LOCUS       NM_174911               5488 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LRAT domain containing 2 (LRATD2), transcript variant
            1, mRNA.
ACCESSION   NM_174911
VERSION     NM_174911.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5488)
  AUTHORS   Zhang,Y. and Yang,F.
  TITLE     FAM84B promotes breast cancer tumorigenesis through activation of
            the NF-kappaB and death receptor signaling pathways
  JOURNAL   Pathol Res Pract 249, 154785 (2023)
   PUBMED   37651838
  REMARK    GeneRIF: FAM84B promotes breast cancer tumorigenesis through
            activation of the NF-kappaB and death receptor signaling pathways.
REFERENCE   2  (bases 1 to 5488)
  AUTHORS   Ren,D., Zhuang,X., Lv,Y., Zhang,Y., Xu,J., Gao,F., Chen,D. and
            Wang,Y.
  TITLE     FAM84B promotes the proliferation of glioma cells through the cell
            cycle pathways
  JOURNAL   World J Surg Oncol 20 (1), 368 (2022)
   PUBMED   36419094
  REMARK    GeneRIF: FAM84B promotes the proliferation of glioma cells through
            the cell cycle pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5488)
  AUTHORS   Wang,M., Li,C. and Shi,W.
  TITLE     FAM84B acts as a tumor promoter in human glioma via affecting the
            Akt/GSK-3beta/beta-catenin pathway
  JOURNAL   Biofactors 47 (4), 600-611 (2021)
   PUBMED   33759248
  REMARK    GeneRIF: FAM84B acts as a tumor promoter in human glioma via
            affecting the Akt/GSK-3beta/beta-catenin pathway.
REFERENCE   4  (bases 1 to 5488)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5488)
  AUTHORS   Dong,Z., Pei,S., Zhao,Y., Guo,S. and Wang,Y.
  TITLE     Identification of Hub Genes in Gastric Cancer with High
            Heterogeneity Based on Weighted Gene Co-Expression Network
  JOURNAL   Crit Rev Eukaryot Gene Expr 30 (2), 101-109 (2020)
   PUBMED   32558489
  REMARK    GeneRIF: Identification of Hub Genes in Gastric Cancer with High
            Heterogeneity Based on Weighted Gene Co-Expression Network.
REFERENCE   6  (bases 1 to 5488)
  AUTHORS   Zanke,B.W., Greenwood,C.M., Rangrej,J., Kustra,R., Tenesa,A.,
            Farrington,S.M., Prendergast,J., Olschwang,S., Chiang,T.,
            Crowdy,E., Ferretti,V., Laflamme,P., Sundararajan,S., Roumy,S.,
            Olivier,J.F., Robidoux,F., Sladek,R., Montpetit,A., Campbell,P.,
            Bezieau,S., O'Shea,A.M., Zogopoulos,G., Cotterchio,M., Newcomb,P.,
            McLaughlin,J., Younghusband,B., Green,R., Green,J., Porteous,M.E.,
            Campbell,H., Blanche,H., Sahbatou,M., Tubacher,E.,
            Bonaiti-Pellie,C., Buecher,B., Riboli,E., Kury,S., Chanock,S.J.,
            Potter,J., Thomas,G., Gallinger,S., Hudson,T.J. and Dunlop,M.G.
