LOCUS       NM_145175               6319 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens LRAT domain containing 1 (LRATD1), transcript variant
            1, mRNA.
ACCESSION   NM_145175
VERSION     NM_145175.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6319)
  AUTHORS   Ding,Y., Wu,L., Zhuang,X., Cai,J., Tong,H., Si,Y., Zhang,H.,
            Wang,X. and Shen,M.
  TITLE     The direct miR-874-3p-target FAM84A promotes tumor development in
            papillary thyroid cancer
  JOURNAL   Mol Oncol 15 (5), 1597-1614 (2021)
   PUBMED   33751775
  REMARK    GeneRIF: The direct miR-874-3p-target FAM84A promotes tumor
            development in papillary thyroid cancer.
REFERENCE   2  (bases 1 to 6319)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6319)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6319)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   5  (bases 1 to 6319)
  AUTHORS   Kobayashi,T., Masaki,T., Sugiyama,M., Atomi,Y., Furukawa,Y. and
            Nakamura,Y.
  TITLE     A gene encoding a family with sequence similarity 84, member A
            (FAM84A) enhanced migration of human colon cancer cells
  JOURNAL   Int J Oncol 29 (2), 341-347 (2006)
   PUBMED   16820875
  REMARK    GeneRIF: up-regulation of FAM84A may play a critical role in
            progression of colon cancer
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY017941.1, AJ417080.1, AC011897.10 and BX113099.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145175.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314463.1, SRR3476690.661105.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295092.3/ ENSP00000295092.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               HY017941.1         38-447
            411-472             AJ417080.1         396-457
            473-473             AC011897.10        42965-42965
            474-2601            AJ417080.1         459-2586
            2602-6009           AC011897.10        45094-48501
            6010-6191           BX113099.1         11-192
            6192-6285           AC011897.10        48684-48777
            6286-6319           BX113099.1         287-320
FEATURES             Location/Qualifiers
     source          1..6319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.3"
     gene            1..6319
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /note="LRAT domain containing 1"
                     /db_xref="GeneID:151354"
                     /db_xref="HGNC:HGNC:20743"
                     /db_xref="MIM:611234"
     exon            1..221
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /inference="alignment:Splign:2.1.0"
     exon            222..6319
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1136
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /note="neurological/sensory 1; neurologic sensory protein
                     1; protein FAM84A; family with sequence similarity 84
                     member A"
                     /codon_start=1
                     /product="protein LRATD1"
                     /protein_id="NP_660158.2"
                     /db_xref="CCDS:CCDS1684.1"
