LOCUS       NM_020862               3579 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat and fibronectin type III domain
            containing 1 (LRFN1), mRNA.
ACCESSION   NM_020862 XM_290842 XM_940573
VERSION     NM_020862.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Ruan,B., Feng,X., Chen,X., Dong,Z., Wang,Q., Xu,K., Tian,J.,
            Liu,J., Chen,Z., Shi,W., Wang,M., Qian,L. and Ding,Q.
  TITLE     Identification of a Set of Genes Improving Survival Prediction in
            Kidney Renal Clear Cell Carcinoma through Integrative Reanalysis of
            Transcriptomic Data
  JOURNAL   Dis Markers 2020, 8824717 (2020)
   PUBMED   33110456
  REMARK    GeneRIF: Identification of a Set of Genes Improving Survival
            Prediction in Kidney Renal Clear Cell Carcinoma through Integrative
            Reanalysis of Transcriptomic Data.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011445.6.
            
            On Nov 22, 2019 this sequence version replaced NM_020862.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.14184.1,
                                           SRR14038192.3799666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248668.5/ ENSP00000248668.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC011445.6         101895-101965       c
            72-104              AC011445.6         99428-99460         c
            105-159             AC011445.6         97184-97238         c
            160-1602            AC011445.6         95033-96475         c
            1603-3579           AC011445.6         87668-89644         c
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3579
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 1"
                     /db_xref="GeneID:57622"
                     /db_xref="HGNC:HGNC:29290"
                     /db_xref="MIM:612807"
     exon            1..71
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /inference="alignment:Splign:2.1.0"
     exon            72..104
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /inference="alignment:Splign:2.1.0"
     exon            105..159
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /inference="alignment:Splign:2.1.0"
     exon            160..1602
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2512
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /note="leucine-rich repeat and fibronectin type III
                     domain-containing protein 1; synaptic adhesion-like
                     molecule 2; CTC-246B18.8"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type III
                     domain-containing protein 1 precursor"
                     /protein_id="NP_065913.1"
                     /db_xref="CCDS:CCDS46071.1"
                     /db_xref="GeneID:57622"
                     /db_xref="HGNC:HGNC:29290"
                     /db_xref="MIM:612807"
                     /translation="MAPGPFSSALLSPPPAALPFLLLLWAGASRGQPCPGRCICQNVA
                     PTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIG
                     QVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAF
                     LSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMT
                     SNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCA
                     TPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWV
                     APDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPL
                     MAPPPAAPPPLTEPGSSDIATPGRPGANDSAAERRLVAAELTSNSVLIRWPAQRPVPG
                     IRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATR
                     VVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGD
                     SRRVKGSRSLPRVSHVCSQTNGAGTGAAQAPALPAQDHYEALREVESQAAPAVAVEAK
                     AMEAETASAEPEVVLGRSLGGSATSLCLLPSEETSGEESRAAVGPRRSRSGALEPPTS
                     APPTLALVPGGAAARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGG
                     GAAGEDGDLGLGSARACLAFTSTEWMLESTV"
     exon            1603..3579
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3305..3310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /note="hexamer: ATTAAA"
     polyA_site      3327
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /note="major polyA site"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="LRFN1"
                     /gene_synonym="SALM2"
ORIGIN      
        1 ggccctcccc ccaccatggc gcggagcgag gcagcggcgg cggggccggg cccggggccc