  TITLE     Genome-wide association scan identifies a colorectal cancer
            susceptibility locus on chromosome 8q24
  JOURNAL   Nat Genet 39 (8), 989-994 (2007)
   PUBMED   17618283
REFERENCE   7  (bases 1 to 5488)
  AUTHORS   Gudmundsson,J., Sulem,P., Manolescu,A., Amundadottir,L.T.,
            Gudbjartsson,D., Helgason,A., Rafnar,T., Bergthorsson,J.T.,
            Agnarsson,B.A., Baker,A., Sigurdsson,A., Benediktsdottir,K.R.,
            Jakobsdottir,M., Xu,J., Blondal,T., Kostic,J., Sun,J., Ghosh,S.,
            Stacey,S.N., Mouy,M., Saemundsdottir,J., Backman,V.M.,
            Kristjansson,K., Tres,A., Partin,A.W., Albers-Akkers,M.T.,
            Godino-Ivan Marcos,J., Walsh,P.C., Swinkels,D.W., Navarrete,S.,
            Isaacs,S.D., Aben,K.K., Graif,T., Cashy,J., Ruiz-Echarri,M.,
            Wiley,K.E., Suarez,B.K., Witjes,J.A., Frigge,M., Ober,C.,
            Jonsson,E., Einarsson,G.V., Mayordomo,J.I., Kiemeney,L.A.,
            Isaacs,W.B., Catalona,W.J., Barkardottir,R.B., Gulcher,J.R.,
            Thorsteinsdottir,U., Kong,A. and Stefansson,K.
  TITLE     Genome-wide association study identifies a second prostate cancer
            susceptibility variant at 8q24
  JOURNAL   Nat Genet 39 (5), 631-637 (2007)
   PUBMED   17401366
REFERENCE   8  (bases 1 to 5488)
  AUTHORS   Yeager,M., Orr,N., Hayes,R.B., Jacobs,K.B., Kraft,P., Wacholder,S.,
            Minichiello,M.J., Fearnhead,P., Yu,K., Chatterjee,N., Wang,Z.,
            Welch,R., Staats,B.J., Calle,E.E., Feigelson,H.S., Thun,M.J.,
            Rodriguez,C., Albanes,D., Virtamo,J., Weinstein,S.,
            Schumacher,F.R., Giovannucci,E., Willett,W.C., Cancel-Tassin,G.,
            Cussenot,O., Valeri,A., Andriole,G.L., Gelmann,E.P., Tucker,M.,
            Gerhard,D.S., Fraumeni,J.F. Jr., Hoover,R., Hunter,D.J.,
            Chanock,S.J. and Thomas,G.
  TITLE     Genome-wide association study of prostate cancer identifies a
            second risk locus at 8q24
  JOURNAL   Nat Genet 39 (5), 645-649 (2007)
   PUBMED   17401363
REFERENCE   9  (bases 1 to 5488)
  AUTHORS   Huang,X.P., Rong,T.H., Wang,J.Y., Tang,Y.Q., Li,B.J., Xu,D.R.,
            Zhao,M.Q., Zhang,L.J., Fang,Y., Su,X.D. and Liang,Q.W.
  TITLE     Negative implication of C-MYC as an amplification target in
            esophageal cancer
  JOURNAL   Cancer Genet Cytogenet 165 (1), 20-24 (2006)
   PUBMED   16490593
REFERENCE   10 (bases 1 to 5488)
  AUTHORS   Adam,P.J., Boyd,R., Tyson,K.L., Fletcher,G.C., Stamps,A.,
            Hudson,L., Poyser,H.R., Redpath,N., Griffiths,M., Steers,G.,
            Harris,A.L., Patel,S., Berry,J., Loader,J.A., Townsend,R.R.,
            Daviet,L., Legrain,P., Parekh,R. and Terrett,J.A.
  TITLE     Comprehensive proteomic analysis of breast cancer cell membranes
            reveals unique proteins with potential roles in clinical cancer
  JOURNAL   J Biol Chem 278 (8), 6482-6489 (2003)
   PUBMED   12477722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084116.7 and AK074285.1.