                     /db_xref="GeneID:151354"
                     /db_xref="HGNC:HGNC:20743"
                     /db_xref="MIM:611234"
                     /translation="MGNQLDRITHLNYSELPTGDPSGIEKDELRVGVAYFFSDDEEDL
                     DERGQPDKFGVKAPPGCTPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVSGG
                     PQGADLSVYAVTALPALCEPGDLLELLWLQPAPEPPAPAPHWAVYVGGGQIIHLHQGE
                     IRQDSLYEAGAANVGRVVNSWYRYRPLVAELVVQNACGHLGLKSEEICWTNSESFAAW
                     CRFGKREFKAGGEVPAGTQPPQQQYYLKVHLGENKVHTARFHSLEDLIREKRRIDASG
                     RLRVLQELADLVDDKE"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /note="hexamer: ATTAAA"
     polyA_site      3499
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /note="major polyA site"
     regulatory      4846..4851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /note="hexamer: ACTAAA"
     polyA_site      4866
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
     regulatory      5524..5529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /note="hexamer: AAGAAA"
     polyA_site      5546
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
     regulatory      6297..6302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
                     /note="hexamer: AATAAA"
     polyA_site      6319
                     /gene="LRATD1"
                     /gene_synonym="FAM84A; NSE1; PP11517"
ORIGIN      
        1 aaagcagagc cgagccggga ctgtccagtg ggagcaggcg ccccggccag cgcagacctg
       61 gaggcgcacg ggcgccgcac cgcacgattc ggctcggggt agagcggagc cgcagcccca
      121 cgcgcagccc aggacccact cgccaccgcc gcttcctcag cacccatggg gaccaggaga
      181 ctttaaagga gtttggggtt tcgggagcag ggaaatcacg gatccccgct cctggccctc
      241 gcctcgccac ctcattgatg ggcaaccaac tggaccgcat cacccacctc aactacagcg
      301 agttgcccac aggggacccg tcggggattg aaaaggacga actgcgggtc ggggttgcct
      361 acttcttctc ggatgatgag gaagacctgg acgaacgcgg gcagcccgac aagtttggcg
      421 tgaaggcccc cccgggttgc accccctgcc cggagagccc cagccgccac caccaccacc
      481 tgctgcacca gctggtcctc aacgagactc agttttccgc ctttcggggc caggaatgca
      541 tcttttccaa agtgagcggt ggccctcagg gcgccgacct aagcgtctac gcggtcaccg
      601 cgctgccagc gctctgcgaa cccggcgacc tgctggagct gctgtggctg cagcccgcgc
      661 cggagccgcc cgcgcccgcc ccgcactggg ccgtctacgt gggcggcggg cagatcatcc
      721 acctgcacca aggcgagatc cgccaggaca gcctgtatga ggcgggcgcg gccaacgtgg
      781 gccgggtggt gaatagctgg taccgctacc gcccgctggt ggccgagctg gtggtgcaga
      841 acgcctgcgg ccacctgggc ctcaagagcg aggagatctg ctggacgaac tcggagagct
      901 tcgccgcctg gtgccgcttt ggcaagcggg agttcaaggc gggaggggag gtgccggcag
      961 gcacgcagcc cccgcagcag cagtactatc tcaaggtgca cctgggagag aacaaggtcc
     1021 acaccgccag gtttcacagc ctggaagacc tcatccgcga gaagcgccgt atcgacgcca
     1081 gcggccgcct gcgagtgctc caggagctcg ccgacctcgt ggacgacaag gagtagccgc
     1141 ctaggggctg ccggcccctc tgcctccccc gcacctcgct cccttccctt ccccgcaccc
     1201 ggacttcgca gtcagcggtt ctcaacctct gccccgcccc gccacgcgcg tccgccgccg
     1261 gtggcccggg cccgggctgc acccccgcat ccccaagcca gcggcaggaa gtctcaggaa
     1321 ctgccccagg gccgaaaggg cgccgctgcg agcgcctggc tgacagccac agcggtggtg
