LOCUS       NM_001387681            4496 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LIM domain containing preferred translocation partner
            in lipoma (LPP), transcript variant 34, mRNA.
ACCESSION   NM_001387681
VERSION     NM_001387681.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4496)
  AUTHORS   Zulfiqar,S., Fiaz,A., Khan,W.A., Hussain,M., Ali,A., Ahmed,N.,
            Ali,B. and Masood,M.A.
  TITLE     Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease
            in Subjects from Punjab, Pakistan
  JOURNAL   Genes (Basel) 15 (7), 852 (2024)
   PUBMED   39062631
  REMARK    GeneRIF: Association of LPP and ZMIZ1 Gene Polymorphism with Celiac
            Disease in Subjects from Punjab, Pakistan.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4496)
  AUTHORS   Howarth,S., Sneddon,G., Allinson,K.R., Razvi,S., Mitchell,A.L. and
            Pearce,S.H.S.
  TITLE     Replication of association at the LPP and UBASH3A loci in a UK
            autoimmune Addison's disease cohort
  JOURNAL   Eur J Endocrinol 188 (1) (2023)
   PUBMED   36651163
  REMARK    GeneRIF: Replication of association at the LPP and UBASH3A loci in
            a UK autoimmune Addison's disease cohort.
REFERENCE   3  (bases 1 to 4496)
  AUTHORS   Wang,H., Han,H., Niu,Y., Li,X., Du,X. and Wang,Q.
  TITLE     LPP polymorphisms are risk factors for allergic rhinitis in the
            Chinese Han population
  JOURNAL   Cytokine 159, 156027 (2022)
   PUBMED   36084606
  REMARK    GeneRIF: LPP polymorphisms are risk factors for allergic rhinitis
            in the Chinese Han population.
REFERENCE   4  (bases 1 to 4496)
  AUTHORS   Zhang,Y., Ma,L., Liu,J., Zhu,H., Lu,L., Deng,K., Ma,W., Pan,H.,
            Wang,R. and Yao,Y.
  TITLE     Case Report: Identification of Potential Prognosis-Related TP53
            Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by Next
            Generation Sequencing: Two Cases
  JOURNAL   Front Endocrinol (Lausanne) 12, 673908 (2021)
   PUBMED   34381423
  REMARK    GeneRIF: Case Report: Identification of Potential Prognosis-Related
            TP53 Mutation and BCL6-LPP Fusion in Primary Pituitary Lymphoma by
            Next Generation Sequencing: Two Cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4496)
  AUTHORS   Grunewald,T.G., Pasedag,S.M. and Butt,E.
  TITLE     Cell Adhesion and Transcriptional Activity - Defining the Role of
            the Novel Protooncogene LPP
  JOURNAL   Transl Oncol 2 (3), 107-116 (2009)
   PUBMED   19701494
  REMARK    GeneRIF: LPP is a nucleocytoplasmatic shuttle protein linking focal
            adhesion dynamics to the transcriptional machinery.
REFERENCE   6  (bases 1 to 4496)
  AUTHORS   Rogalla,P., Lemke,I., Kazmierczak,B. and Bullerdiek,J.
  TITLE     An identical HMGIC-LPP fusion transcript is consistently expressed
            in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
  JOURNAL   Genes Chromosomes Cancer 29 (4), 363-366 (2000)
   PUBMED   11066083
REFERENCE   7  (bases 1 to 4496)
  AUTHORS   Petit,M.M., Fradelizi,J., Golsteyn,R.M., Ayoubi,T.A., Menichi,B.,
            Louvard,D., Van de Ven,W.J. and Friederich,E.
  TITLE     LPP, an actin cytoskeleton protein related to zyxin, harbors a
            nuclear export signal and transcriptional activation capacity
  JOURNAL   Mol Biol Cell 11 (1), 117-129 (2000)
   PUBMED   10637295
REFERENCE   8  (bases 1 to 4496)
  AUTHORS   Petit,M.M., Swarts,S., Bridge,J.A. and Van de Ven,W.J.