            
            On Nov 23, 2018 this sequence version replaced NM_174911.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052957.1, SRR1660809.30055.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304916.4/ ENSP00000302578.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC084116.7         180699-181143       c
            446-5463            AC084116.7         175133-180150       c
            5464-5488           AK074285.1         2772-2796
FEATURES             Location/Qualifiers
     source          1..5488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.21"
     gene            1..5488
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
                     /note="LRAT domain containing 2"
                     /db_xref="GeneID:157638"
                     /db_xref="HGNC:HGNC:24166"
                     /db_xref="MIM:609483"
     exon            1..445
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..5488
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1474
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
                     /note="neurological/sensory 2; breast cancer
                     membrane-associated protein 101; breast cancer membrane
                     protein 101; protein FAM84B; family with sequence
                     similarity 84 member B"
                     /codon_start=1
                     /product="protein LRATD2"
                     /protein_id="NP_777571.1"
                     /db_xref="CCDS:CCDS6358.1"
                     /db_xref="GeneID:157638"
                     /db_xref="HGNC:HGNC:24166"
                     /db_xref="MIM:609483"
                     /translation="MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDED
                     VEPQPPPQGPDGGGLPDGGDGPPPPQPQPYDPRLHEVECSVFYRDECIYQKSFAPGSA
                     ALSTYTPENLLNKCKPGDLVEFVSQAQYPHWAVYVGNFQVVHLHRLEVINSFLTDASQ
                     GRRGRVVNDLYRYKPLSSSAVVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIG
                     GELRIGKQPYRLQIQLSAQRSHTLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPA
                     EPEEGDSNVARTTPPPGRPPAPSSEEEDGEAVAH"
     regulatory      5365..5370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
                     /note="hexamer: AATAAA"
     polyA_site      5390
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
                     /note="major polyA site"
     regulatory      5466..5471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
                     /note="hexamer: AATAAA"
     polyA_site      5488
                     /gene="LRATD2"
                     /gene_synonym="BCMP101; FAM84B; NSE2"
ORIGIN      
        1 gcctgtctct ttaaatgcca cgggctgcgc tcccgcccgg gagcccggag ccggatctac
       61 aatcccgtcc ctccagctcc ggtgcttgtt gctcgcccgg cccaagcggg agctgttgcc
      121 gccaggctgc gaggctgccg tcctctcctc ctcgcgcccc acctcccccg agagctggct
      181 gaggaggggc agcagcccca gctggcggga ggaagcgcgg tgtgaacagg gattgccccc
      241 cgccttcaag tatcggggcg ctacgcagcc gcgggggaaa gacatgcccc tagtctgccc
      301 gctgcgctgc cctctgccca gcctcgctgc cgcccgcgcc gggagaggag ggactgccga
      361 gcctacacct tcaaactcgc cctagaagtc tcggggcgcg gcagggagcc cttccccagg