     1381 acggtgctgg gagaccccgc gtgcgctttc cccttgagat gtaaaccggg aacggggaag
     1441 gggctgaggg gagaaaggac atggccttcc ccgcgagtcc atggccagtg actgtggccc
     1501 gactcgaaaa caaccctctt ctcaaaaggg accatcaccg ccccgagcgt gcgcacacag
     1561 accggtcgga ggcgagaact ggtctctaca gggcacagtt cagctcctct gtggatgcgt
     1621 ccccagatcg caggatttcc aagaaatcga gcctgtccct tgtgcacttg ggaataattc
     1681 cccaagacag cacttcggga ttccgggtta tcctgaggct gcccgggact tttccagctc
     1741 tccagcccca ggtctcctga cattgtgttc caggctgcgg gctaagccag acagtgtttg
     1801 cctccggttc tttccaccgt gggaagcgaa cgccaccccc acccgccttt gcctgcgagt
     1861 ctccctcgct ggcagaaggg aagccggccc ggtcccggga ggaagatggc gctgcgaatt
     1921 cggtgaggac agccggcccc gcccccgaca aggagctcgc tcgttcacct ggtgtctggg
     1981 aacttgaatg tgtgaagggc gcttattgtt ctgaaccctt gattgctccc tcctcgggct
     2041 gcatttcaaa aatagtcata tttttaaagg agttggagga gagggagggg gaggacatgg
     2101 caccattcca gaaaccagca ttgttacaac accatagcca gtatatttag tttggctttt
     2161 cctaacatag aaatcttcaa agctggggaa gtggaaataa agttttaaaa atgagagagc
     2221 agttttccaa ctatgtcaac aaagcctatc gtgttgatgt ttttattgac cattttagca
     2281 acaggctaat aaaatttcaa attgaaattt ttattttcat ggctttaatc catgatagtt
     2341 taaatactgg gggccattaa gagtggatgt agctaagagc ttagctaaca ttgccttttc
     2401 actctatttt tctcagatat tgtaagcatt ctgtttttca atattgtagt taattttttg
     2461 gctttcaaca gcagccctag taatggtgga gttgttaatt aatgtgtata ttgtactgaa
     2521 tttctgtcag ttaaggggtt cactgctttg gtggaaattg gtggaaattg ctagcaggtt
     2581 ccacgatgtt tatttttttc tccatgttgt atatcattac catttcacat acgcgtttct
     2641 atttttcttc ctctcctcct gatctcctta aaaatgaatc tagagttggt ggctttttcc
     2701 ccctcctctt tggccagttc cacagttcag ttcttcctga aaacagggat gatgaacttg
     2761 taggatcagg acaaatgtgt gtttttcaaa aacttaaggc tgggtgtgaa acaccttctg
     2821 tggacaagga tttgtaaact tctctcctcc ctccagctgc ggccccagcc taactgatag
     2881 ttacttgatt cagtgtgcta gacacttaaa tagcatctat gtctctttca agggaatttg
     2941 tcaaataatg ctgtttagct aattgttgca agcaattgca tattaacagc tgtgattttg
     3001 ttggacagca agtattatgg ccaaagccag tttcttggca tttcaaaaat aatgcaataa
     3061 aaactagttg aggttagctg aggctggaaa tgcctttttc atggtaaatg attcacttct
     3121 atatttttct ttctttttct ttttttttct ttggttttca tcctggattc atcccctgat
     3181 cttaaatcaa aacgtcagat caatgaacta tgaactaaag tatttttctt aagcctattg
     3241 agtgatttat tttttaaaaa atgtttaaat gcatatgctt ttctttcagc acaaacaaca
     3301 gcaaaaactt ttgtaataac taacttacct ttgcatgtat gaagaactga gtcatttatt
     3361 tccctaactt actcctcttt caagtaacag gtggcagatc ataaaatgaa ttctttattg
     3421 tatctacaca ctccacattc tttactgtgt cctactactg tatcttggct ccctgctgta
     3481 ttaaacacca tcttaagcac ttgttcctgc aggactcctt cttgacattt tgtctccccc
     3541 ttcaaagtca ctcaaagagt gggacttcat caaaagaaat gaattagtct ctatcacacc
     3601 gaatactaag atttatttcc tctgatggta catagatttc tctctcacta agagggtcac
     3661 tctcatagag gaatgtcttg tcagttttat acttgctgag gctagactga caataaaaat
     3721 gagctgggca gttaaattag catttgttac tatattggcc tataaaggat caggttgatg
     3781 ataatacctc taaaaatatg caataataaa acaatagtta tgaaagaaac ttgaaaggtt