       61 ccccgggctg ggtgctggcc caggccctga ctccctgaag agagatgaag aaaccgagaa
      121 tcagagaggt tcagatactt gctggaggtc acacagctag tctcacctcc cacccctcct
      181 gccttcccac tgcaccatgg ctccaggacc cttctcctcg gccctcctct cgccgccgcc
      241 cgctgccctg ccctttctgc tgctgctctg ggcgggggca tctcgtggcc agccctgccc
      301 cggccgctgc atctgccaga acgtggcgcc cacactgaca atgctgtgcg ccaagaccgg
      361 cttgctcttt gtgccgcccg ccatcgaccg gcgcgtggtg gagctgcggc tcaccgacaa
      421 cttcatcgcc gccgtgcgcc gccgagactt cgccaacatg accagcctgg tgcacctcac
      481 tctctcccgg aacaccatcg gccaggtggc agctggcgcc ttcgccgacc tgcgtgccct
      541 ccgggccctg cacctggaca gcaaccgcct ggcggaggtg cgcggcgacc agctccgcgg
      601 cctgggcaac ctccgccacc tgatccttgg aaacaaccag atccgccggg tggagtcggc
      661 ggcctttgac gccttcctgt ccaccgtgga ggacctggat ctgtcctaca acaacctgga
      721 ggccctgccg tgggaggcgg tgggccagat ggtgaaccta aacaccctca cgctggacca
      781 caacctcatc gaccacatcg cggaggggac cttcgtgcag cttcacaagc tggtccgtct
      841 ggacatgacc tccaaccgcc tgcataaact cccgcccgac gggctcttcc tgaggtcgca
      901 gggcaccggg cccaagccgc ccaccccgct gaccgtcagc ttcggcggca accccctgca
      961 ctgcaactgc gagctgctct ggctgcggcg gctgacccgc gaggacgact tagagacctg
     1021 cgccacgccc gaacacctca ccgaccgcta cttctggtcc atccccgagg aggagttcct
     1081 gtgtgagccc ccgctgatca cacggcaggc ggggggccgg gccctggtgg tggaaggcca
     1141 ggcggtgagc ctgcgctgcc gagcggtggg tgaccccgag ccggtggtgc actgggtggc
     1201 acctgatggg cggctgctgg ggaactccag ccggacccgg gtccgggggg acgggacgct
     1261 ggatgtgacc atcaccacct tgagggacag tggcaccttc acttgtatcg cctccaatgc
     1321 tgctggggaa gcgacggcgc ccgtggaggt gtgcgtggta cctctgcctc tgatggcacc
     1381 cccgccggct gccccgccgc ctctcaccga gcccggctcc tctgacatcg ccacgccggg
     1441 cagaccaggt gccaacgatt ctgcggctga gcgtcggctc gtggcagccg agctcacctc
     1501 gaactccgtg ctcatccgct ggccagccca gaggcctgtg cccggaatac gcatgtacca
     1561 ggttcagtac aacagttccg ttgatgactc cctcgtctac aggatgatcc cgtccaccag
     1621 tcagaccttc ctggtgaatg acctggcggc gggccgtgcc tacgacttgt gcgtgctggc
     1681 ggtctacgac gacggggcca cagcgctgcc ggcaacgcga gtggtgggct gtgtacagtt
     1741 caccaccgct ggggatccgg cgccctgccg cccgctgagg gcccatttct tgggcggcac
     1801 catgatcatc gccatcgggg gcgtcatcgt cgcctcggtc ctcgtcttca tcgttctgct
     1861 catgatccgc tataaggtgt atggcgacgg ggacagccgc cgcgtcaagg gctccaggtc
     1921 gctcccgcgg gtcagccacg tgtgctcgca gaccaacggc gcaggcacag gcgcggcaca
     1981 ggccccggcc ctgccggccc aggaccacta cgaggcgctg cgcgaggtgg agtcccaggc
     2041 tgcccccgcc gtcgccgtcg aggccaaggc catggaggcc gagacggcat ccgcggagcc
     2101 ggaggtggtc cttggacgtt ctctgggcgg ctcggccacc tcgctgtgcc tgctgccatc
     2161 cgaggaaact tccggggagg agtctcgggc cgcggtgggc cctcgaagga gccgatccgg
     2221 cgccctggag ccaccaacct cggcgccccc tactctagct ctagttcctg ggggagccgc
     2281 ggcccggccg aggccgcagc agcgctattc gttcgacggg gactacgggg cactattcca
     2341 gagccacagt tacccgcgcc gcgcccggcg gacaaagcgc caccggtcca cgccgcacct
     2401 ggacggggct ggagggggcg cggccgggga ggatggagac ctggggctgg gctccgccag
     2461 ggcgtgcctg gctttcacca gcaccgagtg gatgctggag agtaccgtgt gagcggcggg
     2521 cgggcgccgg gacgcctggg tgccgcagac caaacgccca gccgcacgga cgctggggcg
     2581 ggactgggag aaagcgcagc gccaagacat tggaccagag tggagacgcg cccttgtccc
     2641 cgggaggggg cggggcagcc tcgggctgcg gctcgaggcc acgcccccgt gcccagggcg
     2701 gggttcgggg accggctgcc ggcctccctt cccctatgga ctcctcgacc cccctcctac
     2761 ccctcccctc gcgcgctcgc ggacctcgct ggagccggtg ccttacacag cgaagcgcgg
     2821 ggaggggcag ggccccctga cactgcagca ctgagacacg agccccctcc cccagcccgt
     2881 cacccggggc cggggcgagg ggcccatttc ttgtatctgg ctggactaga tcctattctg
     2941 tcccgcggcg gcctccaaag cctcccaccc caccccacgc acattcctgg tccggtcggg
     3001 tctggcttgg ggtccccctt tctctgtttc cctcgtttgt ctctatcccg ccctcttgtc
     3061 gtctctctgt agtgcctgtc tttccctatt tgcctctcct ttctctctgt cctgtcgtct
     3121 cttgtccctc ggccctccct ggttttgtct agtctccctg tctctcctga tttcttctct
     3181 ttactcattc tcccgggcag gtcccactgg aaggaccaga ctctcccaaa taaatcccca
     3241 cacgaacaaa atccaaaacc aaatccccct ccctaccgga gccgggaccc tccgccgcag
     3301 cagaattaaa cttttttctg tgtctgaggc cctgctgacc tgtgtgtgtg tctgtatgtg
     3361 tgtccgcgtg tagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttggggg
     3421 agggtgacct agattgcagc ataaggactc taagtgagac tgaaggaaga tgggaagatg
     3481 actaactggg gccggaggag actggcagac aggcttttat cctctgagag acttagaggt
     3541 ggggaataat cacaaaaata aaatgatcat aatagctaa
//