  TITLE     Expression of reciprocal fusion transcripts of the HMGIC and LPP
            genes in parosteal lipoma
  JOURNAL   Cancer Genet Cytogenet 106 (1), 18-23 (1998)
   PUBMED   9772904
REFERENCE   9  (bases 1 to 4496)
  AUTHORS   Petit,M.M., Mols,R., Schoenmakers,E.F., Mandahl,N. and Van de
            Ven,W.J.
  TITLE     LPP, the preferred fusion partner gene of HMGIC in lipomas, is a
            novel member of the LIM protein gene family
  JOURNAL   Genomics 36 (1), 118-129 (1996)
   PUBMED   8812423
REFERENCE   10 (bases 1 to 4496)
  AUTHORS   Schoenmakers,E.F., Wanschura,S., Mols,R., Bullerdiek,J., Van den
            Berghe,H. and Van de Ven,W.J.
  TITLE     Recurrent rearrangements in the high mobility group protein gene,
            HMGI-C, in benign mesenchymal tumours
  JOURNAL   Nat Genet 10 (4), 436-444 (1995)
   PUBMED   7670494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022498.18, AC117507.5,
            AC069226.19 and AC063932.14.
            
            Summary: This gene encodes a member of a subfamily of LIM domain
            proteins that are characterized by an N-terminal proline-rich
            region and three C-terminal LIM domains. The encoded protein
            localizes to the cell periphery in focal adhesions and may be
            involved in cell-cell adhesion and cell motility. This protein also
            shuttles through the nucleus and may function as a transcriptional
            co-activator. This gene is located at the junction of certain
            disease-related chromosomal translocations, which result in the
            expression of chimeric proteins that may promote tumor growth.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR18074967.1424662.1, SRR14038195.55682.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142348, SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC022498.18        60685-60780
            97-219              AC117507.5         11500-11622
            220-276             AC117507.5         127758-127814
            277-478             AC069226.19        127073-127274       c
            479-591             AC069226.19        48682-48794         c
            592-714             AC069226.19        8599-8721           c
            715-4496            AC063932.14        105335-109116       c
FEATURES             Location/Qualifiers
     source          1..4496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3-q28"
     gene            1..4496
                     /gene="LPP"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
     exon            1..96
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            97..219
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            220..276
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            277..478
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1419
                     /gene="LPP"
                     /note="isoform d is encoded by transcript variant 34; LIM
                     protein; lipoma preferred partner"
                     /codon_start=1
                     /product="lipoma-preferred partner isoform d"
                     /protein_id="NP_001374610.1"
                     /db_xref="GeneID:4026"
                     /db_xref="HGNC:HGNC:6679"