     3841 tgcaaggttt ctcctatccc tgttaaaatt atcatttatt atctctttgt cagtgttagt
     3901 aaggtaaccc atgacagaat aatttgagtg atagttcatc atgcagagga tatgatcaag
     3961 atattaccta atggttttat cctgaaaaag gtgtatactt ttagggcact gttaacaatg
     4021 cgagtgaaac caagatggtg caagttccct ttgcagatgg cgtgggcaca cttgattttt
     4081 attatgagtg aatgtaatct ttctgtattt taccagagtt acagcaatta cctgaaaagt
     4141 ttcctaacat tttaataatg ttagggattt cgttttggtt ttagttgtcc tcaagagaca
     4201 acaggttcac agtaatttcc atgatgttgg gtgtggctaa gctggggatt ggttctgttc
     4261 cccctgctcc cgtgtagaga aaagctatat ttatactgca ttctttctca actttcaggt
     4321 aaaacaaact atgatttaaa aaaagaaaaa agaaaagaca ggtactttta cttcaaagag
     4381 tgctttgcta catttttatt taaaccaaaa atcaaataaa ataaggaggg gggctgggta
     4441 tactttaaac aaaaccagtc ctgaaatgct gttattctca aagtacattc caaaaaaaaa
     4501 aaaaaaaaaa aactatagaa tttacgtatg ttacattttt aagtatgagt taaattgata
     4561 taaagtgttc ctcaatattt aataatgtaa gctgttgtca tgacagtatt ttttaaaaat
     4621 aataacgtat attatagtta cgaaacactt gtgccagatt agaacatcaa gcacagaagc
     4681 agctgtatga tttacctgtt tttttgaaac tttaatgttt accttcccct atgtttaatt
     4741 tttctgtggt gaacactttt gttagaacat ggctttttta tttttcttgg aaaaatatgc
     4801 tattagtatt tacaaaataa ttaattacct gaataagcag tatatactaa aagtcttcaa
     4861 acattacttt attgattact tatgttttgt ggtgcgcttt caacatccct aagagttaaa
     4921 tgtcttagtc atctaataca tggaacaggg tcaaacttca atgaaattaa tacttattgc
     4981 acaatcataa tatagcaacc taattttctt ttatttatag gcatatcttt aaagctttct
     5041 tctctttttt gaacaaatga agagaatcca gttagttttt gcctttcaga ggtgatttgc
     5101 cacgtgcaca aagggtctgt aggtgaaaag acaggctttt gggtttcttg aaacatcaaa
     5161 aactgaattt agagaatggt tatctaacac tcaagtcaat gttttttttg aaattactag
     5221 ctattggtat aatatacata tatgtacatg tatacatata catacacaca tatgtacatt
     5281 tacacatatg taagtataca ctcatataca tatatacaca tgtatatata cttgtgtaca
     5341 catacatttt tgcctatagc tagcaattat ttcattcaga tacacacaca cacacacaca
     5401 cacacaggct acttaaaata gagagtgact tgagatatac aaaaacagga agaaaagccc
     5461 tggaggtcat atagctaatg tataactgca cagcaagcag ctatgtctaa agctaacaat
     5521 aaaaagaaaa tgtgggagtt gtgcaattag ttttattctc attttttgga agaatatgtt
     5581 cctggtttct ctaactaaaa ggaaaaaatt caaaggaaag ttgtaaatat taggaagtaa
     5641 ctgaaaaata agaagcaaga taaagtgggg aggctatgag atcatataat gagctaataa
     5701 acttttcaac aggggacacc tgttctccct tctaactgaa gacactaaag agaagctaag
     5761 atcctatctt tcaatcattt agtaattcat aaaatcccat tatttcataa ctcaaagttt
     5821 acctttgagg ttgtatgttt acctcatttg aactcgaaat agaagaggtt taagtatttg
     5881 aataagttgg gaaaaaaagg aaaaatagtc ttccctgccc ttgtcactga tggtgacact
     5941 acttgtaatt actgtatttt ttggcagaac actcagatga acagattcct atgctgtgga
     6001 cttttatcat tctttttgat ggctgatagt agaaagcaca cagtaggtac tccataaatg
     6061 taagactatg gcagctgtct agtacaagtg cttctcactg attcttggtt accaggaaaa
     6121 ccagaaagcc cgtcacttgc cttgcctgca aaggcgagcc taaagaaatt tctctaacca
     6181 aaattggcag gttctttcca ccacaaaagg ctcttggaaa tataacttat ggggcttaag
     6241 gctaatttga gttgaagggt atttgtaata tttgatttgc ttttagcaga gaaaacaata
     6301 aaagaatcca ggaaaagta
//