      421 ccccacggcc ttcacctctc cgcgggtagc ctcagcccct gtccggggac ctgtgcaaat
      481 gaccctggag ttggtttcgc tttctcccct tgcggcggtg tgaacgtgtg tccgcagcgt
      541 gatgggcaac caggtggaga aattgaccca cctaagttac aaggaagttc ccacggccga
      601 cccgactggc gtggaccggg acgacgggcc ccgcattggg gtctcctaca ttttctccaa
      661 tgacgatgag gacgtggagc cgcagccgcc gcctcagggg ccagatggcg gcggcttgcc
      721 cgacggtggg gacgggccgc cgccgcccca gccgcagccc tacgatccgc ggctgcacga
      781 ggtggaatgc tccgtgttct accgggacga atgcatctac cagaagagct tcgcgccggg
      841 ctcggcggcg ctgagtacct acacgcccga gaacctgctc aacaagtgca agccgggcga
      901 tctggtggag ttcgtgtcgc aggctcagta cccgcactgg gccgtatatg tgggtaactt
      961 ccaggtggtg cacctgcacc ggctggaggt gattaacagc ttcctgactg acgccagcca
     1021 gggccgtcgc ggccgcgtgg tcaacgatct gtaccgctac aagccgctaa gctccagcgc
     1081 cgtggtgcgc aacgcgctgg cgcacgtggg tgccaaggag cgcgagctga gctggcgcaa
     1141 ctcggagagt ttcgccgcct ggtgccgcta cggcaagcgc gagttcaaga tcggcggcga
     1201 gctgcgcatc ggcaagcagc cctaccggct gcagattcag ctgtcggcgc agcgcagcca
     1261 cacgctcgag ttccagagtc tagaggacct gatcatggag aagcgacgca acgaccagat
     1321 cgggcgcgcg gccgtgctgc aggagctcgc cacgcacctg cacccggcgg agccggagga
     1381 gggcgacagc aacgtggcgc ggactacgcc gcctcccggg cgcccccctg cgcccagctc
     1441 cgaggaggag gacggagagg cagtggcaca ctgatgggcg agctgagcgc agagctgcga
     1501 aggggaactg tttgcagtag cagccgctgc tccctttctc cctctcttcc tccctctttt
     1561 gccactgtct gggccccatc tgggattcct gggccctttg gaaaagagtt ggtgaaatgc
     1621 gcagccggct gtggacgggg gaggaggaag gggacagagg gagcaggtag gaaacacttt
     1681 agttgggggt ggggggcgtc tccctctggc cccctgtctg tcttcctctc cgcggtggag
     1741 caaactgtgg acttgcctgg cacttaaacc ttggtagatc tgggtttata atcggccatt
     1801 cttaagcacg tggggttggg ggaaagttcg gagtacccat tcctgccgtt gcttcctatc
     1861 ctgggcttgg aagaatcctg gtagaaaggc cagagtgggt ttgtggagtc gccactgcgg
     1921 gaccagcacg aaagctgctt gtctgctttg gcggagctga gctgtgtatg ggatccagga
     1981 ggctggggtg atttatttta tgggattcct ggagcgcagg gctggtgaat ccatgacaag
     2041 gtccgggagc agcagaccaa aaccacagca gcctcctatt aagtgtaaca aatagttaag
     2101 caaactcggg ctacaaacaa agactttgct acctccctcc tccacaaccc ccaagtaatt
     2161 agccttctgg agctggctct tagctgaggc tcctgctacc tcctgctcca cccgcccctt
     2221 cctaggttac aagtaaatca ttgtcaaggg ccagccaggg gaaggtttca attaaggttc
     2281 tgttctgctg cctttgtttc tcccctgctg ttgtaggcac ttacagctgc gttgttatga
     2341 aaggagggaa tagccctttg tgtctttgat ctaattaaac ctgcttggct gtgtttatcc
     2401 gcagggcagg tcacagatag ggttggctgt gccactccat aaagtatcta ttgtggaagc
     2461 agccaaaaag ggctgctgtg gcaggaattg gttaatttct ccttccactt cccttcctga
     2521 atagtgaagg gagccctttt aaaacaaggc tttggtggta atcctgtgat ttttttttct
     2581 cccccatccc ctcactggcc catccctctc accctcactt ttgttctgct ggtgggtaaa
     2641 atcttaggct gaacacatat ttcaatggta agatacttat tttgctatcc acacttgatg
     2701 caattgaatt caaggtgcaa agtcttgtac tgaagcagtc tccttgttgc ttggagaaca
     2761 cctccttcag agccctttgt taaataagag gggcgacgtt gatcatagat gccacctggt
     2821 tagcaccgaa tctgactttg gtgacagtcc taaagcacag ttggtgattg tgagatctgt
     2881 tagcggcagg ctgagcagat actacttggt tttgcttggt atgagatact actgtttgct