                     /db_xref="MIM:600700"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     FAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQ
                     GNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTG
                     HKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSR
                     PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI
                     PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTP
                     PGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKVRNSVT"
     exon            479..591
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..714
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     exon            715..4496
                     /gene="LPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LPP"
                     /note="hexamer: AATGAA"
     polyA_site      4496
                     /gene="LPP"
                     /note="major polyA site"
ORIGIN      
        1 acctcctcct ctgcctctgc ctccgcctcc agccgccgcc gccgccgccg ccgccgccac
       61 caccaccgcc gctgccccgg ctgcctcctc cctgaggtgg gaactttgag gctcagagac
      121 agagcagaag acagaacctg gtcttctgat tccctgtgtt ctgctttttt cattgttcca
      181 ctggacgctc atcagaggga agatcttttt cctcaattgc attgcagttg gctgaacctt
      241 gtgtcaacca tccattccag gagccagcta tctgagattc caacaatgtc tcacccatct
      301 tggctgccac ccaaaagcac tggtgagccc ctcggccatg tgcctgcacg gatggagacc
      361 acccattcct ttgggaaccc cagcatttca gtgtctacac aacagccacc caaaaagttt
      421 gccccggtag ttgctccaaa acctaagtac aacccataca aacaacctgg aggtgagggt
      481 gattttcttc cacccccacc tccacctcta gatgattcca gtgcccttcc atctatctct
      541 ggaaactttc ctcctccacc acctcttgat gaagaggctt tcaaagtaca ggggaatccc
      601 ggaggcaaga cacttgagga gaggcgctcc agcctggacg ctgagattga ctccttgacc
      661 agcatcttgg ctgaccttga gtgcagctcc ccctataagc ctcggcctcc acagagctcc
      721 actggttcaa cagcctctcc tccagtttcg accccagtca caggacacaa gagaatggtc
      781 atcccgaacc aaccccctct aacagcaacc aagaagtcta cattgaaacc acagcctgca
      841 ccccaggctg gacccatccc tgtggctcca atcggaacac tcaaacccca gcctcagcca
      901 gtcccagcct cctacaccac ggcctccact tcttcaaggc ctacctttaa tgtgcaggtg
      961 aagtcagccc agcccagccc tcattatatg gctgcccctt catcaggaca aatttatggc
     1021 tcagggcccc agggctataa cactcagcca gttcctgtct ctgggcagtg tccacctcct
     1081 tcaacacggg gaggcatgga ttatgcctac attccaccac caggacttca gccggagcct
     1141 gggtatgggt atgcccccaa ccagggacgc tattatgaag gctactatgc agcagggcca
     1201 ggctatgggg gcagaaatga ctctgaccct acctatggtc aacaaggtca cccaaatacc
     1261 tggaaacggg aaccagggta cactcctcct ggagcaggga accagaaccc tcctgggatg
     1321 tatccagtca ctggtcccaa gaagacctat atcacagatc ctgtttcagc cccctgtgcg
     1381 ccaccattgc agccaaaggt aagaaactca gtaacataag gaggagaata caggggtgcc
     1441 tatcttagtc tgccttcccc aggaagcgaa gcctaaggca aaagtgtgtg tgttactttt
     1501 atttcactga caaatacaat cccagggaag gatgagtgaa gccagagagg agagagagac
     1561 tacttagtat gttactaata tggccactgt ttagtatcaa atggaattgc ttgctcaatc
     1621 tcagagaatc atcttccaaa gcccacagac accatagcat ctgaggacaa agtgttctga
     1681 tggagaaaga gaaaataatt tatttttcac atccttccct atattggtta aagcttccct
     1741 ctgttgtgca gaaacttcct ctacaccttg catttgcttg gacattaaac aggtctgtag
     1801 tatctcaagc ctcagcaagg gtagtgatct atgggtgaga catgtggagg gcaaaactga
