ccttgctcag ccccaggtgt ggtcagggag ggcttcctgg aggaggacac
     3661 atgtgatctg agaatgacat atgaaggaga taactgggca aagagcagaa ggaaagctct
     3721 ttcaggcaga gggcacagca caagcaaggt ggtggtgtgc cctgggcact gggggtgcta
     3781 tggtagaggt gaggcaggag ggttgagcag ggtctaggac ctccaggctg aggagctcag
     3841 actctggcct gatgatacca gggagccatg gagggttgta tgcaagggag gaatggggtc
     3901 agtttggggc ttcaggaaga tccttctagt gctatgagta gggtggaccc aaggggaaga
     3961 ctgaagctgg gagccccagg ggaagctggg gcagggacct gggtgggtga ggacgaagtt
     4021 ggaccagctg ggctagggaa caagaaaagg gagtgggttg acagagacac tcgggaaact
     4081 gtgggaagct gaggcggtgg gttatggagc tgcggggcca tggggtgggg caggaagatg
     4141 gtggggactg ccctcatata ggaccaggga ggaggagcag gtttgggaaa gatgatatgg
     4201 ccagtgggga acttggtagg tgtagggggc cctgaggatg tccaggatgt ggcattcagg
     4261 agggtgcagg acccctggtc tgaggctgaa gctggaaata gaaatgaggg ctttgtcagc
     4321 agagatggga actgacgctg ctggggttaa gacggcttct tgtgggggat gattccaagt
     4381 ccccactatg ggacattttt tcttttttct tttttttttt tacagatggg gtctcactat
     4441 attgcccagg ctgatcccaa actggcctca agtgatcctc ccgtctcagc ctcctgaatt
     4501 gctgggatta caggcatgag ccactgcccc tggctaggga ctttccatat ttaagggtga
     4561 cgcaaagaaa aacctaacca agactaaaca ggaccagcag gcagagggac agggggaaga
     4621 agaccaagca attcagaccc aagaaactct tgtgttcaat gatataaata aaggctgcgg
     4681 tgacccccca
//