     2941 tagtatgaga ttttttccag cctgtctctt aaactcctgt gacatcttca atgatatgtg
     3001 ccctcagttg cagcatagct tctctgctgc ctattgccat tgctgtctca aaagttgagt
     3061 gaattttgag gcgtcttttt ttttttttcc tctcttggga gtcgttgtaa actactgtgt
     3121 acaagtcatt ttgtgatatg attctgaaca gttggaatag aatcatagtt aagtggtaca
     3181 gccatggcta tcgtcaggcc tgttgcctgg agatctctaa gttaaggcaa caagacttaa
     3241 agaattttct aatacacttg tttcacacat ggacgttgag gccatagtct ttaaaagctt
     3301 ggacctttgt agcacctcaa catgaaaggg cattagctat gtttcctgtt tttacagtga
     3361 tcaccaaaca gatcttgcca ctttgattgt taaaaatgaa ccacattcta gccctggtct
     3421 gggactttgg agggagatga atttcttgtt ggaaatgtaa atctagtgtc catatttaat
     3481 actctcacag ctttgtgttt attctctttg ctcatggaat agcagaacaa gataaacatg
     3541 ggttaagaca tttaggagaa cctgctgtat ctaacccagt tggattttct ttcatgctta
     3601 acacagtagt gaaaatagaa ggtaggccgg gcacagtggc tcatgcctgt aatcccagca
     3661 ctttgggagg ctgaggcagg tagatcacct gaagttagga gttcgagacc agcctggcca
     3721 acatggcgaa accctgtctc taccacaaat acagaaaatt agctgggcgt ggtggcaggc
     3781 gcctgtaatg cctgctactt gggagcctga ggcagaagaa ttgcttgaag ctgggaagca
     3841 gaggttgcag tgagccgaga tcgcaccact gcactccagc ctgggcagca gagcaagtag
     3901 taataaccac cgtgtagaca agtgggaggg aagaatagaa tggcactgtc cagctctggg
     3961 ctagccagat caactccccc acccgtcttc ttcctctgtc ccagaatgga aaatgatgta
     4021 tggtcagtca cgctgaagta tagcagcgac tgtgttaaga gagagcagtg actctctctt
     4081 ctagagaaga ggttttcaat aacagggctt ggaaatgaac tagaatagga aatagatctt
     4141 ttcagatgct gctttcccat gtaatacaag cgtttctaca gggtaccaga ggtgtgaaat
     4201 atgtgacact taagaacagt gatttttatt gggaattttc ttagggttat tacacttaaa
     4261 gcaacaacca actagtaaca gctccaggaa aggggaatga atcaactctt ggttctttcc
     4321 tgaagacggc agtgttgtgg ataagtgagt ttttaatgcc ctggcagtgg ctacatttga
     4381 cactttagaa aaaataaaca tatttaataa tttttgtttc tccttaggaa taagactgta
     4441 gaactgtttt gtactgtgaa ttacggatgc tctttgaagg aaagaaatat cgattctaat
     4501 gttcttcaga agttctggca gggataagca ggacatcgac tggaacgtat gctaaatgaa
     4561 agcagacaaa tttctatttt cttacctgag caaatatttt attgaaactg cttatgtatg
     4621 tcaaaggagc ccacaacttc agctacacaa ctttttgtat tgaaagaact catacttttt
     4681 gtagctttta tttcacattt aatttaaagt gacttttagc actaaaatgc ctagaagatt
     4741 ttactccaga cctataagga aatgtttagt ttttatgaaa aatgacaagt cgatggttaa
     4801 acttctcatg tctttggtgc tttggcccta atagcactgg acaacaccac gaccacatgg
     4861 aaacatattt ttggaagcaa aactttaatt ttatataacg tatgctatgg agagctaaga
     4921 caatttaagg actacttgtt ttctattttt tttcttaata aaatggaatc cactgtgttg
     4981 aagactcttg atatcatgtg cttgtctaac cattttttgt tttataaatt agaataaaat
     5041 atagttgtga taatggtcat cgaatggatt tgtttggaaa gctacatctt atttgtgaaa
     5101 tgttttttaa atcagagtaa ctatcaactg attcagcttt ttgttgtttt gttcttggct
     5161 ataatacttg tgactcatga agaattatgt tgacaaacag gataaattcc acatgcattt
     5221 tatttcccag tgagttgtat aaactttatt tttgttgaag gttgtatgtt aaatcaatgt
     5281 tacattctta tatcacttct tgagaaggaa gttccgattt gaaattgtat catttccttc
     5341 aaaatgaagg gcagtgctta gttaaataaa agattgatga tatcttttaa gccatttcct
     5401 cttcactatg tcttattaaa ataaaacctg tcaagttctt ttcaaaagat gctatgagcg
     5461 tttccaataa accatctatt agagttca
//