     1861 gtgaactgct gtcaggctgt ggccctgtga aggcgattat aactcccgca atgttggtac
     1921 cacagcggtt gctgggccag aacaagtggc caaggaccca ggaaatgggt gaggccaagc
     1981 aggtctaaga taatgcaaat gccttggaca gtttctcctt tgagaagggg ctgcagtata
     2041 atgcagcttg tttgtgaccc cttgtttatt cattttacta atcctccaga aagaatctta
     2101 ttcttcagcc tttagcacta ttaagcaatg tttaaaaact ccttatgagt gacagttact
     2161 tcttatttga tttaattgtc catatgtgga ccttttaagt taacactctc tgttacttcg
     2221 tctgaatagg taaggtgtaa tactacacat gcccactcac cacaacttgg atttttcatt
     2281 agtactggaa ccaacacgat gttgattcct cccattatga ctagaggaac caataagaat
     2341 aacttggaat cggtgaaaat agaggaactg agccagtttc cagccacttg ggttggaaga
     2401 gtgcccttgc ttcttttcag ttagaactgt gagaaatcag aaatttgaga gccctcaatt
     2461 agctagaagt tcaatggtag ttttggggga tggattgggt agaagtttgg actgtatttt
     2521 taaaaattct ttccacattt ttacaagatt gtccatttca agacagatct attcacatat
     2581 tcaacattgt atcaaaaatt tccttatagg gtatttacta aactgttttt cttatatgaa
     2641 agcgtctgcc atattaatgg tgtcctatgt gaatttcaca ttctataggg gaatagagct
     2701 cttcctgaca gtggggactg tgaagagctg gagaaatcct atagccttat gtgtgaccac
     2761 tatatgaaat tggccagcca tgatcccttt ccgatagata gattccaaat tagaatttta
     2821 aatgatttta aacatgactc agtttcttaa gtctctctat gaaaagaaat gttattacag
     2881 ttttttattt ctttttaaaa tgaatttgtc cataatagcc aatctggaca gccttgctct
     2941 ttgttaatgt cgcagtatat ttgcaccagt gcctcctggc ccagtcaagg ggagtctatt
     3001 ttcaaaacaa ccagttcaga gaaacagatt attcaactta accacagttt ttgttttcaa
     3061 caattgcaac agatttaccc agggaagatt acagtaaaat aaaattttag gtcagaacaa
     3121 ctgctgtcaa ggtttaagtt caactagaca gacaatttag ccctgcccaa aacagggtga
     3181 ctgaaaggat ggctgagtga tgttcctgaa ggaatgacat ggtgtctgcc ttgttggagg
     3241 attgtgttat cccacatagg aaccagacat gagagaaagc aaaactatgt gtcttgatga
     3301 gactcacctg gtgagaggta ctgagctagt cttcagatgt tgttttctca ctaagtcact
     3361 gggcactctg gccagcctct cttcagcatt tggaacccat ccattggtgt aggaaaaaga
     3421 atcagccccc actgctagaa ctggatctaa agtgctgggt ccagccacat ccctaacatt
     3481 tggcctgtcc tcaccaactg acacagggag atggaatgaa tttttataaa ccactcatca
     3541 gaaaacatgg aactttattt tacttcttat ttgagcaagg tggttattca agatgatcta
     3601 ttagatgatt acagattttg gatatcagta gatttcatgt tatttttaaa atttttgata
     3661 tatttgtttt tcaacagttt catgtgtttt cacatcatat tcggctgtgc attgaaaaaa
     3721 tgaaaatcaa accatgtact tttcactctg attattaaga gtggttagag gttgatattt
     3781 agccatctgt cctgtctgtg ctttgggaaa gggggaagag gctgatgaag ttatggataa
     3841 attctgggcg cgttgtgagg gcattggctg atgaaagggt gggttccttc acagttggcc
     3901 tttgagcaaa acactactgt attctactgc acctgtgcac agaggacctt attgtcctta
     3961 tattgactgt ttggcttaat tatgtgacta cgggcatgag aaatgagctc cgaattctta
     4021 tcccagttct ttccttgaca ttcctcttcc agtttgagga aaacctctag acctctttat
     4081 gtcatgcttc aaacctcagt aaagtagaac accatcttta ctaattaatt aatgattgca
     4141 aaaggcttgg aaatttccaa aggctgaata attgccaagt gaagactatt cagctttcca
     4201 ctcgctttca tttattttta atttttttta gtcactgatg gaaaacttac cctcatgtct
     4261 gaaaacaatt atactttatt acattgagtg cttctgggga gtttggcatt taacccatta
     4321 aggaaaaagt ttaaaagatg aaataaataa atctccctta tatttgagat gagctgcttt
     4381 agttttccta tatcaggata gtataaaaag aggaatatga tatagtaaaa aagaggagag
     4441 acaggatggg gaaaaggaga aaggaaagaa aaaatgaaaa ggaaaaaatg aagaaa
//
